Masifunde ngakumbi ngeeseli 'ze-eosinophil' emzimbeni wakho.

Ngaba wakha waliva igama elithi 'Eosinophil'? Mhlawumbi ugqirha ukuxelele ngalo emva kokujonga iziphumo zovavanyo lwakho lwegazi, okanye mhlawumbi eli gama litsha kuwe. Nangona kunjalo, ezi eosinophils ngamajoni abaluleke kakhulu emzimbeni wethu. Zenza umsebenzi omhle ekugcineni imizimba yethu iphilile. Ngoko ke, namhlanje siza kuthetha ngokweenkcukacha ngolu hlobo lweseli olubizwa ngokuba yi-eosinophil, oko zikwenzayo, kunye noko kwenzekayo ukuba ziba phantsi kakhulu.

Ngubani le eosinophil?

Ngamafutshane, i-eosinophil luhlobo lweeseli ezimhlophe zegazi egazini lethu. Njengoko usazi, iiseli ezimhlophe zegazi (ii-leukocytes) zezona majoni aphambili kwinkqubo yomzimba wethu yokuzikhusela, inkqubo esikhusela kwizifo. Kukho iintlobo ezahlukeneyo zezi seli ezimhlophe zegazi. Njengokuba kukho iirejimenti ezahlukeneyo emkhosini.

Kukho iintlobo ezintathu eziphambili zeeseli ezimhlophe zegazi:

1. Iigranulocytes

2. Iilymphocytes

3. Iimonocytes

Iqhawe lethu, i-eosinophil, likwiqela elibizwa ngokuba yi-'granulocytes'. Igama elithi `granulocytes' livela kwinto yokuba la maseli anee-granules ezincinci ngaphakathi kwawo. Ukongeza kwi-eosinophils, kukwakho nezinye iintlobo ezimbini ze-granulocytes ezibizwa ngokuba yi-'neutrophils' kunye ne-'basophils'. Zonke ezi seli zisebenza kunye ukulwa neentshaba ezingena emizimbeni yethu.

Indima ye-eosinophils ngokukodwa kukuthintela ukukhula kwezinto eziphilayo zasemzini, ingakumbi iiparasites, ezifihla ngaphakathi kwiiseli zethu kwaye zisigulise.

Zenza ntoni ezi seli ze-eosinophil?

Khawuthelekelele, xa into engaqhelekanga, njengentsholongwane okanye i-allergen, ingena emizimbeni yethu, iiseli zethu ezimhlophe zegazi zisebenza ngoko nangoko. Njengamajoni aqeqeshwe ngokukhethekileyo, zifuna zize zitshabalalise umhlaseli ngaphambi kokuba zenzakalise ezinye iiseli zethu.

Iiseli ze-Eosinophil nazo ziqeqeshwe ngokufanayo ukuba ziphume kumongo wethu wethambo zingene kwizicubu zethu ukuze zibe ngabalindi bokhuseleko. Ngaphakathi kwezi seli kukho iincam zesanti esizikhankanyileyo ngaphambili. Ngaphakathi kwezi granules kukho iproteni enobuthi . Xa kufika umhlaseli, ezi granules zikhupha loo protein inobuthi, zitshabalalise umhlaseli, zize ziyitye.

Ii-Eosinophils zikhusela imizimba yethu kakhulu kwi:

• Usulelo lwezibungu: Umzekelo, izinto ezifana ne-strongyloidiasis, ii-pinworms.
• Kwizinto eziphilayo ezikhula ngaphakathi kwiiseli zethu: Ezinye iintlobo zeebhaktheriya (iibhaktheriya zangaphakathi kwiseli) zifihla ngaphakathi kwiiseli zethu kwaye zibangela izifo. Ii-Eosinophils nazo ziyanceda ekulweni nazo.
• Ezi seli zikwanceda ekulawuleni ukusabela ngokukhawuleza kwe-hypersensitivity ( ii-allergens) ezibangelwa kukuvezwa kwi-allergens .

Zifumaneka phi iiseli ze-eosinophil ezininzi?

Ii-Eosinophils luhlobo lweeseli ezimhlophe zegazi ezihlala kwizicubu zomzimba wethu. Zifumaneka kakhulu kwezi:

• Egazini
• Kumongo wethambo
• Kwizicubu zamafutha (indawo apho amafutha agcinwa khona emizimbeni yethu)
• Emiphungeni
• Elusu
• Esiswini

Zibukeka njani iiseli ze-eosinophil?

