Ama-hormone afana nezithunywa ezincane ezihlanganisa imisebenzi eyahlukahlukene emzimbeni wethu. Cabanga nje, la ma-hormone anezelwa egazini lethu yizindlala emzimbeni wethu. Bese, la ma-hormone ahamba egazini futhi anikeze imiyalezo esithweni ngasinye, njengokuthi "yenza lokhu" nokuthi "yeka lokhu". Eqinisweni, imizimba yethu ayikwazi ukusebenza kahle ngaphandle kwama-hormone. Kodwa ngezinye izikhathi, lezi zithunywa ezinhle zisiza namanye amangqamuzana anomdlavuza "ukukhula kahle futhi ahlukane ngokushesha". Yilapho-ke ukwelashwa ngama-hormone kuba yinto ebalulekile kithi.
Ngakho-ke lokhu kwelashwa kwama-hormone kusebenza kanjani?
Kalula nje, ukwelashwa ngama-hormone kusebenza ngokuvimbela indlela amangqamuzana omdlavuza athola ngayo ama-hormone awadingayo ukuze akhule. Lokhu kungenziwa ngezindlela eziningana. Udokotela wakho uzonquma ukuthi iyiphi indlela okufanele ayisebenzise ngokusekelwe esimweni sakho.
- Ukuyeka ukukhiqizwa kwama-hormone: Amanye amangqamuzana omdlavuza ayakwazi ukuyeka ukukhiqiza ama-hormone awasiza ukuba akhule. Kwezinye izimo, izindlala ezikhiqiza la ma-hormone kungadingeka zisuswe ngokuhlinzwa.
- Ukuvimba ukusebenza kwama-hormone: Kule ndlela, yize umzimba ukhiqiza ama-hormone, amangqamuzana omdlavuza ayavinjelwa 'ekusebenziseni' lawo ma-hormone. Cabanga ngeseli lomdlavuza njengendlu, kanye ne-hormone njengesihluthulelo. Lokhu kwelashwa kufana nokuvala imbobo yesihluthulelo efanelana nesihluthulelo. Khona-ke, noma ngabe isihluthulelo sikhona, umnyango awukwazi ukuvulwa.
- Ukwelashwa kokushintsha ama-hormone: Ngezinye izikhathi, esikhundleni sama-hormone emvelo emizimbeni yethu, sinikeza imizimba yethu uhlobo lwe-hormone yokwenziwa eyenziwe elabhorethri (ama-hormone e-Bioidentical). La ma-hormone okwenziwa awakwazi ukusetshenziswa amangqamuzana omdlavuza ukuze akhule. Ngamanye amazwi, esikhundleni se-hormone edingwa amangqamuzana omdlavuza, awanikeza i-hormone 'mbumbulu' angenakuyisebenzisa, kodwa ebukeka ifana.
Into ebalulekile ukuthi ukwelashwa ngama-hormone kusebenze ngokunqamula ukunikezwa 'kwamafutha' kumaseli omdlavuza. Lokhu kungenziwa wedwa noma kuhlanganiswe nezinye izindlela zokwelapha ezifana nokuhlinzwa, i-chemotherapy, noma ukwelashwa ngemisebe.
Lolu hlobo lokwelapha lusetshenziselwa ziphi izinhlobo zomdlavuza?
Ukwelashwa ngama-hormone akusetshenziselwa zonke izinhlobo zomdlavuza. Kusetshenziswa kakhulu emidlavuzeni encike kuma-hormone. Ezinye zazo zifaka:
- Umdlavuza Wendlala Yesitho Sangasese
- Umdlavuza Webele
- Umdlavuza Wesibeletho
- Umdlavuza Wesibeletho
Ake sibheke ukuthi ukwelashwa ngama-hormone kuthinta kanjani uhlobo ngalunye lomdlavuza ngokwehlukana.
Ukwelashwa ngama-hormone omdlavuza we-prostate
Amaseli omdlavuza we-prostate avame ukudinga ama-hormone wesilisa, ikakhulukazi i-testosterone, ukuze akhule. Ngakho-ke umgomo oyinhloko walokhu kwelashwa ukunciphisa amazinga ala ma-hormone noma ukuwayeka asebenze. Kwezinye izimo, ukususwa ngokuhlinzwa kwe-testicle eyodwa noma zombili, ezikhiqiza i-testosterone, (orchiectomy) kuyenziwa njengengxenye yalokhu kwelashwa.
