Iyini i-G-CSF (i-Granulocyte-Colony Stimulating Factor)? Kungani ibalulekile ekwelapheni umdlavuza?

Kungenzeka ukuthi uke wabona othile emndenini wakho, isihlobo noma umngane ethola ukwelashwa komdlavuza. Kumelwe ukuthi uke wezwa ngokwelashwa okubizwa ngokuthi "i-Chemotherapy" lapho ethola ukwelashwa okunjalo. Cishe uyazi nokuthi phakathi nalokhu kwelashwa nge-chemo, inani lamaseli amhlophe egazi alwa nezifo emzimbeni liyancipha. Esimweni esinjalo, kulesi sihloko, sizokhuluma ngomuthi okhethekile odokotela abawusebenzisa ukusiza uhlelo lokuzivikela lomzimba wethu. Lokho yi-G-CSF.

Iyini ngempela i-G-CSF?

Kalula nje, i-G-CSF iwumuthi osiza imizimba yethu ukuthi yenze amangqamuzana egazi amhlophe engeziwe, ikakhulukazi uhlobo olubizwa ngokuthi "ama-neutrophils."

Cabanga nje ukuthi umzimba wethu ufana nezwe. Khona-ke lawa ma-neutrophil afana namasosha akulelo zwe. Lawa masosha abizwa ngokuthi ama-neutrophil alwa namagciwane angaphandle, okungukuthi, izitha ezifana namagciwane namagciwane, futhi asivikele ezifweni nasezifweni. Ngakho-ke kwenzekani uma la masosha encipha? Izwe lethu, okungukuthi, umzimba wethu, liba lula ukungenwa yizifo.

Nakuba igama elithi G-CSF lingase libonakale liyinkimbinkimbi kancane, uma sichaza incazelo yalo, lilula kakhulu.

• I-Granulocyte: Leli igama elinikezwa uhlobo lweseli elimhlophe legazi. Ama-neutrophil nawo awuhlobo lwe-granulocyte.
• Isici Esivuselela Ikholoni: Lokhu kuyinto "eyala" noma "evuselela" amaseli. Njengomphathi wefektri owabela izisebenzi imisebenzi, le phrotheni iya emnkantsheni wethu bese ithi, "Kulungile, qala ukwenza ama-neutrophil manje."

Ngakho-ke lokho okwenziwa yilesi sidakamizwa esibizwa ngokuthi i-G-CSF ukuthi siya emnkantsheni wamathambo , okuyingxenye efana nesiponji ngaphakathi kwamathambo ethu, bese sitshela amaseli e-stem lapho ukuthi, "Nina bantu kufanele nibe ama-neutrophil ngokushesha, futhi ama-neutrophil akhona kufanele ahlukane futhi ande." Bese la masosha e-neutrophil asanda kwakheka ajoyina igazi futhi aqale ukusebenza ukuze asivikele.

Kuziphi izimo lapho i-G-CSF isetshenziswa khona?

I-G-CSF isetshenziswa kakhulu ukwelapha nokuvimbela isimo esibizwa ngokuthi "i-neutropenia." I-Neutropenia iyinani elingaphansi kunelijwayelekile lama-neutrophil egazini.

Ekwelashweni komdlavuza (i-Chemotherapy)

Imithi yokwelapha ngamakhemikhali esetshenziswa ekwelapheni umdlavuza yenzelwe ukubulala amangqamuzana omdlavuza ahlukana ngokushesha. Kodwa-ke, le mithi ayikwazi ukubona amangqamuzana omdlavuza kuphela, kodwa futhi namaseli anempilo ahlukana ngokushesha emzimbeni wethu. Ngakho-ke, njengoba ama-neutrophils, akhiqizwa emnkantsheni wamathambo, nawo ewuhlobo lweseli elihlukanisa ngokushesha, nawo awonakala ngemithi yokwelapha ngamakhemikhali.

Lokhu kufana nokufafaza ukhula ukuze kususwe ukhula, kodwa futhi kulimaza izitshalo ezinhle.

Yingakho i-neutropenia ivame kakhulu ngemva kokwelashwa ngamakhemikhali. Uma lesi simo siba sibi kakhulu, ngisho nokutheleleka okuncane kungaba yingozi empilweni. Ezimweni ezinjalo, odokotela batusa i-G-CSF ukunciphisa ingozi yokutheleleka nokubuyisela izivikelo zomzimba.

Ekufakweni kweseli le-stem

Kwezinye izinhlobo zomdlavuza kanye nezinkinga zegazi, kudingeka ukufakelwa i-stem cell. I-G-CSF isetshenziswa ngaphambi nangemva kwale nqubo.

• Ngaphambi kokufakelwa: Uma isiguli sinikezwa i-G-CSF, umongo wethambo ukhiqiza inani elikhulu lamaseli okuqala bese uwakhipha egazini. Odokotela babe sebeqoqa lawo maseli okuqala aphilile egazini.
• Ngesikhathi sokufakelwa: Okulandelayo, ukwelashwa ngamakhemikhali noma ngemisebe ephezulu kubhubhisa noma yimaphi amaseli angavamile asele emzimbeni.
• Ngemva kokufakelwa: Ekugcineni, amaseli okuqala aphilile aqoqwe ngaphambilini aphinde afakwa emzimbeni. Lawa maseli kamuva azoba amaseli egazi amasha, anempilo.

