Ake sithole ngezinga lakho le-CK. Iyini le Creatine Kinase (CK)?

Ngezinye izikhathi uma uya kudokotela, ukucela ukuthi wenze ukuhlolwa kwegazi, akunjalo? Esinye sazo yilesi sivivinyo esibizwa ngokuthi i-CK. Ngakho-ke, lapho abantu abaningi bezwa lokhu, kufika umbuzo omncane engqondweni, "Kuyini lokhu ku-CK?" "Kungani lokhu kuhlolwa?" Ungakhathazeki, namuhla sizokhuluma ngale CK, emele i-Creatine Kinase, ngendlela elula ongayiqonda.

Kuyini i-creatine kinase (CK)?

Kalula nje, i-CK iyi -enzyme . I-enzyme uhlobo lweprotheni olusheshisa futhi lusize ngemiphumela ehlukahlukene yamakhemikhali emizimbeni yethu. Le enzyme ye-CK itholakala kakhulu emisipheni yenhliziyo yakho (okungukuthi, emisipheni esenhliziyweni yakho), emisipheni enamathele emathanjeni akho (esiyibiza ngokuthi 'imisipha yamathambo', okungukuthi, imisipha ekusiza ukuthi ushukumise izitho zakho futhi uhambe), futhi inani elincane kakhulu lisebuchosheni .

Ngakho-ke, uma kukhona umonakalo kula maseli emisipha, okungukuthi, imisipha yenhliziyo, imisipha yamathambo, noma amangqamuzana obuchopho, lawo maseli ayaphuka bese okuqukethwe kuphuma. Yilapho-ke le enzyme ye-CK ikhishwa egazini. Ngokuvamile, inani elincane kakhulu le-CK egazini lethu livela kulawo misipha yamathambo.

Ake sithi uvivinye umzimba kanzima kakhulu. Khona-ke imisipha yakho ingase yonakale kancane. Ngezikhathi ezinjalo, amazinga e-CK nawo anganda egazini. Futhi, uma kunezifo zemisipha (`Myopathies`), isibonelo, abantu abanezifo ezifana ne-`Muscular Dystrophy` nabo banamazinga aphezulu e-CK.

Ingabe kukhona izinhlobo zama-enzyme e-CK?

Yebo, kunezinhlobo ezintathu eziyinhloko zale enzyme ye-CK. Njengezingane zakubo emndenini, uhlobo ngalunye lutholakala ezingxenyeni ezahlukene zomzimba wethu:

• I-CK-MM: Lolu hlobo lutholakala kakhulu emisipheni yakho yamathambo .
• I-CK-MB: Lokhu kutholakala kakhulu emisipheni yenhliziyo yakho.
• I-CK-BB: Lolu hlobo lutholakala kakhulu ezicutshini zobuchopho .

Kubalulekile ukwazi lezi zinhlobo, ngoba uma amazinga e-CK ekhuphuka, ngokubheka ukuthi hlobo luni lwe-CK olukhuphukayo, ungathola umbono oqondile wokuthi umonakalo wenzeke kuphi emzimbeni.

Ngakho-ke, iyini i-creatine kinase (CK) test?

Ukuhlolwa kwe-creatine kinase (CK) kulinganisa inani le-CK egazini lakho . Lokhu kuhlolwa kungabonisa ukuthi izinga lakho le-CK liphakeme kunokuvamile. Uma kunjalo, kungabonisa ukuthi kukhona umonakalo noma inkinga ethile emisipheni yakho yamathambo, enhliziyweni, noma ebuchosheni. Lo monakalo ungaba wesikhashana (obukhali) noma wesikhathi eside (ongalapheki).

Lokhu kuhlolwa kwe-CK kubizwa nangokuthi:

• Isamba se-CK
• I-CK creatine
• I-Phosphokinase CPK

Uyini umsebenzi we-enzyme ye-creatine kinase (CK)?

