Indlela entsha yokuxilonga umdlavuza: Konke mayelana ne-liquid biopsy!

Wake wezwa ngegama elithi "i-liquid biopsy "? Mhlawumbe udokotela wakho ukutshelile ngalo, noma uke wafunda ngalo ndawana thize. Lena indlela entsha yokuhlola ebaluleke kakhulu yokuxilonga nokwelapha umdlavuza. Ngakho-ke, ake sixoxe ngakho kalula nangokucacile namuhla. Akukho okufanele ukwesabe, kufana nomngane wakho ekuchazela okuthile.

Kuyini lokhu kuhlolwa koketshezi? Kulula kakhulu!

Kalula nje, i-liquid biopsy iyisivivinyo esithatha inani elincane legazi . Lokhu kungabona ukuthi kukhona yini izimila ezinomdlavuza. Cabanga ukuthi njengoba isimila esinomdlavuza sikhula, izingcezu zaso ezincane zingaqhekeka zingene egazini lakho. Lezo zingcezu yilokho okutholwa yi-liquid biopsy.

Lolu vivinyo lubheka izinto ezimbili eziyinhloko:

• Amaseli Ezicubu Ezijikelezayo (ama-CTC): Lawa amangqamuzana omdlavuza aphuma esimila bese ehamba egazini lakho, njengezinhloli ezincane.
• I-DNA yesimila esijikelezayo (i-ctDNA): Lezi yizingcezu ze-DNA eziphuma emangqamuzaneni omdlavuza bese zingena egazini. Njengoba wazi, i-DNA ifana nencwadi equkethe ikhodi yezakhi zofuzo elawula ukuziphatha kwamangqamuzana ethu. Ngakho-ke, lezi zingcezu ze-ctDNA zingasitshela okuningi ngomdlavuza.

Ukuba khona kwalawa `(CTCs)` noma `(ctDNA)` egazini lakho kuwubufakazi bokuthi kukhona isimila somdlavuza endaweni ethile emzimbeni wakho. Futhi, njengoba lezi zingcezu ziphinde zinikeze `(ulwazi lwezakhi zofuzo )` lomdlavuza, kuzoba usizo olukhulu kudokotela wakho ekunqumeni ukuthi yikuphi ukwelashwa okufanele kakhulu kuwe.

Ukuhlolwa kwe-liquid biopsy kuyindlela entsha kakhulu. Inamandla okwenza umehluko omkhulu emkhakheni wokwelashwa komdlavuza. Sekuvele kunezindlela eziningana ezivunyelwe yi-US Food and Drug Administration (FDA). Ucwaningo ngalokhu lusaqhubeka.

Uyini umehluko phakathi kwe-liquid biopsy kanye ne-biopsy evamile esiyaziyo?

Cishe uke wezwa ngokuhlolwa okuvamile kwezicubu. Kuyo, udokotela uthatha ingxenye encane yezicubu ngqo esigaxeni somdlavuza bese eyihlola elabhorethri ukuze abone ukuthi inawo yini amangqamuzana omdlavuza.

Kodwa-ke, ku-biopsy yoketshezi, ucezu lwesimila aluthathwa ngqo . Kunalokho, lusetshenziselwa ukufuna ubufakazi bomdlavuza, okuyi-"CTC" yamangqamuzana omdlavuza noma i-"ctDNA" yomdlavuza esikhulume ngayo ngaphambili, egazini.

Ukuhlolwa njalo kwe-biopsy okwamanje kubhekwa njengendlela engcono kakhulu yokuthola ukuthi umdlavuza ukhona yini. Kubizwa nangokuthi "izinga legolide."

Ku-biopsy yoketshezi, noma ngabe unomdlavuza, asikho isiqinisekiso esingu-100% sokuthi uzokwazi ukubona izimpawu zawo kusampula eyodwa yegazi . Kodwa-ke, uma umdlavuza utholakala ku-biopsy yoketshezi, ulwazi olunikezayo ngamaseli omdlavuza lubaluleke kakhulu, futhi lungaba usizo kakhulu kodokotela ekuhleleni ukwelashwa.

Kukuziphi izimo lapho kwenziwa khona i-liquid biopsy?

Udokotela wakho angase asikisele i-biopsy yoketshezi ezimweni ezilandelayo:

• Uma unomdlavuza osabalele kwezinye izingxenye zomzimba wakho futhi ukwelashwa kwakho kwamanje kungasebenzi njengoba bekulindelekile . Umdlavuza osabalele uwuhlobo lomdlavuza olunolaka kakhulu olusabalele emzimbeni wakho wonke. Uma usabalala kanje, kungenzeka kakhulu ukuthi izingcezu zomdlavuza ziqhekeke zingene egazini lakho.