Ezi seli ze-eosinophil zincinci kakhulu, kwaye zinokubonwa kuphela nge-microscope. Zingqukuva. Ngokwesiqhelo, emizimbeni yethu, azinambala, oko kuthetha ukuba azinambala. Kodwa xa zijongwa nge-microscope, xa kongezwa umbala okhethekileyo (idayi ye-asidi), umbala wezi seli uyatshintsha, okwenza kube lula ukuwujonga. Lo mbala uguqula iiseli zibe ngumbala opinki omfusa.

Ii-Eosinophils zinkulu kancinci kunezinye iiseli. Enye yezona zinto zibonakalayo lula yinucleus yazo. Ibonakala ngathi ngamathontsi amabini amanzi adityaniswe ngentambo, enamacembe amabini. Uyazi, ngaphakathi kwinucleus kulapho ikhoyo iDNA yeseli. Konke kumalunga nezinto ezibalulekileyo. Le nucleus idada kwiproteni efana nesanti (iigranules ebesithetha ngazo).

Zingaphi ii-eosinophils ezikhona emzimbeni wethu?

Ii-Eosinophils luhlobo lweeseli ezimhlophe zegazi. Iiseli ezimhlophe zegazi zenza malunga ne-1% yenani lilonke leeseli emizimbeni yethu. Kwiiseli ezimhlophe zegazi ezijikeleza emzimbeni womntu omdala osempilweni, ii-eosinophils zenza ngaphantsi kwe-5% . Oko kuthetha ukuba nangona zincinci kakhulu, inkonzo eziyinikayo ayibalulekanga.

Ziveliswa phi ii-eosinophils?

Ezi seli zibalulekileyo ziveliswa kwizicubu ezithambileyo ngaphakathi kwamathambo ethu, ezibizwa ngokuba yi-bone marrow . Emva kokuba zivuthiwe kwi-bone marrow, ii-eosinophils ziyahamba ziye kwizicubu ezinamafutha emzimbeni wethu, njengesisu.

Ziziphi iimeko eziqhelekileyo ezichaphazela ii-eosinophils?

Iimeko ezichaphazela ii-eosinophils aziqhelekanga. Kukho iimeko ezimbini eziphambili ezichaphazela zombini inani eliphantsi neliphezulu le-eosinophils.

Ukuncipha kwee-eosinophils: i-Eosinopenia

I-Eosinopenia ibangelwa kukuba sineeseli ze-eosinophil ezimbalwa kunesiqhelo emizimbeni yethu. Kukho iimeko ezininzi ezinokubangela oku:

• I-Cushing's syndrome: Oku kwenzeka xa umzimba uvelisa i-hormone cortisol eninzi kwaye iiseli ze-eosinophil zinganeli. I-Cortisol yi-hormone elawula amanqanaba eswekile yegazi kwaye iguqula ukutya kube ngamandla.
• I-Sepsis: I-Sepsis yimeko embi kakhulu yezonyango ebangela ukudumba kunye nokuqhekeka kwegazi emzimbeni wonke. Idla ngokuba ngumphumo wosulelo lwebhaktiriya, ifungus, i-parasitic, okanye i-virus.

Kubalulekile: Ngamanye amaxesha, nokuba inani lakho le-eosinophil liphantsi ngamanye amaxesha, lisenokungabi sisongelo esikhulu kwimpilo. Oku kungenxa yokuba ezinye iiseli kwinkqubo yethu yokuzikhusela komzimba zinceda ekubuyiseleni oku kungabikho kwe-eosinophil. Nangona kunjalo, ukuba namanqanaba aphantsi e-eosinophil ixesha elide kuyingozi. Kufuna uncedo lwezonyango ngokukhawuleza.

