Chii chinonzi Somatostatin? Ngatidzidzei nezvehomoni iyi inoshamisa iri mumuviri wedu!

Nhasi tichataura nezvemutumwa wemakemikari anoshamisa uye akakosha zvikuru mukati memiviri yedu. Zita rayo ndi somatostatin. Ungave usati wambonzwa nezvezita iri. Asi waizviziva here, rinobatsira kudzora zvinhu zvakawanda mumiviri yedu, sepfungwa yakavanzika. Ngatitarisei kuti somatostatin chii, kuti inoshanda sei, uye kuti inokosha sei kuhutano hwedu.

Chii chinonzi Somatostatin?

Zvichitaurwa zviri nyore, somatostatin ihormone inogadzirwa mumuviri wedu. Zvino ungave uchishamisika kuti 'mahormone' chii. Zviri nyore kwazvo. Mahormone makemikari anotakura mameseji pakati pezvikamu zvakasiyana zvemuviri wedu. Akafanana ne'postmen' mumuviri wedu. Mashoko aya anoudza nhengo dzedu, ganda, uye tsandanyama kuti dziite chimwe chinhu kana kuti dzirege kuita chimwe chinhu.

Saka, iyi hormone inonzi somatostatin inonyanya kumisa kugadzirwa kwemamwe mahormone, inodzora mamwe mabasa mudumbu redu (mudumbu (GI tract), uye inodzorawo kupatsanurwa nekukurumidza kwemasero (kunyanya masero ekenza). Zvakafanana nemapurisa emumugwagwa, kana chimwe chinhu chakawandisa, anopa chiratidzo chekuti, "Zvakanaka, zvakanaka, mira izvozvi."

Somatostatin iyi inogadzirwa kupi?

Iye zvino ngationei kuti iyi somatostatin hormone inoshamisa inogadzirwa kupi mumuviri wedu. Inogadzirwa munzvimbo dzakasiyana-siyana:

• Nzira yemudumbu (GI): Iyi ndiyo sisitimu yenhengo yakareba yakaita sechubhu inomhanya kubva mumuromo ichienda kuhuro iyo inotibatsira kugaya chikafu chatinodya. Apa ndipo panofanira kuva neura hwako.
• Pancreas: Iri igland riri mudumbu medu. Gland inhengo inogadzira mamwe makemikari. Pancreas inogadzira ma enzymes anobatsira kugaya chikafu, pamwe nemahormone akakosha akadai se insulin ne glucagon .
• Hypothalamus: Iyi iri muuropi hwedu. Yakafanana ne'control centre' yemuviri wedu. Inobatsira kuchengetedza homeostasis (kureva kuchengetedza nharaunda yemukati yakagadzikana). Inopawo mirairo kugland repituitary, riri pasi pehypothalamus, kuti riburitse mamwe mahormone.
• Sisitimu Yepakati Yetsinga (CNS): Izvi zvinosanganisira uropi hwedu nemusana. Mashoko anobva kuuropi anoenda kumuviri wese kuburikidza nesisitimu iyi yetsinga.

Mamwe mazita e somatostatin

Somatostatin inozivikanwawo nemamwe mazita akati wandei. Kana chiremba wako akataura rimwe remazita aya, pamwe anenge achireva chinhu chimwe chete:

• SS, SST kana SOM
• Homoni inodzivirira kukura kwehomoni (GHIH)
• Somatotropin release -inhibiting factor (SRIF)
• Homoni inodzivirira kusunungurwa kweSomatotropin (SRIH)

Ko somatostatin inoshandiswawo semushonga here?

Ehe, dzimwe nguva, vanachiremba vanoshandisa synthetic somatostatin semushonga wekurapa zvimwe zvirwere. Semuenzaniso:

• Zvimwe zvirwere zvemudumbu
• Acromegaly chirwere chisingawanzoitiki apo muviri unoburitsa mahormone ekukura akawandisa.
• Mamwe marudzi egomarara anonzi neuroendocrine tumors (NETs) .
• Zvimwe zvirwere zve endocrine system (kureva, glandular system inogadzira mahormone).

Ndeapi mabasa makuru ehomoni inonzi somatostatin?

Zvakanaka, ngationei kuti basa guru rehomoni iyi ye somatostatin chii.

Zvichitaurwa zviri nyore, basa rayo guru nderekumisa kugadzirwa kwemamwe mahormone anogadzirwa nehurongwa hwedu hwe endocrine uye kudzora kuburitswa kwemamwe mahormone kubva muhurongwa hwe exocrine.

