Ngaba unesifo sesibindi esibizwa ngokuba yiPrimary Biliary Cholangitis ( PBC )? Okanye ngaba kukho umntu omaziyo onale meko? Ngamafutshane, kulapho imibhobho yenyongo esibindini sethu yonakeleyo kwaye inyongo iqokelelana emzimbeni. Oku ngamanye amaxesha kunokuba neempawu ezingaqhelekanga, okanye iimpawu ezinje ngokudinwa kakhulu kunye nokurhawuzelela zinokwenzeka. Ekuhambeni kwexesha, le meko inokuba yingozi. Ngoko ke namhlanje sithetha ngeyeza elitsha elibizwa ngokuba yi-Iqirvo (elafibranor) lokunyanga esi sifo.
Yintoni i-Iqirvo? Isebenza njani?
I-Iqirvo liyeza elinceda ekunyangeni i-primary biliary cholangitis (PBC). Lisebenza ngokunciphisa inani le-bile eqokelelana emzimbeni wakho. Uyazi ukuba lenza njani loo nto? Eli yeza libonisa umzimba wakho ukuba uyeke ukuvelisa i-bile. Oko kukuthi, lilawula ukuveliswa kwe -bile acids .
I-Iqirvo idla ngokunikwa kunye nelinye iyeza. Elo yeza yi-ursodeoxycholic acid. Ugqirha wakho usenokuba ukunike eli yeza.
Luphandwe njani olu yeza?
Njengayo nayiphi na iyeza elitsha, i-Iqirvo ifundwe kakhulu ngaphambi kokuba inikwe abantu. Olu phononongo lubandakanye abantu abali-161 abane-PBC.
- Amaqela amabini: Aba bantu bahlulwe baba ngamaqela amabini. Elinye iqela lanikwa idosi yemihla ngemihla ye-Iqirvo 80 mg. Elinye iqela lanikwa ipilisi ye-placebo .
- Yintoni i-placebo?: Yipilisi engenanto engenalo naliphi na iyeza elisebenzayo kwaye ifana neyeza. Inikwa ukulinganisa isiphumo sokwenyani seyeza.
- Ixesha: Unyango lwalunikwa ngolu hlobo ubuncinane unyaka wonke. Emva koko, abo babefuna banikwa ithuba lokuhlala kuphando unyaka omnye.
Abaphandi bajonge kakhulu amaxabiso elebhu yesibindi egazini ukuze babone ukuba iyeza liyasebenza na. Umzekelo, bajonge ukuba amanqanaba e -alkaline phosphatase kunye ne-bilirubin aphucukile na. Bakwalinganise nendlela abaguli abarhawuzelelwa ngayo besebenzisa isikali esibizwa ngokuba yiWorst Itch Numeric Rating Scale (WI-NRS) kwiiveki ezingama-24 nezingama-52.
Zithini iziphumo zophando?
Ekupheleni kophando, ndifumanise izinto ezibaluleke kakhulu.
Kwabo bathathe i-Iqirvo, ama-51% (oko kukuthi ngaphezulu kwesiqingatha) abonakalise ukuphucuka okukhulu kwiziphumo zovavanyo lwegazi olunxulumene nesibindi.
Nangona kunjalo, yi-4% kuphela yabo bathathe i-placebo ababonakalise olu hlobo lokuphucuka. Oku kubonisa ngokucacileyo ukuba i-Iqirvo inesiphumo esisebenzayo.
Ngokuphathelele ukurhawuzelelwa, nangona abo bathathe i-Iqirvo befumene isiqabu, sasifana kakhulu nesiqabu esafunyanwa ngabo bathathe i-placebo. Ke ngoko, kusenzima ukutsho ukuba yintoni kanye kanye impembelelo ekurhawuzelweni.
Okubaluleke kakhulu: Khumbula, ezi ziziphumo zophando. Iziphumo zakho zinokwahluka. Yiyo loo nto yonke into kufuneka ixoxwe nogqirha wakho.
Ngubani ongafanele athathe i-Iqirvo?
Eli yeza alifanelekanga kuye wonke umntu. Ukuba unenye yezi meko zilandelayo, akufanele usebenzise i-Iqirvo. Qiniseka ukuba uthetha nogqirha wakho ngale nto.
| Imeko | Inkcazo |
|---|---|
| Isifo sesibindi esibi kakhulu | Ukuba unesifo sesibindi esinzima, ingakumbi isifo sesibindi esingasebenzi kakuhle. |
| Ukuvaleka kwenyongo | Ukuba une-biliary evalekileyo kwisibindi sakho. |
| Ukukhulelwa | Ukuba ukhulelwe okanye unethemba lokukhulelwa. |
| Ukuncancisa | Ukuba ungumama oncancisa umntwana wakho. |
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Njengayo nayiphi na iyeza, i-Iqirvo inokubangela iziphumo ebezingalindelekanga kwabanye abantu.Iziphumo ebezingalindelekanga zinokwenzeka.
