Ngaba ugqirha wakho ukuxelele ukuba amathambo akho abuthathaka kancinci, oko kuthetha ukuba une-osteoporosis, isifo esinciphisa amathambo? Kusenokwenzeka ukuba ukuxelele ukuba uqale ukuthatha iyeza elibizwa ngokuba yi-bisphosphonate. Xa usiva eli gama, usenokuba noloyiko oluncinci, uzibuza, "Lithini eli yeza? Liza kwenza ntoni?" Musa ukoyika. Namhlanje, siza kuthetha ngolu hlobo lwamayeza olunokunceda ukuqinisa amathambo akho ngendlela elula kakhulu , ngendlela onokuyiqonda.
Ngamafutshane, zithini ezi bisphosphonates?
IiBisphosphonates ludidi olukhulu lwamayeza asetyenziselwa ukunyanga i-osteoporosis. Khawuthelekelele ukuba amathambo akho ayaphela kancinci kancinci ngokuhamba kwexesha, njengesiqwenga somthi esityiwe zizinambuzane. Emva koko, nokuba ukuwa okuncinci kwandisa umngcipheko wokuphuka kwamathambo akho. I-Osteoporosis yiloo meko. Ngoko ke, iibisphosphonates ziyawathintela amathambo akho ekubeni buthathaka ngakumbi, ziwenze abe namandla, kwaye zinciphise umngcipheko wokuphuka.
Oogqirha banika eli yeza kungekuphela nje kwi-osteoporosis, kodwa nakwezinye izifo ezininzi ezichaphazela uxinano lwamathambo, kwaye kwezinye iimeko zamanqanaba aphezulu kakhulu e-calcium egazini (hypercalcemia).
Ingaba la mayeza ayafumaneka? Makhe sibone.
Ewe, kukho iintlobo ezimbini ze-bisphosphonates.
1. Ii-bisphosphonates zomlomo
2. Ukujova emthanjeni (ii-IV bisphosphonates)
Ugqirha uza kuhlola imeko yakho aze agqibe ukuba loluphi uhlobo olulungele wena.
| Uhlobo lweyeza | Amayeza asetyenziswa rhoqo (anegama leebhrendi) |
|---|---|
| Iipilisi zomlomo |
|
| Iinaliti ezifakwa emthanjeni (IV) |
|
Zeziphi iimeko ezisetyenziselwa ii-bisphosphonates?
Eli yeza livunyiwe kakhulu ukunyanga ezi meko zilandelayo:
- I-Osteoporosis kubafazi abasele beyekile ukuya exesheni.
- I-Osteoporosis kumadoda.
- Ukuthintela ukubhitya kwamathambo.
- I-osteoporosis ebangelwa yi-glucocorticoid ibangelwa kukusetyenziswa ixesha elide kwamayeza athile e-steroid.
- Eminye imidla ibangela amanqanaba aphezulu e-calcium egazini (i-hypercalcemia enxulumene nomhlaza).
- Isifo sethambo sikaPaget sisifo esichaphazela amathambo.
- Imeko yomhlaza ebizwa ngokuba yi-multiple myeloma.
- Kwiimeko apho umhlaza oqale kwenye indawo usasazeke (wasasazeka) waya emathanjeni.
Ngamanye amaxesha, oogqirha basebenzisa eli yeza kwiimeko ezingezizo ezo livunyiweyo kuzo. Umzekelo, ngamanye amaxesha linikwa abantwana kunye nabantu abadala abaneengxaki zemfuza ezibizwa ngokuba yi -osteogenesis imperfecta .
Eli yeza lisebenza njani emzimbeni?
Ukuze siqonde oku, kufuneka siqale sazi kancinci ngamathambo ethu. Amathambo ethu akahlali nje kwindawo enye. Ahlala etshintshwa. Njengodonga apho kususwa khona izitena ezindala kwaye kwakhiwa ezintsha. Umzimba uyaqhekeka ngokwendalo kwaye ususe ithambo elidala. Oku sikubiza ngokuba yi-bone resorption. Emva koko kwakheka ithambo elitsha kwezo ndawo.
