AmayezaJulayi 16, 2026🔄 Updated: Jul 16, 2026⏱ 5 min

Oko kufuneka ukwazi malunga neepilisi zeSafinamide zesifo sikaParkinson

Creator: Dr. Priya Sammani
Published: 2026-07-15T22:42:40.000Z

Dr. Priya Sammani, MBBS, PG Dip. FMMedical Verification

Ngaba wena okanye umntu ohlala nawe unesifo sikaParkinson? Ukuba kunjalo, ugqirha wakho usenokuba unikile iyeza elibizwa ngokuba yi-'Safinamide'. Xa usiva ngale yeza, usenokuba nemibuzo emininzi. "Kuza kwenzeka ntoni ngale nto?", "Ndifanele ndilumke xa ndiyisebenzisa?", "Ngaba kukho iziphumo ebezingalindelekanga?" Izinto ezinjalo zisenokubakho engqondweni yakho. Ungakhathazeki, siza kuthetha ngayo yonke le nto ngokulula nangokucacileyo.

Luhlobo luni lonyango iSafinamide?

Ngamafutshane, i-`Safinamide` liyeza elisetyenziselwa ukulawula iimpawu zesifo sikaParkinson. Likwiqela lamayeza abizwa ngokuba yi-`monoamine oxidase inhibitor (MAOI).` Ngamafutshane, eli yeza lisebenza ngokulinganisela amanqanaba eekhemikhali ezithile (ii-neurotransmitters) engqondweni, linceda ukulawula iimpawu zesifo sikaParkinson, ezifana nokuphazamiseka kokuhamba kunye nokungcangcazela. Oogqirha badla ngokulinika kunye namanye amayeza kaParkinson.

Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale eli yeza

Ngaphambi kokuba uqale ukusebenzisa eli yeza, kubaluleke kakhulu ukunika ugqirha wakho inkcazo epheleleyo ngemeko yakho yempilo . Eli yeza lisenokungahambelani nezinye iimeko zempilo. Ukuba unayo nayiphi na kwezi zilandelayo, qiniseka ukuba uxelela ugqirha wakho ngalo.

Isifo okanye imeko	Kutheni oko kubalulekile?
Izifo zamehlo okanye ukukhubazeka kokubona	Eli yeza linokuchaphazela ezinye izifo zamehlo.
Isifo sesibindi	Ukuba isibindi sibuthathaka, ukususwa kwesiyobisi emzimbeni kunokulibaziseka kwaye iziphumo ebezingalindelekanga zinokwanda.
Uxinzelelo lwegazi oluphezulu okanye oluphantsi	Eli yeza linokubangela utshintsho kuxinzelelo lwegazi.
Isigulo sengqondo	Ezinye iimeko zengqondo zisenokutshintsha ngenxa yale mithi.
Iingxaki zokulala ezifana ne-sleep apnea okanye i-narcolepsy	Kukho umngcipheko wokozela ngequbuliso ngenxa yale mayeza.
Umkhwa wokusela utywala	Ukudibanisa utywala kunye nale mithi kunokunyusa iziphumo ebezingalindelekanga.
Ukuba uzama ukukhulelwa okanye ukhulelwe	Ufanele uthethe nogqirha wakho malunga nokhuseleko lwale mithi ngexesha lokukhulelwa.
Ukuba ungumama oncancisayo	Buza ugqirha wakho ukuba iyeza lidluliselwa kumntwana wakho ngobisi lwebele.
Ukunganyamezelani kwamanye amayeza, ukutya okanye izinto	Kubalulekile ukwazi ukuba une-allergy kwi-safinamide okanye nakweyiphi na izithako zayo.

Ndingayisebenzisa njani kanye kanye le yeza?

Kubaluleke kakhulu ukuthatha idosi echanekileyo ngexesha elifanelekileyo, njengoko ugqirha wakho ekuxelela.

