Ngaba uyalwazi olu hlobo lomhlaza webele olubizwa ngokuba yi-ER+? (Umhlaza webele onee-estrogen Receptor-Positive - ER+)

Ngaba wakha weva ngomhlaza webele? Mhlawumbi omnye wabahlobo bakho ukhe weva. Kukho iintlobo ezahlukeneyo zomhlaza webele. Namhlanje siza kuthetha ngomnye wazo. Lowo ngumhlaza webele one-ER+ (ER positive) . Nangona igama lisenokuvakala linzima kancinci, masilichaze ngokulula.

Yintoni umhlaza webele we-ER+?

Ngamafutshane, umhlaza webele we-ER+ luhlobo lomhlaza webele. Khumbula, abafazi banehomoni ebizwa ngokuba yi-estrogen emizimbeni yabo. Le homoni inceda ngezinto ezininzi. Nangona kunjalo, ngamanye amaxesha le homoni ye-estrogen ikwanceda iiseli zomhlaza zikhule. Ngoko ke, iiseli zomhlaza webele ezikhula ngenxa yehomoni ye-estrogen yile nto siyibiza ngokuba ngumhlaza webele we-ER+. I-'ER' imele i-Estrogen Receptor . Oku kuthetha ukuba ezi seli zomhlaza zineendawo apho i-estrogen 'inokuthi inamathele' khona. Oogqirha bajonga inqanaba lezi receptors ze-estrogen ukuze bacwangcise unyango. Ngokwesiqhelo, utyando kunye nonyango lwehomoni zisetyenziswa njengonyango loku. Abanye abantu babiza oku ngokuthi 'umhlaza webele we-estrogen positive'.

Ixhaphake kangakanani i-ER+ umhlaza webele?

Oku kuqheleke kakhulu kunokuba unokucinga. Uninzi lwabantu abafumana umhlaza webele, malunga nama-70 kwabali-100, banolu hlobo lomhlaza olubizwa ngokuba yi-ER+. Oku kuquka amadoda, kuba amadoda nawo anokufumana umhlaza webele, kodwa awuxhaphakanga kangako. Ngoko ke oku akuqhelekanga kangako.

Zithini iimpawu zomhlaza webele we-ER+?

Umntu onomhlaza webele we-ER+ uhlala ebonisa iimpawu ezifanayo nezomntu onomhlaza webele. Makhe sijonge ukuba zeziphi:

• Ukubona utshintsho kubungakanani, imo, okanye ukwakheka kwelinye lamabele akho . Mhlawumbi elinye ibele lahlukile kwelinye.
• Into eqhumayo okanye enamaqhubu ibanjwa esandleni. Le nto inokuba ncinci njengee-pea.
• Ukuziva ukuqina okanye ukuxinana kwamabele okanye amakhwapha. Kufuneka ukhathazeke ngakumbi ukuba oku kukho kuyo yonke imijikelo yakho yokuya exesheni yenyanga.
• Utshintsho kwinkangeleko okanye ukuvakala kolusu lwebele okanye ingono. Ulusu lusenokubonakala lunamabala, lunamaqhuqhuva, lunamaxolo, okanye luvuvukile. Lusenokuba bomvu okanye lube mnyama kunezinye iibele.
• Ukuziva indawo eqinileyo phantsi kolusu, njengeqhekeza lemabula .
• Ulwelo olunegazi okanye olucacileyo oluphuma kwingono.

Ukuba ucinga ukuba unayo nayiphi na kwezi mpawu, nceda ungoyiki ukubona ugqirha. Okukhona uyibona ngokukhawuleza, kokukhona kulula ukuyinyanga.

Yintoni ebangela umhlaza webele i-ER+?

Kulungile, ngoku masibone ukuba oku kwenzeka njani ngokwenene. Kwiiseli zomzimba wethu, kukhoKukho izinto ezibizwa ngokuba zii-hormone receptors. Ezi zifana neengcango ezincinci, uhlobo lweproteni. I-hormone estrogen esegazini lethu inokubopha kwezi receptors. Kwiiseli eziphilileyo, i-estrogen inceda iiseli ukuba zisebenze kwaye zikhule ngokuqhelekileyo. Yinto eqhelekileyo leyo.

