Ake sifunde kabanzi nge-hormone i-Leptin, ekusiza ukulawula isisindo sakho.

Wake wazibuza ukuthi kungani silamba, ukuthi sizizwa kanjani sigcwele ngemva kokudla, nokuthi kungani kulula kwabanye ukukhuluphala kuyilapho kunzima kwabanye ukwehlisa isisindo? Namuhla sizokhuluma ngesithunywa esincane samakhemikhali esikhiqizwa ngaphakathi emizimbeni yethu esihlobene nakho konke lokhu. Sibizwa ngokuthi i-Leptin. Uma sikhuluma ngokuqondile, i-leptin iyi-hormone ekhishwa amaseli ethu amafutha (izicubu zamafutha) esisisiza ukuba silondoloze isisindo somzimba wethu isikhathi eside.

Iyini i-Leptin? Ake sibheke kalula.

Cabanga ukuthi amafutha omzimba wakho akhiqiza le hormone ebizwa ngokuthi i-Leptin. Ngakho-ke, umsebenzi oyinhloko wale Leptin ukulawula indlala yethu nokusinika umuzwa wokuthi "sekwanele, sengisuthi" (ukusutha) ngemva kokudla. Kufana nomphathi omncane olawula isisindo somzimba wethu.

Ososayensi bathole i-hormone i-leptin ngo-1994. Lokho kusho ukuthi kusekuningi okufanele kufundwe ngayo. Sebevele bacwaninga ukuthi i-leptin ingasetshenziswa yini ekwelapheni ukulawula isisindo, isifo i-Alzheimer's, impilo yokuzala, kanye nokungabi nabantwana.

"Ah... uma i-leptin ilawula isisindo, akufanele yini nathi sikwazi ukulawula i-leptin?" ungase ucabange. Kodwa, iqiniso liwukuthi, le hormone akulula ukuyilawula ngendlela esiyifunayo.

Yini i-leptin eyenzela imizimba yethu?

Umsebenzi oyinhloko we-Leptin ukusiza ukugcina isisindo somzimba wethu sizinzile. Ngokuqondile, kusiza ukugcina ibhalansi yesikhathi eside phakathi kwenani lokudla esikudlayo nendlela umzimba wethu osebenzisa ngayo amandla. Okusho ukuthi, kusiza ekuvimbeleni ukuzizwa silambile lapho umzimba wethu ungadingi amandla (amakhalori).

I-Leptin isebenza kakhulu kwi-hypothalamus, ingxenye yobuchopho bethu elawula ibhalansi yethu yokulamba kanye namandla. Kodwa-ke, ama-receptor azwela i-leptin atholakala nakwezinye izingxenye zomzimba wethu.

Kodwa nakhu okudingeka ukuqonde. I-Leptin akuyona i-hormone esenza silambe ngemva kokudla okukodwa. Kunalokho, isisiza ukuba silondoloze isisindo sethu ngokushintsha inani lokudla esikudlayo ngokuhamba kwesikhathi , silawule indlela esisebenzisa ngayo amandla, futhi isisize silawule isisindo sethu.

Imiphumela ye-Leptin izwakala kakhulu uma uzama ukwehlisa isisindo. Cabanga ngakho, lapho amafutha omzimba wakho ehla, amazinga akho e-leptin nawo ayancipha. Bese ubuchopho buthola isignali ethi, "O, umzimba awunakho ukudla okwanele, kufana nokuthi sizila ukudla." Yingakho ngezinye izikhathi uzizwa ulambile kakhulu futhi ufisa ukudla okuhlukile. Bese ulingeka ukuba udle kakhulu. Lokhu kungenza kube nzima nakakhulu ukwehlisa isisindo.

Ososayensi basacwaninga nge-Leptin. Bakholelwa ukuthi i-Leptin nayo ithinta:

• Ukuguqulwa kwe-Metabolism
• Uhlelo lwe-endocrine - okungukuthi, uhlelo lwethu lwe-hormone
• Isimiso somzimba sokuzivikela - uhlelo oluvikela ezifweni

Amazinga e-leptin alawulwa kanjani?

I-Leptin ikhiqizwa futhi ikhishwe yizicubu ezimhlophe zamafutha emizimbeni yethu. Lesi zicubu ezimhlophe zamafutha uhlobo oluyinhloko lwamafutha emizimbeni yethu. Kalula nje, amafutha agcinwa emzimbeni wakho.

