So wo maame, wo maame nuabea, wo nuabea, anaa w’abusua muni a ɔbɛn wo no anya nufu mu kokoram pɛn? Sɛ ɛba saa a, ɛyɛ ade a ɛfata sɛ wobɛte ehu ne dadwen pii nka, na woasusuw ho sɛ, "So me nso menya?" Mpɛn pii no, wobetumi de kokoram ahorow yi abata asiane a efi awosu mu ho. Ɛnnɛ, yɛbɛka sɔhwɛ titiriw bi a ɛhwehwɛ saa awosu mu asiane no ho asɛm. Ɛno ne BRCA awosu mu abɔde mu nhwehwɛmu no.
Sɛ yɛbɛka no tiawa a, dɛn ne BRCA sɔhwɛ yi?
Okay, momma yɛmfa no saa kwan yi so. Yɛn nyinaa wɔ awosu mu nkwaadɔm ahorow abien wɔ yɛn nipadua mu a wɔfrɛ no BRCA1 ne BRCA2 . Wɔn adwuma titiriw ne sɛ wobesiesie yɛn nipadua mu nkwammoaa DNA na wɔasiw kokoram nkwammoaa a ennyin a wontumi nni so. Ɛte sɛ nipadua no ankasa awɛmfo. Ɛno nti na yɛsan frɛ saa tumor suppressor genes yi.
Afei susuw ho hwɛ, sɛ sintɔ bi, anaa nkwaadɔm mu nsakrae bi wɔ saa awosu mu nkwaadɔm a ɛbɔ ho ban yi mu a, dɛn na ɛba? Afei adeyɛ a ɛma kokoram nkwammoaa nyin no brɛ ase. Eyi ma asiane a ɛwɔ hɔ sɛ wobenya nufu mu kokoram, awotwaa mu kokoram , ne kokoram ahorow pii no yɛ kɛse kɛse.
Nea ɛho hia ne sɛ saa BRCA awosu mu nkwaadɔm mu nsakrae yi fi awosu mu . Ɛno kyerɛ sɛ wobetumi de afi ɛna so akɔ abofra so. BRCA nhwehwɛmu no gye wo mogya na ɛhwɛ sɛ wowɔ asiane mu nsakrae bi wɔ BRCA1 anaa BRCA2 awosu mu nkwaadɔm no mu anaa.
So ɛsɛ sɛ obiara nya BRCA sɔhwɛ yi?
Dabi, ɛnte saa koraa. Saa BRCA awosu mu nkwaadɔm mu sintɔ ahorow yi ntaa mma kɛse wɔ ɔmanfo mu. Enti, nnuruyɛfo nkamfo nhwehwɛmu yi nkyerɛ gye sɛ wowɔ asiane ahorow bi. Eyi nyɛ sɔhwɛ a wɔde ma obi a ɔpɛ sɛ ohu nneɛma pii.
Enti, nnipa bɛn na oduruyɛfo bɛkamfo nhwehwɛmu yi akyerɛ wɔn? Momma yɛnhwɛ.
| Asiane a ɛde ba | Nkyerɛkyerɛmu a ɛnyɛ den |
|---|---|
| Ankorankoro kokoram ho abakɔsɛm | Sɛ w’ankasa woanya nufu mu kokoram, titiriw sɛ na ɛyɛ ansa na woadi mfe 50. Anaasɛ sɛ woanya nufu ne awotwaa mu kokoram nyinaa a. |
| Abusua kokoram ho abakɔsɛm | Sɛ w’abusua no muni biako anaa nea ɛboro saa (te sɛ wo maame, wo nuabea, wo babea, wo maame nuabea) anya nufu mu kokoram, titiriw sɛ ɔbarima bi anya nufu mu kokoram a, ɛno nso yɛ ade a emu yɛ den. |
| BRCA sintɔ bi a wɔahu dedaw | Sɛ wɔagye atom dedaw sɛ obi a ɔwɔ w’abusua mu wɔ BRCA awosu mu abɔde mu sintɔ bi a. |
| Kokoram ahorow afoforo | Sɛ obi a ɔwɔ w’abusua mu anya kokoram te sɛ awotwaa mu kokoram, dwensɔtwaa mu kokoram, anaa prostate kokoram a. |
| Nyarewa a wonya fi awo mu a wɔntaa nhu | Sɛ obi wɔ w’abusua mu wɔ awo mu tebea afoforo a ɛma kokoram ho asiane yɛ kɛse te sɛ Cowden syndrome anaa Li-Fraumeni syndrome a. |
Nea ɛho hia sen biara ne sɛ ɛnsɛ sɛ w’ankasa wusi gyinae sɛ wobɛyɛ sɔhwɛ yi anaasɛ worennyɛ saa. Ɛyɛ papa sɛ wo ne wo duruyɛfo susuw eyi ho na egyina n’afotu so si gyinae.
