Ingxaki enabantu abaninzi eSri Lanka luxinzelelo lwegazi oluphezulu. Kwabanye, kunzima kakhulu ukulawula oku nasemva kokusela amayeza. Kodwa kukho umntu ngaphakathi emizimbeni yethu esingathethi kakhulu ngaye, kodwa ophembelela uxinzelelo lwegazi ngasese. Yiloo nto siza kuthetha ngayo namhlanje. Igama lakhe nguAldosterone.
Ngamafutshane, ngubani le aldosterone?
I-Aldosterone yi-hormone emizimbeni yethu. Ii-hormone zifana nee-postmen emizimbeni yethu. Zithwala imiyalezo kwisitho ngasinye, zisixelela ukuba senze oku, siyeke okuya.
Ngoko ke le hormone ebizwa ngokuba yi-aldosterone yenziwa zii-glands ezimbini ezincinci eziziingxantathu ezifana nesiciko phezu kwezintso zethu. Ezi sizibiza ngokuba zii-adrenal glands. Ezi glands ziyinxalenye yenkqubo yethu ye-endocrine.
Umsebenzi ophambili wale hormone kukugcina uxinzelelo lwegazi lwethu lukwinqanaba elifanelekileyo . Ikwenza oku ngokulawula amanqanaba eeminerali egazini lethu abizwa ngokuba yi-sodium (oko kukuthi ityuwa) kunye ne-potassium. Ezi sodium kunye ne-potassium ziintlobo ezimbini ze-electrolytes . Zezo zigcina amanqanaba olwelo lomzimba elungelelene kwaye zinceda imithambo-luvo kunye nemisipha isebenze kakuhle.
Cinga nge-aldosterone njengomphathi olawula ityuwa namanzi emizimbeni yethu. Ukuba iphezulu kakhulu, kukho iingxaki, kwaye ukuba iphantsi kakhulu, kukho iingxaki.
I-aldosterone ilawula njani uxinzelelo lwegazi?
Le yinkqubo enomdla kakhulu. I-Aldosterone ichaphazela uxinzelelo lwegazi kakhulu ngeendlela ezilandelayo:
1. Ukugcinwa kweSodium: I-Aldosterone inika izintso zethu kunye nekholoni uphawu lokuba "zongeze i-sodium engaphezulu (ityuwa) egazini kwaye zonyuse ubungakanani be-potassium ekhutshwa kumchamo."
2. Ukugcinwa kwamanzi: Xa isodiyam yongezwa egazini, amanzi nawo ayagcinwa emzimbeni. Kufana namanzi atsaleleka kwityuwa.
3. Ukwanda komthamo wegazi: Xa sigcina amanzi emizimbeni yethu, umthamo wegazi lethu lilonke uyanda. Njengokuba ukuzalisa umbhobho wamanzi ngamanzi amaninzi kwandisa uxinzelelo lwawo, xa umthamo wegazi unyuka, uxinzelelo lwegazi nalo luyanda.
Ngale ndlela, xa uxinzelelo lwethu lwegazi lusehla, i-aldosterone ingena ize incede ekubuyiseleni kwinqanaba elisempilweni. Le hormone ikwanceda ngokungathanga ngqo ekulawuleni i-pH (oko kukuthi, ibhalansi ye-acid-base) kunye namanqanaba e-electrolyte egazini.
La manqanaba e-aldosterone alawulwa njani? - Inkqubo emangalisayo!
I-Aldosterone ayisebenzi yodwa. Yinxalenye yeqela elisebenzisanayo. Le nkqubo siyibiza ngokuba yiRenin-Angiotensin-Aldosterone System (RAAS) . Ifana nomdyarho we-relay.
Cinga ngale ndlela.
- Inyathelo lokuqala: Uxinzelelo lwakho lwegazi (BP) luyehla. Izintso zethu ziyakuva oku. Emva koko izintso zikhupha i-enzyme ebizwa ngokuba yi-renin egazini.
- Inyathelo lesibini: Le renin iyaphula iproteni ebizwa ngokuba yi-angiotensinogen, eyenziwa sisibindi sethu, ibe yingcezu ebizwa ngokuba yi-angiotensin I. Kodwa isalele, oko kuthetha ukuba ayinamandla amaninzi.
- Inyathelo Lesithathu: Ngoku, njengoko le angiotensin I ihamba egazini, iyaphulwa yi -angiotensin-converting enzyme (ACE) evela emiphungeni yethu, idala i-hormone enamandla kakhulu ebizwa ngokuba yi-angiotensin II . Eli liqhawe lokwenyani.
- Inyathelo Lesine: Le angiotensin II yenza izinto ezimbini eziphambili.
1. Ibangela ukuba imithambo yegazi emincinci (ii-arterioles) inciphe. Oku kubangela ukuba uxinzelelo lwegazi lunyuke ngoko nangoko.
2. Iya kwi-adrenal glands ize izixelele ukuba, "Ingxamiseko! Yenza i-aldosterone ngokukhawuleza!"
- Inyathelo lokugqibela: Ngoku i-aldosterone ingena ize ixelele izintso ukuba zigcine ityuwa (isodium) namanzi kwaye zikhuphe i-potassium ethile. Oku kwandisa umthamo wegazi kwaye kubuyisela uxinzelelo lwegazi kwisiqhelo.
Xa yonke le nkqubo igqityiwe, kwaye uxinzelelo lwegazi lubuyela esiqhelweni, le nkqubo iyazivala ngokuzenzekelayo. Le yinkqubo yokulawula enzima kakhulu, kodwa iyamangalisa kakhulu.
Amanqanaba e-aldosterone alinganiswa njani?
