Uyalwazi lolu hlobo lomdlavuza webele olubizwa ngokuthi i-ER+? (Umdlavuza Webele One-Estrogen Receptor-Positive - ER+)

Wake wezwa ngomdlavuza webele? Mhlawumbe omunye wabangane bakho wake wezwa ngawo. Kunezinhlobo eziningana zomdlavuza webele. Namuhla sizokhuluma ngomunye wazo. Lowo umdlavuza webele one-ER+ (ER positive) . Nakuba igama lingase lizwakale liyinkimbinkimbi kancane, ake silichaze kalula.

Uyini umdlavuza webele we-ER+?

Kalula nje, umdlavuza webele we-ER+ uhlobo lomdlavuza webele. Khumbula, abesifazane bane-hormone ebizwa ngokuthi i-estrogen emizimbeni yabo. Le hormone iyasiza ngezinto eziningi. Kodwa-ke, ngezinye izikhathi le hormone ye-estrogen iyasiza futhi amangqamuzana omdlavuza akhule. Ngakho-ke, amangqamuzana omdlavuza webele akhula ngenxa ye-hormone ye-estrogen yilokho esikubiza ngokuthi umdlavuza webele we-ER+. I-'ER' imele i-Estrogen Receptor . Lokhu kusho ukuthi lawa maseli omdlavuza anezindawo lapho i-estrogen 'inganamathela khona'. Odokotela bahlola izinga lala ma-receptor e-estrogen ukuze bahlele ukwelashwa. Ngokuvamile, ukuhlinzwa kanye nokwelashwa ngama-hormone kusetshenziswa njengokwelapha lokhu. Abanye abantu bakubiza nangokuthi 'umdlavuza webele one-estrogen positive'.

Uvame kangakanani umdlavuza webele we-ER+?

Empeleni lokhu kuvame kakhulu kunalokho ongakucabanga. Iningi labantu abathola umdlavuza webele, cishe abangu-70 kwabayi-100, banalolu hlobo lomdlavuza olubizwa ngokuthi i-ER+. Lokhu kufaka phakathi amadoda, ngoba amadoda nawo angathola umdlavuza webele, kodwa awuvamile kakhulu. Ngakho-ke lokhu akuyona into engakaze izwakale.

Ziyini izimpawu zomdlavuza webele we-ER+?

Umuntu onomdlavuza webele we-ER+ uvame ukukhombisa izimpawu ezifanayo nezomuntu onomdlavuza webele. Ake sibheke ukuthi ziyini:

• Ukubona ushintsho ngobukhulu, ukuma, noma ukuma kwebele lakho . Mhlawumbe elinye ibele lihlukile kwelinye.
• Into enesigaxa noma enamaqhubu ibanjwa esandleni. Lokhu kungaba kuncane njengephizi.
• Umuzwa wokujiya noma ukuqina kwebele noma ikhwapha. Kufanele ukhathazeke kakhulu uma lokhu kukhona phakathi nomjikelezo wakho wokuya esikhathini wanyanga zonke.
• Ushintsho ekubukekeni noma ekuzweni kwesikhumba sebele noma ingono. Isikhumba singase sibonakale sinamaqhubu, siqhumile, sinamaqhubu, noma sivuvukele. Singaba bomvu noma sibe mnyama kunezinye izingxenye zebele.
• Ukuzwa indawo eqinile ngaphansi kwesikhumba, njengengcezu yemabula .
• Uketshezi olunegazi noma olucacile oluphuma engonweni.

Uma ucabanga ukuthi unezinye zalezi zimpawu, sicela ungesabi ukubona udokotela. Uma usheshe ukuqaphela, kuba lula ukwelapha.

Yini ebangela umdlavuza webele i-ER+?

Kulungile, manje ake sibone ukuthi lokhu kwenzeka kanjani ngempela. Emaseli omzimba wethu, kukhonaKunezinto ezibizwa ngokuthi ama-hormone receptors. Lezi zifana neminyango emincane, uhlobo lweprotheni. I-hormone i-estrogen egazini lethu ingabopha kula ma-receptor. Kumaseli aphilile, i-estrogen isiza amaseli ukuthi asebenze futhi akhule ngendlela evamile. Lokho kuvamile.