Dɛn na yebetumi asua afi BRCA sɔhwɛ mu?
Sɛ nhwehwɛmu yi si so dua sɛ wowɔ BRCA awosu mu abɔde mu sintɔ bi a, ɛkyerɛ sɛ wowɔ asiane kɛse sen sɛnea ɛte daa sɛ wubenya kokoram ahorow bi.
Susuw eyi ho hwɛ: Obi a ɔwɔ BRCA awosu mu nkwaadɔm mu nsakrae no wɔ asiane a ɛkɔ soro mpɛn asia sɛ obenya nufu mu kokoram bere a wadi mfe 80 sɛ wɔde toto nnipa dodow no ara ho a. Ɛda adi sɛ kokoram no nso betumi aba wɔ mmofraase na ɛka nufu abien no nyinaa.
Nufu mu kokoram akyi no, awosu mu sintɔ yi betumi ama asiane a ɛwɔ hɔ sɛ wobenya kokoram ahorow pii no ayɛ kɛse:
- Ovarian cancer : Nea ɛne no wɔ abusuabɔ nso ne fallopian tube kokoram ne peritoneal kokoram.
- Prostate cancer : Ɛyɛ mmarima dea.
- Kokoram a ɛwɔ dwensɔtwaa mu
- Fanconi anemia : Kokoram a ɛntaa nsi a ebetumi aba wɔ mmofraase.
Dɛn na ɛba ansa na sɔhwɛ no aba, bere a wɔayɛ sɔhwɛ no ne bere a wɔawie no?
Saa adeyɛ yi nyɛ den sɛnea ebia wubesusuw no.
Ansa na wɔreyɛ sɔhwɛ no
Mpɛn pii no wɔde wo bɛkɔ awosu ho ɔfotufo nkyɛn . Eyinom yɛ nnipa a wɔn ho akokwaw wɔ awosu mu nkwaadɔm, awosu, ne kokoram ho asiane mu. Ɔbɛkyerɛkyerɛ nea edidi so yi mu akyerɛ wo:
- Sɛ sɔhwɛ no aba yɛ `Positive` anaa `Negative` a, dɛn na ɛkyerɛ?
- Ɔkwan bɛn so na nea efi mu ba no ka asiane a ɛwɔ hɔ sɛ kokoram bɛba no?
- Ɔkwan bɛn so na nea ebefi mu aba yi bɛka w’abusua mufo a aka (mmofra, anuanom)?
Bere a wɔreyɛ sɔhwɛ no
Ɛyɛ mmerɛw yiye. Ɛgye mogya fi ntini bi a ɛwɔ wo basa mu mu ara kwa. Te sɛ mogya a wɔde ma de yɛ mogya mu nhwehwɛmu daa no ara pɛ. Ɛwom sɛ ebia wobɛte ɛyaw kakra bere a wode ade no ahyɛ mu de, nanso adeyɛ no nyinaa gye nea ennu simma anum.
Sɔhwɛ no akyi
Ebia ebegye adapɛn pii ansa na nea efi mu ba no asan aba. Sɛ nea efi mu ba no san ba wie a, ɛsɛ sɛ wo ne w’awosu ho ɔfotufo no san hyia bio. Ɔbɛboa wo ma woate nea ebefi mu aba no ase na woasusuw anammɔn a ɛsɛ sɛ woyɛ akyi.
Dɛn na nea efi mu ba no kyerɛ?