Ukwanda kwee-eosinophils: i-Eosinophilia

I-Eosinophilia kuxa sineeseli ze-eosinophil ezininzi egazini lethu kunesiqhelo. Ugqirha uya kuyixilonga le meko ngokusekelwe apho zifumaneka khona ii-eosinophil:

• Iingxaki zesisu ezibangelwa yi-Eosinophilic (EGID): Ezi ziimeko ezichaphazela inkqubo yethu yokugaya ukutya. Kule meko, iqela leeseli ze-eosinophil liqokelelana kwindawo echaphazelekayo, nto leyo ebangela ukudumba. Le yeyona meko ixhaphakileyo enxulunyaniswa nee-eosinophils. Ezi meko (EGID) zinokuchaphazela amathumbu amakhulu (i-eosinophilic colitis), i-esophagus (i-eosinophilic esophagitis), isisu (i-eosinophilic gastritis), isisu kunye namathumbu amancinci (i-eosinophilic gastroenteritis), kunye nesinye (i-eosinophilic cystitis).
• Iingxaki zemiphunga ezibangelwa yi-eosinophilic: Oku kuquka i-asthma ye-eosinophilic, i-bronchitis, kunye ne-pneumonia. Yimeko efana ne-asthma enzima, i-bronchitis, kunye ne-pneumonia. Kule meko, imiphunga izaliswa ziiseli ezidumbileyo kwaye ixinene. Oku kwenza kube nzima kakhulu ukuphefumla.
• Iingxaki zegazi kunye nezicubu ezibangela i-Eosinophilic: Ezi zichaphazela izicubu ezinxibelelanayo phantsi kolusu lwethu (i-eosinophilic fasciitis), ulusu (i-eosinophilic pustular folliculitis), kunye neeseli egazini lethu, imithambo yegazi, kunye nezitho ezibalulekileyo ezifana nentliziyo kunye nezintso (i-eosinophilic granulomatosis ene-polyangiitis, eyayisaziwa njenge-Churg-Strauss syndrome). Ezi meko zenzeka xa ii-eosinophils ezininzi zihlasela kwaye zonakalise imithambo yegazi. Ukuba azinyangwa, oku kunokukhokelela ekuhambeni kwegazi okungalunganga emzimbeni wonke.

Ziziphi iimpawu eziqhelekileyo zezifo ezinxulumene ne-eosinophil?

Ezi mpawu zihlala zibonakala ngokunxulumene nendawo yokwenzakala. Nazi ezinye zeempawu eziqhelekileyo:

• Ukudinwa, ukudinwa
• Izilonda zesikhumba, ukurhawuzelela
• Amadyungudyungu azele bubovu eluswini
• Ubunzima bokuphefumla, ukuphefumla okunzima
• Intlungu yesisu nesisu
• Ukudumba

Zithini izizathu ze-eosinophilia?

Kukho izinto ezininzi ezichaphazela ubungakanani be-eosinophils egazini lethu:

• Ukunxila kotywala
• Ii-aleji
• Iingxaki zesisu
• I-leukemia (uhlobo lomhlaza wegazi)
• Imveliso egqithisileyo yehomoni i-cortisol
• Usulelo lwezibungu

Ngaba i-eosinophilia yimiphumo yosulelo?

Ukwanda kwee-eosinophils (i-eosinophilia) kunokubangela usulelo, kodwa akusoloko kuyimbangela ephambili . Iintsholongwane zinokubangela ukwanda kwee-eosinophils. Ezi ntsholongwane zinokudluliselwa ukusuka komnye umntu ukuya komnye okanye ukusuka kwisilwanyana ukuya komnye umntu, ngakumbi ukusuka ezinjeni ukuya kwiikati. Ugqirha wakho uza kukuvavanya ukuze abone ukuba unesifo esibangelwa ziintsholongwane. Ukuba kunjalo, ukunyanga kuya kubuyisela amanqanaba akho eosinophils kwisiqhelo.

Ziziphi iimvavanyo eziqhelekileyo ezijonga impilo yeeseli zakho ze-eosinophil?