Kodwa-ke, kumdlavuza webele we-ER+, le hormone ye-estrogen ibopha amaprotheni angaphakathi kwamangqamuzana omdlavuza, okwenza lawo maseli omdlavuza akhule kakhulu. Cabanga ngakho njengokuthi i-estrogen ifana 'nomanyolo' wamangqamuzana omdlavuza. Ngezinye izikhathi, hhayi i-estrogen kuphela, kodwa nenye i-hormone ebizwa ngokuthi i-progesterone nayo inegalelo ekukhuleni kwala maseli omdlavuza. Sibiza lawo ma-cancer anamazinga aphezulu e-progesterone umdlavuza webele we-PR-positive (PR+). Amanye ama-cancer angaba yi-ER+ kanye ne-PR+.

Yiziphi izinto ezibangela lokhu?

Kunezici ezithile eziyingozi ezingathinta ukukhula komdlavuza webele we-ER+. Ake sibheke ukuthi ziyini.

Izici eziyingozi kwabesifazane:

Kwabesifazane, ingozi enkulu ukuchayeka isikhathi eside ku-hormone i-estrogen . Lokhu kusho ukuthi amazinga e-estrogen emzimbeni ahlala ephezulu isikhathi eside. Ake sibone ukuthi lokho kwenzeka kanjani:

• Ukuthomba kwasekuqaleni (ukuqala kokuya esikhathini kwasekuqaleni).
• Ukunqamuka kokuya esikhathini okulibazisekile .
• Ukuthola abantwana sekwephuzile noma ukungabi nabantwana nhlobo.
• Ukuthatha ukwelashwa ngama-hormone (ikakhulukazi lawo aqukethe i-estrogen) ngezimpawu ezenzeka ngemva kokunqamuka kokuya esikhathini.

Izici eziyingozi kwabesilisa:

Kwabesilisa, le ngozi ihlotshaniswa namazinga aphezulu e-estrogen kunavamile kanye namazinga aphansi e-testosterone emizimbeni yabo. Lokhu kubizwa ngokuthi ukungalingani kwama-hormone . Ezinye izibonelo yilezi:

• Ukukhuluphala ngokweqile .
• Isifo Sikashukela (i-Diabetes Mellitus) .
• Izimo ezifana ne -cirrhosis yesibindi .

Umdlavuza webele we-ER+ uhlolwa kanjani ngokunembile?

Uma usola ukuthi unomdlavuza webele, udokotela wakho uzoqala ngokuthatha i -biopsy yebele . Lokhu kuhilela ukuthatha isampula encane yezicubu ezivela eqhubu elinomdlavuza. Le sampula ithunyelwa elabhorethri. Lapho, isazi sezifo zezokwelapha , udokotela ogxile ekuhloleni izicubu, uzohlola izicubu ukuze abone ukuthi zinama-hormone receptors.

Uma umphumela wokuhlolwa kungu -Hormone Receptor-Positive (HR+) , kusho ukuthi i-estrogen, i-progesterone, noma womabili lawa ma-hormone asiza amangqamuzana omdlavuza ukukhula. I-ER+ nayo iyingxenye ye-HR+. Kusho ukuthi kukhona ama-receptor e-estrogen. Ngakho-keUma ukuhlolwa kubonisa ukuthi amazinga e-estrogen awaphezulu, umdlavuza webele ubhekwa njengone -estrogen receptor-negative (ER-negative) .

Yiziphi izindlela zokwelapha umdlavuza webele we-ER+?

Odokotela basebenzisa izindlela eziningana eziyinhloko lapho belapha umdlavuza webele we-ER+. Lezi zindlela zifaka:

• Ukuhlinzwa komdlavuza webele : Lokhu kuhilela ukususa izimila ezinomdlavuza.
• Ukwelashwa ngemisebe : Imisebe enamandla aphezulu isetshenziselwa ukubhubhisa amangqamuzana omdlavuza.
• Ukwelashwa ngamakhemikhali : Kulokhu kwelashwa, imithi isetshenziswa ukubulala amangqamuzana omdlavuza noma ukulawula ukukhula kwawo.
• Ukwelashwa ngama-hormone : Lokhu kubaluleke kakhulu kumdlavuza we-ER+. Kunezindlela ezimbili zokwenza lokhu:
• I-Aromatase inhibitors : Le mithi isebenza ngokunciphisa ukukhiqizwa kwe-hormone i-estrogen emzimbeni wakho, okusho ukuthi amangqamuzana omdlavuza awanakudla.
• Ama-Selective Estrogen Receptor Modulators (ama-SERM) : Le mithi isebenza ngokuvimbela i-hormone estrogen ekunamatheleni kumaseli omdlavuza. Futhi iyasiza ekunciphiseni ingozi yokubuya komdlavuza.

Udokotela uzohlola isimo sakho bese enquma ukuthi yikuphi kwalokhu kwelashwa okufanele wena nokuthi uzokunikeza kanjani.

Iyini imiphumela emibi yokwelashwa?

Njenganoma yikuphi ukwelashwa, lokhu kwelashwa kungaba nemiphumela emibi. Ungakhathazeki, odokotela bazochaza konke lokhu kusenesikhathi.

Imiphumela emibi evamile ye-chemotherapy kanye nokwelashwa ngemisebe ihlanganisa:

• Ukuzizwa ukhathele kakhulu (Ukukhathala)
• Isicanucanu nokuhlanza

Imiphumela emibi elandelayo ingabonakala ngesikhathi sokwelashwa ngama-hormone :

• Ubuhlungu noma ukuqina kwamalunga
• Ukukhathala
• Ukwanda kwesisindo
• Ukuncipha noma ukuphelelwa yisithakazelo kwezocansi
• Ukushisa komzimba - umuzwa wokushisa ovela ngaphakathi emzimbeni .
• Amabele athambile noma avuvukile

Uma welashwa umdlavuza webele we-ER+, buza udokotela wakho ngokunakekelwa kokunciphisa ubuhlungu . Lokhu kungakusiza ukuphatha izimpawu zomdlavuza wakho kanye nemiphumela emibi yokwelashwa kwakho.

Lingakanani izinga lokusinda komdlavuza webele we-ER+?

Lona umbuzo abantu abaningi abawubuzayo. Ngokusho kwedatha evela kwiNational Cancer Institute (NCI) , ngokuvamile, abesifazane abanomdlavuza webele eminyakeni emihlanu ngemuva kokuxilongwa.Abantu abangaphezu kuka-90% bayaphila. Lezi yizindaba ezinhle ngempela. Kodwa-ke, i-NCI ayizange inikeze idatha ehlukile ngesilinganiso sokusinda kwabesilisa abanomdlavuza we-ER+.

Uma ucabanga ngamazinga okusinda, kubalulekile ukukhumbula ukuthi lezi yizibalo ezisekelwe kokuhlangenwe nakho kweqembu elikhulu labantu . Futhi, zingaba izilinganiso ezisekelwe ezimweni ezazikhona eminyakeni eminingi edlule. Ukwelashwa kuyathuthuka nsuku zonke. Ngakho-ke, kungcono ukukhuluma nodokotela wakho ngesimo sakho nokuthi yini ongayilindela.

Ingabe umdlavuza we-ER+ ungabuya ngemva kokwelashwa?

Nakuba umdlavuza webele we-ER+ ubhekwa njengongenalo ulaka kangako kunezinye izinhlobo zomdlavuza, kunengozi yokuphinda ubuye ngemva kokwelashwa. Le ngozi ingenzeka ngisho noma umdlavuza we-ER+ utholakala kusenesikhathi futhi welashwa ngomdlavuza we-ER+ onobungozi obuphansi. Uma ukhathazekile ngokuthi umdlavuza wakho ungase ubuye, khuluma nodokotela wakho womdlavuza mayelana nengozi yakho siqu nokuthi yini ongayenza ukuze unciphise ingozi yakho.

Uzinakekela kanjani ngomdlavuza webele we-ER+?

