Ingabe ngezinye izikhathi uzizwa sengathi imilenze yakho ivuvukile, ibuhlungu, noma isifuba sakho siqinile? Lezi akuzona nje izinto ezingahleliwe. Mhlawumbe isizathu salokhu ukungalingani okuncane enqubweni yokujiya kwegazi emzimbeni wakho. Eqinisweni, ukujiya kwegazi emzimbeni wethu kubalulekile ukuze kusindiswe impilo. Kodwa uma kwenzeka kakhulu, ngokungadingekile, nakho kuyingozi kakhulu. Namuhla sikhuluma ngokuhlolwa kwegazi okubalulekile okubheka lokho kulinganisela.
Kuyini iProtheni S?
Kalula nje, iProtheyini S uhlobo olukhethekile lweprotheyini elakhiwe yisibindi sethu. Umsebenzi wayo oyinhloko ukulawula inqubo yokujiya kwegazi emzimbeni wethu.
Cabanga ngohlelo lwakho lokujiya kwegazi njengohlelo lwamabhuleki emoto. Uma silimala, ukujiya kwegazi kubalulekile ukuze kumiswe ukopha. Kufana nokushaya amabhuleki ukuze kumiswe imoto ngaphambi kokuba ishayise. Kodwa kwenzekani uma amaqhubu egazi akheka emithanjeni yakho ngaphandle kwesizathu? Kufana nalapho ushayela emgwaqweni bese ngokuzumayo amabhuleki akho evala bese wonke amasondo amane ema.
Ngokufanayo, uma amahlule egazi eba khona emithanjeni, angavimba ukuhamba kwegazi futhi abangele izimo eziyingozi. Iphrotheni S iyinto elawula ukujiya kwegazi okungadingekile, njengengxenye ebalulekile yesistimu yamabhuleki yomzimba wethu. Iphrotheni S yenza lo msebenzi obalulekile ngokubambisana namanye amaprotheni afana neProtheni C kanye ne-anti-thrombin.
Kuyini ukuntuleka kweProtheyini S?
Ukuntuleka kwe-Protein S kusho ukuthi umzimba wakho awunayo eyanele le phrotheni ebalulekile. Uma lokho kwenzeka, kufana nokuthi uhlelo lwamabhuleki engikhulume ngalo ekuqaleni lubuthakathaka. Lokho kusho ukuthi ingozi yokwakheka kwamahlule egazi emithanjeni yegazi iyanda ngokungadingekile. Kwezokwelapha, lesi simo sibizwa ngokuthi ingozi ye-Venous Thromboembolism (VTE).
Lesi kungaba yisifo sofuzo esidluliselwa kusuka esizukulwaneni kuya kwesinye. Kodwa akuvamile kakhulu. Kodwa-ke, kwezinye izimo, ingozi yalokhu kuqhekeka kwegazi ingaba phezulu nakakhulu. Isibonelo:
- Ngesikhathi sokukhulelwa
- Uma kwenziwa ukuhlinzwa
- Uma uthatha amaphilisi okuvimbela inzalo aqukethe ama-hormone
- Uma uthatha ukwelashwa kokufaka esikhundleni sama-hormone (HRT)
- Uma uhlala endaweni efanayo isikhathi eside, njengasezindizeni.
Kodwa khumbula, ngezinye izikhathi amahlule egazi angenzeka ngaphandle kwesizathu esithile. Le ngozi iyanda kancane ngemva kweminyaka engu-55.
Yiziphi izimo eziyingozi ezenzeka uma kungekho iProtheyini S eyanele?
Ukuntuleka kwe-protein S kungaholela ezimweni ezimbili eziyingozi kakhulu. Ake siqonde lokhu ngethebula.
| Isimo | Kuchazwe kalula kanye nezimpawu |
|---|---|
| I-Deep Vein Thrombosis (DVT) | Lokhu kwenzeka lapho kwakheka ihlule legazi (i-thrombus) emthanjeni ojulile emzimbeni. Ngokuvamile kwenzeka emilenzeni. Izimpawu zingase zihlanganise ukuvuvukala, ubuhlungu, umuzwa ofana nokuqaqamba emlenzeni owodwa noma engalweni, ukufudumala lapho uthintwa, kanye nokuvuvuka komthambo. |
| I-Pulmonary Embolism (PE) | Lokhu kuyingozi nakakhulu. I-PE yilapho ingxenye yehlule legazi elakheka ngesikhathi se-DVT iphuka, idlule egazini iye enhliziyweni, bese isuka lapho inamathela emthanjeni wegazi emaphashini. Lesi yisimo esiphuthumayo, esingasongela ukuphila! Izimpawu zifaka phakathi ukuphelelwa umoya ngokuzumayo, ubuhlungu besifuba obubukhali obuba bubi kakhulu uma uphefumula kakhulu, ukushaya kwenhliziyo okusheshayo, futhi ngezinye izikhathi ukhwehlela igazi. Uma uhlangabezana nalezi zimpawu, kufanele uye emnyangweni wezimo eziphuthumayo wesibhedlela (ETU) ngokushesha. |
Kuyini Ukuhlolwa Komsebenzi We-Protein S?