Nangona kunjalo, kumhlaza webele we-ER+, le hormone ye-estrogen ibopha kwiiproteni ezingaphakathi kwiiseli zomhlaza, nto leyo ebangela ukuba ezo seli zomhlaza zikhule ngakumbi. Cinga ngayo njengokuba i-estrogen ifana 'nesichumisi' kwiiseli zomhlaza. Ngamanye amaxesha, ayisiyo-estrogen kuphela, kodwa nenye i-hormone ebizwa ngokuba yi-progesterone nayo inegalelo ekukhuleni kwezi seli zomhlaza. Sibiza ezi cancers zinezinga eliphezulu le-progesterone umhlaza webele we-PR-positive (PR+). Ezinye ii cancers zinokuba yi-ER+ kunye ne-PR+.

Zithini izinto ezibangela oku?

Kukho izinto ezinobungozi ezinokuchaphazela ukukhula komhlaza webele we-ER+. Makhe sijonge ukuba zeziphi.

Izinto ezibangela umngcipheko kubasetyhini:

Kwabasetyhini, ingozi enkulu kukufumana i-hormone ye-estrogen ixesha elide . Oku kuthetha ukuba amanqanaba e-estrogen emzimbeni ahlala ephezulu ixesha elide. Makhe sibone ukuba oko kwenzeka njani:

• Ukufikisa kwangethuba (ukuqala kwangoko kokuya exesheni).
• Ukuyekiswa kokuya exesheni okulibazisekileyo .
• Ukuba nabantwana emva kwexesha okanye ukungabi nabantwana kwaphela.
• Ukuthatha unyango lweehomoni (ingakumbi ezo zine-estrogen) kwiimpawu ezenzeka emva kokuya exesheni.

Izinto ezibangela umngcipheko kumadoda:

Kumadoda, le ngozi inxulunyaniswa namanqanaba aphezulu e-estrogen kunesiqhelo kunye namanqanaba aphantsi e-testosterone emizimbeni yawo. Oku kubizwa ngokuba yi-hormonal imbalance . Eminye imizekelo yile:

• Ukutyeba kakhulu .
• Isifo seswekile (iDiabetes Mellitus) .
• Iimeko ezinje nge -cirrhosis yesibindi .

Umhlaza webele we-ER+ uchongwa njani ngokuchanekileyo?

Ukuba ukrokrela ukuba unomhlaza webele, ugqirha wakho uya kuqala enze i -biopsy yebele . Oku kuquka ukuthatha isampuli encinci yezicubu ezivela kwiqhubu elinomhlaza. Emva koko le sampuli ithunyelwa kwilebhu. Apho, ingcali yezonyango , ugqirha ogxile ekuhloleni izicubu, uya kuhlola izicubu ukuze abone ukuba zinayo na i-hormone receptors.

Ukuba iziphumo zovavanyo ziyiHormone Receptor-Positive (HR+) , oko kuthetha ukuba i-estrogen, iprogesterone, okanye zombini ezi hormone zinceda iiseli zomhlaza zikhule. I-ER+ ikwayinxalenye ye-HR+. Oko kuthetha ukuba kukho ii-receptors ze-estrogen. Ngoko ke, i-estrogen receptors iyasebenza.Ukuba uvavanyo lubonisa ukuba amanqanaba e-estrogen akaphezulu, umhlaza webele uthathwa njengongenayo i-estrogen receptor (ER-negative) .

Ziziphi iindlela zonyango zomhlaza webele we-ER+?

