Ngatidzidzei nezvechirwere cheTangier, chinoitika kuvanhu vane cholesterol yakaderera (HDL) mumuviri.

Wakambonzwa nezverudzi rwecholesterol inonzi good cholesterol (HDL / high-density lipoprotein) here? Ehe, hongu... Nhasi tichataura nezvechirwere chisingawanzoitiki chinoitika kana huwandu hweiyi good cholesterol mumuviri wedu hwakaderera zvikuru. Ichi chinonzi Tangier Disease . Ungave usingazive zita iri, asi zvakakosha zvikuru kuziva nezvaro.

Chii chinonzi Tangier Disease? Ngatizvinzwisise zviri nyore!

Zvakanaka, ngatitangei kubva pakutanga. Chirwere cheTangier chirwere chisingawanzoitiki chatinowana kubva kuvabereki vedu, ndiko kuti, chakagarwa nhaka nemajini . Vanhu vane chirwere ichi vane mwero wakaderera we good cholesterol (HDL) mumiviri yavo. Waizviziva here kuti, iyi HDL cholesterol hainzi "good cholesterol" pasina. Ndivo vanobatsira kuchengetedza miviri yedu yakachena nekubvisa cholesterol yakaipa (LDL / low-density lipoprotein) inowanzo ungana mutsinga dzedu dzeropa, ndiko kuti, mutsinga dzedu .

Chimbofunga nezvezvinoitika kana cholesterol yakanaka iyi (HDL) yadzikira. Iyo cholesterol yakaipa (LDL) nemamwe marudzi emafuta (lipids) anotanga kuungana mutsinga dzedu. Sezvinongoita tsvina inonamira mupombi yemvura. Izvi zvinogona kukonzera matambudziko pamwoyo yedu, kurwara nemoyo , kana kutotungamira kuzvirwere zvakaita sestroke . Kwete izvozvo chete, chirwere ichi chinogona kukanganisa dzimwe nhengo dzakawanda mumuviri wedu.

Sei yakanzi "Tangier"?

Iyi inyaya inonakidza zvikuru. Chirwere ichi chinonzi "Tangier" nekuda kwechitsuwa cheTangier , chiri mhiri kwegungwa kubva kuhurumende yeVirginia yeUS. Chirwere ichi chakatanga kuwanikwa pakati pevanhu vaigara pachitsuwa ichocho. Zvisinei, izvi hazvirevi kuti ichi chinhu chinongowanikwa pachitsuwa ichocho chete. Kune vanhu vane chirwere ichi mune dzimwe nyika dzepasi rose zvakare.

Chirwere cheTangier chakajairika zvakadii?

Kutaura zvazviri, chirwere cheTangier chirwere chisingawanzoitiki . Vanhu vashoma chete, vanosvika zana, ndivo vakaonekwa pasi rose. Ndosaka chisinganyanyi kutaurwa nezvacho. Asi kunyangwe chisingawanzoitiki, zvakakosha kuziva nezvechirwere ichi, handiti?

Chirwere cheTangier chinokanganisa sei miviri yedu?

Hezvino zvinoitika. Kana tine chirwere cheshuga, huwandu hwakanaka hwecholesterol (HDL) mumuviri wedu hushoma, saka mafuta (lipids) haagone kutakurwa kuenda kuchiropa chedu nemazvo. Chiropa ndicho chinobvisa mafuta aya asingadiwe mumuviri. Saka, mafuta aya asingabviswe zvishoma nezvishoma anotanga kuungana munzvimbo dzakasiyana dzemuviri wedu. Kana mafuta aya aungana, nhengo iyoyo inogonawo kukura zvishoma.

Mafuta anowanzoiswa muropa nenzira iyi:

• Chiropa: Chiropa chinogona kukura.
• Chidendene:Chidende chinogonawo kuzvimba uye kukura.
• Matonsi: Matonsi ari pahuro pedu. Anogona kuita ruvara rweyero-orenji kana akazara nemafuta.
• Manodhi elymph: Aya ndiwo chikamu chemuviri wedu wekudzivirira muviri. Anogonawo kuzvimba.
• Mwoyo: Izvi zvinogonawo kukanganisa mashandiro emoyo.
• Uropi: Dzimwe nguva uropi hunogonawo kukanganiswa.

Kuwedzera kune izvi, mamwe matambudziko anogona kuitika:

• Matambudziko etsinga: Matambudziko etsinga, akadai sekushaya simba mumakumbo, anogona kuitika.
• Ma triglyceride akakwira: Urwu rudzi rwemafuta anowanikwa muropa, kungofanana necholesterol.
• Matambudziko ekuona: Panogona kunge paine makore asingawanzoonekwi mumaziso, uye dzimwe nguva kuona kunogona kuderera.

Ndezvipi zviratidzo zvechirwere cheTangier?