Ngenxa yokuthi i-Leptin ikhiqizwa amaseli amafutha, inani le-Leptin egazini lakho lihlobene ngqo nenani lamafutha emzimbeni wakho. Lokho kusho ukuthi, uma unamafutha omzimba amancane, une-Leptin encane. Uma unamafutha omzimba amaningi, une-Leptin eningi. Kulula, akunjalo?

Uma isisindo samafutha emzimbeni wakho sikhula ngokuhamba kwesikhathi, amazinga akho e-leptin azokhula. Ngakolunye uhlangothi, uma isisindo samafutha emzimbeni wakho sincipha, amazinga akho e-leptin azoncipha.

Kwenzekani uma i-leptin ikhuphuka?

Amazinga e-Leptin avame ukuba phezulu kubantu abanokukhuluphala ngokweqile. Lokhu kubizwa ngokuthi i-hyperleptinemia. Uma amazinga e-leptin ephakeme njalo, ubuchopho bethu bungase bungasabeli kahle ku-leptin. Lokhu kubizwa ngokuthi ukumelana ne-leptin .

Kunezinye izimo eziningana ezingase zihlotshaniswe ne-hyperleptinemia:

• Ukucindezeleka
• Umlutha wokudla
• Izinkinga ze-Neurodegenerative
• Isifo sesibindi esinamafutha esingadakwanga
• I-Rabson-Mendenhall syndrome - Lesi yisimo esingavamile kakhulu sofuzo.

Kuyini Ukumelana ne-Leptin?

Uma une-Leptin Resistance, ubuchopho bakho abuphenduli ku-Leptin ngendlela evamile. Cabanga nje, i-Leptin iqhubeka nokuthumela izimpawu ebuchosheni ithi "Ngidle ukudla okwanele, sengisuthi," kodwa ubuchopho abubonakali bunendaba. Ngakho-ke, awuzizwa usuthi. Ngenxa yalokhu, uyaqhubeka nokudla, yize unamafutha amaningi agcinwe emzimbeni wakho.

Akukhona lokho kuphela, kodwa ngenxa yokuthi i-Leptin ayisebenzi kahle, ubuchopho bucabanga ukuthi umzimba uyalamba nokuthi uyalamba. Bese, ukuze kulondolozwe amandla, ubuchopho buyanciphisa amazinga ethu amandla, futhi bunciphise nenani lamakhalori esiwasebenzisayo lapho siphumule. Kalula nje, i-Basal Metabolic Rate (BMR) yethu iyancishiswa.

Ngakho-ke uyabona, ukumelana ne-leptin kukwenza uzizwe ulambile ngaso sonke isikhathi, futhi kunciphisa ne-BMR yakho. Uma lezi zinto ezimbili zihlangana, ukukhuluphala kuba kubi nakakhulu.

Ososayensi okwamanje bacwaninga ngemithi engelapha ukumelana ne-leptin.

Yiziphi izimpawu zokumelana ne-Leptin?

Izimpawu eziyinhloko zokumelana ne-leptin umuzwa oqhubekayo wendlala enkulu (hyperphagia) kanye nokudla ngokweqile. Lezi zimpawu zenzeka ngisho noma kunamafutha amaningi agcinwe emzimbeni.

Kodwa-ke, kunezinye izici nezimo ezingabangela lezi zimpawu. Ukumelana ne-Leptin akuyona yodwa. Njengoba ososayensi besafunda nge-leptin, kungenzeka ukuthi izimpawu ezengeziwe zokumelana ne-leptin zizotholakala esikhathini esizayo.

Kwenzekani uma i-leptin yehla?

Ukuntuleka kwe-Leptin kuyisimo esingavamile kakhulu. Isifo esiyinhloko esihambisana nakho ukuntuleka kwe-leptin yokuzalwa. Lesi yisimo sofuzo esiba khona lapho umuntu ezalwa. Abantu abanalesi simo abakhiqizi i-leptin ezicutshini zabo zamafutha.

Uma i-leptin ingekho, umzimba ucabanga ukuthi akukho mafutha emzimbeni. Lokhu kubangela indlala engalawuleki, indlala enkulu kanye nesifiso sokudla. Ngenxa yalesi sizathu, izingane ezizalwa nazo zinesifo sokukhuluphala ngokweqile (ukukhuluphala kwesigaba sesi-3) zisencane kakhulu, futhi ukuthomba kuyalibaziseka.