Ukuba ugqirha wakho unengxaki yokulawula uxinzelelo lwegazi, okanye ukuba unenguqu kumanqanaba e-potassium egazini lakho, unokurhanela ukuba i-aldosterone ikwimeko entle. Uvavanyo oluphambili loku luvavanyo lwe-aldosterone:renin ratio .
Ngenxa yokuba i-aldosterone kunye ne-renin zisebenza kunye, ukulinganisa amanqanaba azo zombini kunokunceda ekufumaneni indawo echanekileyo yengxaki. Oku kudla ngokwenziwa ngokuthatha igazi elincinci kumthambo osengalweni yakho.
Ukongeza, amanqanaba e-aldosterone anokulinganiswa ngokwahlukeneyo egazini okanye emchameni oqokelelweyo kwiiyure ezingama-24.
Kuthekani ukuba amanqanaba e-aldosterone ayanda?
Xa inqanaba le-aldosterone emzimbeni liphezulu kunesiqhelo, silibiza ngokuba yi -hyperaldosteronism . Eyona nto ibangela oku yimeko ebizwa ngokuba yi-primary aldosteronism . OkuIkwabizwa ngokuba yiConn's syndrome.
Le meko idla ngokubangelwa sisisu esincinci, esingengomhlaza (esingenobungozi) esikhula kwi-adrenal gland. Esi sisu sibangela ukuba i-gland ivelise i-aldosterone eninzi kakhulu. Oku kubangela ukwanda kwe-sodium (ityuwa) egazini, ukwehla kwe-potassium, kunye nokungalingani kwe-electrolyte.
| Iimpawu zeHyperaldosteronism | |
|---|---|
| Uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi oluphezulu) | Uxinzelelo lwegazi oluphezulu olunzima ukululawula nokuba usebenzisa amayeza. |
| Intloko ebuhlungu | Intloko ebuhlungu rhoqo. |
| Ubuthathaka bemisipha | Ukuziva ubuthathaka, ingakumbi xa amanqanaba e-potassium ephantsi kakhulu. |
| Ukoma kakhulu kunye nokuchama rhoqo | Unxano olungapheliyo nokuba usela amanzi angakanani na kwaye ufuna ukuchama rhoqo. |
Ukuba unale mpawu, ingakumbi ukuba unengxaki yokulawula uxinzelelo lwakho lwegazi, qiniseka ukuba uthetha nogqirha wakho ngale nto.
Kuthekani ukuba amanqanaba e-aldosterone ehla?
Kwakhona, xa inqanaba le-aldosterone emzimbeni liphantsi kunesiqhelo, silibiza ngokuba yi -hypoaldosteronism . Oku kwenzeka xa i-hormone ye-aldosterone iveliswa kancinci kakhulu okanye umsebenzi wayo uphazamiseka. Oku kunokubangela amanqanaba aphantsi esodium (ityuwa) egazini, amanqanaba aphezulu e-potassium, kunye nemeko ebizwa ngokuba yi -metabolic acidosis (ukwanda kwe-asidi egazini) .
Zithini izizathu zoku?
- Isifo sika-Addison:Esi sisifo esingaqhelekanga sokuzikhusela komzimba. Oku kuthetha ukuba inkqubo yokuzikhusela yomzimba iyazijikela yona ize yonakalise amadlala e-adrenal. Oku kunciphisa ukuveliswa kweehomoni i-aldosterone kunye ne-cortisol.
- I-Congenital Adrenal Hyperplasia (CAH): Le yimeko yemfuza ekhoyo ekuzalweni. Ibangela ukungabikho kwee-enzyme ezithile ezifunekayo ukwenza iihomoni kwi-adrenal glands.
- Ezinye iimeko zempilo: Le meko inokwenzeka kubantu abanesifo seswekile, isifo sezintso, kunye nabo bagula kakhulu.
- Amanye amayeza: Le meko inokubangelwa zii-painkillers (NSAIDs) , izithibisi zegazi ezifana ne-heparin, kunye namanye amayeza entliziyo.
| Iimpawu ze-Hypoaldosteronism | |
|---|---|
| Uxinzelelo lwegazi oluphantsi (iHypotension) | Ukuba noxinzelelo lwegazi oluphantsi rhoqo, uzive utyhafile. |
| Ubuthathaka bemisipha | Umzimba ongenabomi, izihlunu ziyashukuma. |
| Isicaphucaphu | Ukuziva ngathi uhlanza. |
| Ukubetha kwentliziyo | Ukuva ukubetha kwentliziyo yakho ngokwakho. |
| Ukubetha kwentliziyo okungaqhelekanga (i-Arrhythmia) | Ukubetha kwentliziyo okungaqhelekanga. |
Ukuba unale mpawu, kubaluleke kakhulu ukwenza idinga lokubona ugqirha wakho size sithethe ngale nto.
Umyalezo Wokuya Ekhaya
- I-Aldosterone yi-hormone ebalulekileyo ekulawuleni uxinzelelo lwegazi lwethu.
- Ilawula ikakhulu amanqanaba etyuwa (i-sodium) kunye ne-potassium emzimbeni.
- Amanqanaba agqithisileyo (i-Hyperaldosteronism) okanye aphantsi (i-Hypoaldosteronism) ale hormone anokubangela iingxaki ezahlukeneyo zempilo.
- Ukuba uneempawu ezifana noxinzelelo lwegazi oluphezulu okunzima ukuzilawula, ubuthathaka bemisipha, ukoma kakhulu, okanye ukuquleka, thetha nogqirha ngaloo nto.
- Uvavanyo olulula lwegazi okanye lomchamo lunokukuxelela ukuba angakanani amanqanaba akho e-aldosterone.
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