Acute Fatty Liver of Pregnancy (AFLP): Eyi yɛ aniberesɛm, momma yɛnhwɛ yiye!

So wunim sɛ ɛtɔ mmere bi a akwahosan ho haw a wɔnhwɛ kwan betumi asɔre wɔ nyinsɛn mu? Ɛnnɛ yɛrebɛka tebea bi a ebetumi ayɛ aniberesɛm a ɛfata sɛ yehu ho asɛm, sɛ ɛyɛ nea wɔnhwɛ kwan kakra mpo a. Ɛwom sɛ eyi mma nnipa dodow no ara de, nanso sɛ ɛba saa a, ehia sɛ wɔsa no ntɛm ara.

Dɛn ne nea wɔfrɛ no srade mmerɛbo mu yare (AFLP) yi wɔ nyinsɛn mu?

Sɛ yɛbɛka no tiawa a, Acute Fatty Liver of Pregnancy (AFLP) yɛ tebea a ɛntaa nsi nanso emu yɛ den yiye. Eyi ne bere a srade ahyɛ wo mmerɛbo mu ma dodo bere a wonyinsɛn no. Eyi betumi ama mmerɛbo no ayɛ adwuma yiye na wanya ɔhaw afoforo a ɛde ne nkwa to asiane mu. Nokwarem no, wobu no sɛ ɛyɛ aduruyɛ mu asɛm a egye ntɛmpɛ . Sɛ eyi ba a, ade a eye sen biara a ɛsɛ sɛ woyɛ ne sɛ wobɛwo akokoaa no ntɛm ara sɛnea wubetumi.

AFLP abu so dɛn?

Mma ɛnhaw wo, eyi nyɛ nea abu so kɛse. Saa tebea a wɔfrɛ no AFLP yi ho yɛ na ankasa. Wɔkyerɛ sɛ ɛka nyinsɛn 10,000 kosi 20,000 biara mu biako pɛ afe biara. Enti ɛnyɛ biribi a wotaa hu.

Dɛn ne AFLP ho sɛnkyerɛnne ahorow? (Hwɛ eyinom yiye)

AFLP taa fi ase wɔ nyinsɛn no fã a ɛto so abiɛsa awiei – bɛyɛ adapɛn 36 – na wɔtaa hu. Nanso, ɛtɔ mmere bi a ebetumi aba ntɛm, anaasɛ mpo akosi sɛ wɔbɛwo akokoaa no pɛɛ.

Nsɛnkyerɛnne ahorow bi wɔ hɔ a wɔtaa hu wɔ tebea yi mu:

• Akisikuru ne ɔfe: Ɛwom sɛ ebia eyi bɛyɛ te sɛ nea ɛyɛ ade a ɛfata wɔ nyinsɛn mu de, nanso ɛtɔ mmere bi a ebetumi ayɛ AFLP ho sɛnkyerɛnne.
• Yafunu mu yaw: Ɛyaw yi ba titiriw wɔ yafunu no atifi nifa so.
• Ɔbrɛ a emu yɛ den: Ɛnyɛ ɔbrɛ nko, na mmom ɔbrɛ a ɛtra so ho atenka.
• Nkate a ɛma wo ho nyɛ wo dɛ wɔ nipadua no mu: Nkate a ɛma wo ho nyɛ wo dɛ wɔ nipadua no mu, te sɛ nea worenya yare bi.
• Anorexia: Adidi ho akɔnnɔ nyinaa a wɔhwere.
• Sukɔm kɛse a wobɛte nka : Ɛmfa ho nsu dodow a wobɛnom no, ɛda so ara te sɛ nea ɛnnɔɔso.
• Jaundice: Wo were ne w’ani fitaa dan kɔkɔɔ. Eyi yɛ sɛnkyerɛnne a ɛda adi pefee.
• Adwene a ɛyɛ basaa anaasɛ wontumi mfa n’adwene nsi biribi so: Ɛyɛ den sɛ wode w’adwene besi biribi so, te nka sɛ wo ho nyɛ no dɛ.

