Mwana wako anowanzo kurwara here? Ingava chirwere chisingawanzoitiki cheWHIM Syndrome here?

Mwana wenyu anowanzobatwa nedzihwa, kukosora, hutachiona hwenzeve, kana hutachiona hweganda here? Chirwere chimwe chinova nani pane chimwe here? Kazhinji, tinofunga kuti dziviriro yemuviri yemwana yakaderera zvishoma uye kuti ari kubata zvirwere kuchikoro uye munzvimbo dzekutamba. Zvisinei, mune zviitiko zvisingawanzoitiki, izvi zvinogona kukonzerwa nechirwere chegene chinonzi WHIM Syndrome . Kunyangwe izvi zvisinganyanyi kutaurwa nezvazvo, zvakakosha kuti uzvizive.

Chii chinonzi chirwere ichi cheWHIM?

Zvichitaurwa zviri nyore, chirwere cheWHIM chirwere chisingawanzoitiki chinokanganisa masoja emuviri wedu. Zita rekuti WHIM rinobva pamavara ekutanga ezviratidzo zvina zvikuru zvechirwere.

• Marwati (marwati)
• Hypogammaglobulinemia (huwandu hushoma hwemasoja ekudzivirira chirwere muropa)
• Utachiona (hutachiona hunowanzoitika)
• Kubuda ropa kweropa mumapfupa ( Myeloalveolar hemorrhage)

Fungidzira kuti muviri wedu une uto remasero machena eropa. Basa remasoja aya nderekurwisa vavengi vakaita semabhakitiriya nemavhairasi anokonzera zvirwere. Mumunhu ane chirwere cheWHIM, masoja akakosha muuto iri, masero machena eropa anonzi neutrophils , anonamira muhwaro hwawo, mumongo wemapfupa. Haakwanise kubuda, muropa, kuti arwe nezvirwere. Saka, dziviriro yemuviri inodzikira, uye vanotanga kurwara kakawanda.

Ndezvipi zviratidzo zveWHIM syndrome?

Zviratidzo izvi zvinogona kusiyana zvikuru kubva pamunhu kusvika pamunhu. Vamwe vanhu vane zviratidzo zvishoma. Vamwe vanogona kuwana hutachiona hwakakomba hunogona kuisa hupenyu panjodzi. Zviratidzo izvi zvinowanzotanga pahudiki, asi dzimwe nguva chirwere ichi chinogona kusaonekwa kusvika munhu akura.

Kunyanya nezvemapundu uye njodzi yekenza

Vanhu vazhinji vakatipoteredza vanogona kutapukirwa nehutachiona hwehuman papillomavirus (HPV), hunokonzera maronda. Zvisinei, mumunhu ane immune system yakanaka, hutachiona uhwu hunonyangarika mumuviri zviri nyore. Zvisinei, nekuti immune system yemunhu ane WHIM syndrome haina simba, zvakaoma kurwisa hutachiona uhwu hweHPV. Nokudaro, hutachiona hunogara mumuviri kwenguva yakareba, zvichikonzera maronda, uye mune dzimwe nguva, zvichiwedzera njodzi yekenza.

Chii chinokonzera izvi? Izvi zvinotapuriranwa here?

Chikonzero chikuru cheWHIM syndrome kuchinja kwemajini kunonzi `CXCR4` mumuviri wedu. Funga nezvejini iri sechirongwa chinodzidzisa masero edu. Kana jini iri richichinja, masero machena eropa (Neutrophils) ataurwa pamusoro apa anomira kubuda mumongo wemapfupa.

Nekuti ichi chirwere chemajini, hachigone kupararira kubva kumunhu kuenda kune mumwe kuburikidza nekuhotsira kana kubata . Zvisinei, chinogona kutapurirwa kubva kuvabereki kuenda kuvana. Kana mubereki mumwe nemumwe aine gene mutation iyi, mwana wese waanaye ane mukana we50% wekugara nhaka chirwere ichi .

Ungaongorora sei chirwere ichi nemazvo?