'Endocrine system' inoreva sisitimu inoburitsa mahormone kubva mumagland ari mumuviri wedu zvakananga muropa. Mienzaniso inosanganisira thyroid gland, pituitary gland, uye adrenal glands . 'Exocrine system' inoreva sisitimu inoburitsa zvigadzirwa zvinogadzirwa nemagland kuburikidza ne duct. Mienzaniso inosanganisira magland emate ne sweat glands .

Saka, kungofanana nekudzima pombi yemvura, somatostatin inomisa kwenguva pfupi kufamba kwemahormone nezvimwe zvinobuda mumuviri wedu zvisingadiwe. Ingofunga, kana ukangosiya pombi yemvura yakavhurika, mvura inorasika, handiti? Saizvozvowo, kana muviri ukagadzira mahormone akawanda kupfuura aunoda, matambudziko anogona kumuka. Somatostatin inodzora izvozvo.

Chimwe chinhu ndechekuti somatostatin inobatsirawo kumisa masero kuti asapatsanuke nekukurumidza, senge masero ekenza.

Inoshandawo se neurotransmitter mu central nervous system yedu (CNS). Neurotransmitter imutumwa wemakemikari anoburitswa ne neurons imwe kuti ashandise simba kune imwe sero.

Mashandiro anoita somatostatin muzvikamu zvakasiyana zvemuviri wedu

Zvino ngationei kuti somatostatin inokanganisa sei chikamu chimwe nechimwe chemuviri wedu:

• Mu hypothalamus: Somatostatin inomisa kuburitswa kwemahormone anogadzirwa ne pituitary gland yedu, akadai se growth hormone , thyroid-stimulating hormone (TSH) , uye prolactin .
• Mupancreas: Pano, insulin ,Inodzivisa kuburitswa kwemahormone epancreas akadai seglucagon negastrin , uye inodzorawo kuburitswa kwemaenzymes epancreas anobatsira kugaya chikafu.
• Mudumbu (GI tract): Inoderedza kubuda kwemvura mudumbu, uko kunokurudzirwa patinodya. Inoderedzawo kuburitswa kwemahormone ekugaya akadai se secretin ne gastrin .
• Muhurongwa hwetsinga huru (CNS): Pano, zvinobatsira pakuchinja nzira inotumirwa nayo mameseji kuburikidza netsinga (neurotransmission) uye nzira iyo ndangariro dzinoumbwa nayo.

Chii chinokonzera kuburitswa kwe somatostatin?

Zvakanaka, saka ikozvino ungangove uchishamisika kuti, 'Somatostatin iyi inoburitswa sei? Chii chinokonzera?' Kutaura chokwadi, masayendisiti haasati anzwisisa zvizere kuti miviri yedu inodzora sei kuburitswa kweSomatostatin iyi, uye kuti ndeapi matishu anokonzera kuburitswa kwayo. Kusvika pari zvino, zvakaonekwa kuti kune marudzi akasiyana-siyana emasero nemapuroteni anobatanidzwa.

Imwe ongororo yakaratidza kuti glucose , sosi huru yesimba remuviri wedu, haingodzori chete kuburitswa kwe somatostatin, asiwo inobatsira mukugadzirwa kwayo. Muongororo iyoyo, masayendisiti akaona kuti kana huwandu hweshuga muropa hwaderera, insulin inokurudzira kuburitswa kwe somatostatin (kureva, inomisa kugadzirwa kwe insulin), uye kana huwandu hweshuga muropa hwakakwira , glucagon inokurudzira kuburitswa kwe somatostatin (kureva, inomisa kugadzirwa kwe glucagon).

Nemamwe mashoko, sezvo insulin ichideredza huwandu hweshuga muropa, kana shuga yako iri shoma muropa, somatostatin inoburitswa kudzivirira kuti isadzike, kumisa kuburitswa kweinsulin. Zvinoshamisa kuti zvinhu zvinodzorwa sei mumiviri yedu, handiti?

Matambudziko nemamiriro ezvinhu ane chekuita neSomatostatin

Kazhinji, matambudziko makuru ne somatostatin haawanzoitiki. Asi chirwere chikuru chinoitika imhando yekenza isingawanzoitiki inonzi somatostatinoma . Iri ibundu rinokura mu endocrine system. Bundu iri rinokura mu pancreas kana mu digestive system (GI tract). Izvi zvinokonzera kugadzirwa kwe somatostatin yakawandisa.

