Ngaba ugqirha wakho ukuxelele okanye umntu osapho lwakho ukuba niqale ukuthatha i-aromatase inhibitor? Kuqhelekile ukuba uzive usoyika kwaye unomdla xa usiva loo nto. "Luhlobo luni lonyango olu?", "Kutheni ndinikwa oku?", "Kuza kwenzeka ntoni kum?", "Ngaba kuza kubakho naziphi na iziphumo ebezingalindelekanga?" Mhlawumbi unemibuzo emininzi engqondweni yakho. Ngoko ke ungoyiki. Namhlanje, siza kuthetha ngale mayeza abizwa ngokuba yi-aromatase inhibitor ngolwimi olulula kakhulu onokuluqonda, ngokungathi uthetha nomhlobo.
Yintoni i-Aromatase Inhibitor (AI) ngokulula?
Ngamafutshane, i-Aromatase Inhibitor luhlobo lonyango lwehomoni olusetyenziselwa umhlaza. Zisetyenziswa kakhulu ukunyanga uhlobo lomhlaza webele olubizwa ngokuba yi -Estrogen Receptor-Positive (ER+) .
Ngoku mhlawumbi uyazibuza, "Ithetha ukuthini le `ER+`?" Ithetha into efana nale. Ezinye iiseli zomhlaza wamabele zincedwa ukuba zikhule kwaye zisasazeke yihomoni ebizwa ngokuba yi-estrogen emizimbeni yethu. Kanye njengokuba isityalo sifuna amanzi kunye nesichumisi ukuze sikhule, ezi seli zomhlaza zisebenzisa ihomoni i-estrogen "njengokutya" kwazo. Ngoko ke, ii-cancer ezikhuthazwa yile hormone i-estrogen zezo sizibiza ngokuba zii-cancer ze-`ER+`.
Oko kwenziwa yi-Aromatase Inhibitor kukuthintela iiseli zomhlaza ekufumaneni oko "kutya". Yenza oku ngokuthi: Umzimba wethu une-enzyme ebizwa ngokuba yi-Aromatase . Le enzyme iguqula ezinye iihomoni emzimbeni zibe yi-estrogen. Ngoko ke eli yeza lithintela ukusebenza kwe-enzyme ye-Aromatase. Emva koko imveliso yomzimba ye-estrogen iyancipha kakhulu. Xa i-estrogen iphelile, iiseli zomhlaza zilahlekelwa "kukutya" ezikufunayo ukuze zikhule, kwaye ziyafa kancinci kancinci.
Ngamafutshane, i-Aromatase Inhibitor iyalambisa iiseli zomhlaza kwaye iyayekisa ukukhula kwazo.
Olu nyango lusebenza ngakumbi kubafazi abangaphezu kweminyaka engama-50 abaye bafikelela kwixesha lokuyeka ukuya exesheni , kuba emva kokuyeka ukuya exesheni, i-estrogen emzimbeni womfazi iveliswa kakhulu ngale enzyme ye-aromatase.
Kuxa kutheni apho olu nyango lunikwa khona?
Kukho iimeko ezininzi apho oogqirha banokucebisa unyango lwe-Aromatase Inhibitor. Makhe sijonge ukuba ziintoni ezo.
- Emva kotyando lomhlaza webele we-ER+: Eli yeza linikwa ukuthintela umhlaza ukuba ungabuyi, oko kukuthi, ukunciphisa umngcipheko wokuphinda ubuye.
- Ukuba umhlaza usasazeke kwiindawo ze-lymph ezikufutshane: Olu nyango lunceda ukulawula ukusasazeka komhlaza.
- Ukuba umhlaza usasazeke (usasazeka) kwamanye amalungu omzimba:Umhlaza webele ngamanye amaxesha unokusasazeka uye kwiindawo ezikude ezifana nemiphunga, amathambo, ingqondo, okanye isibindi. Olu nyango lukwasetyenziswa kwiimeko ezinjalo.
- Ukuba ufumana umhlaza webele we-ER+ ngaphambi kokuba uyeke ukuya exesheni: Ekubeni ama-ovari esavelisa i-estrogen kule minyaka, kuya kufuneka uthathe i-aromatase inhibitor kunye nolunye unyango oluthintela ama-ovari ekuveliseni i-estrogen.
- Ukuba usengozini enkulu yokuba nomhlaza webele we-`ER+`: Ezinye izifundo zibonise ukuba la mayeza anciphisa umngcipheko womhlaza webele. Nangona kunjalo, awakavunywa ngokusemthethweni ngale njongo.
