Wakambonzwa nezveWaldenström Macroglobulinemia here? Izita refu, rakaoma kutaura, handiti? Chaizvoizvo imhando yekenza inokura zvishoma nezvishoma muropa. Ungave usina kunzwa nezvayo, nekuti chirwere chisingawanzoitiki. Asi hazvina kuipa, nhasi tichataura nezvazvo zviri nyore, nenzira yaunogona kunzwisisa.
Chii chinonzi Waldenstrom macroglobulinemia (WM)?
Muchidimbu, Waldenstrom macroglobulinemia, kana kuti WM muchidimbu, ikenza yeropa . Imhando yekenza inonzi non-Hodgkin lymphoma, inozivikanwawo se lymphoplasmacytic lymphoma. Hazviwanzoitiki. Ingofunga, kunyangwe munyika yakaita seAmerica, vanhu vatatu kusvika vana chete pamamiriyoni vanorwara nechirwere ichi.
Saka, `(WM)` iyi inokura sei? Tine mupfupa mumuviri wedu, uye ndipo panogadzirwa masero edu eropa. Chirwere ichi chinotanga apo mamwe masero anonzi `(masero eB)` (aya rudzi rwesero muimmune system yedu, kureva masero anotidzivirira kubva kuzvirwere) mupfupa iyi anova masero ekenza.
Masero egomarara aya, pachinzvimbo chekusiyiwa ari ega, anotanga kugadzira mamwe masero akafanana nawo. Sezvakaita sora musango. Chii chinoitika ipapo? Masero eropa ane hutano anodiwa nemuviri wedu haana nzvimbo, uye anotanga kudzikira.
- Kana masero matsvuku eropa akaderera, pane chirwere chekushaya ropa. Izvi zvinoita kuti unzwe kuneta uye kucheneruka.
- Kana masero machena eropa akaderera, chirwere chinonzi ``neutropenia'' chinoitika, zvichiita kuti uve nyore kubatwa nechirwere.
- Kana maplatelet (masero anobatsira kuumba ropa) akaderera (thrombocytopenia), kubuda ropa kunogona kusamira zviri nyore.
Kwete izvozvo chete, masero egomarara aya anogadzira puroteni isina kujairika inonzi `(immunoglobulin M)` kana `(IgM)`. Kana puroteni iyi `(IgM)` yakakwira zvakanyanya muropa, ropa redu rinova gobvu, sehuchi . Izvi zvinonzi `(hyperviscosity syndrome).` Kana ropa rikanyanya kuoma seizvi, zvinova zvakaoma kuti ropa riyerere nepakati petsinga diki dzeropa mumuviri wese. Zvadaro, zviratidzo zvakakomba zvinogona kuoneka.
Chinhu chakakosha ndechekuti hapasati pava nemushonga weWM. Asi musazvidya moyo. Kune mishonga inogona kubatsira kudzora zviratidzo, dzimwe nguva kutozvibvisa, uye kukubatsirai kuti murambe muine hutano hwakanaka. WM inowanzova chirwere chinokura zvishoma nezvishoma, saka munogona kurarama nacho zvakanaka kwemakore.
Ndezvipi zviratidzo zvechirwere ichi chinonzi `(WM)`?
Fungidzira, munhu mumwe chete pavanhu vana vane chirwere ichi haaratidzi zviratidzo . Vanongoziva nezvechirwere ichi chete pavanoenda kunoona chiremba nekuda kwechimwe chikonzero. Asi, kana zviratidzo zvikaonekwa, zvinowanzouya zvishoma nezvishoma . Ngationei kuti zviratidzo izvi ndezvipi:
- Kushaya simba uye kuneta nguva dzose:Zvinoita sekunge bhatiri rapera.
- Fivha: Muviri unonzwa kupisa pasina chikonzero.
- Kushaya chikafu: Kunzwa kuda kudya.
- Kudikitira husiku: Kudikitira zvakanyanya paunenge wakarara.
- Kuderedza huremu: Unova mutete pasina chikonzero chaicho.
- Kuvhiringidzika: Kuomerwa nekutarisa, kuvhiringidzika zvishoma.
- Kuzvimba kwechiropa, spleen, kana lymph nodes: Chiremba chete ndiye anogona kukuudza chokwadi.
- Zviratidzo zve peripheral neuropathy, zvakaita sekuoma kweminwe nezvigunwe : Zvinonzwa sekunge uri kunzwa kukwenya, kana kurasikirwa nekunzwa.
- Zviratidzo zvekugwamba kweropa: kubuda ropa mumhino, kubuda ropa mukanwa paunenge uchikwesha mazino, dzungu, musoro, uye kuona zvisipo.
Kungoti une chimwe kana zviviri zvezviratidzo izvi hazvirevi kuti une WM. Asi kana zviratidzo izvi zvikaramba zviripo, zvakanaka kutsvaga rubatsiro rwechiremba.
Ndezvipi zvikonzero zvekuumbwa kwe `(WM)`?