Nansi into ebalulekile. Akukho ukuxhumana okukhulu phakathi komsebenzi ojwayelekile we-enzyme ye-CK nalokho ekushoyo lapho izinga le-CK liphezulu egazini. Umsebenzi wangempela we-enzyme ye-CK ukwengeza iqembu le-phosphate entweni ebizwa ngokuthi i-creatine ngaphakathi kwamaseli ethu emisipha. I-Creatine yinto esiza imisipha ukuthi ikhiqize amandla. Ngakho-ke, lapho i-enzyme ye-CK ifaka i-phosphate kule creatine, iba yi-molecule enamandla aphezulu ebizwa ngokuthi i-phosphocreatine . Imizimba yethu isebenzisa le phosphocreatine ukukhiqiza amandla.

Ngakho-ke, uma imisipha yakho, inhliziyo, noma ubuchopho bakho konakala, lawo maseli ayaphuka. Bese i-enzyme ye-CK engaphakathi kwalawo maseli, kanye nezinye izinto, ikhishwa iye egazini. Yileyo ndlela izinga le-CK egazini elikhuphuka ngayo. Lokho kusho ukuthi izinga le-CK liyakhuphuka, hhayi ngenxa yokusebenza kwalo okuvamile, kodwa ngoba amaseli alimele futhi i-CK ivuza iye egazini.

Zisetshenziselwa ini izivivinyo ze-CK?

Odokotela bavame ukusebenzisa ukuhlolwa kwe-CK ukuze baxilonge futhi baqaphe izinkinga zemisipha . Lokho kusho ukuthi:

• Izifo zemisipha (`Izifo zemisipha` / `I-Myopathies`): Izibonelo zalezi yilezi:
• I-Duchenne muscular dystrophy (DMD): Lesi yisifo esingavamile, esizuzwe njengefa esibangela ukuba imisipha yamathambo ibe buthaka, iphuke, futhi ilahlekelwe ukusebenza. Sivame ukuthinta abafana.
• I-Rhabdomyolysis: Lesi yisimo lapho izicubu zemisipha ziphuka khona ngokushesha okukhulu. Lokhu kungabangelwa ukulimala okukhulu, isifo semisipha, noma esinye isimo.
• Ukulimala kwemisipha: Lokhu kungaba:
• Ukuqina kwemisipha, ukucindezeleka, ukudabuka, noma ukudonsa ngenxa yengozi noma ukuzivocavoca ngokweqile.
• Ukusha kwezinga lesithathu.
• Ukushaqeka kukagesi.
• Ukuvuvukala kwemisipha (Myositis): Izibonelo zalokhu zifaka:
• I-Polymyositis: Lesi yisifo sokuvuvukala esenza imisipha ibe buthaka. Ngokuvamile sithinta imisipha eseduze nomzimba.
• I-Dermatyositis: Lesi yisimo esingavamile esibangela ubuthakathaka bemisipha kanye nokulimala kwesikhumba.
• I-Pyomyositis: Lokhu ukutheleleka okungavamile kwemisipha okubangelwa amagciwane. Ngokuvamile kwakheka ithumba.

Ngenxa yokuthi izimpawu zemisipha ngezinye izikhathi zingaba izimpawu zezinye izimo eziningi, udokotela wakho angase akucele ezinye izivivinyo eziningana kanye nokuhlolwa kwe-CK. Isibonelo:

• Ama-electrolyte
• I-BUN (i-nitrogen ye-urea egazini)
• I-Creatinine
• I-Myoglobin emchameni

Ukuhlolwa kwe-CK kanye nokwehluleka kwenhliziyo

Esikhathini esidlule, ukuhlolwa kwe-CK kwakusetshenziselwa ukuxilonga ukuhlaselwa yinhliziyo. Kodwa manje akuvamile ukwenziwa. Ngoba manje sekusetshenziswa i-Troponin.Kukhona olunye uhlobo lokuhlolwa olubizwa ngokuthi i-troponin, olungcono kune-CK ekutholeni umonakalo wenhliziyo. Yingakho manje, isikhathi esiningi, uma kusolwa ukuthi kukhona ukuhlaselwa yinhliziyo, i-troponin iwukuhlolwa okuhlolwayo.

Kungani ngidinga ukuhlolwa kwe-CK?

Uma unezimpawu zokuphazamiseka kwemisipha, udokotela wakho angase akucele ukuhlolwa kwe-CK. Lezi zimpawu zifaka:

• Ubuhlungu bemisipha kanye/noma ukuqina.
• Ubuthakathaka bemisipha.
• Izinkinga ngokulinganisela komzimba.
• Ukungazweli noma ukuzwa ukucasuka.
• Umchamo onombala omnyama (njengophuzi).

