Oko kufuneka ukwazi malunga ne-R-CHOP, unyango lomhlaza (R-CHOP)

Xa wena okanye umntu omthandayo nifunyaniswa ukuba ninomhlaza, kuyinto eqhelekileyo ukuziva nisoyika kwaye nixhalabile xa ugqirha wenu ethetha ngonyango olufana ne-R-CHOP. Kukho imibuzo emininzi efika engqondweni, efana nokuba la magama athetha ukuthini, olu nyango lunjani, kwaye kuza kwenzeka ntoni ngenxa yoko. Yiyo loo nto, ngokungathi umhlobo wakho ebekuxelela ngalo ngamazwi alula, siza kuthetha ngayo yonke into malunga nonyango lwe-R-CHOP namhlanje.

Kalula nje, yintoni i-R-CHOP?

I-R-CHOP lunyango lomhlaza. Ngokuchanekileyo, ludibaniso lwamayeza amahlanu. Isetyenziselwa ngokukodwa ukunyanga uhlobo lomhlaza olubizwa ngokuba yi -Non-Hodgkin Lymphoma . Olu dibaniso lwamayeza luquka amayeza amathathu e-chemotherapy, iyeza lonyango elijoliswe kulo, kunye ne-corticosteroid.

Unobumba ngamnye kweli gama umele uhlobo oluthile lweyeza. Kulula kakhulu, uyabona.

Ngenxa yokuba uninzi lwala mayeza ngamayeza e-chemotherapy, abanye abantu babiza olu nyango ngokuthi "i-R-CHOP chemo." Kodwa ngenxa yokuba iyeza iRituximab linceda amajoni ethu omzimba, ugqirha wakho usenokulibiza ngokuba "yi-immuno-chemotherapy."

Zeziphi iintlobo zezifo ezisetyenziselwa unyango lwe-R-CHOP?

Oogqirha basebenzisa kakhulu i-R-CHOP ukunyanga uhlobo lomhlaza olubizwa ngokuba yi -non-Hodgkin lymphoma . Ikwalunyango olusebenzayo kakhulu kwenye yezona ntlobo zixhaphakileyo ze- lymphoma, i-diffuse large B-cell lymphoma (DLBCL) .

Ukongeza, i-R-CHOP ikwasetyenziswa kwezi meko zilandelayo:

• I-follicular lymphoma ephucukileyo
• I-Mantle cell lymphoma
• I-Waldenstrom macroglobulinemia

Lwenzeka njani unyango? (Umjikelo Wonyango)

Uza kufumana unyango lwe-R-CHOP ngemijikelo. Umjikelo ngamnye uhlala iiveki ezintathu (iintsuku ezingama-21). Lo mjikelo wahlulwe waba ziinxalenye ezimbini:

1. Iintsuku zonyango: Iintsuku onikwa ngazo amayeza.

2. Iintsuku zokuphumla: Iintsuku zokuvumela umzimba wakho ukuba uphile, oko kukuthi, uphile, ngaphambi komjikelo olandelayo.

Zihamba njani iintsuku zonyango?

Kuya kufuneka uthathe amayeza kangangeentsuku ezintlanu. I-steroid ebizwa ngokuba yiPrednisone (P) ithathwa njengepilisi. Amanye amayeza amane (R, C, H, O) anikwa wena ngokufaka i-intravenous infusion (IV). Oku kuthetha ukuba afakwa emthanjeni ofana ne-saline. Kuya kufuneka uye esibhedlele okanye eklinikhi ukuze wenze oku.

Ngexesha lonyango, uza kuhlala esitulweni. Umatshini uza kukunika iyeza ngetyhubhu yeplastiki ungene emthanjeni osengalweni yakho, esandleni, okanye esifubeni. Ngamanye amaxesha, ukuze kube lula ukuqhubeka ufumana unyango, isixhobo esincinci esibizwa ngokuba yi-chemo port sifakwa phantsi kwesikhumba sesifuba sakho.Ikwabizwa ngokuba yinye.

Umjikelo wokuqala wonyango uhlala ngolu hlobo:

• Ngaphambi kokuba unyango luqale, uza kunikwa amayeza okuthintela ukuhlanza kunye nokucaphuka .
• Kwakhona, amayeza anikwa ukuthintela i-allergies . Kuqhelekile ukuba nempendulo encinci (umz., ukuziva ushushu, isiyezi) xa unikwa iyeza iRituximab (R). Nangona kunjalo, iyeza langaphambili lithintela kakhulu iimpendulo ezinzima.

Ukubaluleka kweentsuku zokuphumla

Kumjikelo oqhelekileyo we-R-CHOP, ufumana iintsuku ezili-16 zokuphumla emva kweentsuku ezintlanu zonyango. Eli xesha libaluleke kakhulu. Kuba xa i-R-CHOP itshabalalisa iiseli zomhlaza, ikwadinisa kakhulu umzimba. Ngoko ke kuqhelekile ukuziva udiniwe kakhulu emva konyango. Ngezi ntsuku zokuphumla, licebo elihle ukucela ilungu losapho okanye umhlobo ukuba akuncede ngemisebenzi yakho yemihla ngemihla.

Ngexesha lokuchacha kwakho, ukuba unako ukusebenza, ugqirha wakho unokucebisa ukuba wenze imisebenzi emincinci, njengokuhamba, ukusela amanzi amaninzi, nokutya ukutya okunesondlo.

Olu nyango lufanele lwenziwe ixesha elingakanani?

