Ngaba ukhe weva ngesifo sikaParkinson? Okanye ukungakwazi ukuzibamba okungapheliyo emilenzeni ngamanye amaxesha, oko kukuthi, i-Restless Legs Syndrome? Namhlanje siza kuthetha ngohlobo oluthile lwamayeza asetyenziselwa ukunyanga iimeko ezininzi ezinjalo. Ezi zibizwa ngokuba yiDopamine Agonists. Nangona igama liyinkimbinkimbi kancinci, indlela ezisebenza ngayo ilula kakhulu.
Zithini kanye kanye ii-dopamine agonists?
Ukuze siqonde oku, makhe sicinge ngengqondo yethu okomzuzwana. Iiseli zemithambo-luvo ezikwingqondo yethu ziyanxibelelana, okanye zitshintshiselana imiyalezo, ngeekhemikhali ezikhethekileyo. Ezi sizibiza ngokuba zii-neurotransmitters . Cinga ngeeseli zethu zengqondo njengezitshixo ezihambelanayo. Ezi neurotransmitters zifana nezitshixo ezikhethekileyo ezinokuvula ezo zitshixo.
I-Dopamine "sisitshixo" esibaluleke kakhulu. Le khemikhali ibalulekile xa sifunda into ethile, xa siziva sonwabile kwaye sanelisekile, kwaye xa silawula iintshukumo zomzimba wethu.
Ngamafutshane, ii-dopamine agonists ziziyobisi ezisebenza njenge-dopamine, kodwa aziyo-dopamine ngokwenene. Zifana ne-'key' ebizwa ngokuba yi-dopamine. Ngenxa yokuba iiseli zethu zengqondo azikwazi ukubona umahluko phakathi kwezi zimbini, xa zifumana i-dopamine agonist, zicinga ukuba zifumana i-dopamine. Ke ngoko, la mayeza anceda ukoyisa iingxaki ezivelayo xa amanqanaba e-dopamine ephantsi.
Zeziphi izifo ezisetyenziselwa eli yeza?
Ukwehla kwamanqanaba e-dopamine emzimbeni kunokukhokelela kwiimeko ezahlukeneyo zempilo. Nazi ezinye zeemeko zempilo ezisetyenziswa kakhulu kwi-dopamine agonists.
| Imeko yezonyango | Ingcaciso elula |
|---|---|
| Isifo sikaParkinson kunye neengxaki ezinxulumene nokuhamba | Imeko ebangelwa kukungabikho kwe-dopamine kwiindawo zengqondo ezilawula iintshukumo zomzimba. |
| Isifo seMilenze eNgaphumliyo | Umnqweno onamandla wokuhambisa imilenze, ingakumbi ebusuku, kunye nokuziva ungakhululekanga. |
| I-Hyperprolactinemia | Ukwanda kwamanqanaba e-hormone prolactin emzimbeni. Oku kunokubangela iingxaki ezifana nemijikelo yokuya exesheni engacwangciswanga. |
| Isifo se-Neuroleptic Malignant | Ingxaki engaqhelekanga kodwa eyingozi enokubangelwa ngamayeza athile asetyenziselwa ukunyanga izifo zengqondo. |
| Uhlobo lwesibini lwesifo seswekile | Ezinye ii-dopamine agonists zikwanceda ekulawuleni amanqanaba eswekile egazini. |
Zithini iingenelo zala mayeza?
Kukho izizathu ezahlukeneyo zokuba kutheni udidi lwamayeza abizwa ngokuba yi-dopamine agonists lubaluleke kangaka kwizigulana.
- Izinga lempumelelo ephezulu: Uphando luye lwabonisa ukuba olu hlobo lweyeza lusebenza kakhulu ekunyangeni izifo ezininzi.
- Ingasetyenziselwa izifo ezahlukeneyo: Njengoko sixoxile ngasentla, ezi zisetyenziselwa izifo ezahlukeneyo, ukusuka kwiingxaki zokunyakaza kwengqondo ukuya kwiingxaki zehomoni.
- Ukudibanisa namanye amayeza: Umzekelo omhle sisifo sikaParkinson. Ukudibanisa i-dopamine agonist kunye neyeza elithi 'Levodopa' elisetyenziselwa esi sifo kunokubonelela ngesiphumo esiphezulu nokuba idosi ye-levodopa iphantsi. Zikwanceda ukulibazisa ukuqala kwe-levodopa.
- Ukusindisa ubomi: Ngamanye amaxesha la mayeza anokunceda nasekusindiseni ubomi. Umzekelo, anokulawula imeko eyingozi ebizwa ngokuba yi-'Neuroleptic Malignant Syndrome'.
Ngaba akukho zingozi kunye nemiphumo emibi?
Njengakweminye imithi, kukho iziphumo ebezingalindelekanga. Kodwa ungoyiki. Eyona nto ibalulekileyo kukwazi ezi zinto. Ngokubanzi, xa idosi iphezulu, kokukhona amathuba okuba iziphumo ebezingalindelekanga abe makhulu.