Uma kusetshenziswa imithi, imithi elandelayo ingasetshenziswa kakhulu.
| Uhlobo lwesidakamizwa | Indlela esebenza ngayo |
|---|---|
| I-abiraterone acetate | Lo muthi uvimba ukukhiqizwa kwama-hormone wesilisa (ama-androgen) ngaphakathi kwamaseli omdlavuza we-prostate. Uvame ukunqunyelwa amadoda angasabeli kwezinye izindlela zokwelapha ngama-hormone. |
| Ama-agonist e-LHRH | Le mithi itshela i-pituitary gland ebuchosheni bethu ukuthi iyeke ukukhulula i-hormone etshela amasende ukuthi akhiqize i-testosterone. Ngakho-ke, lapho ukutholakala kwe-testosterone kuyeka, amangqamuzana omdlavuza ayayeka ukukhula. |
| Ama-antiandrogens | Lokhu kusebenza ngokuvimbela i-testosterone ekhiqizwa emzimbeni ukuthi ingabi seduze namaseli omdlavuza. Lokhu kusho ukuthi noma ngabe i-hormone ikhona, iseli lomdlavuza alikwazi ukuzuza kuyo. |
Imiphumela emibi engaba khona
Eminye imiphumela emibi ingase ivele uma uthatha lo muthi. Kodwa-ke, lokhu akwenzeki kuwo wonke umuntu futhi abanye abantu bangase bangabi nemiphumela emibi. Kungcono ukukhuluma nodokotela wakho ngalokhu.
- Ukwanda kwesisindo.
- Ukuncipha noma ukuphelelwa yisifiso socansi.
- Ukungasebenzi kahle kwe-Erectile.
- Ukwehla kobuningi bamathambo (i-Osteoporosis).
Ukwelashwa ngama-hormone omdlavuza webele
Cishe umdlavuza webele ongu-8 kwabayishumi uncike kuma-hormone. Kalula nje, i-estrogen, i-hormone yesifazane, isiza lawa maseli omdlavuza ukuthi akhule. Cabanga ngamaseli omdlavuza njengane-'antenna' encane ebusweni bawo enganamathela kuma-hormone. Sibiza lawa ma-hormone receptors. Uma i-estrogen ibopha kula ma-antenna, iseli lomdlavuza lithola isignali yokukhula. Sibiza lawa ngokuthi 'ama-hormone receptor-positive' .
Ukwelashwa ngama-hormone kusebenza ngokunciphisa amazinga e-estrogen emzimbeni noma ukuvimbela i-hormone estrogen ekubopheleni kumaseli omdlavuza. Lokhu kwelashwa kuvame ukunikezwa ngemva kokuhlinzwa ukuze kuncishiswe ingozi yokuthi umdlavuza uphinde ubuye.
| Uhlobo lwesidakamizwa | Indlela esebenza ngayo |
|---|---|
| Izithibi ze-Aromatase | Le mithi inciphisa amazinga e-estrogen emzimbeni ngokuvimbela i-enzyme ebizwa ngokuthi i-aromatase, eguqula amanye ama-hormone abe yi-estrogen. Ngokuvamile inikezwa abesifazane asebedlule esikhathini sokunqamuka kokuya esikhathini. |
| Ama-SERM (ama-modulator e-estrogen receptor akhethiwe) | Le mithi ivimbela i-hormone estrogen ekubopheni kuma-receptor kumaseli omdlavuza webele, ngakho-ke amaseli omdlavuza awatholi isignali yokukhula. |
| Ama-ERD (abalawuli be-estrogen receptor down) | Lokhu kuvimbela ukusebenza kwe-estrogen futhi kunciphisa inani lama-receptor e-estrogen kumaseli omdlavuza, okwenza kube lula ukuthi abophezele ku-estrogen. |
Imiphumela emibi engaba khona
- Ubuhlungu noma ukuqina kwamalunga.
- Ukukhathala.
- Isicanucanu nokuhlanza.
- Ukwanda kwesisindo.
- Ukuncipha kwesifiso sobulili.
- Ukushisa okukhulu.
- Ubuhlungu bebele noma ukuvuvukala.
