Ngaba ukhe weva ngalo mhlaza ungaqhelekanga obizwa ngokuba yi-DSRCT? (Desmoplastic Small Round Cell Tumor) Makhe sithethe ngeenkcukacha!

Namhlanje siza kuthetha ngohlobo lomhlaza oluntsonkothileyo nolungaqhelekanga. Lubizwa ngokuba yiDesmoplastic Small Round Cell Tumor, okanye iDSRCT njengoko lubizwa njalo phakathi koogqirha. Usenokuba awukaze uve ngeli gama ngaphambili, kuba sisifo esichaphazela abantu abambalwa kakhulu. Kodwa ukuqaphela iimeko ezinjalo kunokuba yinto ebalulekileyo kuthi nakubantu esibathandayo.

Ngoko ke yintoni le DSRCT?

Ngamafutshane, i-DSRCT sisifo esibangela iithumba ezinomhlaza ezikhula ngokukhawuleza . Esi sisifo esikwiqela le- soft tissue sarcoma . Oku kuthetha ukuba ezi thumba zinokuvela kwiindawo ezithambileyo zomzimba wethu ezingenamathambo, njengemisipha, amafutha, kunye nemithambo-luvo. Nangona kunjalo, kwi-DSRCT, ezi thumba zikhula ikakhulu kwi-membrane egubungela isisu sethu (i-peritoneum) . Cinga ngayo, le yi-membrane encinci ekhusela amalungu anjengesibindi namathumbu ngaphakathi kwesisu sethu. Ke kulapho ezo seli zomhlaza zahlukana khona ngokukhawuleza kwaye ziqale ukwenza iithumba.

Nangona esi sifo sinokukhula nakubani na, sidla ngokubonakala kakhulu kubafana abaneminyaka ephakathi kwama-20 nama-30. Ayimangalisi loo nto? Kukho unyango loku, kwaye ngamanye amaxesha iimpawu ziyanyamalala kwaye esi sifo sinokufunyanwa kwiimvavanyo, oko kukuthi, xa siphelile . Nangona kunjalo, into ebuhlungu kukuba esi sifo sincitshisiweyo ngale ndlela sinokuthi siphinde sivele, oko kukuthi, siphinde sibuye .

Ingaba esi sifo sibizwa ngokuba yi-DSRCT sinqabile kangakanani?

Kunqabile kangangokuba awunakukwazi nokuyicinga. Ukusukela oko abaphandi baqala ukuqaphela esi sifo ngo-1989, kuye kwaxelwa ukuba sifunyenwe kubantu abamalunga ne-1 kwibhiliyoni enye kwihlabathi liphela. Oko kuthetha ukuba, xa kuthelekiswa nabemi baseSri Lanka, kunzima ukufumana umntu nokuba kube kanye emva kweminyaka embalwa. Kunqabile kangako.

Zithini iimpawu ze-DSRCT?

Ixesha elininzi, iithumba ezikhula ngaphakathi esiswini azibangeli zimpawu zinkulu de zibe nkulu kakhulu, zithathe indawo esiswini, kwaye zichaphazele inkqubo yokugaya ukutya. Nangona kunjalo, kukho iimpawu ezimbalwa eziqhelekileyo ezinokubonwa:

• Intlungu yesisu: Intlungu yesisu engapheliyo, ngamanye amaxesha iba mandundu.
• Ukuqhinwa: Ubunzima bokuhamba kwamathumbu rhoqo.
• Urhudo: Ukuhlanza.
• Isisu esivuvukileyo: Isisu sibonakala sikhulu kwaye sidumbile.
• Isicaphucaphu nokuhlanza: Ukulahlekelwa ngumdla wokutya okuhambisana nesicaphucaphu nokuhlanza.
• Ukwehla kobunzima ngendlela engachazekiyo: Ukwehla kobunzima ngequbuliso ngaphandle kwemiqathango ethile yokutya.