Ukuxilongwa kweemeko ezinxulumene ne-eosinophil kuqala ngokubalwa kwegazi elipheleleyo (i-CBC) . Oku kuquka ukuthatha isampuli yegazi lakho nokubala inani leeseli ezikuyo, ingakumbi iiseli ezimhlophe zegazi, ukuze kubonwe ukuba ziphantsi kakhulu okanye ziphezulu kakhulu na. Ukongeza, kukho nezinye iimvavanyo:

• Inani le-eosinophil epheleleyo: Olu luvavanyo lwegazi. Lufana nokubalwa kwegazi okupheleleyo. Lulinganisa ngokukodwa inani le-eosinophil kwisampulu yegazi lakho. Ugqirha uthatha inani elincinci legazi elivela emthanjeni aze ajonge isampuli phantsi kwe-microscope. Kongezwa idayi ukuze iiseli zibonakale ngakumbi, kwaye ugqirha ubala inani le-eosinophil kwiiseli ezili-100. Inani le-eosinophil epheleleyo libalwa ngokuphindaphinda loo pesenti ngenani leeseli ezimhlophe zegazi lakho lilonke.
• Uvavanyo lwe-bone marrow biopsy: Kolu vavanyo, ugqirha usebenzisa inaliti ukuthatha isampuli encinci yomongo wakho wethambo. Emva koko iyavavanywa ukuze kubonwe inani, umgangatho, kunye nendawo ezikuyo iiseli emzimbeni wakho.

Ukuze afumane indawo echanekileyo ye-eosinophilia, ugqirha unokwenza uvavanyo olukhethekileyo ngakumbi:

• I-X-reyi yesifuba
• Uvavanyo lokusebenza kwesibindi
• Uvavanyo lwesampuli yestulo
• I-biopsy yezicubu
• Uvavanyo lomchamo

Ingakanani inqanaba eliqhelekileyo le-eosinophil?

Umntu ophilileyo kufuneka abe neeseli ze-eosinophil eziphakathi kwama-30 nama-350 kwi-microliter yegazi. Ukuba kukho iiseli ezingaphezu kwama-500 kwi-microliter yegazi, lixabiso eliphezulu. Ukuba kukho iiseli ezingaphantsi kwama-30, lixabiso eliphantsi.

Khumbula, ukwehla kube kanye kwenani le-eosinophils, nokuba lithontsi nje, kusenokungabi sisongelo esikhulu. Ezinye iiseli zegazi ezimhlophe kwinkqubo yakho yokuzikhusela komzimba zinceda ekulungiseni ukusilela.

Iyintoni inqanaba eliphezulu le-eosinophil?

Ugqirha wakho uza kuhlela ubunzima be-eosinophilia, ngokusekelwe kwiziphumo zenani elipheleleyo le-eosinophil:

• Ubuncinci: Phakathi kwama-500 kunye nama-1,500 eeseli ze-eosinophil kwi-microliter nganye yegazi.
• Iphakathi: Phakathi kwe-1,500 kunye ne-5,000 eosinophils kwi-microliter nganye yegazi.
• Inzima: Ngaphezulu kwe-5,000 eosinophils kwi-microliter nganye yegazi.

Ngaba inqanaba eliphezulu le-eosinophil luphawu lomhlaza?

Nangona oku kunqabile, amanqanaba aphezulu e-eosinophil anokuba luphawu lokuba unomhlaza . Amanqanaba aphezulu e-eosinophil anokunxulunyaniswa neentlobo ezahlukeneyo zomhlaza:

• Umhlaza webele
• Umhlaza weColoral
• Umhlaza womlomo wesibeleko
• I-lymphoma yeHodgkin
• Umhlaza wesibeleko
• Umhlaza weprostate

Ukuba ugqirha wakho urhanela ukuba umhlaza, uza kwenza olunye uvavanyo, olufana ne-biopsy, uvavanyo lwegazi olongezelelweyo, okanye uvavanyo lwemifanekiso, ukuze kufunyaniswe isifo kwaye kuqalwe unyango.

Ziziphi iindlela eziqhelekileyo zonyango lwamanqanaba aphezulu eosinophils?

Unyango lweemeko ezinamazinga aphezulu eosinophil luyahluka ngokuxhomekeke kwindawo kunye nobunzima besifo. Unyango lokunciphisa amanqanaba aphezulu eosinophil luquka:

• Ukuba une-esophagitis, kuphephe ukutya okuthile (ukutya okunamafutha, okuneziqholo, okune-asidi).
• Ukuba unefuthe leziyobisi kwiyeza elithile, yeka ukulisebenzisa okanye utshintshe umthamo walo.
• Ukuthatha amayeza okulwa nokuvuvukala.

Iimeko ezinamazinga aphezulu kakhulu eosinophil azihlali ixesha elide , oko kuthetha ukuba zifuna unyango kunye nolawulo lwexesha elide.