Ukwelashwa kwama-hormone omdlavuza wesibeletho kanye nomdlavuza wesibeletho
Ukwelashwa ngama-hormone kusetshenziswa kwezinye izinhlobo ezingavamile zomdlavuza wesibeletho kanye nomdlavuza wesibeletho. Kumdlavuza wesibeletho, umuthi obizwa ngokuthi i-progestin, osebenza njenge-hormone i-progesterone, uvame ukusetshenziswa. Lokhu kunciphisa ukukhula kwamaseli omdlavuza.
Imithi efana nama-agonist e-LHRH, i-tamoxifen, kanye nama-aromatase inhibitors nayo ingasetshenziswa ukwelapha zombili izinhlobo zomdlavuza.
Imiphumela emibi engaba khona
- Ukushisa okukhulu.
- Ukoma kwesitho sangasese sowesifazane.
- Ukwehla kobuningi bamathambo (i-Osteoporosis).
- Ubuhlungu bamalunga nemisipha.
- Ukwanda kwesisindo.
- Ukujuluka ebusuku.
Yiziphi izindlela zokwelapha kanye nezingozi?
Ukwelashwa ngama-hormone kunikezwa ngezindlela ezimbili eziyinhloko. Eyokuqala iwukuthatha amaphilisi noma ama-capsule ngomlomo (imithi yomlomo) . Enye iwukujova . Le ndlela iyahlukahluka kuye ngohlobo lokwelashwa olunikezwayo.
Njenganoma yikuphi ukwelashwa komdlavuza, ukwelashwa ngama-hormone kunengozi yemiphumela emibi. Kodwa-ke, lokhu kuyahlukahluka kakhulu kumuntu nomuntu. Izinto eziningi zithinta lokhu, okuhlanganisa impilo yakho iyonke kanye nohlobo lokwelashwa ngama-hormone okutholayo.
Into ebaluleke kakhulu ukukhuluma ngokukhululekile nodokotela wakho mayelana nemiphumela emibi engaba khona nokuthi ungayiphatha kanjani ngaphambi kokuqala ukwelashwa. Uzokuchazela konke.
Yiziphi izinzuzo kanye namazinga empumelelo okwelashwa ngama-hormone?
Inzuzo eyinhloko yokwelashwa ngama-hormone ukuthi kusiza ekumiseni noma ekunciphiseni ukukhula komdlavuza. Kusebenza kahle kakhulu uma kusetshenziswa kanye nezinye izindlela zokwelapha. Ngezinye izikhathi, kungasetshenziswa ukunciphisa isimila ngaphambi kokuhlinzwa nokuvimbela umdlavuza ukuthi ungabuyi ngemva kokuhlinzwa.
Kunzima ukusho ukuthi lokhu kwelashwa kusebenza kahle kangakanani. Kuncike ezintweni eziningi, okuhlanganisa uhlobo lomdlavuza onawo, ukuthi ususakazeke kangakanani, iminyaka yakho, kanye nempilo yakho iyonke. Ulwazi olungcono kakhulu ngesimo sakho lungatholakala kuphela kudokotela wakho okwelaphayo. Ngakho-ke ungesabi ukumbuza ngalokhu.
Uma uthola ukwelashwa ngama-hormone, kubaluleke kakhulu ukuya emitholampilo futhi uhlolwe ngesikhathi njengoba kuyalelwe udokotela wakho.
Umlayezo Wokuya Nawe Ekhaya
- Ama-hormone ayizithunywa zamakhemikhali ezilawula imisebenzi ehlukahlukene emizimbeni yethu.
- Ezinye izinhlobo zomdlavuza, njenge-prostate kanye nebele, zincike kuma-hormone ukuze zikhule.
- Ukwelashwa ngama-hormone kusebenza ngokunqamula ukutholakala kwama-hormone adingwa amangqamuzana omdlavuza noma ukuvimba ukusebenza kwawo.
- Lokhu kwelashwa kunikezwa njengamaphilisi noma imijovo.
- Imiphumela emibi ingenzeka, kodwa iyahlukahluka kumuntu nomuntu futhi ingalawulwa.
- Kubaluleke kakhulu ukukhuluma ngokukhululekile nodokotela wakho nganoma yimiphi imibuzo noma ukukhathazeka onakho.
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