Ingabe uqala usuku lwakho ngomgogodla oqinile kanye nobuhlungu uma uvuka ekuseni? Ingabe ukhathele ubuhlungu obuvela emalungeni akho uma uhamba noma uhambahamba? Lokhu kungaba izimpawu ze- ankylosing spondylitis , noma i-AS ngamafuphi. Lesi yisimo sokuvuvukala sesikhathi eside esenzeka emgogodleni nakwamanye amalunga. Ngakho-ke uma unalesi simo, udokotela wakho kungenzeka ukuthi ukhulume ngohlobo olukhethekile lomuthi olubizwa ngokuthi i-TNF Inhibitors. Ake sixoxe ngalokhu kalula nangokucacile namuhla.
Kungani amalunga ebuhlungu ku-AS? Kuyini i-TNF?
Kulungile, ake sikubeke kalula lokhu. Sonke sinesimiso sokuzivikela emizimbeni yethu. Yiso esisivikela ngokulwa namagciwane abangela izifo. Kodwa ezimweni ezifana ne-AS, lesi simiso sokuzivikela sisebenza ngokweqile. Sifana nonogada ohlala eqaphile.
Uma lokhu kwenzeka, imizimba yethu iqala ukukhiqiza iphrotheni ekhethekile ebizwa ngokuthi i-Tumor Necrosis Factor, noma i-TNF . Le phrotheni ye-TNF yiyo ebangela ukuvuvukala emalungeni ethu, okusho ukuvuvukala, ukuvuvukala, ukubomvu, kanye nobuhlungu. Yingakho amalunga afana nomhlane wakho nezinqe eqina, evuvukala, futhi eba buhlungu.
Ngakho-ke ziyini lezi zithiyo ze-TNF?
Kalula nje, ama-TNF inhibitors awuhlobo lomuthi 'ovimba' iphrotheni ye-TNF esikhulume ngayo ngaphambilini, okuyiyona ebangela ukuvuvukala. Lokhu akufani nama-painkiller avamile. Ama-painkiller acindezela ubuhlungu okwesikhashana kuphela. Kodwa ama-TNF Inhibitors asebenza ngokujule kakhulu kunalokho.
Le mithi iya ngqo kuphrotheni ye-TNF ebangela ukuvuvukala futhi iyimise ukusebenza kwayo. Lokhu kunciphisa ukuvuvukala emalungeni, kulawula ubuhlungu, ukuvuvukala, kanye nokuqina. Futhi kuyasiza ekuvimbeleni ukulimala kwamalunga ngokuhamba kwesikhathi.
Odokotela babiza le mithi ngokuthi 'ama-TNF blockers', 'biologics', noma 'imithi yokulwa ne-TNF'. Kunezinhlobo eziningana zama-TNF inhibitors avunyelwe i-AS:
- I-Adalimumab
- I-Certolizumab pegol
- I-Etanercept
- I-Golimumab
- I-Infliximab
Udokotela wakho uzovame ukucabangela lokhu kwelashwa uma izimpawu zakho zingalawulwa yimithi yokwelapha izinhlungu (ama-NSAID). Akuwona wonke ama-TNF inhibitors asebenza kuwo wonke umuntu. Umuthi owodwa ungasebenza kahle kwabanye abantu, kodwa hhayi kwabanye. Ngakho udokotela wakho angazama imithi ehlukene aze athole osebenza kahle kuwe.
Isetshenziswa kanjani le mithi?
Kunezindlela ezimbili eziyinhloko zokunikeza lo muthi , ezizohluka kuye ngohlobo lomuthi owunikezwe wona.
1. Njengomjovo ngaphansi kwesikhumba (Umjovo)
Eminye imithi iza njengemijovo. Ingxenye engcono kakhulu ukuthi ungayinika ekhaya. Udokotela wakho noma umhlengikazi oqeqeshiwe uzokukhombisa ukuthi ungayinika kanjani ngendlela efanele. Ngokuvamile inikezwa esikhumbeni sesisu noma sethanga lakho. Into ebalulekile ukushintsha indawo yomjovo, hhayi efanayo njalo.
2. Njengesixazululo sikasawoti esifakwe emthanjeni (Intravenous Infusion)
Imithi efana ne-Golimumab ne-Infliximab inikezwa njengesixazululo sikasawoti emithanjeni. Lokhu kudinga ukuthi uye esibhedlela noma esikhungweni sokufaka umuthi. Lokhu kwelashwa kungathatha amahora amaningana. Udokotela uvame ukukunikeza umuthi cishe amahora amabili bese ekugcina uqashwe amanye amahora amabili ukuze abone ukuthi une-allergy enkulu yini. Kungase kudingeke ukuthi uthathe lo muthi njalo emavikini amabili ekuqaleni, kodwa lesi sikhathi singancishiswa ngokuhamba kwesikhathi.
Yiziphi izinzuzo ze-TNF Inhibitors?
Izifundo zikhombisile ukuthi abantu abane- AS bathola izinzuzo ezinkulu kulokhu kwelashwa.
- Ubuhlungu buncishiswe kakhulu.
- Ukusebenza kwamalunga kanye nokuguquguquka kwawo kuyathuthuka.
- Izimpawu ezinjengokuqina kwamalunga ekuseni kanye nokuvuvukala kungenzeka kakhulu ukuthi zinciphe.