Oogqirha basebenzisa iindlela ezininzi eziphambili xa benyanga umhlaza webele we-ER+. Ezi ziquka:

• Utyando lomhlaza webele : Oku kuquka ukususa iithumba ezinomhlaza.
• Unyango ngemitha : Imitha enamandla aphezulu isetyenziselwa ukutshabalalisa iiseli zomhlaza.
• Unyango lweKhemotherapy : Kolu nyango, amayeza asetyenziswa ukubulala iiseli zomhlaza okanye ukulawula ukukhula kwazo.
• Unyango lweehomoni : Oku kubaluleke kakhulu kumhlaza we-ER+. Kukho iindlela ezimbini zokwenza oku:
• Izithinteli ze-Aromatase : La mayeza asebenza ngokunciphisa imveliso ye-hormone ye-estrogen emzimbeni wakho, nto leyo ethetha ukuba iiseli zomhlaza azifumani kutya.
• IiSelective Estrogen Receptor Modulators (iiSERM) : La mayeza asebenza ngokuthintela i-hormone ye-estrogen ekunamatheleni kwiiseli zomhlaza. Akwanceda ekunciphiseni umngcipheko wokubuya komhlaza.

Ugqirha uza kuvavanya imeko yakho aze agqibe ukuba loluphi unyango olukufaneleyo kunye nendlela yokulusebenzisa.

Zithini iziphumo ebezingalindelekanga zonyango?

Njengakwezinye iindlela zonyango, ezi ndlela zonyango zinokuba nemiphumo emibi. Ungakhathazeki, oogqirha baza kukuchazela konke oku kwangaphambili.

Iziphumo eziqhelekileyo ze-chemotherapy kunye ne-radiation therapy ziquka:

• Ndiziva ndidiniwe kakhulu (Ndidinwe kakhulu)
• Isicaphucaphu nokuhlanza

Ezi ziphumo zilandelayo zingabonakala ngexesha lonyango lwe-hormone :

• Intlungu okanye ukuqina kwamalungu
• Ukudinwa
• Ukutyeba kwakho
• Ukungakhathali okanye ukuphelelwa ngumdla kwisondo
• Ubushushu obuvela emzimbeni - ukuziva ubushushu buvela ngaphakathi emzimbeni .
• Amabele athambileyo okanye avuvukileyo

Ukuba unyangwa umhlaza webele we-ER+, buza ugqirha wakho malunga nonyango lokudambisa iintlungu . Oku kunokukunceda ukulawula iimpawu zomhlaza wakho kunye nemiphumo emibi yonyango lwakho.

Ingakanani izinga lokusinda kumhlaza webele we-ER+?

Lo ngumbuzo abantu abaninzi abawubuzayo. Ngokwedatha evela kwiNational Cancer Institute (NCI) , ngokubanzi, abafazi abanomhlaza webele emva kweminyaka emihlanu bexilongiwe.Abantu abangaphezu kwama-90% bayaphila. Ezi ziindaba ezimnandi ngokwenene. Nangona kunjalo, i-NCI ayikhange inike idatha eyahlukileyo malunga nezinga lokusinda kwamadoda anomhlaza we-ER+.

Xa ucinga ngamazinga okusinda, kubalulekile ukukhumbula ukuba la ngamanani asekelwe kumava eqela elikhulu labantu . Kwakhona, asenokuba ngamanani asekelwe kwiimeko ezazikho kwiminyaka emininzi eyadlulayo. Unyango luyaphucuka yonke imihla. Ke ngoko, kungcono ukuthetha nogqirha wakho malunga nemeko yakho kunye noko unokukulindela.

Ngaba umhlaza we-ER+ ungabuya emva konyango?

Nangona umhlaza webele we-ER+ uthathwa njengongenabungozi kangako kunezinye iintlobo zomhlaza, kukho umngcipheko wokuphinda ubuye emva konyango. Le ngozi inokwenzeka nokuba umhlaza we-ER+ ufunyenwe kwangethuba kwaye unyangwa ngomhlaza we-ER+ ongenabungozi bungako. Ukuba ukhathazekile ukuba umhlaza wakho ungabuya, thetha nogqirha wakho wezifo zomhlaza malunga nomngcipheko wakho kunye nento onokuyenza ukunciphisa umngcipheko wakho.

Uzinyamekela njani umhlaza webele we-ER+?