Kae sɛ AFLP ho sɛnkyerɛnne betumi ayɛ te sɛ aduruyɛ mu tebea afoforo de. Enti ɛho hia sɛ wo ne wo duruyɛfo kasa fa sɛnkyerɛnne biara a ɛyɛ soronko a wubehu bere a wonyinsɛn no ho. AFLP yɛ aduruyɛ mu tebea a egye ntɛmpɛ a ɛhwehwɛ sɛ wɔsa no ntɛm ara.

Dɛn nti na saa AFLP yi ba? Dɛn nti na ɛte saa?

Nhwehwɛmufo da so ara nnim nea ɛde AFLP ba ankasa. Yɛn mmerɛbo no dwumadi titiriw biako ne sɛ ɛbɛpaapae srade a ɛwɔ nipadua mu no mu. Wɔ AFLP mu no, ɔhaw bi wɔ sɛnea mmerɛbo no tumi bubu srade yi mu, na ɛma srade a ɛboro so boaboa ano wɔ mmerɛbo no mu no ho. Afei srade yi kɔhyɛ mmerɛbo no mu, na ɛmma mmerɛbo no nyɛ adwuma sɛnea ɛsɛ. Eyi betumi de nkwa ato asiane mu sɛ wɔansa a.

So abusuabɔ bi wɔ awosu mu? (LCHAD a enni hɔ) .

Nhwehwɛmu ahorow bi ada no adi sɛ ebia AFLP wɔ awosu mu nkɛntɛnso . Ɛne sɛ, ebia enzyme bi a enni nipadua mu a wɔfrɛ no long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) a enni nipadua mu na ɛde ba .

Saa (LCHAD) a enni hɔ yi yɛ ɔyare a ɛntaa nsi koraa, (autosomal recessive) . Sɛ yɛbɛka no tiawa a, sɛ akokoaa benya eyi afi awo mu a, ɛsɛ sɛ awofo baanu no nyinaa nya awosu mu abɔde a ɛfata ma no. Akokoaa a (LCHAD) nni no ntumi nsakra srade a ɛwɔ nipadua mu no yiye. Afei srade yi fa awotwaa no mu kɔ ɛna no mogya mu. Eyi betumi ama srade aboaboa ano wɔ ɛna no mmerɛbo mu. Susuw sɛnea nsakrae a ɛba akokoaa no nipadua mu nneɛma a ɛsakra mu no ka ɛna no ho hwɛ!

Dɛn ne asiane ahorow a ɛma obi nya AFLP?

Seesei yenim sɛ saa tebea yi a wɔfrɛ no AFLP no betumi afi awosu mu. Ɛno kyerɛ sɛ wobetumi anya afi awofo hɔ. Nea ɛka ho no, asiane afoforo pii wɔ hɔ:

• Sɛ eyi ne wo nyinsɛn a edi kan a.
• Sɛ worehwɛ mmanoma anaa nea ɛboro saa kwan a.
• Sɛ worehwɛ abarimaa kwan a.
• Sɛ wowɔ asikreyare a.
• Sɛ wowɔ intrahepatic cholestasis a ɛyɛ nyinsɛn a.
• Sɛ wowɔ preeclampsia a.
• Sɛ woyɛ kɛse mmoroso a.

Nanso, wɔ asiane ahorow yi nyinaa mpo mu no, wo duruyɛfo ntumi nkyerɛ sɛ ebia wubenya AFLP anaa. Na ɛnyɛ biribi a wubetumi ahyɛ nkɔm na woasiw ano. Ɛno na ɛma ɛyɛ nea ɛhaw adwene kakra.

