Ingabe uvame ukuba nesifo sohudo? Noma unomuzwa wokushisa esifubeni sakho noma umuzwa emphinjeni wakho? Ngezikhathi ezinjengalezi, abaningi bethu bajwayele ukuthatha umuthi ekhemisi. Ngokuvamile, uhlobo lomuthi oluthathwa ngale ndlela yi-Proton Pump Inhibitors, noma njengoba sikubiza kanjalo, "umuthi we-gastritis". Kodwa, ingabe siyazi kahle ukuthi iyini le mithi, isebenza kanjani, nokuthi kufanele ithathwe isikhathi esingakanani? Namuhla, sizoxoxa ngalokhu.
Ziyini lezi zithiyo ze-proton pump (PPIs)?
Kalula nje, lolu uhlobo lwemithi enciphisa i-asidi, noma i-asidi, esiswini sakho. Manje ungase ucabange, "Akukuhle yini ukuba ne-asidi esiswini?" I-asidi yesisu empeleni yinto esingenakukwazi ukuphila ngaphandle kwayo. Isisiza ukugaya ukudla esikudlayo futhi ibulala namagciwane ayingozi angena ekudleni.
Kodwa inkinga iqala lapho le acid iba ningi kakhulu, noma lapho iya lapho kungafanele ibe khona, njengomhudo wakho. Yilapho izinkinga ezifana nesilungulela kanye nezilonda zesisu ziqala khona. Yilapho le mithi ebizwa ngokuthi ama-PPI isiza khona.
Yiziphi izimo eziyinhloko eziphathwa ngama-PPI?
Ama-PPI asetshenziselwa ukwelapha izifo eziningi ezihlobene ne-asidi yesisu. Ake sibheke eziyinhloko.
| Isimo sezokwelapha | Kalula nje, okwenzekayo |
|---|---|
| I-GERD / I-Chronic Acid Reflux | Yilokhu esivame ukukubiza ngokuthi isilungulela. I-asidi yesisu ekhuphukela emsopheni ingabangela umonakalo emsopheni (i-erosive esophagitis) . Ama-PPI anciphisa i-asidi yesisu futhi avumele umonakalo ukuthi uphole. |
| Izilonda Zesisu (Izilonda Zesisu Nezincane Zamathumbu) | I-asidi yesisu ingalimaza ulwelwesi oluvikelayo lwesisu noma amathumbu amancane, okubangela izilonda. Lezi zilonda zingakhula futhi ngokuqhubeka nokusebenzisa imithi ethile yokudambisa izinhlungu (ama-NSAID) . Ama-PPI angasiza ekwelapheni lezi zilonda. |
| Ukutheleleka kwe-H. pylori | Leli yigciwane elibangela izilonda esiswini. Ama-PPI anikezwa kanye nama-antibiotic ukubulala leli gciwane. Lokhu kunciphisa i-asidi esiswini, okuvumela ama-antibiotic ukuthi asebenze kangcono. |
| I-Zollinger-Ellison syndrome | Lesi yisimo esingavamile. Amanye amathumba emzimbeni akhiqiza i-hormone ebangela ukuthi isisu sikhiqize i-asidi eningi kakhulu. Ama-PPI angalawula lesi simo. |
Lomuthi usebenza kanjani?
Kulula kakhulu ukukuqonda lokhu. Cabanga ukuthi kukhona 'amaphampu' amancane esiswini sakho enza i-asidi. Ngokwesayensi, lawa abizwa ngokuthi amaphampu e-hydrogen-potassium ATPase. Ngamafuphi, "amaphampu e-proton."
Manje, lokho okwenziwa yilesi sidakamizwa se-PPI 'ukuvimbela' umsebenzi walawo maphampu akhiqiza i-asidi, okungukuthi, uyawamisa. Kufana nokuvala iswishi ku-motor yamanzi.
Kodwa lokhu akuvimbeli konke ukukhiqizwa kwe-asidi esiswini. Uma uthatha i-PPI cishe izinsuku ezi-5 zilandelana, ukukhiqizwa kwe-asidi esiswini kuzoncishiswa cishe ngo-65%. Ama-35% asele anele ukugaya ukudla. Ngakho-ke akukho okufanele ukhathazeke ngakho.
Yiziphi izinhlobo ezivame kakhulu zama-PPI?
Kunezinhlobo eziningana zama-PPI. Amanye angathengwa ngaphandle kwemithi kadokotela (OTC) ekhemisi ngaphandle kwemithi kadokotela, kanti amanye adinga imithi kadokotela.
| Igama Elijwayelekile | Amagama Omkhiqizo Avamile |
|---|---|
| Izinhlobo ezitholakala ngomuthi kadokotela noma ngaphandle kwawo | |
| I-Esomeprazole | I-Nexium® |
| I-Lansoprazole | I-Prevacid® |
| I-Omeprazole | I-Prilosec® |
| Izinhlobo zitholakala kuphela ngomuthi kadokotela | |
| I-Dexlansoprazole | I-Dexilant® |
| I-Pantoprazole | I-Protonix® |
| I-Rabeprazole | I-AcipHex® |
Kufanele zisetshenziswe kanjani lezi zinto?
Lo muthi uza ngesimo se-capsule noma sethebhulethi. Kulabo abanenkinga yokugwinya amaphilisi, amanye ama-capsule angaxutshwa nento efana ne-applesauce ukuze kuthathwe impuphu.