Ngoku khangela, ezi zinto ezifana nokuqhina, urhudo, kunye nokugabha zinokubonakala nakwizifo ezincinci esihlala sizifumana, akunjalo? Ngoko ke ayisiyongcinga ilungileyo ukoyika isifo esinzulu kuba nje unazo ezi mpawu.Nangona kunjalo, ukuba ezi mpawu ziyaqhubeka kangangeentsuku ezimbalwa okanye zisiba mandundu, kububulumko ukubonana nogqirha.

Kutheni le DSRCT isenzeka? Yintoni isizathu?

Abaphandi bafumanise ukuba i-DSRCT ibangelwa lutshintsho kwiichromosomes kwiiseli zethu. Olu tshintsho ludala i-gene engaqhelekanga ebizwa ngokuba yi -EWS-WT1 . Le gene inoxanduva lokukhula kweeseli zomhlaza. Nangona kunjalo, akukaziwa ukuba kutheni ezi chromosomes zitshintsha ngolu hlobo. Leyo yeyona nto inzima kwezi zifo.

Oogqirha bayixilonga njani le meko ye-DSRCT?

Ukuze bafumanise oku, oogqirha badibanisa iimvavanyo ezininzi ukuze bafikelele kwisigqibo:

• Uvavanyo lomzimba: Okokuqala, ugqirha uza kuchukumisa isisu sakho ukuze abone ukuba kukho into onokuyiva, efana namaqhuma.
• Uvavanyo lokufota: Olu luquka ii-CT scans , ii-MRI scans , kunye novavanyo lwe-ultrasound . Olu vavanyo lunokunceda ekuqinisekiseni ukuba kukho iithumba kwi-peritoneum, ukuba zikhulu kangakanani, kwaye nokuba zisasazeke na kwezinye iindawo.
• Uvavanyo lwemfuza: Olu vavanyo lunceda ekuqinisekiseni ukuba kukho na utshintsho lwemfuza lwe-EWS-WT1 olukhankanyiweyo ngaphambili. Yile nto inokubonisa ngokuchanekileyo ukuba yi-DSRCT.

Ziziphi iindlela zonyango ze-DSRCT?

Oogqirha basebenzisa iindlela ezahlukeneyo zokunyanga i-DSRCT. Ezona ziphambili zezi:

• Utyando: Ukususwa kweethumba ezinomhlaza ezininzi kangangoko kunokwenzeka ngotyando.
• I-HIPEC (Hyperthermic Intraperitoneal Chemotherapy): Olu lonyango olukhethekileyo kancinci. Emva kokuba ithumba lisusiwe ngotyando, amayeza e-chemotherapy ashushu afakwa kwisisu ukuze kutshatyalaliswe naziphi na iiseli zomhlaza eziseleyo.
• I-Chemotherapy: Unyango olunamandla olunikwa umzimba ukuze lutshabalalise iiseli zomhlaza.
• Unyango ngemitha: Ukusetyenziswa kwemitha enamandla aphezulu ukutshabalalisa iiseli zomhlaza.

Olu nyango lunokufaka isifo esiphelweni , oko kuthetha ukuba akukho zimpawu kwaye akukho vavanyo lunokufumanisa isifo. Nangona kunjalo, olu nyango aluhlali ixesha elide. Esi sifo sinokuphinda sibuye , ngoko ke unyango olutsha okanye iindlela ezahlukeneyo zonyango zinokufuneka ziqalwe.

Kubalulekile: Nokuba ufumana luphi unyango, unyango oluthomalalisayo oluvela kwiqela lakho lezonyangoQiniseka ukuba ubuza ngayo. Oku kwenzelwa ukunciphisa iintlungu zomzimba kunye noxinzelelo lwengqondo olubangelwa sesi sifo kwaye kukunike inkxaso yezonyango, yentlalo, neyengqondo oyifunayo ukuze uphile nesi sifo kangangoko kunokwenzeka. Olu asilonyango oluphilisa umhlaza, kodwa lunokuphucula kakhulu umgangatho wobomi bakho.