Uma uphila nomdlavuza webele we-ER+, kubalulekile ukuzinakekela kahle. Nazi ezinye iziphakamiso ezingakusiza:

• Phumula ngokwanele. Umdlavuza webele kanye nokwelashwa kwawo kungaba yinto ekhathazayo kakhulu. Khumbula ukuphumula noma nini lapho uzizwa ukhathele, hhayi nje lapho uzizwa sengathi ufuna.
• Yidla kahle. Isifiso sakho sokudla singashintsha ngenxa yokwelashwa. Ukudla okuhlanganisa izithelo, imifino, amaprotheni angenawo amafutha amaningi, kanye nokusanhlamvu okunempilo kuzokusiza uhlale unamandla ngesikhathi sokwelashwa.
• Lawula ukucindezeleka. Ukubhekana nomdlavuza kuyinkinga enkulu. Ukuzivocavoca kuyindlela enhle yokusiza ngalokhu. Ungenza noma yini kusukela ekuhambeni nsuku zonke kuya ekuhlanganyeleni ezinhlelweni zokuzivocavoca.
• Thola ukwesekwa. Ungumuntu osindile kumdlavuza webele, futhi lokho kuqala ngosuku otholakala ngalo ukuthi unesifo. Buza udokotela wakho ngezinhlelo zokusinda kumdlavuza . Lezi zingakusiza ukuthi ubhekane nezinselele zokuphila nomdlavuza webele.

Kunini lapho udinga ukubonana nodokotela ngokushesha okukhulu?

Uma uzizwa sengathi izimpawu zakho ziya ziba zimbi kakhulu, noma uma uba nezimpawu ezintsha, njengobuhlungu noma ubuthakathaka kwenye indawo emzimbeni wakho, bheka udokotela wakho ngokushesha.

Yimiphi imibuzo ebalulekile okufanele uyibuze udokotela?

Uma ubona udokotela wakho, ungesabi ukubuza noma yimiphi imibuzo onayo. Nansi eminye imibuzo ongayibuza:

• Hlobo luni lokwelashwa olungincomayo?
• Ingabe ngizodinga kokubili ukwelashwa ngamakhemikhali kanye nokwelashwa ngemisebe, noma ingabe ukwelashwa ngama-hormone kuphela kuzokwanela?
• Ingabe kuzodingeka ngithathe ukwelashwa ngama-hormone impilo yami yonke?
• Yiziphi imiphumela emibi yalezi zindlela zokwelapha? Yini engingayenza ukuze ngiyinciphise?
• Ayini amathuba ami okululama?

I-ER+ umdlavuza webele ungasakazeka kuphi?

Umdlavuza webele ngezinye izikhathi ungasakazekela kwezinye izingxenye zomzimba, njengamaphaphu , ubuchopho, amathambo, nesibindi . Umdlavuza webele i-ER+ ubanga cishe u-70% wazo zonke izinhlobo zomdlavuza webele, ngakho-ke kubalulekile ukuqaphela lokhu kusabalala.

Okokugcina, izinto ezimbalwa okufanele uzikhumbule

Kulungile, ake siphinde sixoxe ngamaphuzu abaluleke kakhulu esikhulume ngawo namuhla.

Umdlavuza webele i-ER+ uhlobo lomdlavuza olukhula ngenxa ye-hormone i-estrogen. Nakuba le hormone ivame ukusiza amangqamuzana akhule, iphinde inikeze 'ukudla okunempilo' kumaseli omdlavuza.

Odokotela bahlola amazinga e-estrogen emaseli omdlavuza webele bese behlela ukwelashwa ngokufanele. Ukwelashwa ngama-hormone, ikakhulukazi, kusebenza ukunciphisa umthelela wale hormone estrogen emaseli omdlavuza.

Uma unomdlavuza webele we-ER+, ungesabi ukukhuluma nodokotela wakho . Qiniseka ukuthi uyalalela futhi uyaqonda ukuthi yiziphi izinketho zakho zokwelashwa nokuthi ukwelashwa ngakunye kuzokusiza kanjani. Awuwedwa, futhi kunodokotela abaningi nezinsizakalo zokusekela ezitholakalayo ukukusiza.

Ungakhohlwa ukuthi lesi simo singalawulwa kahle ngokutholwa kusenesikhathi kanye nokwelashwa okufanele.

Umdlavuza Webele we - ER+, i-Estrogen, Izimpawu Zomdlavuza Webele, Ukwelashwa Ngama-Hormone, Ukwelashwa Komdlavuza, Impilo Yabesifazane, Umdlavuza Webele One-Estrogen Receptor Positive