Njengoko sikhula, ingakumbi kubasetyhini emva kokuya exesheni, le nkqubo ayilungelelani. Oko kukuthi, ithambo elidala liqala ukuqhekeka lize lisuswe ngesantya esikhawulezayo kunokuba ithambo elitsha lenziwe. Kulapho ke amathambo eba buthathaka kancinci kancinci aze angabi ngqindilili, nto leyo ekhokelela kwi-osteoporosis.
IiBisphosphonates zisebenza ngokunciphisa isantya apho ithambo elidala liqhekeka lize lisuswe khona. Ngamanye amazwi, "zisusa izitena ezindala." Oku kuvumela ixesha elingakumbi lokwakheka kwamathambo amatsha, nto leyo enyusa uxinano lwamathambo kwaye iwenze aqine.
Ndingayisebenzisa njani le yeza? Oku kubaluleke kakhulu!
Indlela yokusebenzisa iyahluka ngokuxhomekeke kuhlobo lwamayeza owafumanayo.
Ukuba iipilisi zithathwa ngomlomo...
Le yeyona nxalenye ekufuneka uyilumkele kakhulu . Ugqirha uza kukuxelela ukuba uthathe ezi pilisi kanye ngemini, kanye ngeveki, okanye kanye ngenyanga. Nangona kunjalo, kufuneka uthathe ezi pilisi.Kukho indlela ekhethekileyo .
- Ufanele uthathe le pilisi kwangoko xa uvuka kusasa, ngaphambi kokuba utye okanye usele nantoni na .
- Ipilisi mayithathwe kuphela ngeglasi epheleleyo yamanzi acocekileyo . Akuvumelekanga ngokupheleleyo ukuyithatha neti, ikofu, ubisi, okanye iziselo zeziqhamo.
- Emva kokusela ipilisi, akufanele ulale okanye ulale ubuncinane imizuzu engama-30 (mhlawumbi imizuzu engama-60). Ufanele uhlale okanye ume nkqo.
- Kwakhona, awunakuthatha naluphi na olunye uhlobo lokutya, isiselo, okanye amayeza ngeli xesha lemizuzu engama-30-60.
Kubalulekile ukulandela le mithetho ngokuchanekileyo. Ngaphandle koko, iyeza lisenokungafunxwa kakuhle ngumzimba kwaye linokubangela i-allergies emqaleni nasesiswini. Ugqirha wakho uza kukuchazela oku ngokweenkcukacha.
Ukuba yinaliti yemithambo yegazi...
Oku kudla ngokunikwa esibhedlele okanye ekliniki. Ngokuqhelekileyo, olu gonyo lunikwa kube kanye ngonyaka . Nangona kunjalo, ngokuxhomekeke kwimeko, lunokunikwa rhoqo.
Ngaba ufuna ukwenza ezinye izinto ngeyeza?
Ewe. Ngelixa usebenzisa eli yeza, ugqirha wakho uya kucebisa oku kulandelayo:
- Yitya ukutya okutyebileyo kwi-calcium (umz. ubisi, iyogathi, itshizi, intlanzi encinci, imifuno eluhlaza)
- Ukuba unesiphene sevithamini D, thatha isongezelelo sevithamini D.
- Ukuba awufumani i-calcium eyaneleyo ekutyeni, sela iipilisi ze-calcium .
Ndingalithatha ixesha elingakanani eli yeza?
Oku kuxhomekeke kwimeko yakho kunye nendlela umzimba wakho osabela ngayo kumayeza. Ngokwesiqhelo, oogqirha banciphisa ixesha lokusebenzisa iipilisi eziselwayo ukuya kwiminyaka emi-5 kwaye inaliti ye-zoledronic acid efakwa emthanjeni ukuya kwiminyaka emi-3 . Oku kukukhusela kwimiphumo emibi engaqhelekanga enokwenzeka ngokusetyenziswa kwala mayeza ixesha elide. Nangona kunjalo, abanye abantu banokufuna unyango ixesha elide. Ugqirha wakho ngumntu ofanelekileyo ukuba athathe isigqibo.
Masifunde nangeziphumo ebezingalindelekanga.