Nneɛma ahorow abiɛsa na ebetumi afi mu aba. Momma yɛnka wɔn ho asɛm pefee mmiako mmiako.
| Nea efi mu ba no su | Dɛn na ɛno kyerɛ? |
|---|---|
| 1. Nea efi mu ba no yɛ papa. | |
| Kyerɛ | Eyi kyerɛ sɛ wowɔ nkwaadɔm mu nsakrae bi wɔ wo BRCA1 anaa BRCA2 awosu mu abɔde mu a ɛma asiane a ɛwɔ hɔ sɛ wubenya kokoram no yɛ kɛse. Nanso, eyi nkyerɛ sɛ wowɔ kokoram anaasɛ akyinnye biara nni ho sɛ wubenya bi. Nea ɛkyerɛ ara ne sɛ asiane a ɛwɔ hɔ no dɔɔso. |
| Dɛn na ɛsɛ sɛ woyɛ akyi? | Afei wubetumi ayɛ nneɛma bi de atew asiane a ɛwɔ hɔ no so. Bere a wo ne wo duruyɛfo asusuw eyi ho awie no, wubetumi asusuw nneɛma te sɛ:
|
| 2. Nea efi mu ba no yɛ nea enye. | |
| Kyerɛ | Ɛkyerɛ sɛ wunni BRCA awosu mu abɔde mu sintɔ biara wɔ wo nipadua mu. Ɛno kyerɛ sɛ wo mma rennya BRCA awosu mu abɔde mu sintɔ biara mfi wo hɔ. |
| Nanso... | Eyi nkyerɛ sɛ worennya kokoram da. Nea ɛkyerɛ ara ne sɛ asiane a wowɔ no te sɛ obi a ɔwɔ nnipa dodow no ara mu de. Nanso, sɛ wowɔ abusua abakɔsɛm a emu yɛ den a wowɔ kokoram a, ebia wowɔ awosu mu nkwaadɔm mu nsakrae foforo a ɛma asiane a ɛwɔ hɔ sɛ wubenya kokoram no yɛ kɛse. Wo ne w’awosu ho ɔfotufo nka eyi ho asɛm. |
| 3. Nea ebefi mu aba no yɛ nea wontumi nsi pi (Ucertain / VUS) . | |
| Kyerɛ | Eyi yɛ nea ɛyɛ den kakra. Wei kyerɛ sɛ nsakraeɛ (`variant`) wɔ wo BRCA gene mu, nanso nyansahufoɔ nnya nhunuu sɛ nsakraeɛ no yɛ asiane, ɛma kokoram ho asiane kɔ soro, anaa nsakraeɛ a ɛfata, a asiane biara nni ho. Wɔfrɛ eyi `Variant of Unknown Significance (VUS).` |
| Dɛn na ɛsɛ sɛ woyɛ akyi? | Mma wo ho nnpopo wɔ saa bere yi mu. W’awosu ho ɔfotufo no bɛkyerɛkyerɛ eyi mu akyerɛ wo akɔ akyiri. Ebia ɛho behia sɛ wɔsɔ abusua no mufo afoforo hwɛ anaasɛ wɔbɔ wo amanneɛ daakye sɛ nsɛm foforo ba a. Mprempren de, wɔtaa bu nea efi mu ba a ɛte sɛɛ sɛ nea efi mu ba a enye. |
Nkrasɛm a Wɔde Kɔ Fie
- BRCA sɔhwɛ no yɛ awosu mu nhwehwɛmu titiriw bi a ɛhwehwɛ asiane a efi awosu mu ma nufu, awotwaa, ne kokoram ahorow pii.
- Eyi nyɛ sɔhwɛ a ɛsɛ sɛ obiara nya. Nnuruyɛfo kamfo kyerɛ nnipa a wɔwɔ asiane ahorow bi te sɛ abusua mu abakɔsɛm a wɔanya kokoram nkutoo.
- Adepa a efi mu ba no nkyerɛ sɛ wowɔ kokoram. Ɛkyerɛ sɛ asiane a wowɔ no dɔɔso na wubetumi ayɛ nneɛma bi de adi saa asiane no ho dwuma.
- Ɛho hia yiye sɛ wo ne oduruyɛfo ne awosu ho ɔfotufo susuw eyi ho ansa na woanya nea afi mu aba no ne bere a woanya akyi.
- Nimdeɛ yɛ tumi. Asiane ahorow a wubehu no yɛ ade titiriw a wobɛfa so abɔ wo ne w’abusua daakye akwahosan ho ban.
💬 Comments (0)
Wɔnnya nyɛɛ nsɛm biara. Fa wo nsɛm no ka ho wɔ ha nea edi kan.
Fa wo nsɛm no ka ho