Futhi, uma uke waba nokulimala kwemisipha noma isifo sohlangothi, kungadingeka futhi ukuthi kwenziwe lokhu kuhlolwa ngaleso sikhathi. Kwezinye ukulimala, kungathatha izinsuku ezimbili ukuthi amazinga e-CK afinyelele phezulu. Ngakho kungadingeka ukuthi kwenziwe lokhu kuhlolwa izikhathi ezingaphezu kwesisodwa.

Ubani owenza ukuhlolwa kwe-CK?

Ngokuvamile, isampula yegazi, okungukuthi, isampula yegazi lokuhlolwa kwe-CK, ithathwa yisisebenzi sezempilo esibizwa ngokuthi i-phlebotomist . Kodwa-ke, noma yisiphi isisebenzi sezempilo esiqeqeshwe ukuthatha igazi singakwenza lokhu. Isampula yegazi ithunyelwa elabhorethri. Lapho, usosayensi welabhorethri yezokwelapha ulungisa isampula bese eyihlola ngama -analyzer .

Ngilungiselela kanjani ukuhlolwa kwe-CK?

Ezimweni eziningi, akukho okudingeka ukwenze ukuze ulungiselele ukuhlolwa kwegazi kwe-CK ngqo.

Kodwa-ke, uma udokotela wakho eyalela lokhu kuhlolwa kwe-CK ukuze abheke noma yiziphi izinkinga zemisipha, kufanele unciphise ukuzivocavoca kwakho okunzima ezinsukwini eziholela ekuhlolweni. Lokhu kungenxa yokuthi ukuzivocavoca kungabangela nokucindezeleka kwemisipha okwesikhashana, okungakhuphula amazinga e-CK egazini. Ngakho-ke, yenza imisebenzi yakho evamile.

Yini ongayilindela lapho uthatha ukuhlolwa kwegazi kwe-CK?

Nakhu okwenzekayo uma unikela ngegazi:

1. Uzohlala esihlalweni. Isisebenzi sezempilo sizothola umthambo olula engalweni yakho wokukhipha igazi kuwo. Ngokuvamile, kukhethwa umthambo ngaphakathi kwengalo yakho, ohlangothini oluphambene nengqiniba yakho.

2. Uma umthambo usutholakele, indawo iyahlanzwa bese kufakwa umuthi wokubulala amagciwane.

3. Bese kufakwa inaliti encane kulowo mthambo bese kuthathwa isampula yegazi. Kuleli qophelo, ungase uzizwe sengathi ulunywe yintuthwane encane.

4. Ngemva kokufaka inaliti, igazi elincane lizoqoqwa epayipini lokuhlola.

5. Ngemva kokuthathwa kwesampula yegazi, inaliti iyasuswa bese kubekwa ucezu lwekotini noma i-gauze endaweni bese kufakwa ingcindezi ukuze kumiswe ukopha.

6. Bese kufakwa iplasta endaweni. Yilokho kuphela.

Lonke lolu hlelo luthatha imizuzu engaphansi kwemihlanu.

Kwenzekani ngemva kokuhlolwa kwe-CK?

Ngemva kokuthathwa kwesampula yegazi lakho, lithunyelwa elabhorethri. Uma imiphumela yokuhlolwa isifikile, udokotela wakho uzokwazisa imiphumela.

Ingabe zikhona izingozi zokuhlolwa kwegazi le-CK?

Ukuhlolwa kwegazi kuyindlela evamile kakhulu yokuhlolwa kwezokwelapha edingekayo. Azikho izingozi ezinkulu zokunikela ngegazi. Ungase uzizwe ubuhlungu noma ulimale kancane lapho igazi likhishwe khona. Kodwa lokho kuzoshesha kube ngcono.

Ngizoyazi nini imiphumela yokuhlolwa kwe-CK?

Esikhathini esiningi, kufanele uthole imiphumela yokuhlolwa kwe-CK yakho zingakapheli izinsuku ezimbili , kodwa ngezinye izikhathi kungathatha isikhathi eside.

Imiphumela yokuhlolwa kwe-CK isitshelani?