Izvi zvakakosha zvikuru. Zviratidzo zveTangier Disease zvinogona kusiyana kubva pamunhu kusvika pamunhu. Zvinoenderana nekuti mafuta ari mumuviri ari kupi, sezvandambotaura. Vamwe vanhu vanogona kuratidza zviratidzo pakuzvarwa, nepo vamwe vangasaratidza zviratidzo zvikuru kusvika vava nemakore 60-65 ekuberekwa.

Heano mamwe ezviratidzo zvakajairika:

• Kurwadziwa kwemudumbu kana kuda kurutsa.
• Mafuta ari mutsinga dzeropa (atherosclerosis): Izvi zvinowedzera njodzi yechirwere chemwoyo.
• Ganda rakaoma.
• Kutenderedzwa kwemaziso mukati (Ectropion): Ichi chiratidzo chisingawanzoitiki.
• Anemia: Izvi zvinoreva kushaya ropa.
• Kushaya simba kwetsandanyama mumaoko, makumbo, maoko, kana tsoka.
• Ma lymph nodes akazvimba kwenguva yakareba pasina hutachiona.

Yeuka, dzimwe nguva zviratidzo izvi zvinogona kufungidzirwa kuti zvine chekuita nezvimwe zvirwere, ndosaka zvichikosha kuti uwane chirwere chakarurama.

Chii chinokonzera chirwere cheTangier? Ngatitaurei nezvemajini!

Chirwere cheTangier chinokonzerwa nekusakwana kuri mujini rinonzi ABCA1 gene ratakagara nhaka kubva kuvabereki vedu. Zvichitaurwa zviri nyore, jini reABCA1 rine mirairo yekubvisa cholesterol kubva mumasero edu uye kuiisa mucholesterol yakanaka (HDL). HDL inotakura cholesterol iyi kuchiropa, uko inoburitswa.

Zvino, kana paine chikanganiso kana shanduko mujini iri reABCA1, mirairo iyoyo haishande nemazvo. Saka kubviswa kwecholesterol kubva mumasero uye kuumbwa kweHDL hazviitike nemazvo. Mugumisiro wacho ndewekuti mazinga eHDL anodzikira zvakanyanya.

Aya ndiwo maitiro ayo ekugara nhaka:

• Kana vabereki vese vakagara nhaka yejini reABCA1 risina kunaka, mwana achava nechirwere cheTangier.
• Kana mubereki mumwe chete akagara nhaka jini rakakanganisika, mwana ndiye anenge aine chirwere ichi. Vangasaratidze zviratidzo, asi huwandu hwavo hweHDL hunogona kunge hwakaderera pane hwakajairwa.

Zvino fungidzira kuti vabereki vese vari vaviri vane jini iri risina kunaka, zvichireva kuti vangave vasina zviratidzo, asi vese vane jini racho. Kana vabereki vakadaro vaine mwana:

• Pane mukana we25% (1/4) wekuti mwana awane chirwere cheTangier.
• Pane mukana we50% (1/2) wekuti mwana wacho achava mutakuri wechirwere ichi.
• Pane mukana we25% (1/4) wekuti mwana haazogari nhaka yemajini asina kunaka uye achave neutano hwakanaka.

Izvi zvakafanana nekukanda mari wobva watora misoro kana miswe. Mikana iyi yakafanana pakubata pamuviri pese.

Vanachiremba vanoongorora sei chirwere cheTangier?

Kuti uzive kana uine chirwere cheTangier, unofanirwa kuona chiremba. Iye achatanga aita bvunzo yemuviri uye obvunza nezvezviratidzo zvako. Zvadaro, vacharaira kuongororwa kweropa kakawanda. Kuongororwa kweropa uku kunonyanya kutarisa huwandu hweHDL cholesterol yako uye kuti protein yako inonzi apolipoprotein A1 (ApoA1) yakaderera zvakadii. Zvese izvi zvakaderera zvikuru kuvanhu vane chirwere cheTangier.

Kuongororwa kwemajini kunogonawo kuitwa kuti kusimbiswe chirwere chacho. Kunogona kutarisa kana paine shanduko chaiyo mujini reABCA1. Zvisinei, kuongororwa kwemajini kungasawanikwe kwese kwese. Muzviitiko zvakadaro, chiremba wako anogona kutora chidimbu chidiki chenyama (biopsy) kubva kunhengo yemuviri wako, senge matoni ako, ganda, kana chiropa. Rudzi rwemafuta ari munyama idzi runogona kushandiswa kuwana pfungwa yechirwere chacho.

Ndeapi mapuroteni asina kukwana muTangier Disease?

Muchirwere cheTangier, puroteni inonzi apolipoprotein A1 (ApoA1) inodzikira zvakanyanya. ApoA1 iyi chikamu chikuru chemorekuru yeHDL cholesterol. Saka kana ApoA1 yadzikira, huwandu hweHDL hunodzikirawo.