- Kunciphisa ukuvuvukala okuzungeze umgogodla kanye namanye amalunga.
- Kunciphisa umonakalo ohlala njalo emalungeni ngokuhamba kwesikhathi.
Abantu abaningi baqala ukuqaphela umehluko ngemva kokuthatha imithamo emibili noma emithathu yomuthi. Kodwa-ke, ngezinye izikhathi kungathatha izinyanga ezintathu ukubona imiphumela ephelele yalo muthi. Ngakho-ke, kubalulekile ukuba nesineke ngokwelashwa.
Siyazi futhi ngemiphumela emibi.
Njenganoma yimuphi umuthi, lo ungaba nemiphumela emibi. Kodwa-ke, abantu abaningi bathola imiphumela emibi emincane kuphela. Into ebaluleke kakhulu ukuqaphela lokhu futhi wazise udokotela wakho ngokushesha uma unezinkinga.
Ngenxa yokuthi le mithi icindezela ukusebenza kwesimiso sethu somzimba sokuzivikela, ikhono lethu lokulwa namagciwane lingase linciphe kancane. Lokhu kwandisa kancane ingozi yokutheleleka .
Kukhona ingozi yokuthi isifo sofuba (TB) sibuye. Ungakhathazeki, udokotela wakho uzokuhlolela isifo sofuba nezinye izifo ngaphambi kokuba uqale lo muthi.
Ngezansi kuneminye imiphumela emibi evamile engase ivele.
| Umphumela ongemuhle | Incazelo kanye nalokho okufanele ukwazi |
|---|---|
| Ukusabela kwendawo yomjovo | Kungase kube nokubomvu, ukulunywa, kanye nokuvuvukala endaweni yokujova. Lokhu kuvame ukuphela phakathi nesonto. |
| Ingozi yokutheleleka | Ingozi yokuthola izinto ezifana nomkhuhlane, umkhuhlane, i-pneumonia, kanye nezifo zesikhumba inganda. Tshela udokotela wakho uma uqala umkhuhlane noma ukukhwehlela. |
| Ezinye izifo ezivamile | Ikhanda elibuhlungu, ukuqubuka kwesikhumba, isicanucanu, ubuhlungu besisu, uhudo, i-sinusitis, njll. |
| Ukusabela okungathi sína (okungavamile) | Izinto ezifana nokuvuvukala kwezindebe, ubunzima bokuphefumula, umfutho wegazi ophansi, njll. Uma kwenzeka into efana nale, funa iseluleko sezokwelapha ngokushesha noma uye eMnyangweni Wezimo Eziphuthumayo (ETU) oseduze. |
Kwezinye izimo, lo muthi ungandisa kancane ingozi yokuba nomdlavuza wesikhumba (umdlavuza wesikhumba ongeyona i-melanoma), ngakho udokotela wakho uzokwazi nalokho.
Ubani okungafanele asebenzise lo muthi?
Ama-TNF Inhibitors awafanele wonke umuntu. Udokotela wakho angeke akunike imithi uma unezinye zezimo ezilandelayo:
- Uma ungumama oncelisayo .
- Okwamanje unesifo esithathelwanayo.Uma kukhona ukutheleleka okusebenzayo.
- Uma unomlando wezifo ezifana ne -lupus noma i-multiple sclerosis .
- Uma unomdlavuza noma amaseli angaphambi komdlavuza (lokhu kungahluka kuye ngesinqumo sikadokotela ezimweni zomdlavuza ezingaphezu kweminyaka eyi-10 ubudala futhi esezelashwe futhi zalashwa).
- Uma unomlando wesifo senhliziyo esibi kakhulu .
Ingabe lezi zingasetshenziswa ngesikhathi sokukhulelwa?
Lona umbuzo obalulekile kubantu abaningi. Ucwaningo lubonise ukuthi iningi lale mithi liphephile ukuyisebenzisa ngesikhathi sokukhulelwa. Kodwa-ke, eminye imithi, ikakhulukazi ku-trimester yesibili noma yesithathu yokukhulelwa, ingawela i-placenta iye enganeni.
Ngakho-ke uma ukhulelwe umntwana, khuluma nodokotela wakho wamathambo ngalokhu. Angase akwazi ukuncoma umuthi ofanele wena, njenge-Certolizumab, engaweli i-placenta.
Umlayezo Wokuya Nawe Ekhaya
- Ama-TNF Inhibitors ayiqembu elithile, elinamandla lemithi elawula ukuvuvukala, imbangela eyinhloko ye-ankylosing spondylitis (AS).
- Lokhu akufani nemithi yokubulala izinhlungu ejwayelekile; kuphazamisa inqubo yesimiso somzimba sokuzivikela esiyisisekelo salesi sifo.
- Ngenxa yengozi enkulu yokutheleleka, udokotela wakho uzokuqapha ngokucophelela ngaphambi nangesikhathi sokwelashwa.
- Tshela udokotela wakho ngokushesha nganoma yiziphi izimpawu ezintsha ozizwayo, ikakhulukazi umkhuhlane noma izimpawu zokutheleleka.
- Uma uhlela ukukhulelwa noma ukhulelwe, kubalulekile ukukhuluma nochwepheshe wakho ngalo muthi.
- Ungalokothi ushintshe umthamo noma uyeke ukuthatha imithi ngaphandle kweseluleko sikadokotela.
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