Umbiko wokuhlolwa kwegazi, okungukuthi, umbiko wokuhlolwa kwe-CK, uvame ukuqukethe ulwazi olulandelayo:

• Igama lokuhlolwa kwegazi, noma lokho okulinganiswe egazini lakho.
• Inombolo noma isilinganiso somphumela wokuhlolwa kwegazi lakho.
• Ububanzi bokulinganisa obujwayelekile balolo vivinyo.
• Ulwazi olufana nokuthi umphumela wakho ujwayelekile, awujwayelekile, uphezulu, uphansi, muhle, noma mubi.

Ayini amazinga ajwayelekile e-creatine kinase (CK)?

Izinga le-CK elijwayelekile kumuntu omdala onempilo lingahluka kuye ngezici eziningana:

• Ubulili bakho.
• Uhlanga lwakho.
• Izinga lomsebenzi wakho (okungukuthi, ukuthi uvivinya umzimba kangakanani kanye nokuzikhandla ngokomzimba).

Futhi, la mazinga ajwayelekile angahluka kuye ngezindlela zokuhlola ezisetshenziswa yilebhu ngayinye. Ngakho-ke, hlola njalo ububanzi bokubhekisela obunikezwe embikweni wakho webhu. Ngokwesilinganiso, amadoda anamazinga e-CK aphezulu kancane kunabesifazane.

Abantu abanemisipha eminingi (okungukuthi, labo abanamafutha amaningi emzimbeni) bangase babe namazinga aphezulu e-CK kunabanye.

Kusho ukuthini ukuthi izinga le-creatine kinase (CK) liphezulu?

Uma izinga lakho le-CK liphezulu, noma uma izinga lakho le-CK liphakama njalo ekuhlolweni kwe-CK okuphindaphindiwe, ngokuvamile kusho ukuthi muva nje uke waba nohlobo oluthile lomonakalo wemisipha. Kodwa-ke, ukuhlolwa kwe-CK kuphela akukwazi ukusho ngqo ukuthi yimuphi umsipha owonakele, noma ukuthi yini ebangele umonakalo.

Okubalulekile: Ungesabi uma izinga lakho le-CK liphakeme. Udokotela wakho kungadingeka enze izivivinyo ezengeziwe ukuze athole imbangela.

Odokotela bavame ukwenza uchungechunge lwezivivinyo ze-CK ukuze babone ukuthi amazinga akho e-CK ashintsha kanjani. Uma amazinga akho e-CK ephakama bese ehla kancane kancane, lokho kusho ukuthi umonakalo wemisipha yakho uyehla. Kodwa uma amazinga akho e-CK eqhubeka ekhuphuka, noma ehlala ephezulu, kungabonisa ukuthi ubhekene nomonakalo wemisipha oqhubekayo noma ukuwohloka kwemisipha.

Uma imiphumela yakho ikhombisa ukuthi amazinga akho e-CK aphezulu kunokujwayelekile, udokotela wakho angase a-ode ukuhlolwa kwezinhlobo zama-enzyme e-CK engikhulume ngawo ekuqaleni (CK-MM, CK-MB, CK-BB) ukusiza ekunqumeni ukuthi hlobo luni lwemisipha elimele:

• Ama-enzyme e-CK-MM: Uma la mazinga ephezulu, kungabonisa ukulimala kwemisipha noma isifo semisipha, isibonelo, isimo esifana ne-muscular dystrophy noma i-rhabdomyolysis.
• I-enzyme ye-CK-MB:Uma la mazinga ephezulu, kungabonisa ukuthi unokuvuvukala emisipheni yenhliziyo yakho, noma ukuthi uqala ukuhlaselwa yinhliziyo noma usanda kuba nakho.
• Ama-enzyme e-CK-BB: Uma la mazinga ephezulu, kungase kubonise ukuthi uke waba nesifo sohlangothi noma ukulimala kobuchopho.