Chikonzero chikuru cheWaldenstrom's macroglobulinemia ikuchinja kwemajini . Vanhu vanopfuura 90% vane chirwere ichi, kana kuti vanhu vapfumbamwe pagumi, vane kuchinja kwemajini kunonzi MYD88. Vanhu vanosvika 40% vane kuchinja kwemajini kunonzi CXCR4. Kuchinja kwemajini uku kwese kunobatsira masero asina kujairika muWM kupatsanurana nekukurumidza.
Chinhu chakakosha ndechekuti shanduko idzi dzemajini hadzisi dzenhaka . Kureva kuti, hadzisi chinhu chaunowana kubva kuvabereki vako, uye hadzisi chinhu chaunopfuudza kuvana vako. Dzinoitika muhupenyu hwako hwese. Zvisinei, vaongorori havasati vava nechokwadi chekuti chii chinokonzera shanduko idzi dzemajini pakutanga.
Ndiani ari panjodzi huru yekubatwa nechirwere ichi? (Zvinhu zvine njodzi)
Pane zvimwe zvinhu zvinowedzera mikana yekukura kwe `(WM)`. Ngationei kuti chii:
- Zera: Chirwere ichi chinowanzoonekwa nevanhu vane makore 65 zvichikwira.
- Rudzi: Chirwere ichi chinonyanya kuwanikwa pakati pevanhu vachena.
- Murume kana Mukadzi: Varume vane mukana mukuru wekuwana chirwere ichi.
- Zvimwe zvirwere: Unogona kunge uri panjodzi yakakura kana uine zvirwere zvakaita se `(Hepatitis C)`, `(AIDS)`, `(Sjögren's Syndrome)`, kana chirwere chinonzi `(MGUS - Monoclonal Gammopathy of Undetermined Significance)` (izvi zvinotangira `(WM)`). Zvisinei, zvakakosha kuyeuka kuti havasi vese vane `(MGUS)` vachava ne `(WM)`.
- Nhoroondo yemhuri: Kana hama dzako dzeropa dzakambova neWM kana mamwe marudzi elymphoma, iwe unogona kunge uri panjodzi.
Ndezvipi zvinetso zvinogona kukonzera chirwere ichi?
Mune zvimwe zviitiko zvakakomba, WM inogona kukonzera mamwe matambudziko.
- Amyloidosis: Apa ndipo apo mapuroteni asina kunaka anoiswa munhengo dzakadai semwoyo, mapapu, neitsvo.
- Cryoglobulinemia: Mumamiriro ezvinhu aya, mamwe mapuroteni eropa anopindura kutonhora anoungana mumakumbo uye anobatana. Izvi zvinogona kukonzera kurwadziwa uye ruvara rwebhuruu/chena (cyanosis).
Vanachiremba vanoongorora sei chirwere ichi? (Kuongororwa)
Chiremba wako anogona kushandisa bvunzo dzakasiyana-siyana kuti aone kana une WM. Dzinonyanya kutsvaga masero ekenza neproteni yeIgM yatakambotaura nezvayo.
- Kuongororwa kweropa neweti: Kuongororwa kweropa neweti kunotorwa kuti kuonekwe zviratidzo zveWM. Kunotsvaga zvinhu zvakaita sehuwandu hwemasero eropa mashoma uye mapuroteni eIgM asina kujairika.
- Miedzo yekufungidzira: Kuongororwa kweCT kana CT-PET, inova musanganiswa weCT nePET scan, inoshandiswa kutsvaga zviratidzo zveWM mumuviri. Miedzo iyi inotsvaga zvinhu zvakaita senhengo dzakazvimba uye ma lymph nodes.
- Kuongororwa kweziso: Kuongororwa kana ropa riri kubuda mukati meziso. Ichi chiratidzo chekugwamba kweropa.
- Kuongororwa kwemapfupa emubofu: Izvi zvinosanganisira kutora sampuli diki yemapfupa emubofu woitarisa pasi pemaikorosikopu kuti uone kana paine masero ekenza.
`(WM)` inorapwa sei?
Sezvatakambotaura, hapasati pava nemushonga wechirwere ichi. Saka, mushonga wakanakisa ndewekuderedza zviratidzo pasina migumisiro yakawanda . Chiremba wako achataura newe uye achagadzira hurongwa hwekurapa hwakakunakira. Heano mamwe emhando dzekurapa kwe `(WM)`:
- Kumirira wakangwarira: Kana usina zviratidzo, chiremba wako anogona kusatanga kurapwa. Vamwe vanhu vane WM vanogona kusada kurapwa kwemakore.
- Kuchinjana kweplasma / plasma: Izvi zvinosanganisira kushandisa muchina kuchenesa protein yeIgM isina kujairika kubva muplasma, chikamu chemvura cheropa rako. Plasma yakacheneswa inozodzorerwa muropa rako. Kurapa uku kunoshandiswa kuderedza zviratidzo zvekugwamba kweropa.
- Kurapa Nezvirwere Zvinodzivirira Muviri: Kurapa uku kunoshandisa masoja emuviri wako kuparadza kana kuderedza kukura kwemasero eWM. Mushonga weRituximab (Rituxan®) unowanzopihwa wega kana pamwe chete nechemotherapy.