Njengayo nayiphi na iyeza, ii-bisphosphonates zinokubangela iziphumo ebezingalindelekanga, kodwa ayinguye wonke umntu ozifumanayo.
| Uhlobo lweyeza | Iziphumo ebezingalindelekanga eziqhelekileyo ezinokubakho |
|---|---|
| Iipilisi zomlomo | Iingxaki zenkqubo yokugaya ukutya. Umzekelo: I-GERD, izilonda emqaleni nasesiswini, i-gastritis. (Yiyo loo nto besithi yima ume nkqo emva kokusela ipilisi!) |
| Iinaliti ezifakwa emithanjeni | Iimpawu zomkhuhlane okanye umkhuhlane, ezinje ngomkhuhlane, iintlungu zomzimba, kunye nentlungu yamathambo nemisipha, zinokuvela kwiintsuku ezi-1-3 emva kogonyo. Ezi zihlala zilawulwa ngamayeza anjengeparacetamol. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga kodwa ezinokuba yingozi kakhulu (zombini ezithethwayo kunye ne-IV) | |
| |
Musa ukoyika ngezi ziphumo zingaqhelekanga. Iingenelo zokusebenzisa eli yeza zingaphezulu kakhulu komngcipheko wokuphuka kwethambo elikhulu njenge-hip ngenxa ye-osteoporosis.
Ingaba eli yeza liyasebenza ngokwenene?
Ewe, ngokuqinisekileyo. Izifundo zibonise ukuba la mayeza andisa uxinano lwamathambo kwaye anciphisa kakhulu umngcipheko wokuqhekeka kwamathambo.
- I-Alendronate: Inciphisa ukwaphuka komqolo ngama-50% kwaye iyanciphisa ukwaphuka kwesinqe kunye nezinye izihlunu ngama-30%.
- I-Risedronate: Yehlisa ukwaphuka komqolo kunye nezinye izifo ngama-40%.
- I-Zoledronic acid: Inciphisa ukwaphuka komqolo ngama-70% kwaye iyanciphisa ukwaphuka kwesinqe nezinye izihlunu ngama-35%.
Ndifanele ndimbone nini ugqirha?
Ukuba usela eli yeza, yenza njengoko ugqirha ekuxelela.Kubaluleke kakhulu ukuya kwiikliniki ngexesha. Oku kuya kusinceda sibone ukuba amayeza ayasebenza na kwaye kukho naziphi na iziphumo ebezingalindelekanga. Ugqirha wakho unokucebisa ukuba kwenziwe i-DXA scan, elinganisa uxinano lwamathambo akho.
Khumbula ngokukodwa:
Ukuba ubusebenzisa i-bisphosphonates iminyaka engaphezu kwemithathu kwaye ufumana intlungu entsha ethangeni okanye emqolo wakho , musa ukuyityeshela. Xelela ugqirha wakho ngoko nangoko.
Eli yeza liyeza elibaluleke kakhulu elinokuphucula umgangatho wobomi bakho kwaye likukhusele kwiingxaki ezinzima ezinokubakho ngenxa yokwaphuka kwethambo. Ukuba unemibuzo okanye iinkxalabo malunga noku, qiniseka ukuba uxoxa ngazo ngokukhululekileyo nogqirha wakho.
Umyalezo Wokuya Ekhaya
- IiBisphosphonates liqela lamayeza athintela i-osteoporosis kwaye aqinise amathambo.
- Ukuba usela iipilisi eziselwayo, landela imiyalelo kagqirha ngokuchanekileyo (isisu sakho singenanto kusasa, ngamanzi kuphela, uze uhlale phantsi emva kokuzisela).
- Kubalulekile ukufumana i-calcium kunye ne-vitamin D eyaneleyo ngelixa usebenzisa eli yeza.
- Nangona iziphumo ebezingalindelekanga zinokwenzeka, uninzi lwabantu alubi nazo. Iingenelo zokusebenzisa eli yeza zinkulu kakhulu kuneengozi zokuqhekeka kwamathambo.
- Ukuba unenkxalabo okanye uloyiko malunga namayeza, ungaze ungathandabuzi ukuxoxa ngayo nogqirha wakho.
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