Ndezvipi zviedzo zvinoshandiswa pakuongorora chirwere uye kutevera?

Vanachiremba vanogonawo kuita mimwe miedzo yakati wandei kuti vaongorore chirwere ichi uye vatarise migumisiro yechirwere ichi pamuviri.

• Kuongororwa kwetsinga netsandanyama (Electromyograms / EMGs): Tarisa kana tsinga dzakakuvara uye tsandanyama dzisina simba.
• Kuongororwa kwemaziso: Tarisa kana paine matambudziko ekuona zvisina kujeka kana kuona zvakanaka.
• Ultrasound padumbu/mudumbu mako: Tarisa mamiriro enhengo dzakadai sechiropa nespleen.
• Ultrasound patsinga dzeropa rako: Tarisa kana paine mafuta akawanda mutsinga huru dziri mumutsipa wako.
• CT angiogram yemwoyo wako:Tarisa kana paine tsinga dzinopa ropa kumoyo.
• Echocardiogram: Kuongororwa kwemoyo kuti uone mashandiro uye chimiro chemoyo.
• Kuedza kushushikana kwemuviri: Ona kuti mwoyo unoita sei kana uchiita maekisesaizi.

Chirwere cheTangier chinorapwa sei?

Kutaura chokwadi, hapana mushonga chaiwo unogona kurapa chirwere cheTangier zvachose. Nekuti chirwere ichi chinokonzerwa nemajini, pane zvakawanda zvaunogona kuita kudzora zviratidzo uye kuderedza matambudziko.

Dzimwe nguva, nhengo yemuviri inenge yakuvadzwa nemafuta akaunganidzwa, semuenzaniso matonsi kana chirebvu, ingangoda kubviswa nekuvhiyiwa .

Zvokudya nezvinwiwa zvinogona kubatsira here?

Ehe, zvinogoneka zvechokwadi. Kune zvimwe zvekudya zvinogona kubatsira kuwedzera zvishoma huwandu hwedu hwe good cholesterol (HDL), uye zvakare kubatsira kuderedza huwandu hwedu hwe bad cholesterol (LDL).

• MaAvokadho
• Mafuta emuorivhi
• Nyemba dzakadai sebhinzi nenyemba (Bhinzi)
• Zviyo zvese (semuenzaniso, mupunga wehupfu hwese, mupunga wehupfu hwese)
• Hove dzine mafuta ( semuenzaniso salmon, mackerel, herring)
• Nzungu ( semuenzaniso nzungu, maarumondi, macashew - asi pasina munyu)
• Michero ine faibha yakawanda (semuenzaniso magwava, mango, bhanana)
• Mbeu dzeChia nembeu dzeflax

Kuedza kuisa zvekudya izvi mukudya kwako nguva dzose kuchakubatsira kuchengetedza huwandu hwakanaka hwecholesterol.

Ndezvipi zvinoshandiswa pakurapa nemishonga uye mararamiro?

Chiremba wako anogona kukupa mishonga inoderedza cholesterol , yakadai se statins.

Inokurudzirawo kuchinja mararamiro ako nenzira dzakasiyana-siyana dzinogona kubatsira kuwedzera huwandu hweHDL:

• Kurovedza muviri kakawanda: Izvi zvinosanganisira kufamba kana kumhanya kwemaminitsi makumi matatu pazuva.
• Kusashandisa zvigadzirwa zvefodya: Unofanira kurega kusvuta fodya zvachose.
• Kuramba uine huremu hwakanaka.
• Idya mafuta asina mafuta akawanda panzvimbo pemafuta akawandisa: Mafuta akazara anowanikwa mumafuta akaita semafuta ekokonati, mafuta emuchindwe, nemafuta emhuka. Mafuta asina mafuta akawanda anowanikwa mumafuta emuorivhi nemaavocado.

Ndezvipi migumisiro yekurapwa?

Mishonga inoderedza cholesterol dzimwe nguva inogona kukonzera migumisiro midiki. Havasi vese vanoiwana, asi zvakanaka kuziva nezvayo.

• Musoro
• Kurwadza kwetsandanyama
• Kuzvimba
• Dumbu rakagumbuka

Kana chimwe chinhu chakadai chikaitika, unofanira kuudza chiremba wako. Ipapo anogona kuchinja mushonga kana kukupa mamwe mazano.

Chirwere cheTangier chinogona kudzivirirwa here?

Sezvo ichi chiri chirwere chemajini, hatigone kuchidzivisa kukura kwacho. Izvi zvinoreva kuti kana uine dambudziko iri mumajini ako, harigone kuchinjwa. Zvisinei, kana uine chirwere ichi, kana kuti uri mutakuri wechirwere ichi, unogona kubvunza nyanzvi yemajini kuti uone njodzi yekuti vana vako vagochigara nhaka. Zvadaro, uchifunga nezvemamiriro emajini emumwe mubereki, unogona kuwana pfungwa yakajeka yemikana yekuti vana vako vawane chirwere ichi.