Sela le pilisi neglasi yamanzi.
Ungayithatha nokuba utya okanye ungenakutya, kodwa kungcono ukuyithatha ngexesha elifanayo yonke imihla.
Ziqhelise ukusela amayeza akho ngexesha elifanayo yonke imihla . Oku kuya kukunceda ugcine amanqanaba afanayo eyeza emzimbeni wakho.
Ungaze uyeke ukuthatha amayeza akho okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho. Ukwenza njalo kunokwenza iimpawu zakho zibe zimbi ngakumbi.

Kuthekani ukuba umthamo weyeza unyusiwe? (Ukugqithisa)

Ukuba ucinga ukuba uthathe amayeza amaninzi kunokuba ucinga, fowunela iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko. Okanye yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.

Kuthekani ukuba ndiphoswa lidosi leyeza?

Ukuba ulibele ukuthatha idosi, yithathe kwangoko xa ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha lokuthatha idosi yakho elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye ukuze ubuyisele idosi oyilibeleyo.

Amanye amayeza abangela iingxaki ngeSafinamide

Oku kubaluleke kakhulu. Ukusela iSafinamide kunye neminye imithi ethile kunokubangela iingxaki ezinkulu . Ngoko ke, xelela ugqirha wakho ngayo yonke imithi oyithathayo (eyalelwe ngabanye oogqirha, amayeza athengiswa ngaphandle kwemvume kagqirha, amayeza emifuno, kwaneevithamini).

Isilumkiso: Ukuba uthatha naliphi na kula mayeza alandelayo, akuvumelekanga ngokupheleleyo ukusebenzisa iSafinamide. Qiniseka ukuba uthetha nogqirha wakho ngale nto.

Sukuthabatha neSafinamide
Amanye amayeza e-MAOI (umz. i-Azilect, iMarplan, iNardil)	I-Dextromethorphan (equlethwe kwiisiraphu zokukhwehlela)
Ezinye izinto zokudakumba	I-Meperidine, iMethadone, iTramadol (izinto zokubulala iintlungu)
I-Cyclobenzaprine (isiphumzi semisipha)	I-St. John's Wort (amayeza esintu)
Amayeza okukhuthaza izifo ezifana ne-ADHD	I-Atomoxetine, iViloxazine

Ukongeza, amayeza okukhwehlela, umkhuhlane, amayeza okubangela ukunganyamezelani komzimba, izitshizi zeempumlo, utywala, kunye namayeza okubangela ukulala nazo zinokusebenzisana neSafinamide. Ngoko ke , qiniseka ukuba uthetha nogqirha wakho ngaphambi kokuba uthathe naliphi na iyeza elitsha.

Izinto ekufuneka uzilumkele xa usebenzisa amayeza

Ukozela kunye nesiyezi: Eli yeza linokukwenza uzive ulele okanye unesizungu. Ngoko ke, musa ukuqhuba okanye ukusebenzisa oomatshini ude wazi ukuba eli yeza likuchaphazela njani. Ingakumbi ukuba umdala, yima kancinci xa uvuka kwindawo ohleli kuyo okanye ebhedini. Kungenjalo, ungaziva unesizungu uze uwe.
Ukulala ngequbuliso: Oku kubaluleke kakhulu. Abanye abantu balala ngequbuliso ngaphandle kwesilumkiso xa besebenzisa eli yeza. Oku kunokwenzeka nokuba baqhuba okanye bethetha. Ukuba oku kuyenzeka kuwe, xelela ugqirha wakho ngoko nangoko.
Ukuziphatha ngokungxama: Akuqhelekanga ukuba abanye abantu babe neemvakalelo ezingaqhelekanga ngelixa besebenzisa eli yeza. Umzekelo, banokuba nomnqweno ongalawulekiyo wokungcakaza, ukuchitha imali ngokugqithisileyo, okanye ukulala nomntu okanye ukutya. Ukuba wena okanye amalungu osapho lwakho nibona naluphi na utshintsho kwindlela eniziphatha ngayo, xelela ugqirha wakho.
Utshintsho kwindlela yokutya (ukutya okuqulethe iTyramine): Oku kubaluleke kakhulu. Xa uthatha i-'Safinamide', kufuneka uphephe ukutya ukutya okuqulethe ikhemikhali ebizwa ngokuba yiTyramine . Ukuba ezi zinto zimbini zidityanisiwe, uxinzelelo lwegazi lunokunyuka ngendlela eyingozi. Oku sikubiza ngokuba yi-'hypertensive crisis'.