Ezinye izizathu zokuthi kungani amazinga e-creatine kinase (CK) engase akhuphuke

Ezinye izimo zezokwelapha kanye nokulimala okungahlobene ngqo nemisipha yakho nakho kungabangela amazinga aphezulu e-CK. Nazi ezinye zezimbangela:

• Izinkinga ze-endocrine, njengesifo se-thyroid, isifo sika-Addison, noma i-Cushing's syndrome.
• Ukuhlinzwa kwesikhathi eside.
• Ukuquleka.
• Izifo (ezibangelwa amagciwane, amagciwane, isikhunta noma ama-parasitic).
• Izifo zezicubu ezixhumeneyo, isibonelo, i-lupus kanye ne-rheumatoid arthritis.
• Isifo se-Celiac.
• Ukwehluleka kwezinso.
• Umkhuhlane omkhulu kanye nokuthuthumela.
• Ihlule legazi.
• Noma yimuphi umuthi noma ubuthi obuphazamisa ukukhiqizwa kwamandla emisipha noma okwandisa izidingo zamandla.
• Uma ufaka imijovo.

Ingabe kufanele ngikhathazeke uma izinga lami le-creatine kinase (CK) liphakeme kunokuvamile?

Ngisho noma imiphumela yokuhlolwa kwakho kwe-CK ikhombisa ukuthi izinga lakho le-CK liphezulu, akusho ukuthi unesifo esithile. Izinga lakho le-CK lingakhuphuka okwesikhashana ngezizathu eziningi, njengokuzivocavoca umzimba, ukuphuza imithi ethile, noma ukuthola imijovo. Kungenzeka futhi ukuthi kukhona okungahambanga kahle ngesikhathi sokuhlolwa.

Lapho ethatha isinqumo ngemiphumela yakho, udokotela wakho uzocabangela izici eziningi, njengemithi oyiphuzayo njengamanje, indlela ophila ngayo, kanye nezimpawu zakho. Uzokutshela ukuthi udinga ukuhlolwa okwengeziwe.

Uma unemibuzo mayelana nemiphumela yakho, ungesabi ukukhuluma nodokotela wakho.

Kufanele ngimbone nini udokotela?

Ubuhlungu bemisipha kanye nobuthakathaka ngokuvamile kungokwesikhashana. Kodwa uma unezinkinga zemisipha eziqhubekayo , khuluma nodokotela wakho ngezimpawu zakho. Uzoyala ukuhlolwa kwe-CK kanye nezinye izivivinyo ukuze azame ukuthola imbangela yezimpawu zakho.

Kuvamile ukuzizwa wesaba uma ubona umphumela wokuhlolwa ongajwayelekile. Kodwa khumbula, izinga eliphezulu le-CK akusho ukuthi unesifo esibucayi futhi udinga ukwelashwa. Udokotela wakho uzokutshela uma udinga ukuhlolwa okwengeziwe ukuthola imbangela yezinga elingajwayelekile. Ungesabi ukubuza udokotela wakho imibuzo. Bakhona ukukusiza.

Izinto okufanele uzikhumbule kulesi sihloko (Umyalezo Wokuya Ekhaya)

Kulungile, ngakho-ke sesikhulume kakhulu nge-CK namuhla, akunjalo? Nazi izinto ezimbalwa okufanele uzikhumbule ngamafuphi:

• I-CK iyi-enzyme eqoqana egazini uma kukhona umonakalo emisipheni, enhliziyweni, noma ebuchosheni.
• Ukuhlolwa kwe-CK kulinganisa izinga le-CK egazini. Uma liphezulu, kungase kubonise ukulimala kwemisipha.
• Kungaba nezizathu eziningi zokwanda kwe-CK. Kungabangelwa futhi yizinto ezifana nokuzivocavoca umzimba, imithi ethile, kanye nokulimala.
• Awukwazi ukusho ngokuqinisekile ngesifo ngokubheka nje izinga lakho le-CK. Udokotela wakho uzokwenza isinqumo ngokusekelwe kwezinye izimpawu zakho kanye neminye imiphumela yokuhlolwa.
• Uma unemibuzo mayelana nombiko wakho we-CK, ungesabi ukubuza udokotela wakho.

Ngakho-ke, ngithemba ukuthi lolu lwazi luwusizo kuwe. Hlala uphilile!

I- Creatine Kinase, Ukuhlolwa kwe-CK, Ubuhlungu Bemisipha, Isifo Semisipha, Ama-Enzyme, Ukuhlolwa Kwegazi, Impilo