Into ebaluleke kakhulu ukuthi uwuthatha nini umuthi. Ama-PPI amaningi asebenza kahle kakhulu uma uthathwa ungenalutho esiswini . Ngokuvamile kunconywa ukuthi uwuthathe imizuzu engama-30 kuya kwehora ngaphambi kokudla kwasekuseni. Isizathu ukuthi lokhu kunikeza umuthi isikhathi sokumuncwa bese uqala ukusebenza, ngaphambi kokuba i-asidi yesisu iqongeleleke ngemva kokudla.
Kufanele ngithenge malini?
Lokhu ngokuqinisekile kuyinto udokotela wakho azoyinquma. Abanye abantu bangadinga iphilisi elilodwa ekuseni. Abanye bangatshelwa ukuthi baphuze elilodwa ekuseni nelilodwa ebusuku. Kuye ngesimo sakho sezempilo. Ngakho-ke, kubaluleke kakhulu ukulandela imiyalelo kadokotela wakho.
Kuthatha isikhathi esingakanani ukuthi ama-PPI asebenze?
Lona akuyona imithi yokwelapha ngokushesha. Kungathatha usuku olulodwa kuya kwezine ukuze uzizwe imiphumela ephelele yomuthi.
Ake sithi udle ukudla okubabayo futhi ngokuzumayo uzwe umuzwa oshisayo esifubeni sakho. Ngezikhathi ezinjalo, umuthi wokuvimbela i-asidi (isib. i-Digene) noma umuthi wokuvimba i-histamine (H2) (isib. i-Famotidine) unganikeza impumuzo esheshayo kune-PPI. Kodwa-ke, imiphumela yawo iyaphela ngokushesha.
Ama-PPI ayindlela yokwelapha enikeza imiphumela yesikhathi eside, efaneleka kakhulu kubantu abanezinkinga ze-asidi ezingamahlalakhona.
Ingabe ikhona imiphumela emibi kulokhu?
Iningi labantu alibi nemiphumela emibi, kodwa njenganoma yimuphi umuthi, abanye abantu bangase babe nemiphumela emibi emincane.
- Isisu esibuhlungu
- Ukuqunjelwa
- Uhudo
- Isiyezi
- Umlomo owomile
- Ikhanda elibuhlungu
- Imfiva
- Ukugcwalisa isisu
- Ukuluma nokuhlaba
Izingozi zokusetshenziswa isikhathi eside
Nakuba ama-PPI ngokuvamile ebhekwa njengemithi ephephile, abacwaningi bathole izingozi ezithile ezihlobene nokuwasebenzisa isikhathi eside ngaphandle kweseluleko sezokwelapha .
- Ukutheleleka kwe-Clostridium difficile (C. diff): Ibhalansi phakathi kwamagciwane amahle namabi emathunjini iyashintsha, okubangela uhudo oluyingozi.
- Ukuphuka: Kungenza kube nzima ngomzimba ukumunca i-calcium, okungandisa ingozi yokuphuka kwe-hip, esihlakaleni, noma emgogodleni.
- Isifo sezinso: Ukusetshenziswa isikhathi eside kungandisa ingozi yokuthola isifo sezinso esingamahlalakhona (CKD).
- Ukushoda kokudla okunempilo: Umzimba unganciphisa ukumuncwa kwawo i-magnesium ne-vitamin B12. Lezi izakhamzimba ezibalulekile ohlelweni lwethu lwezinzwa kanye nemisipha.
Lezi zingozi zisacwaningwa, ngakho odokotela bavame ukuzama ukulawula izimpawu zakho ngokukunikeza umthamo ophansi kakhulu ngesikhathi esifushane kakhulu .
Kufanele ngimbone nini udokotela?
Uma udokotela ekunike ama-PPI, kufanele ukhulume nodokotela wakho mayelana nokuyeka umuthi noma ukushintsha umthamo.
Uma usebenzisa ama-PPI athengiswa ngaphandle kwemithi kadokotela (i-OTC) futhi uthola ukuthi uwadinga nsuku zonke ukulawula izimpawu zakho, kufanele nakanjani ubone udokotela ukuze uthole ukuxilongwa okufanele nokwelashwa.
Uma uhlangabezana nezimpawu ezilandelayo, bona udokotela wakho ngokushesha:
| Isibonakaliso | Incazelo |
|---|---|
| Ukusabela kokungezwani komzimba | Ukucasuka kwesikhumba, ukulunywa okukhulu, ukuvuvukala. |
| Izimpawu zokulimala kwezinso | Ukwehla kokukhishwa komchamo, ukuvuvukala kwezandla, amaqakala, noma izinyawo. |
| Izimpawu zokuntuleka kwe-magnesium | Ukukhathala okukhulu, ukushaya kwenhliziyo okungajwayelekile, ubuhlungu bemisipha. |
| Izimpawu zokuntuleka kwe-vitamin B12 | Ubuhlungu, ukungazweli, isiyezi , ukudideka ezingalweni noma emilenzeni. |
| Uhudo olunzima noma umkhuhlane | Uhudo oluqhubekayo noma umkhuhlane. |
Umlayezo Wokuya Nawe Ekhaya
- Ama-PPI ayindlela yokwelapha izinkinga ze-asidi zesikhathi eside, hhayi ukwelapha ngokushesha.
- Njalo thatha imithi yakho ngesikhathi esinqunyiwe (ngokuvamile ngaphambi kokudla), njengoba kuyalelwe udokotela wakho.
- Gwema ukusebenzisa ama-PPI njalo isikhathi eside ngaphandle kweseluleko sikadokotela.
- Uma udinga lo muthi nsuku zonke noma uma kuvela imiphumela emibi, qiniseka ukuthi ubona udokotela wakho.
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