Ziziphi iindlela eziqhelekileyo zonyango lwamanqanaba aphantsi eosinophil?

Unyango lweemeko ezinamazinga aphantsi eosinophil luquka:

• Ukuthatha ii-corticosteroids.
• Ukunciphisa ukusetyenziswa kotywala.

Ixesha elininzi, umzimba wakho uya kuqaphela ukungabikho kwee-eosinophils kwaye lonke inkqubo yakho yomzimba yokuzikhusela iya kunceda ekulungiseni ukungabikho. Nangona kunjalo, ukuba amanqanaba akho eosinophil akabuyeli kwisiqhelo ngenxa yemeko yempilo engaphantsi, unyango lwexesha elide lunokufuneka.

Ndingazigcina njani iiseli zam ze-eosinophil ziphilile?

Nazi ezinye izinto onokuzenza ukuze ugcine iiseli zakho ze-eosinophil ziphilile:

• Ziphephe izinto ezibangela i-allergen.
• Yitya ukutya okunesondlo esifanelekileyo. Pheka ukutya kakuhle uze ukufudumeze ukuya kubushushu obufanelekileyo bangaphakathi ngaphambi kokuba ukutye.
• Nciphisa ukusetyenziswa kotywala.
• Landela iindlela ezifanelekileyo zococeko, njengokuhlamba izandla zakho rhoqo.

Zithini ii-Acidophils?

Ii-Acidophils lelinye igama, kodwa elingaqhelekanga, lee-eosinophils. Igama elithi "acidophilic" livela kwigama elithi "acidophilic," elithetha "ukuthanda i-asidi." Eli gama livela kwindlela ii-granules kwiiseli ze-eosinophil ezitshintsha ngayo umbala phantsi kwe-microscope xa zidaywe ngedayi ye-asidi stain. Le dayi iguqula iiseli zibe pinki okanye zimfusa, nto leyo eyenza kube lula ukuzibona.

Ngoko ke, ii-eosinophils ziyinxalenye ebaluleke kakhulu kwinkqubo yethu yokuzikhusela. Zidlala indima enkulu ekukhuseleni imizimba yethu kubahlaseli bamanye amazwe. Ukuba ugqirha wakho ukrokrela ukuba amanqanaba e-eosinophil yakho angaphezulu komlinganiselo oqhelekileyo, uya kwenza uvavanyo lwegazi ukujonga impilo yeeseli zakho. Uninzi lwexesha, amanqanaba aphantsi e-eosinophil ayisiyonto inkulu, kuba ezinye iiseli zinceda ukubuyisa intsilelo kwaye zigcine umzimba wakho usebenza.

Masikhumbule ezona zinto zibalulekileyo (Umyalezo Wokuya Ekhaya)

Kulungile, masishwankathele ezona zinto zibalulekileyo ekufuneka uzikhumbule koko sithethe ngako.

• Ii-Eosinophils luhlobo lweeseli ezimhlophe zegazi. Ziyinxalenye yenkqubo yethu yokuzikhusela komzimba.
• Ngokuyintloko zilwa nosulelo lwezibungu, izinto eziphilayo ezikhula ngaphakathi kwiiseli, kunye neempendulo ze-allergy .
• Ukwehla kwenani lee-eosinophils (eosinopenia) okanye ukwanda kwenani lee-eosinophils (eosinophilia) kunokubangelwa ziimeko ezahlukeneyo zonyango.
• Uvavanyo lwegazi lunokwenziwa ukuze kufunyanwe amanqanaba e-eosinophil yakho.
• Ngokwesiqhelo, umntu ophilileyo uneeseli ze-eosinophil eziphakathi kwama-30 nama-350 kwi-microliter nganye yegazi.
• Ukuba ubona utshintsho kumanqanaba akho eosinophil, kungcono ungoyiki uze ubone ugqirha ukuze akunike ingcebiso.

Ndiyathemba ukuba uyiqonda kakuhle i-eosinophils. Ukwazi izinto ezinje kunceda kakhulu ekunyamekeleni impilo yethu.

I- Eosinophil, iiseli ezimhlophe zegazi, inkqubo yomzimba yokuzikhusela, i-allergy, usulelo olubangelwa zizinambuzane, i-eosinophilia, i-eosinopenia, uvavanyo lwegazi