Dɛn ne nsɛnnennen a ebetumi afi AFLP mu aba? (Eyi betumi ayɛ nea asiane wom)

mmerɛbo mu srade a emu yɛ den (AFLP) bere a wɔyem no betumi akum obi . Wo ne wo ba no wɔ asiane mu sɛ wobenya nsɛnnennen ahorow. Ebi ne:

• Mmɛn a entumi nyɛ adwuma yiye.
• Asaabo a entumi nyɛ adwuma yiye.
• Ahurututu mu huammɔdi.
• Nsaneɛ.
• Mogya a ɛtɔ gu nipadua no mu.

Ɛyɛ hu sɛ wobɛte saa nneɛma yi, ɛnte saa? Ɛno nti na ɛho hia sɛ wohu tebea yi.

Ɔkwan bɛn so na wobehu AFLP tebea?

Esiane sɛ AFLP betumi ama akwaa ahorow no ayɛ adwuma yiye nti, .Ɛho hia sɛ wohu yare no ntɛm na wofi ase sa yare no ntɛm. Nea wobetumi ahu no pɛpɛɛpɛ sen biara ne mmerɛbo mu nhwehwɛmu . Eyi ne baabi a wo duruyɛfo de afiri a wɔde hwɛ nneɛma nketenkete hwehwɛ wo mmerɛbo mu ntini mu. Nanso, ɛnyɛ bere nyinaa na eyi yɛ nea asiane biara nni ho sɛ wɔbɛyɛ bere a wɔyem no. Enti, mpɛn pii no, wo duruyɛfo betumi agyina wo sɛnkyerɛnne ne w’akwahosan ho abakɔsɛm so ahu AFLP.

Dɛn na mogya mu nhwehwɛmu hwehwɛ?

Wo duruyɛfo bɛhyɛ sɛ wɔnyɛ mogya mu nhwehwɛmu mfa nhwɛ sɛ AFLP anaa. Ɛtɔ mmere bi a wo duruyɛfo betumi agyina nea efi mogya mu nhwehwɛmu a wɔyɛe wɔ mmerɛbo dwumadi mu ba so besusuw sɛ AFLP . Saa sɔhwɛ ahorow yi taa kyerɛ nneɛma te sɛ:

• mmerɛbo mu enzymes a ɛkɔ soro.
• Ɔhaw ahorow a ɛwɔ wo mogya a ɛtwetwe no ho.
• Ammonia, uric acid, ne protein dodow a ɛkɔ soro wɔ mogya no mu.
• Asikre a ɛwɔ mogya mu a ɛba fam.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ asaabo asɛe.

Sɔhwɛ afoforo

Nea ɛbɛyɛ na wo duruyɛfo no akyerɛ sɛ woahu yare no, obetumi akra sɛ wɔnyɛ no ultrasound scan anaa CT scan . Eyinom betumi ama yɛanya mmerɛbo no ho mfonini a ɛkɔ akyiri.

Ɔkwan bɛn so na wɔsa AFLP? (Ayaresa a wɔyɛ no ntɛm ho hia!)

Nea ɛbɛyɛ na woakwati nsɛnnennen a ɛde wo nkwa to asiane mu no, wo duruyɛfo bɛkamfo akyerɛ sɛ wowo wo ba no ntɛm ara sɛnea wubetumi . Sɛ woyi akokoaa no ne awotwaa no fi hɔ wie a, wo mmerɛbo no befi ase ayɛ yiye nkakrankakra. Eyi ne ayaresa titiriw ne biako pɛ a wɔde sa tebea yi.

So biribi wɔ hɔ a metumi ayɛ de atew asiane a ɛwɔ hɔ sɛ menya AFLP no so?

Eyi yɛ ɔhaw a nnipa pii wɔ. AFLP yɛ tebea a ɛntaa nsi. Na, biribiara nni hɔ a wubetumi ayɛ de asiw ano anaasɛ woadi kan ahu . Eyi ne yare yi fã a ɛyɛ awerɛhow.

Sɛ mewɔ AFLP a, dɛn na ɛba?