Nekuti ichi chirwere chisingawanzoitiki, zvakaoma kuona kana uchingoongororwa kamwe chete. Chiremba wako achanyatsoongorora zviratidzo zvako nemwana wako, kuti vanobatwa nehutachiona kangani, uye anogona kukukurudzira kuti uongorore kakawanda.

• Kuverengwa Kweropa Rakazara (CBC): Izvi zvinotarisa masero machena eropa asina kuzara, kunyanya ma neutrophils, muropa.
• Kuongororwa kweAntibody (Immunoglobulin G - IgG blood test):Kuongororwa uku kunoitwa kuti kuonekwe kana huwandu hwemasoja ekudzivirira chirwere huchirwisa hutachiona hwakaderera.
• Kuongororwa kweBone Morrow Biopsy: Mukuita uku, sampuli diki yebone morrow inotorwa kubva mubhonzo rehudyu pasi peanesthesia yakapfava uye inoongororwa pasi pemaikorosikopu. Izvi zvinogona kuona nemazvo kana masero machena eropa akavharirwa mubonzo morrow (myelokathexis).
• Kuongororwa kwemajini: Kuongororwa uku kunogona kusimbisa kana paine shanduko mujini re'CXCR4' inokonzera chirwere cheWHIM.

Ndeipi mishonga yekurapa WHIM syndrome?

Hapana mushonga wechirwere ichi parizvino. Zvisinei, kune nzira dzakasiyana-siyana dzekurapa dzinogona kubatsira kudzora zviratidzo, kudzivirira hutachiona, uye kukubatsira kurarama hupenyu hwakajairika.

Mhando dzemishonga

• Xolremdi: Uyu mushonga mutsva wakatenderwa muna 2024. Unobatsira kuburitsa masero machena eropa anenge abatwa mumongo wemapfupa. Izvi zvinogona kuderedza njodzi yekutapukirwa ne40%.
• Kurapa kweG-CSF: Iyi ijekiseni. Inokurudzira mwongo wemapfupa uye inobatsira kuti igadzire masero machena eropa akawanda.
• Kurapa neIgG: Kune avo vane ma antibodies mashoma, masoja emuviri anosimbiswa nekupa ma antibodies kubva kunze.
• Mishonga inorwisa mabhakitiriya: Kana utachiona hwemabhakitiriya (senge pneumonia, hutachiona hweganda) hukatanga, chiremba wako achakupa mishonga iyi kuti aidzivirire.

Kurapa kwezvipundu

Kana mapundu achiitika kakawanda, unogona kuona chiremba weganda kuti abviswe. Kune nzira dzakasiyana siyana dzekuita izvozvo.

• Kuvhiyiwa kweCryosurgery
• Kuvhiya kweElectrosurgery
• Kurapwa neLaser
• Mhando dzemachira akakosha

Nzira yekurarama uine hutano neWHIM syndrome?

Kana uchirarama nechirwere chisingawanzoitiki kudaro, unofanira kufunga zvakanyanya nezvehutano hwako.

• Kudya kwakanaka: Kudya kunovaka muviri kwakakosha zvikuru kuti masoja emuviri wako arambe akasimba. Isa miriwo yakawanda, michero, zviyo, hove, nehuku mukudya kwako.
• Kurovedza muviri: Kurovedza muviri kunobatsira kuti muviri urambe wakasimba uye kunowedzera dziviriro yemuviri. Ita chimwe chinhu chaunoda, senge mutambo, kufamba, kana kushambira, zuva nezuva.
• Dziviriro kubva kuzvirwere:
• Dzivisa nzvimbo dzine vanhu vakawanda sezvinobvira.
• Geza maoko ako nesipo nguva nenguva.
• Taura nachiremba wako uye sarudza kuti ndeapi majekiseni aunoda iwe nemhuri yako.Taurai zvakananga nezvezvinhu zvakaita semushonga weHPV, mushonga wepneumonia, uye mushonga wefuruwenza wegore negore.

Pamusoro pechiremba wemhuri yako, ungangoda rubatsiro rwevanachiremba vakasiyana-siyana, vakaita senyanzvi yekudzivirira muviri, nyanzvi yeropa, uye nyanzvi yeganda, kuti vakurape.