- Ukuba indoda ifumana umhlaza webele othi `ER+`: Ewe, amadoda nawo anokufumana umhlaza webele. Akwanamanqanaba aphantsi e-hormone i-estrogen emizimbeni yawo. Ke ngoko, kukho amaxesha apho amadoda anokunikwa olu nyango.
Ziziphi iintlobo ze-Aromatase Inhibitors ezisetyenziswa kakhulu?
Kukho iintlobo ezahlukeneyo zala mayeza kwimarike. Ugqirha wakho uza kukucebisa eyona ifanelekileyo kuwe. Ezi zezona ntlobo zintathu zisetyenziswa kakhulu.
| Igama eliqhelekileyo leyeza |
|---|
| I-Letrozole |
| I-Anastrozole |
| I-Exemestane |
Ndingayisebenzisa njani le yeza? Ndingayisebenzisa ixesha elingakanani?
Ii-Aromatase inhibitors luhlobo lweepilisi ozithatha yonke imihla . Usenokunikwa eli yeza xa uqala unyango. Okanye, kwezinye iimeko, ugqirha wakho angakunika olunye unyango lwehomoni olubizwa ngokuba yi-tamoxifen iminyaka embalwa aze akutshintshele kwi-aromatase inhibitor.
Ngokwesiqhelo, olu nyango luqhubeka kangangeminyaka emihlanu . Ekupheleni kweminyaka emihlanu, ukuba awunazo iimpawu zomhlaza kwaye uvavanyo alubonisi mhlaza, uthathwa njengomntu osele ephilile.
Kodwa kukho into ebalulekileyo ekufuneka uyikhumbule. Ezinye izifundo zibonise ukuba umhlaza webele ungabuya emva kweminyaka engama-20 emva konyango. Oku kubizwa ngokuba kukubuyela umva kade . Ngoko ke kubalulekile ukuthetha nogqirha wakho ngalo mngcipheko, ngokusekelwe kwimeko yakho.
Ziziphi iingenelo kunye neengozi zale ndlela yonyango?
Njengakwezinye iindlela zonyango, kukho iingenelo kunye neengozi zeziphumo ebezingalindelekanga ezithile.
Inzuzo ephambili
Eyona nzuzo inkulu nebaluleke kakhulu yolu nyango lithuba lokuphelisa ngokupheleleyo umhlaza webele i-'ER+'. Izifundo zibonisa ukuba ama-95% abantu abafumana olu nyango emva kotyando abayi kuba nazimpawu zomhlaza konke konke emva kweminyaka emihlanu. Eli lizinga eliphezulu lempumelelo.
Iziphumo ebezingalindelekanga (iingozi) ezinokubakho
Njengoko besitshilo ngaphambili, eli yeza lisebenza ngokunciphisa amanqanaba e-estrogen emzimbeni. I-estrogen yi-hormone ebalulekileyo kwimpilo yokuzala kunye nempilo yamathambo nentliziyo . Ngoko ke xa amanqanaba e-estrogen ehla, kunokubakho iziphumo ebezingalindelekanga ezinxulumene nayo.
| Imiphumela | Ingcaciso elula |
|---|---|
| I-Osteoporosis kunye nokuqhekeka kwamathambo | Njengoko amanqanaba e-estrogen ehla, amathambo aya engasenamandla aze aqale ukubhitya, nto leyo eyandisa umngcipheko wokuqhekeka kwamathambo nokuba kukuwa okuncinci. |
| Intlungu yemisipha (iMyalgia) kunye nentlungu yamalungu | Esi sisiphumo esixhaphakileyo. Usenokuba neentlungu zamalungu kunye nokushukuma kwemisipha kwiindawo ezifana neengalo, imilenze, nomqolo. |
| Ubushushu obugqithisileyo | Usenokuziva ushushu kwaye ubila ebusweni, entanyeni, nasesifubeni. Oku kufana nophawu lokuya exesheni. |
| Ukoma kwesisu | Ukwehla kwamanqanaba e-estrogen kunokubangela ukuncipha komswakama kwilungu lobufazi, ukoma, kunye nokungonwabi. |
| Isifo sentliziyo | Ngenxa yokuba i-estrogen ikwakhusela impilo yentliziyo, ukwehla kwayo kunokunyusa kancinci umngcipheko wesifo sentliziyo kwixesha elide. |
Yintoni onokuyenza ukuba unengxaki yeziphumo ebezingalindelekanga?
