So wowɔ saa sɛnkyerɛnne ahorow a ɛyɛ nwonwa yi? Momma yɛnka Carcinoid Syndrome ho asɛm!

Ɛtɔ da bi a, yennim nea ɛrekɔ so wɔ yɛn nipadua mu ankasa, ɛnte saa? So wo ho atɔ wo mpofirim, ɛyɛ den sɛ wobɛhome, wo yafunu mu yɛ wo yaw, na woayɛ akisikuru pɛn? Eyinom nyɛ nneɛma a wɔanhyɛ da kɛkɛ. Ɛtɔ mmere bi a eyinom betumi ayɛ tebea bi a ɛntaa nsi a wɔfrɛ no Carcinoid Syndrome ho sɛnkyerɛnne. Momma yɛnka eyi ho asɛm nkɔ akyiri nnɛ.

Dɛn ne Carcinoid Syndrome?

Sɛ yɛbɛka no tiawa a, carcinoid syndrome yɛ sɛnkyerɛnne ahorow a kokoram bi a enyin wɔ wo nipadua mu a wɔfrɛ no neuroendocrine tumors (NETs) de ba . Saa neuroendocrine nkwammoaa yi yɛ nkwammoaa titiriw bi a ɛka yɛn ntini ne hormone nhyehyɛe ahorow ho. NET ahorow ba bere a nkwammoaa yi mu paapae mpofirim na ɛdɔɔso ntɛmntɛm, na ɛyɛ akisikuru no.

Afei ebia woresusuw ho sɛ ebia eyi yɛ yare a ɛka obiara anaa. Dabi, nokwarem no, ɛyɛ tebea a ɛntaa nsi . Nhwehwɛmu ahorow kyerɛ sɛ bɛyɛ nnipa baanum biara a wɔwɔ neuroendocrine tumors (NETs) mu biako nya carcinoid syndrome. NET nso ntaa mma saa, na wobu akontaa sɛ ɛba 100,000 biara mu 5 wɔ United States.

Saa NET ahorow yi, titiriw nea ɛwɔ wo yafunu mu anaa w’ahurututu mu no, ma nkwaadɔm pii te sɛ serotonin ne nnuru afoforo kɔ nipadua no mu prɛko pɛ. Ɛno ne bere a carcinoid syndrome ho sɛnkyerɛnne ahorow no da adi. Ɛtɔ da bi a, wudi kan hu sɛ wowɔ NET bere a saa yare yi ho sɛnkyerɛnne ada adi akyi.

Ɛntaa mma koraa sɛ sɛ wɔanhu saa kokoram yare yi yiye na wɔansa a, ebetumi de tebea a egye ntɛmpɛ a ɛde nkwa to asiane mu a wɔfrɛ no ‘carcinoid haw’ aba. Enti, ɛho hia paa sɛ yehu eyi.

Dɛn ne Carcinoid Syndrome ho sɛnkyerɛnne ahorow?

Momma yɛnhwɛ tebea yi ho sɛnkyerɛnne a ɛtaa ba. Hwɛ sɛ wowