Ukuba wena okanye umntu kusapho lwakho unesifo se-sickle cell, akufuneki nithethe ngentlungu embi eza naso, akunjalo? Intlungu evela kumalungu omzimba ukuya esifubeni kunzima ukuyichaza ngamazwi. Kukho amaxesha amaninzi apho ungakwazi ukwenza nto yonke imihla kwaye kufuneka ubalekele esibhedlele. Kukho amaxesha apho le meko yenze ubomi bube nzima. Nangona kunjalo, ngokuhambela phambili kwesayensi yezonyango, kuye kwavela unyango olutsha oluzisa isiqabu kwizigulana ezinjalo. Elinye ithemba elitsha lolugonyo olubizwa ngokuba yiCrizanlizumab. Makhe sithethe ngale nto namhlanje.
Ngamafutshane, yintoni iCrizanlizumab?
I-Crizanlizumab (ebizwa ngokuba yi-Krizan-li-soo-mab) sisitofu esikhethekileyo esinikwa ukulawula iimpawu zabantu abanesifo se-sickle cell . Igama lophawu lwayo yi -ADAKVEO .
Cinga ngale ndlela: imithambo yegazi emizimbeni yethu ifana neendlela. Iiseli ezibomvu zegazi zifana nezithuthi ezithwala ioksijini kwezi ndlela. Iiseli ezibomvu zegazi zomntu ophilileyo zingqukuva kwaye zigudile, ngoko ke zihamba ngokulula kwimithambo yegazi ngaphandle kokunamathela.
Kodwa iiseli ezibomvu zegazi zomntu onesifo se-sickle cell zahlukile kancinci. Zigobile zibe yi-sickle shape (uhlobo lwe-C) kwaye zinamathela. Ngenxa yoku, ezi seli zinamathelana ngaphakathi kwemithambo yegazi, zihlangana, kwaye zivale ukuhamba kwegazi. Kufana nokuxinana kweemoto xa iimoto ezininzi zinamathelene endleleni. Xa ukuhamba kwegazi kuvaliwe ngale ndlela, ioksijini iyancitshiswa iye kwiindawo ezahlukeneyo zomzimba. Kulapho kuvela khona intlungu enganyamezelekiyo. Oku sikubiza ngokuba yingxaki yeentlungu . Ngamanye amaxesha ukuba le meko yenzeka esifubeni, ibizwa ngokuba yi -Acute Chest Syndrome , imeko eyingozi kakhulu.
Isitofu sokugonya iCrizanlizumab siyayithintela loo seli zinamathelayo ukuba zingadibani. Oko kukuthi, sinciphisa ukuxinana kwemithambo yegazi. Emva koko igazi lihamba kakuhle , kwaye umzimba ufumana ioksijini oyifunayo. Oku kunokunciphisa kakhulu ukuphindaphindeka kwezo ntlungu ziqatha.
Oku kukwiqela lamayeza abizwa ngokuba yi -monoclonal antibodies . Oko kukuthi, iproteni eyenzelwe ngokukodwa kwilebhu, njengeendawo ezithile zenkqubo yomzimba wethu yokuzikhusela. Iya ngqo ekujoliseni nasekumiseni inkqubo ebangela ukuba ezo seli zinamathele kunye.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza
Ngaphambi kokuba uqale olu nyango, kubaluleke kakhulu ukuxelela ugqirha wakho imbali yakho epheleleyo yempilo. Qiniseka ukuba ubaxelela oku kulandelayo:
- Malunga ne-allergies zakho: Ukuba une-allergies kwi-crizanlizumab, naluphi na olunye unyango, ukutya, iidayi, okanye izithinteli, nceda usazise kuqala.
- Ukuba ukhulelwe okanye uzama ukukhulelwa:Akukaziwa ngokupheleleyo ukuba eli yeza liza kumchaphazela njani umntwana ngexesha lokukhulelwa. Ngoko ke, ukuba ukhulelwe okanye uceba ukuba nomntwana kungekudala, kufuneka uxoxe ngale nto nogqirha wakho.
- Ukuba ungumama oncancisayo: Akukho lwazi luninzi malunga nokuba eli yeza liyadlulela na kubisi lwebele. Ke ngoko, ukuba ungumama oncancisayo, kungcono ukuxoxa ngezibonelelo kunye neengozi zonyango nogqirha wakho ngaphambi kokuba wenze isigqibo.
Igonyo linikwa njani?
Eli asiloyeza onokulithatha uye nalo ekhaya. Isitofu sokugonya i-crizanlizumab sinikwa esibhedlele okanye ekliniki ngabasebenzi bezonyango abaqeqeshiweyo.
- Isitofu sinikwa umthambo . Oku kudla ngokuthatha malunga nemizuzu engama-30.
- Imeko yakho iya kuhlolwa ngokusondeleyo ngabasebenzi bezonyango ngexesha lonyango nangexesha elithile emva konyango, njengoko abanye abantu banokufumana iimpendulo zokufakwa kwe-infusion xa befumana i-vaccine.
- Olu nyango ludla ngokunikezelwa kubantu abaneminyaka eli-16 nangaphezulu . Ukuba olu nyango lunikwa abantwana abangaphantsi kwaloo minyaka, kufuneka kuthathwe ingqalelo ekhethekileyo. Ugqirha wakho uya kugqiba.
Okubaluleke kakhulu: Eli yeza limiselwe wena wedwa. Musa ukwabelana ngeli yeza nabanye abantu nangasiphi na isizathu.
Yintoni omawuyenze ukuba ugqithisile?
Ekubeni oku kunikwa esibhedlele, umngcipheko wokusebenzisa i-overdose uphantsi kakhulu. Nangona kunjalo, ukuba ucinga ukuba ukhe wachaphazeleka yinto efana nale, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke ngoko nangoko. Okanye yiya kwiSebe leNgxamiseko (ETU) lesibhedlele esikufutshane.
Kuthekani ukuba ndiphoswa lusuku endifanele ndithathe ngalo iyeza?
Kubaluleke kakhulu ukuba olu nyango luphumelele ukuba uthabathe amayeza ngemihla emiselweyo nangamaxesha amiselweyo. Ungaphoswa lixesha lakho elicwangcisiweyo, oko kukuthi, usuku oxelelwa ukuba uze ngalo ukufumana amayeza.
Ukuba awukwazi ukuza ngaloo mini ngenxa yesizathu esithile esingxamisekileyo, nceda ufowunele ugqirha wakho okanye ikliniki ngokukhawuleza uze ubazise. Baza kukwazisa ngosuku olulandelayo.
Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?
Njengayo nayiphi na iyeza, abanye abantu banokufumana iziphumo ebezingalindelekanga xa begonyelwa iCrizanlizumab. Kodwa ayinguye wonke umntu ozifumana zonke. Ezinye zincinci kwaye ziyaphela kwiintsuku ezimbalwa. Kodwa kukho izinto ekufuneka siziqaphele.
Oku kunokuqondwa ngokucacileyo kwitheyibhile engezantsi.
| Uhlobo lwesiphumo esibi | Iimpawu ekufuneka uzixhalabele |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Iimpendulo zokungenisa | Intlungu esifubeni, ubunzima bokuphefumla, isiyezi, okanye ukuquleka. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Iintlungu zomzimba | Intlungu yomqolo, intlungu yamalungu. |
| Ezinye iimpawu | Umkhuhlane, intloko ebuhlungu, isicaphucaphu, iintlungu zesisu. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga ukongeza kwezi, thetha nogqirha wakho ngayo.
Ngaba kukho iingxaki ngamanye amayeza?
Ngokwendlela eyaziwayo ngayo ngoku, akukho ngxelo zithi i-Crizanlizumab gonyo ibangela ukudibana okukhulu namanye amayeza.
Nangona kunjalo, oko akuthethi ukuba akufanele uxelele ugqirha wakho malunga namayeza onke owasebenzisayo.
Nika ugqirha wakho uluhlu olupheleleyo lwazo zonke izinto ozithathayo:
- Amayeza amiselwe ngoogqirha kwezinye izifo
- Amayeza afana neepilisi zokuthomalalisa iintlungu owathenga kwikhemesti.
- Iivithamini, amayeza esintu, amayeza e-Ayurvedic okanye ezinye izongezo
- Kwakhona, sixelele ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi.
Ezinye izinto zinokusebenzisana namayeza ngeendlela esingazilindelanga. Ngoko ke kukhuseleko lwakho ukuba ucacelwe yonke into.
Umyalezo Wokuya Ekhaya
- I-Crizanlizumab sisitofu esikhethekileyo esinikwa ukunciphisa ukuxhaphaka kweentlungu ezinzima kunye nezinye iingxaki ezibangelwa sisifo se-sickle cell.
- Eli yeza lithintela iiseli ezibomvu zegazi ukuba zinganamatheli kwaye zihlangane ngaphakathi kwemithambo yegazi.
- Olu lunyango olunikwa ngemithambo esibhedlele okanye ekliniki. Alunakusetyenziswa ekhaya.
- Ngaphambi kokuba uqale unyango, xelela ugqirha wakho ngazo zonke izinto ezikubangela ukuba ungabi namdla, nokuba ukhulelwe okanye uncancisa, kunye nazo zonke ezinye iziyobisi ozisebenzisayo.
- Ungaphoswa ziintlanganiso zakho ezicwangcisiweyo. Ukuba awukwazi ukuya, nceda wazise ugqirha kwangaphambili.
- Ukuba ufumana iimpawu ezinzima ezifana nobunzima bokuphefumla, iintlungu zesifuba, okanye ukudumba kobuso ngexesha okanye emva kokugonywa, funa ingcebiso kagqirha ngokukhawuleza.
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