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
|---|---|
| - Ukuqhinwa | - Isicaphucaphu nokuhlanza |
| - Isiyezi | - Intloko ebuhlungu |
| - Iingxaki zokugaya ukutya | - Ukuquleka xa umile (i-Orthostatic hypotension) |
Iingxaki zoLawulo lweeMpembelelo
Le yinto ekufuneka ixoxwe ngayo ngokweenkcukacha. I-Dopamine yikhemikhali esinceda sizive izinto ezinje ngolonwabo nolwaneliseko. Nangona la mayeza evuselela loo nkqubo, anokuchaphazela nokukwazi kwabanye abantu ukulawula iminqweno yabo . Oko kukuthi, abakwazi ukulawula iminqweno yabo yokwenza into ethile. Umzekelo:
- Ukuthanda kakhulu ukungcakaza.
- Ukuthenga izinto ngaphandle kokulawula, nokuba awuzidingi.
- Ukuxinezeleka ngokwesini.
- Ukutya kakhulu ngokungalawulekiyo.
Oku kubaluleke kakhulu. Ukuba wena okanye usapho lwakho nibona naluphi na utshintsho olungaqhelekanga kwindlela eniziphatha ngayo, musani ukuba neentloni nize nithethe nogqirha wenu ngokukhawuleza. Kubalulekile ukwazisa ugqirha wenu ngale nto, kuba inokuba yimpembelelo embi yeyeza.
Kuza kwenzeka ntoni ukuba uyeka ukusebenzisa amayeza ngequbuliso?
Le yingongoma ebaluleke kakhulu. Ukuba uyeka ukusebenzisa amayeza e-dopamine agonist ngequbuliso okanye wehlisa umthamo ngaphandle kwengcebiso kagqirha , abanye abantu banokufumana uthotho lweentlungu. Siyibiza ngokuba yi -Dopamine Agonist Withdrawal Syndrome (DAWS) . Iimpawu ezinokubakho zezi:
- Ixhala kunye nokungazoli
- Ukubila okugqithisileyo
- Ukudinwa
- Intlungu yomzimba
- Isicaphucaphu
Ngoko ke, eyona nto ibalulekileyo ekufuneka uyikhumbule kukuba ungaze uyeke ukuthatha eli yeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
Ngaba kukho naziphi na iimeko apho kungalungelanga ukusela eli yeza?
Ewe, abanye abantu abafanelekanga kolu hlobo lwamayeza. Sibiza ezi "zii-contraindications."
- Oomama abakhulelweyo nabancancisayo:Eli yeza alikhuthazwa ngeli xesha kuba linokuchaphazela ukuncancisa.
- Abantu abanoxinzelelo lwegazi oluphezulu: Amanye ama-dopamine agonists anokunyusa uxinzelelo lwegazi ngakumbi.
- Abantu abanesifo sezintso okanye sesibindi: Kuba ezi zifo zichaphazela inkqubo yokususwa kwamayeza emzimbeni.
- Abantu abasebenzisa amanye amayeza: Ingakumbi ukuba usebenzisa amayeza e-MAOI, kufuneka uyeke ukuwasebenzisa ubuncinane iiveki ezimbini ngaphambi kokuba uqale la mayeza.
- Abantu abanembali yesifo sengqondo: La mayeza anokunyusa umngcipheko weempawu zengqondo.
Ukuba unayo nayiphi na kwezi meko, xelela ugqirha wakho ngayo ngaphambi kokuba uqale unyango.
Yintoni umahluko phakathi kwe-dopamine kunye ne-dopamine agonists?
Lo ngumbuzo abantu abaninzi abanawo. Ukuba i-dopamine incinci, kutheni unika i-dopamine agonists endaweni yokunika i-dopamine ngokuthe ngqo? Kukho izizathu ezahlukeneyo.
Isizathu esiphambili sisithintelo segazi-ubuchopho . Cinga ngengqondo yethu njengesihluzo esikhuselayo. I-dopamine ekhutshwa ngaphandle ayinakudlula kwesi sihluzo ize ingene engqondweni. Nangona kunjalo, amayeza e-dopamine agonist anokudlula kwesi sithintelo aze angene ngqo engqondweni. Yiyo loo nto esebenza ngakumbi.
Umyalezo Wokuya Ekhaya
- I-dopamine agonist luhlobo lwamayeza avuselela iiseli zobuchopho ngendlela efana ne-dopamine yekhemikhali, kodwa ayisiyo i-dopamine ngokwayo.
- Ezi zisetyenziselwa ukunyanga iimeko ezininzi, ezifana nesifo sikaParkinson kunye ne-Restless Legs Syndrome.
- Njengazo zonke iziyobisi, ezi zinokuba nemiphumo emibi, ingakumbi imiba yokulawula impembelelo.
- Ukuba wena okanye usapho lwakho nibona naluphi na utshintsho olungaqhelekanga, thetha nogqirha wakho ngoko nangoko.
- Ungaze uyeke ukuthatha eli yeza ngequbuliso okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha.
- Ukuthetha ngokukhululekileyo nangokunyaniseka nogqirha wakho yeyona ndlela ilungileyo yokufumana iziphumo eziphumelelayo.
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