Uninzi lwabantu lufumana imijikelo emithandathu ye-R-CHOP. Umjikelo ngamnye uneeveki ezintathu, ngoko ke ixesha lonyango lilonke limalunga neeveki ezili-18. Nangona kunjalo, inani lemijikelo oyifunayo lixhomekeke kwimeko yakho. Abanye abantu banokufuna imijikelo esibhozo. Abanye oogqirha banokucebisa imijikelo yeeveki ezimbini endaweni yemijikelo yeeveki ezintathu.

Ziziphi iingenelo zonyango lwe-R-CHOP?

Eyona nzuzo inkulu yoku kukuba ayisiyoyobisi enye, kodwa yindibaniselwano yamayeza amahlanu. Eli chiza ngalinye libulala iiseli zomhlaza ngeendlela ezahlukeneyo. Ngoko ke, endaweni yokuba isosha elinye lilwe, kufana nomkhosi wonke ohlanganayo ukulwa nomhlaza.

Izinga lempumelelo yonyango lwe-R-CHOP liphezulu kakhulu . Umzekelo, ukuya kuthi ga kwi-70% yabantu abanohlobo lomhlaza olubizwa ngokuba yi-DLBCL bafumana ukuphumla okupheleleyo. Oku kuthetha ukuba zonke iimpawu ziyanyamalala. Ukuba isifo asiphindi sibuye kangangeminyaka emihlanu, umhlaza uhlala uthathwa njengongenakuphinda ubuye.

Kakade ke, olu nyango alunakuqinisekisa ukuba luya kuyiphelisa ngokupheleleyo umhlaza okanye luwuthintele ukuba ungabuyi kuwo wonke umntu. Nangona kunjalo, i-R-CHOP ithathwa njengolunye lonyango olukhuselekileyo nolusebenzayo olufumanekayo kwi-non-Hodgkin lymphoma.

Iziphumo Ezingalindelekanga kunye Neengozi

Njengalo naluphi na unyango, i-R-CHOP ineziphumo ebezingalindelekanga. Kodwa ungakhathazeki. Ugqirha wakho uza kukunika amayeza okuthintela ezi ziphumo zimbi (ezifana nokuhlanza) kunye nokulawula izinto ezifana neeseli ezimhlophe zegazi ezisezantsi. Kubalulekile ukuthetha ngokukhululekileyo ngezi ngozi nogqirha wakho ngaphambi kokuba uqale unyango.

Iimpendulo zokufakwa

Abantu abaninzi banokuba nempendulo encinci kwiRituximab ngexesha lonyango lwabo lokuqala. Yiyo loo nto oogqirha benika eli yeza kancinci ekuqaleni. Kuqhelekile ukuba uzive unesizungu okanye ushushu, kwaye liza kuphela emva kwexesha elithile. Nangona kunjalo, ukuba uneempawu zempendulo enzima, kufuneka ufune unyango ngoko nangoko . Ezi mpawu ziquka:

• Ukuqhambuka kwesikhumba
• Ukurhawuzelela
• Ukudumba komlomo okanye imilebe
• Ukuziva ngathi umqala wakho uxinekile

Abasebenzi bezonyango baza kukubeka esweni ngelixa unikwa amayeza. Nangona kunjalo, ukuba ufumana naziphi na ezi mpawu emva kokuba ubuyele ekhaya, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngoko nangoko.

Iziphumo ebezingalindelekanga eziqhelekileyo

Zonke iziyobisi ezikwi-R-CHOP zinokubangela iziphumo ebezingalindelekanga. Kodwa ayinguye wonke umntu ozifumanayo. Ziyahluka kumntu nomntu. Makhe sijonge ezona ziphumo bezingalindelekanga ziqhelekileyo kunye nendlela yokuzisingatha.

Ukongeza, ezinye iziphumo ebezingalindelekanga zinokwenzeka:

• Izilonda zomlomo
• Intloko ebuhlungu
• Ukuqhinwa okanye urhudo
• Isitshiso sentliziyo
• Ubuthathaka bemisipha
• Ukungalali
• Utshintsho lweemvakalelo
• Ukubetha kwentliziyo

Iziphumo ezinokwenzeka zexesha elide emva konyango

Uninzi lweziphumo ebezingalindelekanga ziyaphela emva kwexesha elithile emva kokuba unyango luphelile.

Nangona kunjalo, kuxhomekeke kwizinto ezifana namandla amayeza owafumanayo, unyango lwe-R-CHOP lunokunyusa kancinci umngcipheko wakho wokuba nesifo sentliziyo okanye ezinye iintlobo zomhlaza kwixesha elizayo. Lunokuchaphazela nokuzala . Oku kuthetha ukuba ukuba uceba ukuba nabantwana kwixesha elizayo, thetha nogqirha wakho ngale nto kwangaphambili. Usenokukwazi ukuxoxa ngeendlela ezifana nokukhenkceza amaqanda akho okanye isidoda.

Yintoni umahluko phakathi kwe-R-CHOP kunye ne-CHOP?

Ngamafutshane, i-R-CHOP yinguqulelo ephuculweyo yonyango lwe-CHOP. I-CHOP yaqaliswa ngeminyaka yoo-1990 kwaye yayilolona nyango lubalaseleyo lwe-non-Hodgkin lymphoma ngelo xesha.

Kodwa ekuqaleni kweminyaka yoo-2000, abaphandi bongeza iyeza lonyango elijoliswe kulo iRituximab (R) kunyango lwe-CHOP. Olu longezo lonyusa izinga lokunyanga nangakumbi. Namhlanje, i-R-CHOP lolona nyango lusebenzayo, oluthatha indawo ye-CHOP.