Ezinye izifo ezingase zihlotshaniswe nalesi simo:

• I-Dyslipidemia - ukungalingani kwamafutha njenge-cholesterol kanye ne-triglycerides
• Isifo sesibindi esinamafutha
• Ukutheleleka njalo kwamagciwane
• I-Hyperinsulinemia - okusho ukukhiqiza i-insulin eningi kakhulu
• I-hypogonadotropic hypogonadism - okusho amazinga aphansi ama-hormone ocansi

Hlobo luni lokuhlolwa okwenziwayo ukuhlola amazinga e-leptin?

Amazinga e-Leptin angalinganiswa ngokuhlolwa kwegazi. Kodwa-ke, odokotela abavamisile ukuhlola amazinga e-leptin awo wonke umuntu. Bancoma ukuhlolwa kwe-leptin ezimweni ezilandelayo:

• Uma ingane yakho encane inokukhuluphala kwesigaba sesi-3 .
• Uma ukhuluphele futhi ulambile njalo .

Amazinga ajwayelekile e-leptin kufanele abe njani?

Amazinga e-Leptin ngokuvamile angasukela ku:

• Kwabesifazane: 0.5 kuya ku-15.2 nanograms nge-milliliter (ng/mL)
• Kwabesilisa: 0.5 kuya ku-12.5 nanograms nge-milliliter (ng/mL)

Kodwa khumbula, la mazinga ajwayelekile angahluka kancane phakathi kwama-laboratory ahlukene. Ngakho-ke, kungcono ukuhlola ububanzi obujwayelekile embikweni wakho. Noma, kungcono ukubuza udokotela wakho ngakho.

Ngingawandisa kanjani amazinga ami e-leptin?

Uma sikhuluma iqiniso, kuncane kakhulu esingakwenza ukwandisa amazinga ethu e-leptin ukuze sinciphise indlala kanye nesifiso sokudla. Ngoba, njengoba kushiwo ngaphambili, amazinga akho e-leptin ahlobene ngqo nenani lamafutha onawo emzimbeni wakho.

Ucwaningo olulodwa luthole ukuthi abantu abalala kancane banamazinga aphezulu e-hormone yendlala i-ghrelin kanye namazinga aphansi e-hormone i-leptin. Ngakho-ke, ukulala ngokwanele, okuseqophelweni eliphezulu kungasiza ekulawuleni ama-hormone akho.

Ososayensi baphenya nobudlelwano phakathi kwe-leptin nohlobo lwamafutha olubizwa ngokuthi ama-triglycerides. Olunye ucwaningo lukhombisile ukuthi amazinga aphezulu e-triglyceride athinta indlela i-leptin esebenza ngayo. Kodwa kusenemibono ehlukene ngalokhu. Abanye ososayensi bacabanga ukuthi uhlelo lokudla olunciphisa ama-triglycerides lungasiza ekuthuthukiseni amazinga e-leptin. Kodwa abanye abavumelani.

Yikuphi ukudla okune-Leptin eningi?

Yilapho abantu abaningi benza khona iphutha. I-Leptin iyi-hormone ekhiqizwa emizimbeni yethu, hhayi isakhamzimba esingasithola ekudleni okufana ne-vitamin C noma iphrotheni. Ngakho-ke, ayikho into efana nokudla okuqukethe i-leptin.

Okokugcina, ezinye zezinto ezibaluleke kakhulu okudingeka sizikhumbule

I-Leptin empeleni iyinto entsha etholakele, ngakho ososayensi basafunda kabanzi ngayo, ikakhulukazi ukuthi ithinta kanjani ukukhuluphala kanye nokwehla kwesisindo. Njengoba ubona, njengoba umzimba wakho ulahlekelwa amafutha, amazinga e-leptin ehla, okubonisa ukuthi umzimba wakho "uzila ukudla," okwenza kube nzima ukunciphisa isisindo.

Uma ukhathazekile ngesisindo sakho noma udinga isiqondiso sendlela yokwehlisa isisindo ngendlela enempilo, kungcono ukukhuluma nodokotela wakho. Ungakhuluma nodokotela we-endocrinologist mayelana nezinhlelo zokulawula isisindo.

Khumbula, konke lokhu kuzokusiza ukuthi uhlale uphilile. Kubalulekile ukuqaphela umzimba wakho.

I- Leptin, ukulawula isisindo, ama-hormone, indlala, ukukhuluphala, amafutha, i-metabolism