Xa uphila nomhlaza webele we-ER+, kubalulekile ukuzinyamekela kakuhle. Nazi ezinye iingcebiso ezinokukunceda:

• Phumla ngokwaneleyo. Umhlaza webele kunye nonyango lwawo lunokudinisa kakhulu. Khumbula ukuphumla nanini na xa uziva udiniwe, kungekuphela nje xa uziva ufuna njalo.
• Yitya kakuhle. Ukutya kwakho kunokutshintsha ngenxa yonyango. Ukutya okuquka iziqhamo, imifuno, iiproteni ezingenamafutha, kunye neenkozo ezisempilweni kuya kukunceda uhlale unamandla ngexesha lonyango.
• Lawula uxinzelelo. Ukujongana nomhlaza kuxinzelelo olukhulu. Ukuzilolonga yindlela entle yokunceda koku. Ungenza nantoni na ukusuka ekuhambeni imihla ngemihla ukuya ekuthatheni inxaxheba kwiinkqubo zokuzilolonga.
• Fumana inkxaso. Ungumntu osindileyo kumhlaza webele, kwaye oko kuqala ngosuku ofunyaniswa ngalo isifo. Buza ugqirha wakho ngeenkqubo zokusinda kumhlaza . Ezi zinokukunceda ulawule imingeni yokuphila nomhlaza webele.

Kunini apho kufuneka ubone ugqirha ngokukhawuleza?

Ukuba uziva ngathi iimpawu zakho ziya zisiba mandundu, okanye ukuba ufumana iimpawu ezintsha, ezinje ngentlungu okanye ubuthathaka kwenye indawo emzimbeni wakho, bonana nogqirha wakho ngoko nangoko.

Yeyiphi imibuzo ebalulekileyo ekufuneka uyibuze ugqirha?

Xa ubona ugqirha wakho, ungoyiki ukubuza nayiphi na imibuzo onayo. Nazi ezinye zemibuzo onokuyibuza:

• Luhlobo luni lonyango olundicebisayo?
• Ngaba ndiza kuyidinga zombini i-chemotherapy kunye ne-radiation therapy, okanye ngaba unyango lwe-hormone kuphela luya kwanela?
• Ngaba kuya kufuneka ndithathe unyango lwe-hormone ubomi bam bonke?
• Zithini iziphumo ebezingalindelekanga zezi ndlela zonyango? Ndingenza ntoni ukuze ndizinciphise?
• Zithini iithemba zam zokubuyela esimeni?

Ingasasazeka phi i-ER+ umhlaza webele?

Umhlaza webele ngamanye amaxesha unokusasazeka uye kwezinye iindawo zomzimba, njengemiphunga , ingqondo, amathambo, nesibindi . Umhlaza webele we-ER+ umalunga ne-70% yazo zonke iintlobo zomhlaza webele, ngoko ke kubalulekile ukuba uqaphele oku kusasazeka.

Okokugqibela, izinto ezimbalwa ekufuneka uzikhumbule

Kulungile, masiphinde sichaze ezona ngongoma zibalulekileyo esithethe ngazo namhlanje.

Umhlaza webele i-ER+ luhlobo lomhlaza olukhula ngenxa yehomoni i-estrogen. Nangona le homoni idla ngokunceda iiseli zikhule, ikwabonelela 'ngesondlo' kwiiseli zomhlaza.

Oogqirha bavavanya amanqanaba e-estrogen kwiiseli zomhlaza webele baze bacebe unyango ngokufanelekileyo. Unyango lweehomoni, ngakumbi, lusebenza ukunciphisa impembelelo yale hormone estrogen kwiiseli zomhlaza.

Ukuba unomhlaza webele we-ER+, ungoyiki ukuthetha nogqirha wakho . Qiniseka ukuba uyamamela kwaye uyaqonda ukuba zeziphi iindlela zonyango lwakho kunye nendlela unyango ngalunye oluya kukunceda ngayo. Awuwedwa, kwaye kukho oogqirha abaninzi kunye neenkonzo zenkxaso ezikhoyo ukukunceda.

Ungalibali ukuba le meko ingalawuleka kakuhle ngokuyifumanisa kwangethuba kunye nonyango olufanelekileyo.

Umhlaza Webele we - ER+, i-Estrogen, Iimpawu Zomhlaza Webele, Unyango LweeHormone, Unyango Lomhlaza, Impilo Yabasetyhini, Umhlaza Webele One-Estrogen Receptor-Positive