Udokotela angase acele i-liquid biopsy ukuze athole izinto ezifana nalezi:

• Thola isibikezelo: Ama-biopsy e-liquid angathola amangqamuzana esimila ajikelezayo (ama-CTC) ezinhlobo eziningi zomdlavuza . Inani eliphansi lamangqamuzana omdlavuza egazini libonisa isibikezelo esingcono. Inani eliphezulu lamangqamuzana omdlavuza libonisa isibikezelo esibi kakhulu. Ngakho-ke, udokotela wakho angenza lokhu kuhlolwa ngezikhathi ezithile ukuze aqaphe isimo sakho futhi alungise ukwelashwa kwakho uma kudingeka.
• Yenza izinqumo zokwelapha: Kunezindlela zokwelapha eziqondisa kuphela amangqamuzana athile omdlavuza (ukwelashwa okuqondisiwe). Lokhu kusho ukuthi uma iseli lomdlavuza linephutha elithile (ukuguqulwa) ku-DNA yalo, linganikezwa umuthi othize owenzelwe ukuhlasela lelo phutha. I-biopsy yolwelo ingathola la maphutha. Udokotela wakho angakunikeza ukwelashwa okuqondene nalelo phutha.

Futhi, ungenza i-liquid biopsy noma ngabe i-biopsy ejwayelekile ingenzeki ukuthola umdlavuza. Lokhu kungenxa yokuthi i-biopsy evamile iyinqubo ehlasela kakhulu kune-liquid biopsy. Ungase ungabi nempilo enhle ngokwanele ukuba wenze i-biopsy. Noma, kuye ngokuthi isimila sikuphi , kungaba nzima ukususa ingxenye yaso ngaphandle kokulimaza izitho ezibalulekile eziseduze.

Yiziphi izivivinyo ze-biopsy eziwuketshezi ezivunyelwe yi-FDA?

Ukuhlolwa okuvunyiwe yi-U.S. Food and Drug Administration (FDA) yilawo acwaningwe kahle futhi afakazelwe ukuthi aphephile futhi anembile. Ukuhlolwa okuningana kwe-liquid biopsy kusesesigabeni sokucwaninga. Kunezivivinyo ezine eziyinhloko ezivunyiwe yi-FDA njengamanje:

1. Ukuhlolwa kwe-Cell Search® Circulating Tumor Cell (CTC): Lokhu kuhlolwa kwe-CTC. Ibele, i-prostateLokhu kusetshenziselwa ukuthola umbono ngesimo sesikhathi esizayo sabantu abanomdlavuza osusakazekele emathunjini noma emathunjini. Uma kune-CTC ezimbalwa egazini, lokho kuyisibonakaliso esihle. Uma kune-CTC eziningi, lokho akulungile.

2. Ukuhlolwa Kokuguquka Kwe-EGFR kwe-cobas® v2: Lokhu kuhlola i-ctDNA. Kuthola ukuguquka kwezakhi zofuzo okubizwa nge-EGFR, okuvame kakhulu kumdlavuza wamaphaphu ongewona amaseli amancane (i-NSCLC). Lolu lwazi lungasiza udokotela wakho ukuthi anqume ukuthi yikuphi ukwelashwa okungcono kakhulu ukubhekisa kulolo guquko.

3. I-Guardant360® CDx: Lokhu kubheka ne-ctDNA. Isetshenziselwa ukuthola amaphutha ofuzo avamile kumaseli omdlavuza. Lokhu kusiza udokotela ukuthi akhethe ukwelashwa okusebenza kahle kakhulu.

4. I-FoundationOne® Liquid CDx: Lokhu kubheka ne-ctDNA. Lokhu kusiza ekutholeni amaphutha ofuzo (ukuguqulwa kwezakhi zofuzo) ezinhlotsheni ezahlukene zomdlavuza. Lokhu kusiza udokotela ukuthi anqume ukuthi yikuphi ukwelashwa okufanele kakhulu.

Kwenziwa kanjani ukuhlolwa kolwelo? Ingabe kuyabuhlungu?

I-biopsy yoketshezi iyindlela elula kakhulu yokuhlola igazi . Njengoba nje ubunganikeza isampula yegazi ukuze lihlolwe njalo. Udokotela noma umhlengikazi uzothatha isampula yegazi engalweni yakho alithumele elabhorethri ukuze lihlolwe.

Elabhorethri, umshini uhlukanisa igazi lakho libe izingxenye zamaseli (ingxenye eqinile) kanye ne-plasma (ingxenye ewuketshezi). Ngemuva kwalokho, isazi sezifo, uchwepheshe oqeqeshwe ukuhlaziya amasampula oketshezi kanye nezicubu, sibheka izimpawu zesifo engxenyeni ye-plasma, ebizwa ngokuthi ama-CTC noma i-ctDNA.