Ngaba kukho naziphi na iziphumo ebezingalindelekanga zonyango?

Ewe, utyando, i-chemotherapy, kunye nonyango lwe-radiation zonke zinokubangela iziphumo ebezingalindelekanga. Emva kotyando lokususa iithumba ze-DSRCT, unokufumana iziphumo ebezingalindelekanga ezifana nokusabela kwi-anesthesia okanye ukopha. Iziphumo ebezingalindelekanga eziqhelekileyo zonyango lwe-radiation kunye ne-chemotherapy ziquka:

• Urhudo
• Ukudinwa
• Isicaphucaphu nokuhlanza

Ezi ziphumo ebezingalindelekanga azenzeki ngendlela efanayo kuye wonke umntu, abanye abantu banokuba neengxaki ezimbalwa, abanye banokuba neengxaki ezingaphezulu. Ugqirha wakho uza kukwazisa ngale nto.

Ithini i-prognosis yesigulana kwi-DSRCT?

Le yeyona nto inzima ukuthetha ngayo, kwaye wonke umntu ufuna ukuyazi. Ukuxela kwangaphambili yinto oogqirha abathi ungayilindela emva konyango. Bathatha esi sigqibo ngokusekelwe kwizinto ezifana nokuba umhlaza ukuphi, ukuba usasazeke na, kunye nokuba ungakanani na osusiweyo ngexesha lotyando.

Ngenxa yokuba i-DSRCT ngumhlaza ongaqhelekanga, uphando alukho kangako ngayo. Ngoko ke kunzima koogqirha ukutsho kanye into onokuyilindela okanye ixesha onokuphila ngalo. Oku kuyaphula intliziyo ngokwenene.

Idatha yangoku ibonisa ukuba izinga lokusinda kweminyaka emihlanu kwi-DSRCT emva kokufunyaniswa kwesifo liphakathi kwe-15% kunye ne-38% . Oku kuthetha ukuba ayinguye wonke umntu oya kuphila. Nangona kunjalo, olunye uhlalutyo lubonise ukuba ipesenti encinci yezigulane ezine-DSRCT esasazekileyo zinyangwa ngokupheleleyo ngonyango. Kwakhona, malunga nama-60% abo banyangwa ngaphambi kokuba umhlaza usasazeke bayaphila emva kweminyaka emihlanu. Ngoko ke, ungabona ukuba kubaluleke kangakanani ukuwubona kwangethuba kwaye uqale unyango ngokukhawuleza, akunjalo?

Ndingazinyamekela njani mna ngale meko?

I-DSRCT ngumhlaza ongaqhelekanga nonzima. Ungabuya emva kweenyanga okanye iminyaka emva konyango. Ukuphila noloyiko lokuba umhlaza ungabuya akulula. Nangona kunjalo, kukho izinto ezimbalwa ezinokukunceda kolu hambo:

• Qonda imeko yakho: Ngenxa yokuba i-DSRCT inqabile, kunokuba nzima ukufumana ulwazi oluchanekileyo noluhlaziyiweyo ngayo. Ngoko ke, ungaze ungathandabuzi ukubuza iqela lakho lezonyango ukuba lilindele ntoni. Bakwazi ngcono wena kunye nemeko yakho.
• Buza malunga nokuthatha inxaxheba kwiimvavanyo zeklinikhi:Abaphandi bavavanya iindlela ezintsha zokunyanga i-DSRCT. Buza ugqirha wakho ukuba ungakwazi na ukuthatha inxaxheba kuvavanyo lweklinikhi .
• Cinga ngokusinda kumhlaza: Ukususela ngomhla owafunyaniswa ukuba unomhlaza, ubusoloko ungumlwi kwaye usindile ubomi bakho bonke. Buza iqela lakho lezonyango malunga neenkqubo ezikhethekileyo zabantu abanomhlaza ophindaphindayo.
• Fumana inkxaso: Buza iqela lakho lezonyango malunga namaqela enkxaso kubantu abanomhlaza ongaqhelekanga. Ukuchitha ixesha nokuthetha nabantu abanamava afanayo nawe okanye abanamava afanayo kunokunceda ukunciphisa ubulolo bokuphila ne-DSRCT.