Kana ndine chirwere cheTangier, chii chichaitika mune ramangwana?

Kufanotaura kwevanhu vane chirwere cheTangier Disease kazhinji kwakanaka, asi zvinoenderana nekuti zviratidzo zvako zvakura sei. Sezvakaita chero chirwere chipi zvacho, kuongororwa kwekutanga ndiko kwakanakisisa, zviratidzo zvisati zvanyanya kuipa.

Kunyange hazvo pasina mushonga chaiwo weizvi parizvino, pane tariro yekuti zvinhu zvakaita sekurapa majini zvichabatsira mune ramangwana. Tsvagiridzo ichiri kuenderera mberi.

Chirwere cheTangier chinotora nguva yakareba sei?

Sezvo ichi chirwere chinokonzerwa nemajini, chinogara kwenguva refu. Zvisinei, kana chikaonekwa nekukurumidza uye chichiongororwa nguva nenguva, chirwere ichi chinogona kurapwa zvakanaka uye kurarama nacho.

Ndinozvitarisira sei?

Kana uine chirwatata chakakura nekuda kwechirwere cheTangier, unofanira kudzivisa mitambo yekubata nhengo dzemuviri, nekuti kubata kwakadaro kunogona kukonzera kuti chirwatata chitsemuke, izvo zvine njodzi.

Pamusoro pezvo, zvimwe zvinhu zvinokonzera chirwere chemwoyo zvinofanirawo kudzorwa:

• Kudzora BP yakakwira .
• Kana uine chirwere cheshuga , chidzore zvakanaka.
• Kudzivisa kushandiswa kwefodya.

Ndinofanira kuona chiremba rini?

Kana uine chirwere cheTangier, unofanira kuona chiremba wako nguva nenguva . Nenzira iyi, kana zviratidzo zvako zvikawedzera, unogona kutora matanho nekukurumidza.

Chiremba anowanzo tarisa zvinhu izvi:

• Sisitimu yetsinga.
• Mwoyo.
• Maziso.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Kana ukaona chiremba wako, unogona kubvunza mibvunzo yakaita seiyi:

• Ndinofanira kutora mishonga here kuti ndiwedzere cholesterol yangu?
• Pane boka rekutsigirana rinogona kujoinhwa nevanhu vane chirwere cheTangier here?
• Ndinofanira kuuya kuzokuonai kangani?

Sezvo chirwere cheTangier chichigona kukanganisa nhengo dzakasiyana dzemuviri, zvakanaka kuti ugare uchiongororwa nhengo imwe neimwe. Ungangoda kuona nyanzvi dzakasiyana-siyana. Tora mushonga sezvawakarairwa nachiremba wako, uye ita zvese zvaunogona kuti urambe uchidya zvine hutano uye uchirovedza muviri.

Zvinhu zvakakosha zvatinofanira kurangarira (Mharidzo Yekuenda Kumba)

Zvakanaka, regai ndipfupise zvimwe zvezvinhu zvaunofanira kurangarira kubva pane zvatataura nezvazvo.

• Chirwere cheTangier chirwere chisingawanzoitiki, chine majini chinokonzera kudzikira kukuru kwecholesterol yakanaka (HDL).
• Izvi zvinogona kukonzera kuti cholesterol yakaipa (LDL) nemafuta zviungane mumuviri uye zvichikanganisa nhengo dzakadai sechiropa, spleen, tonsils, nemoyo.
• Zviratidzo zvinosiyana, uye vamwe vanhu vanogona kusangana nematambudziko etsinga, matambudziko eganda, uye matambudziko ekuona.
• Izvi zvinokonzerwa nekusakwana kuri mujini reABCA1 .
• Chirwere ichi chinoonekwa kuburikidza nekuongororwa kweropa, kuongororwa kwemajini, uye dzimwe nguva kuongororwa kwenyama (biopsy) .
• Kunyange hazvo pasina mushonga chaiwo, zviratidzo zvinogona kudzorwa nekudya, kuchinja mararamiro, mishonga, uye mamwe maoparesheni.
• Kuonekwa kwechirwere nekukurumidza uye kurapwa nguva nenguva kwakakosha zvikuru.

Saka, ndinovimba ruzivo urwu ruchakubatsira. Kana uine mimwe mibvunzo nezveizvi, usazeza kutaura nachiremba. Ramba uine hutano hwakanaka!

Chirwere cheTangier , HDL cholesterol, LDL cholesterol, zvirwere zvemajini, kutonga cholesterol, njodzi yezvirwere zvemwoyo, ApoA1