Ukuqhekeka kwamathambo
Nangona oku kungaqhelekanga, kwizifundo, abanye abantu abathathe i-Iqirvo baye baphuka amathambo. Xelela ugqirha wakho ukuba ukhe waphuka amathambo ngaphambili okanye ukuba usemngciphekweni wokuphuka amathambo (njenge- osteoporosis ). Ezi zinto zinokukunceda ugcine amathambo akho eqinile:
- Yitya ukutya okutyebileyo kwi-calcium: izinto ezifana neyogathi, i-tofu, i-salmon. Ukuba kuyimfuneko, thatha iipilisi ze-calcium njengoko ugqirha wakho ekuyalele.
- Fumana iVithamin D : IVithamin D ifumaneka ekutyeni okufana neentlanzi ezinamafutha, amaqanda , kunye nelanga.
- Yenza umthambo rhoqo: Oku kuqinisa izihlunu kwaye kunciphisa umngcipheko wokuwa.
- Kuphephe ukutshaya.
- Lawula iswekile kunye notywala.
Ezinye iziphumo ebezingalindelekanga eziqhelekileyo
Apha ngezantsi kukho ezinye zeziphumo ebezingalindelekanga abantu abaninzi abazifumanayo kunye nezinto ezilula onokuzenza ngazo. Kodwa ukuba ezi ziyaqhubeka , qiniseka ukuba ubona ugqirha wakho .
| Imiphumela | Izinto onokuzenza |
|---|---|
| Isicaphucaphu nokuhlanza | Sela iziselo ezifana nejinja okanye amanzi. Ukutya okungeyomfuneko okufana neecrackers kunye netoast kunokunceda. |
| Ukuqhinwa | Sela amanzi amaninzi. Yitya iziqhamo, imifuno kunye nefayibha engaphezulu. Iiprobiotics ezifana neyogathi kunye ne-kefir zilungile. |
| Isitshiso sentliziyo | Ziphephe izinto ezibangela ukudumba, ezifana netshokholethi, ukutya okunamafutha, ikofu, kunye notywala. Yitya ukutya okuncinci endaweni yokutya kakhulu ngaxeshanye. Ungabuza ugqirha wakho malunga nokuthatha amayeza okunciphisa i-asidi. |
| Umlomo owomileyo | Hlafuna itshungama okanye iilekese ezingenaswekile. Sela amanzi amaninzi. Zama ukuphefumla ngeempumlo zakho endaweni yokuphefumla ngomlomo. |
Ngaba i-Iqirvo ingasebenzisana namanye amayeza? (Ukusebenzisana kwamayeza)
Ewe, eli linqaku elibaluleke kakhulu. I-Iqirvo inokusebenzisana namanye amayeza owasebenzisayo. Oku kunokunciphisa ukusebenza kakuhle kwamayeza okanye kwandise iziphumo ebezingalindelekanga.
| Uhlobo lweyeza | Iziphumo ezinokubakho kunye neengcebiso |
|---|---|
| Iipilisi/iindlela zokulawula ukukhulelwa | Ukusebenzisa i-Iqirvo kunokunciphisa ukusebenza kweendlela zokulawula ukuzalwa ngokwehomoni (iipilisi, amabala). Ke ngoko, kubalulekile ukusebenzisa olunye uhlobo lokulawula ukuzalwa, njengeekhondom, ukongeza. |
| Iistatins, uhlobo lwesiyobisi esinciphisa i-cholesterol | Ukusela la mayeza mabini kunye kunokunyusa umngcipheko weentlungu okanye umonakalo wemisipha. Ukuba ufumana loo ntlungu, xelela ugqirha wakho ngoko nangoko. |
| Izinto ezidibanisa i-bile acid | La mayeza akwasetyenziswa kwi-cholesterol. La mayeza anokuthintela umzimba ekufunxeni i-Iqirvo. Ngoko ke, eli yeza kufuneka lithathwe kwiiyure ezi-4 ngaphambi okanye emva kokuthatha i-Iqirvo. |
| I-Rifampin | Le yi-antibiotic esetyenziselwa ukunyanga isifo sephepha. Inganciphisa inani le-Iqirvo emzimbeni wakho. Ukuba usebenzisa la mayeza omabini, ugqirha wakho uza kwenza uvavanyo lwegazi. |
Kungoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho malunga namayeza onke owasebenzisayo, nokuba yivithamini okanye iyeza le-Ayurvedic.
Umyalezo Wokuya Ekhaya
- I-Iqirvo liyeza elitsha elisetyenziselwa ukunyanga i-primary biliary cholangitis (PBC).
- Oku kusebenza kakhulu ngokunciphisa ukuveliswa kwenyongo emzimbeni nokulawula umonakalo kwisibindi.
- Uphando lubonise ukuba oku kusebenza kakhulu ekuphuculeni iziphumo zovavanyo lwegazi olunxulumene nesibindi.
- Oku akufanelekanga kubafazi abakhulelweyo, abafazi abancancisayo, kunye nabo banesifo sesibindi esinzima.
- Kubalulekile ukwazisa ugqirha wakho ngamanye amayeza owasebenzisayo, njengoko amanye amayeza anokuchaphazela i-Iqirvo.
- Thetha ngokukhululekileyo nogqirha wakho malunga naziphi na iziphumo ebezingalindelekanga okanye izinto ezikuxhalabisayo.
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