Sɛ wowɔ AFLP a, ɛsɛ sɛ wowo wo ba no ntɛm ara . Wo mmerɛbo dwumadi befi ase asan ayɛ sɛnea na ɛte wɔ bɛyɛ nnafua 10 akyi wɔ awo akyi. Ɛho behia sɛ ayaresabea hɔ nnuruyɛfo hwɛ wo kosi sɛ nea efi wo mmerɛbo mu nhwehwɛmu mu ba no bɛsan ayɛ sɛnea na ɛte kan no.

Ɛrentumi nyɛ yiye sɛ wobɛka asiane a ɛwɔ wo mu sɛ wobɛsan anya AFLP bio no ankasa. Ebia wo duruyɛfo bɛkamfo akyerɛ sɛ wɔnyɛ awosu mu nhwehwɛmu nhwɛ sɛ ebia nneɛma bi a ɛnteɛ wɔ srade a ebia ɛde AFLP bae no mu anaa. Ebia wobetu fo nso sɛ sɛ wunyinsɛn bio daakye a, ɛsɛ sɛ woma ɛna ne awotwaa mu aduruyɛ ho ɔbenfo hwɛ wo nyinsɛn no so .

Dɛn na ɛhaw akokoaa no?

Mpɛn pii no, sɛnea tebea no mu yɛ den wɔ ɛna no mu no na ɛkyerɛ sɛnea ɛka akokoaa no kɛse. Nkokoaa binom wɔ asiane mu sɛ wobenya tebea bi a wɔfrɛ no nonketotic hypoglycemia (a wontumi nyɛ amino acid ahorow ho adwuma yiye). Ebia afoforo nso benya tebea horow te sɛ dilated cardiomyopathy (koma ntini a ayɛ mmerɛw) anaa neuropathy (ntini a ɛsɛe). Nanso, mpɛn pii no, asiane a ɛwɔ hɔ ma akokoaa no sua sen asiane a ɛwɔ hɔ ma ɛna no.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Ɛho hia sɛ woka w’aduruyɛ ho abakɔsɛm a edi mũ kyerɛ wo duruyɛfo bere a wonyinsɛn no na woma wohu sɛnkyerɛnne biara a worehu. Sɛ woka nokware a, ɛbɛboa wo ma woanya ayaresa a eye sen biara a wuhia.

Sɛ wuhu sɛnkyerɛnne ahorow a edidi so yi mu biara wɔ nyinsɛn mu a, kɔ oduruyɛfo nkyɛn ntɛm ara :

• Yafunu anaa akyi berɛmo mu yaw a ɛnkɔ.
• Ɔbrɛ anaa adwenemhaw a ɛtra so.
• Akisikuru ne ɔfe a ɛkɔ so tra hɔ.
• Ti a ɛyɛ yaw a ɛrenkɔ.

Eyinom betumi ayɛ nyinsɛn ho sɛnkyerɛnne a ɛfata, nanso ebetumi ayɛ biribi a anibere wom ho sɛnkyerɛnne nso. Enti mma w’adwene mu nyɛ wo naa.

Nsɛm bɛn na ɛsɛ sɛ mibisa me duruyɛfo?

Fa no sɛ, sɛ wo duruyɛfoɔ ka kyerɛ wo sɛ wowɔ AFLP... ɛyɛ ade a ɛfata sɛ wobɛnya nsɛmmisa pii. Ebia wobɛpɛ sɛ wubisa wo ho nsɛm te sɛ:

• "Oduruyɛfo, ɛsɛ sɛ mewo akokoaa no mprempren?"
• "So me nkwa da asiane mu?"
• "So me ba no nkwa da asiane mu?"
• "So AFLP tebea yi bɛkɔ yiye?"
• "Ayaresa bɛn na mihia?"
• "So eyi bɛsan asi bio sɛ ​​me nyinsɛn bio a?"
• "Adɛn nti na eyi too me, oduruyɛfo?"

Bisa asɛm biara a wubetumi asusuw ho te sɛ eyi. Mma nkura biribiara mu.