- Kurapa nemakemikari: Mishonga inouraya masero ekenza inogona kupihwa yoga kana pamwe chete ne immunotherapy.
- Corticosteroids: Mhando yemishonga yesteroid, yakaita sedexamethasone, inogona kupihwa pamwe chete nekurapwa kwekudzivirira muviri uye chemotherapy. Inobatsira kurwisa kenza ukuwo ichideredzawo migumisiro yemishonga.
- Kurapa kwakanangana:Kurapa uku kunoshanda nekuvharira mapuroteni anoshandiswa nemasero egomarara kukura. Ibrutinib (Imbruvica®) uye zanubrutinib (Brukinsa®) inzira mbiri dzekurapa dzakatenderwa neU.S. Food and Drug Administration (FDA) kurapa WM.
- Kuisirwa kwemasero emuviri: Mukuita izvi, mwongo wemapfupa wakagwinya unosimwa kuti utsive mwongo wemapfupa wakakanganiswa nemasero asina kujairika. Izvi hazviitwe kakawanda, uye zvinongoitwa chete kune varwere vakasarudzwa.
Ndinofanira kutsvaga mazano ekurapa rini?
Kana waonekwa kuti une WM, taura nachiremba wako nekukasika kana uine zviratidzo zvitsva kana kuti uri kunetseka nezvezviratidzo zviripo. Kana waonekwa kuti une WM, zvakakosha kubvunza mibvunzo kuti uzive zvekutarisira. Heano mimwe mibvunzo yaunogona kubvunza chiremba wako:
- `(WM)` yakakomba zvakadini? Izvi zvichakanganisa sei hupenyu hwangu?
- Chii chandinofanira kutarisira munguva pfupi nerefu?
- Ndinofanira kutanga kurapwa nekukasika here?
- Munokurudzira rudzii rwekurapwa?
- Ndezvipi zvimwe zvinokanganisa zvinogona kutarisirwa kubva mukurapwa?
Chii chandingatarisira kana ndine chirwere ichi?
Havasi vanhu vese vane chirwere chinokura zvishoma nezvishoma seWaldenstrom's macroglobulinemia vakafanana. Tsvagiridzo inoratidza kuti 66%, kana kupfuura vanhu vaviri pavanhu vatatu, vachiri vapenyu makore gumi mushure mekuonekwa vaine chirwere ichi. Zvisinei, nguva yekupona inogona kusiyana nezera . Vanhu vazhinji vanopfuura makore makumi matanhatu nemashanu (boka rezera rinowanzoonekwa vaine chirwere ichi) vanofa nezvikonzero zvisina chekuita neWM.
Zvinhu zvakawanda zvinokanganisa kufambira mberi kwechirwere chako. Semuenzaniso:
- zera rako
- Zvakabuda pakuongororwa ropa
- Rudzi rwekuchinja kwemajini (dzimwe nguva kusavapo kwekuchinja kwe`(MYD88)` kunogona kuratidza mhedzisiro yakaipa)
Kana muine mibvunzo nezvechirwere chenyu, taurai nachiremba wenyu . Iye anonyatsoziva zvamunoita uye zvinhu zvinogona kukanganisa hutano hwenyu.
Pane chandingaita here kuti ndinzwe zviri nani?
Kurarama nechirwere chelymphoma chakaita seWaldenstrom's macroglobulinemia kunogona kureva kuchinja kukuru muhupenyu hwako. Zvakakosha kushandisa zvese zvaunazvo. Taura nachiremba wako nezvekudya zvekudya uye matanho ekuzvitarisira .
Kuti usanzwa kusurukirwa, batana nevamwe vane chirwere ichi chisingawanzoitiki. Kunyangwe uchinzwa saizvozvo pakutanga paunoziva kuti une chirwere ichi, hausi wega uri parwendo urwu . Bvunza chiremba wako uye batana nemapoka ekutsigirana.
Pakupedzisira, yeuka izvi.
Vaongorori havasati vawana mushonga weWaldenstrom macroglobulinemia (WM). Zvisinei, vakawana nzira dzakasiyana-siyana dzekurapa dzinoita kuti kurarama nechirwere ichi kuve nyore . Vanhu vazhinji vanorarama nechirwere ichi kwemakore vasina zviratidzo. Nzira itsva dzekurapa dziri kubvumira vanhu vane WM kurarama kwenguva yakareba kupfuura kare, vasingakanganisi hupenyu hwavo.
Kana ukabatwa nechirwere ichi, usavhunduka wobvunza chiremba wako nezveramangwana renguva pfupi nerenguva refu. Vachakubatsira kusarudza nzira yakanakisisa yekurapa. Yeuka, nerubatsiro rwechiremba rwakakodzera, unogona kurarama nechirwere ichi zvakanaka.
Waldenstrom macroglobulinemia, WM, kenza yeropa, IgM protein, hyperviscosity syndrome, bone marrow, lymphoma
💬 Comments (0)
Hapana zvakataurwa parizvino. Isa mhinduro yako pano kekutanga.
Wedzera zvaunofunga