Dambudziko iri, rinonzi somatostatinoma, rinogona kuitika zvisina tsarukano, kana kuti rinogona kunge rakabatana nemamwe majini syndromes . Mamwe ematambudziko aya ndeaya:

• Multiple Endocrine Neoplasia (MEN type 1):Ichi chirwere chisingawanzoitiki, chine majini umo mabundu akawanda anokura muzvikamu zvakasiyana zve endocrine system.
• Neurofibromatosis rudzi 1 (NF1): Ichi chirwere chinogara nhaka. Chinokonzera mavanga emudumbu (café-au-lait spots) uye bundu risina njodzi paganda.
• Chirwere cheVon Hippel-Lindau: Ichi chirwere chisingawanzoitiki chinogarwa nhaka. Chinogona kukonzera bundu risina njodzi kana rakaipa kuumbwa muuropi, musana, maziso, itsvo, pancreas, uye adrenal glands.

Kana somatostatin ikagadzirwa zvakanyanya, kugadzirwa kwemamwe mahormone akawanda eendocrine kunodzikira zvakanyanya. Zviratidzo zveizvi zvinogona kunge zvakafanana nezviratidzo zvezvimwe zvirwere zvakawanda. Nokudaro, dzimwe nguva zvinogona kuoma kuona chirwere chinonzi somatostatinoma nemazvo.

Chinhu chakakosha ndechekuti matambudziko aya ane chekuita ne somatostatin haawanzoitiki , zvichireva kuti vanhu vazhinji havana chekunetseka nacho.

Uyewo, kwave nemishumo mishoma yekuti huwandu hwe somatostatin huri pasi pane hwakajairika mumuviri wemunhu.

Ndezvipi zvidzidzo zvinoongorora huwandu hwe somatostatin?

Nekuti matambudziko ane chekuita nesomatostatin haawanzo kuwanikwa, vanachiremba havawanzo ongorora huwandu hwesomatostatin hwemunhu wese. Zvisinei, kana paine fungidziro yebundu risingawanzo kuwanikwa rinoburitsa somatostatin yakawandisa inonzi somatostatinoma, sezvambotaurwa, kuongororwa kweropa kunonzi somatostatin-like-immunoreactivity (SLI) kunoshandiswa kuona kuti rine chirwere ichi.

Ndirini pandinofanira kuona chiremba nezvehuwandu hwangu hwe somatostatin?

Kazhinji haufanirwe kunetseka nezvehuwandu hwe somatostatin mumuviri wako, sezvo paine matambudziko mashoma ane chekuita neizvi.

Zvisinei, kana nhengo yemhuri yepedyo (mubereki kana munin'ina) akaonekwa aine chirwere chakadai se multiple endocrine neoplasia type 1 (MEN type 1), neurofibromatosis type 1 (NF1), kana chirwere cheVon Hippel-Lindau, zvakakosha kuudza chiremba wako. Nekuti izvi zvirwere zvinogarwa nhaka, unogona kunge uri panjodzi yekubatwa ne somatostatinoma. Chiremba wako anogona kuita bvunzo kuti aone kana uine chirwere ichi.

Zvinhu zvakakosha zvekurangarira (Mharidzo Yekuenda Kumba)

Zvakanaka, hezvino zvinhu zvakakosha zvaunofanira kurangarira kubva pane zvatataura nezvazvo nhasi:

• Somatostatin ihormone 'master' inoita basa rakakosha mumuviri wedu, ichidzora mamwe mahormone.
• Inonyanya kudzora zvinhu zvakaita sekugadzirwa kwemamwe mahormone, kushanda kwegadziriro yekugaya chikafu, uye kupatsanurwa kwemasero nekukurumidza.
• Matambudziko ne somatostatin anowanzo kuve mashoma.Dambudziko guru ibundu risingawanzoitiki rinonzi somatostatinoma.
• Kana paine munhu mumhuri yako ane zvirwere zvemajini zvakaita seMEN type 1, NF1, kana chirwere cheVon Hippel-Lindau , taura nachiremba wako nezvazvo.
• Musatya izvi pasina chikonzero. Zvakakosha kuziva nezvemaitiro aya anoshamisa ari mumiviri yedu.

Saka, somatostatin chinhu chisingatauri, asi chakakosha zvikuru, mumiviri yedu. Chero bedzi ichiita basa rayo nemazvo, hatina chekutya!

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