Nsonsonoe bɛn na ɛda AFLP ne HELLP yare no ntam?

HELLP syndrome ( Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome)** yɛ tebea a ɛba bere a wɔyem na ɛte sɛ AFLP. Nsonsonoe titiriw a ɛda tebea abien no ntam ne sɛnea mogya mu nhwehwɛmu mu aba sesa bere a bere kɔ so no. Mpɛn pii no, AFLP fa ɔhaw ahorow a ɛfa mogya a ɛtwetwe ne nsakrae a ɛba mogya nkwammoaa dodow mu ho. Nanso, mpɛn pii no, HELLP yare no hwehwɛ sɛ mogya nkwammoaa dodow a ɛso tew nkakrankakra.

Bio nso, nnipa a wɔwɔ AFLP no taa nya osuahu:

• Nneɛma a ɛnteɛ a emu yɛ den wɔ mmerɛbo dwumadi ho nhwehwɛmu mu.
• Asikre dodow a ɛwɔ mogya mu a ɛnteɛ biara.
• Nsɛnkyerɛnne a ɛkyerɛ sɛ asaabo no dwumadi nyɛ nea ɛfata.
• Bilirubin dodow a ɛkɔ soro (bilirubin yɛ ade a wɔsɛe no) wɔ sɔhwɛ ahorow mu.
• Acidosis (mogya no mu acid a ɛkɔ soro).
• (Proteinuria) .(Protein a ɛwɔ nsu mu).
• Nsakrae a ɛba amemene no dwumadi mu (sɛ nhwɛso no, wontumi nsusuw nneɛma ho yiye, adwene a ɛyɛ basaa).

So ɛyɛ ade a ɛfata sɛ wubenya mmerɛbo a srade wom bere a wonyinsɛn no?

Wɔ nnipa a wɔnyɛ nyinsɛn mpo mu no, mmerɛbo mu yare a srade wom yɛ tebea a abu so, na wotumi sa. Nnipa dodow no ara wɔ srade bi wɔ wɔn mmerɛbo mu. Nanso, sɛ srade yi dɔɔso a, ebetumi ama mmerɛbo no asɛe. Eyi yɛ asiane titiriw wɔ nyinsɛn mu , efisɛ mmerɛbo ne ɔkwan a nipadua no fa so yi awuduru fi hɔ. Sɛ wo mmerɛbo (anaa wo ba no mmerɛbo) ntumi nyɛ adwuma yiye a, nneɛma a epira betumi ayɛ kɛse wɔ wo mogya mu.

Awiei koraa no, eyi ne nea ɛsɛ sɛ meka kyerɛ wo (Take-Home Message) .

AFLP, anaa mmerɛbo mu yare a emu yɛ den a srade wom a ɛba bere a wɔyem no yɛ tebea a ɛntaa nsi nanso emu yɛ den. Wontumi nsiw ano anaasɛ wontumi nhyɛ nkɔm. Eyi kyerɛ sɛ ɛho hia sɛ wo ne wo duruyɛfo kasa fa w’akwahosan ho abakɔsɛm ne sɛnkyerɛnne biara a ɛyɛ soronko a wubetumi anya wɔ wo nyinsɛn mu ho. Saa nkɔmmɔbɔ ahorow yi bɛboa wo duruyɛfo ma wahu nsɛnnennen a ebetumi aba na wama wo ayaresa a wuhia.

Mma wo ho nnpopo, nanso hwɛ yiye . Hwɛ wo nipadua no yiye. Sɛ wote nka sɛ biribi a ɛyɛ soronko anaa ɛyɛ soronko a, hwehwɛ aduruyɛfo afotu ntɛm ara. Nea ɛho hia sen biara ne sɛ wo ne wo ba no bɛkɔ so anya apɔwmuden.

` Srade mmerɛbo bere a nyinsɛn, AFLP, nyinsɛn mu nsɛnnennen, mmerɛbo mu yare, jaundice, awo, LCHAD a enni hɔ