Ndifanele ndiphinde ndimbone nini ugqirha wam?

I-DSRCT yimeko enokuthi ibuye kwakhona. Ngoko ke, ugqirha wakho unokucebisa uvavanyo lwemifanekiso (njenge -CT scan) rhoqo kwiinyanga ezintathu ukuya kwezintandathu ukujonga iithumba ezintsha kulwelo lwesisu okanye kwenye indawo. Kubaluleke kakhulu ukuba ungaphoswa zezi zilingo zokulandelela .

Ndingayibuza yiphi imibuzo ugqirha wam?

Ngexesha elinje, usenokuba nemibuzo emininzi. Kunzima ukuqonda yonke into ngaxeshanye. Musa ukoyika, funda konke oku kancinci kancinci. Nazi ezinye zemibuzo onokuzibuza njengesiqalo:

• Ndingaqiniseka njani ukuba iimpawu zam zibangelwa yile meko ibizwa ngokuba yi-DSRCT?
• Ngaba oku kunganyangwa ngokupheleleyo ngonyango?
• Loluphi unyango olucebisayo?
• Zithini iziphumo ebezingalindelekanga zezo ndlela zonyango?
• Ngaba ndifanele ndicinge ngokuthatha inxaxheba kuvavanyo lweklinikhi?

Ukuba ufunyaniswe une-DSRCT, inokuba sisiganeko esitshintsha ubomi bakho. Usenokuziva uxinezelekile ziimvakalelo. Usenokuba nexhala malunga nokuba kuza kwenzeka ntoni emva koko, ukuba unyango luza kuba njani, kunye nokuba ikamva lakho liza kuba njani. Kunokuba yinto edimazayo ukufumana ulwazi malunga nesifo esichaphazela ipesenti encinci yabantu ehlabathini.

Iqela lakho lezonyango liyayiqonda yonke le mvakalelo. Baza kukunika ixesha elaneleyo lokuqonda okwenzekayo kuwe kunye noko kusenokwenzeka emva koko. Musa ukoyika ukuthetha nabo kwaye ubuze nayiphi na imibuzo onayo.

Umyalezo Wokugqibela Wokuya Ekhaya

Kuqhelekile ukuziva uxinezelekile xa ufunda ngale meko ibizwa ngokuba yi-DSRCT. Nangona kunjalo, khumbula la manqaku:

• I-DSRCT ngumhlaza ongaqhelekanga kakhulu noyingozi. Kubalulekile ukuqaphela oko kuqala.
• Lumka ngeempawu. Ukuba unentlungu yesisu engapheliyo, ukudumba, okanye ukwehla kobunzima, funa ingcebiso kagqirha.
• Ukufunyanwa kwangoko kunye nonyango olukhawulezileyo kubalulekile. Oku kunokutshintsha indlela esiqhubeka ngayo isifo ngandlela ithile.
• AWUKHO wedwa.Iqela lezonyango, usapho, kunye namaqela enkxaso akhona ukukunceda.
• Ngokuqinisekileyo cinga ngononophelo lokuthomalalisa iintlungu. Oku kunokuphucula kakhulu umgangatho wobomi bakho.
• Musa ukoyika ukubuza imibuzo. Qiniseka ukuba uva yonke into ngokucacileyo kugqirha wakho.

Siyathemba ukuba olu lwazi lukuncedile ukuba uqonde kakuhle esi simo singaqhelekanga. Khumbula, ukuqonda yeyona nto inamandla okujongana nayo nayiphi na ingxaki.

I- DSRCT, i-Desmoplastic Small Round Cell Tumor, umhlaza, umhlaza wesisu, umhlaza ongaqhelekanga, iimpawu zomhlaza, unyango lomhlaza, umhlaza we-peritoneum