Ukuhlolwa kwegazi okubaluleke kakhulu ukuze kutholakale ukuthi usengozini yini yiProtein S Activity Test. Lokhu kuhlolwa akugcini nje ngokukala inani leProtein S egazini lakho, kodwa futhi nokuthi 'isebenza' kangakanani. Okusho ukuthi, kulinganisa ikhono layo lokumisa ukujiya kwegazi. Kungabona cishe zonke izinhlobo zokuntuleka kweProtein S.
Uma wenza lokhu kuhlolwa...
Uma udokotela wakho ekucela ukuthi wenze lolu vivinyo, kufanele nakanjani utshele udokotela wakho ngayo yonke imithi oyithathayo (ikakhulukazi imithi yokunciphisa igazi nama-hormone). Ngoba eminye imithi ingashintsha imiphumela yalolu vivinyo. Ngakho-ke, kubaluleke kakhulu ukusho konke ngaphandle kokufihla lutho.
Ungawaqonda kanjani amanani embikweni wokuhlolwa?
Ububanzi obujwayelekile bomsebenzi weProtheyini S embikweni buvame ukuba phakathi kuka -60% no-150% . Kodwa-ke, lokhu kungahluka kancane kusuka elabhorethri kuya elabhorethri. Ngakho-ke, udokotela wakho uzoqhathanisa imiphumela yakho nobubanzi obujwayelekile embikweni wakho futhi achaze kahle ukuthi kusho ukuthini.
- Umsebenzi Ophansi Weprotheyini S: Lokhu kusho ukuthi ikhono lomzimba wakho lokulawula ukujiya kwegazi liphansi. Lokhu kusho ukuthi usengozini enkulu yokuthola izimo ezifana ne-DVT noma i-PE.
- Uma inani lomsebenzi we-Protein S liphezulu (Eliphezulu): Leli nani liyakhuphuka kwabanye abantu, ikakhulukazi njengoba bekhula. Kodwa-ke, akukatholakali ukuthi libangela izinkinga ezinkulu zempilo. Okusho ukuthi, ukwanda kwaleli nani akukhulisi ingozi yokopha.
Ubani ofuna ukwenza lolu vivinyo?
Udokotela wakho angase akuncome lokhu kuhlolwa uma ucabanga ukuthi usengozini yokuthola isifo sokujiya kwegazi, ikakhulukazi uma:
- Uma unegazi eliqhekekile emzimbeni wakho ngaphandle kwesizathu esibonakalayo (isibonelo, ukuhlinzwa, uhambo olude, njll.).
- Uma othile emndenini wakho enomlando wokuqhekeka kwegazi njalo (i-Venous Thromboembolism - VTE).
- Uma othile emndenini wakho esevele etholakale enokuntuleka kweProtein S.
- Uma uke waphuphunyelwa yisisu izikhathi ezingaphezu kwesisodwa.
Ngokusekelwe emiphumeleni yalolu vivinyo, udokotela wakho uzokwazi ukukunikeza imithi ezokusiza ukuvimbela ukuqhekeka kwegazi okungavamile.
Umlayezo Wokuya Nawe Ekhaya
- Iphrotheni S iyiphrotheni ebalulekile elawula ukujiya kwegazi emzimbeni wethu, isebenza njenge-"brake".
- Uma leli zinga leProtheyini S lehla, ingozi yokuba nezimo eziyingozi njenge-DVT (deep vein thrombosis) kanye ne-PE (pulmonary embolism) iyanda.
- Ukuhlolwa Komsebenzi Weprotheni S kuwukuhlolwa kwegazi okubalulekile ukuhlola le ngozi.
- Uma uhlolwa lokhu, kubalulekile ukwazisa udokotela wakho ngayo yonke imithi oyiphuzayo.
- Uma wena noma umndeni wakho ninomlando wokuqhekeka kwegazi okungachazeki, khuluma nodokotela wakho ngakho bese uthola iseluleko esidingekayo.
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