Ezi ziphumo ebezingalindelekanga, ingakumbi iintlungu zamalungu, zinokuba nzima kangangokuba abanye abantu abakwazi ukwenza imisebenzi yemihla ngemihla. Kodwa akufuneki ukhathazeke buthule . Kukho izisombululo. Eyona nto ibalulekileyo kukuthetha ngokukhululekileyo nogqirha wakho malunga nokungonwabi okuvayo. Unokukunceda.
Ugqirha wakho unokucebisa izinto ezifana nezi:
- Amayeza okulwa nokuvuvukala: Amayeza angengo-steroidal anti-inflammatory (NSAIDs) afana ne-ibuprofen anokunikwa ukunciphisa iintlungu. Nangona kunjalo, la mayeza kufuneka athathwe kuphela phantsi kwengcebiso kagqirha.
- Ukutshintshela kwi-Aromatase Inhibitor eyahlukileyo: Ngamanye amaxesha iziphumo ebezingalindelekanga zohlobo oluthile lwe-AI azibonakali kolunye uhlobo. Ngoko ke ugqirha wakho angakuxelela ukuba uzame ipilisi eyahlukileyo ye-AI.
- Ukutshintshela kwiTamoxifen: Ukuba iziphumo ebezingalindelekanga azinyamezeleki, kusenokubakho ukhetho lokutshintshela kolunye unyango lweehomoni olubizwa ngokuba yiTamoxifen.
Ufanele umfowunele nini ugqirha?
Qiniseka ukuba uthetha nogqirha wakho kwezi meko zilandelayo:
- Ukuba iziphumo ebezingalindelekanga zinzima kakhulu kunokuba ubulindele kwaye kunzima ukuzinyamezela.
- Ukuba amayeza anikwe ngugqirha awancedi kwiziphumo ebezingalindelekanga.
- Ukuba ubona naluphi na utshintsho emzimbeni wakho ocinga ukuba lunokuba ziimpawu zomhlaza obuyayo (umz. iqhuma elitsha, intlungu engaqhelekanga). (Buza ugqirha wakho ukuba zeziphi iimpawu ekufuneka uziqwalasele).
Lubaluleke kangakanani olu nyango?
Unyango lwe-Aromatase inhibitor lunciphisa kakhulu umngcipheko wokubuya komhlaza webele one-hormone. Izifundo zifumanise ukuba abafazi abasebenzisa unyango lwe-aromatase inhibitor emva kotyando banomngcipheko ophantsi wama-40% wokufa ngenxa yomhlaza webele emva kweminyaka eli-10, xa kuthelekiswa nabo bangathathi naluphi na unyango lwe-hormone.
Olunye uphando lubonise ukuba ukuthatha iyeza elithi 'Letrozole' kunokunciphisa umngcipheko wokufa ngenxa yomhlaza ngama- 24% ukuya kuma-35% .
Ezi zibalo zibonisa indlela olu nyango olubaluleke ngayo ekusindiseni ubomi bakho. Usenokufuna ukuyeka olu nyango ngenxa yeziphumo ebezingalindelekanga. Kodwa ngaphambi kokuba wenze njalo, kungcono ukuthetha nogqirha wakho ngezi ngxaki, uzilawule, kwaye uzame ukugqiba olu nyango lusindisa ubomi.
Umyalezo Wokuya Ekhaya
- I-Aromatase Inhibitors (AI) lunyango olusebenzayo kakhulu lwe-hormonal kumhlaza webele we-ER+, ingakumbi emva kokuya exesheni.
- Oku kunciphisa izinga le-hormone ye-estrogen emzimbeni, kumisa ukukhula kweeseli zomhlaza, kwaye kunciphisa kakhulu umngcipheko wokuphinda umhlaza.
- Iziphumo ezinje ngeentlungu zamalungu kunye nobuthathaka bamathambo zinokubakho, kodwa kukho iindlela zokuzilawula. Ungaze ubandezeleke buthule; thetha nogqirha wakho rhoqo.
- Ukuze ufumane iziphumo eziphezulu kwaye uthintele umhlaza ukuba ungabuyi, kubaluleke kakhulu ukuthatha amayeza njengoko kuchaziwe, ngesiqhelo iminyaka emihlanu.
- Yazisa ugqirha wakho ngoko nangoko xa kukho naziphi na iimpawu ezintsha okanye eziya zisiba mandundu emzimbeni wakho.
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