Ukutya okuneTyramine eninzi ekufuneka ukuphephe: Itshizi egugileyo, inyama ezicociweyo (isoseji, isalami), inyama ezitshayiweyo okanye intlanzi, ukutya okubilisiweyo, kunye neziselo ezinxilisayo (umz., iibhiya, iwayini ebomvu). Cela ugqirha wakho uluhlu olupheleleyo.

Iziphumo ebezingalindelekanga ezinokubakho ngenxa yamayeza

Njengayo nayiphi na iyeza, iSafinamide inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye ziyingozi, ngelixa ezinye zixhaphakile.

Ukuba ufumana ezi mpawu, xelela ugqirha wakho ngoko nangoko.
• Iimpendulo ze-allergy - ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi.	• Iimpawu zoxinzelelo lwegazi oluphezulu okanye uxinzelelo lwegazi oluphantsi (isiyezi, ukuquleka).
• Utshintsho embonweni, ukubona izinto ezingekhoyo.	• Iintshukumo ezingalawulekiyo zamalungu afana neengalo, imilenze, ubuso, nentamo.
• Ukulala ngequbuliso.	• Intloko ebuhlungu kakhulu, ukubona okufipheleyo, iintlungu zesifuba, ukuhlanza (iimpawu zengxaki ye-hypertension).
• Utshintsho olukhulu kwimeko yengqondo okanye ekuziphatheni, iminqweno engaqhelekanga.
Ezi zihlandlo azibalulekanga kangako, kodwa ukuba ziyaqhubeka, xelela ugqirha wakho.
• Isicaphucaphu	• Isisu esimoshakele
• Ingxaki yokulala

Ugcina njani amayeza akho ekhuselekile?

Gcina kude nabantwana kunye nezilwanyana zasekhaya .
Gcina kubushushu begumbi (phakathi kwama-20-25 degrees Celsius).
Musa ukusebenzisa amayeza aphelelwe lixesha. Lahla ngokufanelekileyo. Nxibelelana nogqirha wakho ngale nto.

Umyalezo Wokuya Ekhaya

I-Safinamide liyeza elisetyenziselwa ukunyanga isifo sikaParkinson. Sebenzisa eli chiza kanye njengoko ugqirha wakho ekuxelele .

Xelela ugqirha wakho ngazo zonke ezinye iindlela ozisebenzisayo, kuquka iivithamini kunye namayeza esintu.

Kuphephe ukutya okune-tyramine eninzi (itshizi edala, inyama egciniweyo) ngelixa usela amayeza.

Ukozela okanye ukozela ngequbuliso ngenxa yamayezaInokwenzeka. Ngoko ke, lumka kakhulu xa uqhuba kwaye usenza imisebenzi efuna ingqalelo.

Ukuba kukho iziphumo ebezingalindelekanga ezinzulu (ii-allergies, uxinzelelo lwegazi oluphezulu, utshintsho kwindlela yokuziphatha), funa ingcebiso kagqirha ngoko nangoko .

Musa ukuyeka ukuthatha amayeza okanye ukutshintsha idosi nangasiphi na isizathu ngaphandle kwengcebiso kagqirha wakho.

I-Safinamide, isifo sikaParkinson, i-MAOI, isifo sikaParkinson, amayeza, iziphumo ebezingalindelekanga, i-Xadago

⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.