Uma ungumnikeli wamaseli e-stem, kungadingeka futhi ukuthi uthole umjovo we-G-CSF ngaphambi kwenqubo.

Ezinye izimo ezibangela ama-neutrophil aphansi

Amazinga e-neutrophil nawo angaba phansi ngenxa yezimo ezithile ezikhona lapho kuzalwa (i-neutropenia yokuzalwa enzima kakhulu) noma ezimweni lapho imbangela ingaziwa khona (i-idiopathic neutropenia). Ezimweni ezinjalo, i-G-CSF isetshenziselwa ukwandisa amazinga e-neutrophil.

Izinhlobo ze-G-CSF nokuthi zinikezwa kanjani

I-G-CSF iyatholakala emakethe ngamagama ahlukahlukene. Izinhlobo ezimbili ezivame ukusetshenziswa yilezi:

1. I-Filgrastim: Lolu uhlobo olusebenza isikhathi esifushane. Ngokuvamile ludinga ukunikezwa njengomjovo wansuku zonke.

2. I-Pegfilgrastim: Lolu uhlobo lomuthi olusebenza isikhathi eside, ngakho-ke kuvame ukwanele ukuthola umjovo owodwa phakathi kwemijikelezo emibili ye-chemotherapy.

Le mithi itholakala ngaphansi kwamagama ahlukahlukene emikhiqizo kanye nama-biosimilar. Isibonelo, udokotela wakho angase akwazi ukukutshela ngamagama afana ne-Neupogen®, i-Neulasta®, i-Nivestym®, kanye ne-Zarxio®.

Lo muthi unikezwa kanjani emzimbeni?

I-G-CSF ivame ukunikezwa njengomjovo ongaphansi kwesikhumba , kodwa kwezinye izimo inganikezwa futhi njengokufakwa kwe-IV .

• Kungase kudingeke uye emtholampilo nsuku zonke ukuze ugonywe.
• Noma, umhlengikazi uzokufundisa ngokusobala wena noma ilungu lomndeni ukuthi ungawujova kanjani umuthi wokugoma ekhaya. Akunzima kangako.

Ingabe wonke umuntu uyayidinga i-G-CSF?

Cha. I-G-CSF ayinikezwa wonke umuntu othola ukwelashwa ngamakhemikhali noma one-neutrophils ephansi. Njenganoma yimuphi umuthi, i-G-CSF inezinzuzo kanye nezingozi zemiphumela emibi. Udokotela wakho uzocabangela izici eziningana ngaphambi kokukunikeza lo muthi.

• iminyaka yakho
• Isimo sakho sempilo iyonke
• Uhlobo lomdlavuza onalo
• Uhlobo lwe-chemotherapy olutholayo
• Kungakhathaliseki ukuthi usuvele unezimpawu ze-neutropenia (njengomkhuhlane)

Izinzuzo kanye nemiphumela emibi engaba khona ye-G-CSF

Uma kunconywa i-G-CSF, khumbula ukuthi izinzuzo zidlula kakhulu izingozi.

Izinzuzo eziyinhloko:

• Ingozi yokutheleleka okukhulu, okungaba yingozi empilweni incishiswe kakhulu.
• Amazinga aphansi e-neutrophil angavimbela ukwelashwa ngamakhemikhali ukuthi kubambezeleke noma kuncishiswe umthamo , okuvumela ukwelashwa komdlavuza ukuthi kuqhubeke njengoba kuhleliwe.

Imiphumela emibi engaba khona

Imiphumela eminingi emibi ingeyesikhashana futhi iyanyamalala ngemva kokumiswa kwe-G-CSF.

Izinto okufanele uzikhumbule lapho uthatha i-G-CSF

• Tshela udokotela wakho umlando wakho wezokwelapha ophelele. Qiniseka ukuthi uyamtshela nganoma yiziphi ezinye izifo onazo kanye nanoma yimiphi eminye imithi oyiphuzayo (kufaka phakathi amavithamini).
• Akukhuthazwa ukuthatha i-G-CSF uma ukhulelwe, uzama ukukhulelwa, noma uncelisa . Khuluma nodokotela wakho ngalokhu.
• Ungakhathazeki ngemiphumela emibi. Uma uhlangabezana nanoma yimiphi imiphumela emibi, tshela udokotela wakho noma umhlengikazi. Bazokusiza ukuthi uyilawule.
• Hlola igazi lakho ngesikhathi. Udokotela wakho uzohlola amazinga akho e-neutrophil bese enquma ukuthi udinga ukwelashwa isikhathi esingakanani.

I-G-CSF iyisengezo esibaluleke kakhulu enkambisweni yokwelashwa komdlavuza. Inikeza isikhuthazo esikhulu sokwenza ukwelashwa ngamakhemikhali kuphephe futhi kuphumelele kakhudlwana. Uma uneminye imibuzo mayelana nalokhu, sicela ungangabazi ukubuza udokotela wakho okwelaphayo.