Ingabe lokhu kuyabuhlungu? Cha, ukuhlolwa koketshezi kufana nokunikela ngegazi. Uma inaliti ifakwa engalweni yakho, ungase uzizwe umuzwa omncane wokucasuka, njengokulunywa yintuthwane. Kodwa lokho kungakhululeki kuyaphela ngokushesha.

Enye inzuzo ye-liquid biopsy ukuthi inqubo ayiphazamisi kakhulu futhi ayibuhlungu kakhulu kune-biopsy evamile.

Ithini imiphumela yalolu vivinyo?

Imiphumela yokuhlolwa ikutshela ukuthi isampula yakho yegazi iqukethe `(CTCs)` noma `(ctDNA)` (`positive`) noma cha (`negative`) .

• Uma umphumela uthi ``ulungile`` , kusho ukuthi izinto ezishiwo zikhona egazini. Ngemuva kwalokho, lezi zivivinyo zingasiza ekutholeni ukuthi hlobo luni lomdlavuza onalo. Ikakhulukazi, izivivinyo ezifuna ``(ctDNA)`` zingakhomba futhi amaphutha avamile ofuzo ahlobene nezinhlobo ezithile zomdlavuza.

Kuthatha isikhathi esingakanani ukuthola imiphumela? Inembile kangakanani i-liquid biopsy?

Imiphumela yokuhlolwa kufanele itholakale zingakapheli amasonto amabili kuya kwamathathu .

Manje ake sibheke ukunemba kwalokhu. Ukuhlolwa kwe-biopsy okuwuketshezi okuvunyelwe yi-FDA, kuklanyelwe ini, futhi kwenza lowo msebenzi kanye.

• Udokotela angathola umbono ngesimo sesikhathi esizayo sesifo sakho futhi aqaphe isimo sesifo sakho ngokusebenzisa izivivinyo ze-`(CTC)`.
• Ngenxa yokuthi ukuhlolwa kwe-``(ctDNA)`` kungathola amaphutha ezakhi zofuzo ku-DNA yamaseli omdlavuza, kuyasiza ekwenzeni izinqumo zokwelashwa.

Kodwa-ke, i-biopsy yoketshezi ayinakuthenjelwa ngaso sonke isikhathi ekuxilongeni umdlavuza ngokuqiniseka okungu-100% . I-biopsy ejwayelekile iyadingeka ukuqinisekisa ukuba khona komdlavuza.

Ukuhlolwa kwe-liquid biopsy okwamanje kuyindawo yocwaningo olusebenzayo kanye nentuthuko. Ikhono lokuthola nokuqapha umdlavuza ngokuhlolwa kwegazi okulula liyinto enkulu. Ucwaningo luyaqhubeka ukuthuthukisa ukuhlolwa kwe-liquid biopsy okungabona umdlavuza ngaphambi kokuba ukhule. Kodwa-ke, kudingeka ucwaningo olwengeziwe ukuze kuqondwe amandla aphelele e-liquid biopsies. Kakade, bayasiza ekuxilongeni izinhlobo ezithile zomdlavuza futhi benze izinqumo zokwelashwa ezimweni ezithile. Esikhathini esizayo, cishe bazoba nezinzuzo ezinkulu nakakhulu.

Okokugcina, izinto okudingeka sizikhumbule

Kulungile, ngakho-ke sesikhulume kakhulu nge-liquid biopsy. Nazi izinto ezimbalwa okufanele uzikhumbule:

• I-Liquid biopsy iyisivivinyo esisha esibheka izimpawu zomdlavuza egazini .
• Lokhu kungabona `(ama-CTC)` (amangqamuzana omdlavuza) kanye `(ama-ctDNA)` (i-DNA yomdlavuza).
• Akukho ukungakhululeki okukhulu noma ubuhlungu njengokuhlolwa njalo kwezicubu.
• Lokhu kusiza ukuthola umbono ngesimo somdlavuza wesikhathi esizayo kanye nokunquma ukwelashwa .
• Ezinye izivivinyo ezivunyelwe yi-FDA sezivele zikhona.
• Kodwa-ke, ukuze kuqinisekiswe umdlavuza, kungase kudingeke ukuthi kwenziwe i-biopsy njalo .
• Lobu ubuchwepheshe obusathuthuka futhi obungaba usizo kakhulu esikhathini esizayo.

Into ebaluleke kakhulu ukuthi, uma unemibuzo noma ukukhathazeka ngalokhu, khuluma nodokotela wakho nakanjani. Angakuchazela konke ngendlela engcono kakhulu kuwe.

Ngiyethemba ukuthi lolu lwazi luwusizo kuwe! Hlala uphilile!

I- Liquid Biopsy, Umdlavuza, Ukutholwa Komdlavuza, i-ctDNA, ama-CTC, Ukuhlolwa Kwegazi, Ukwelashwa Komdlavuza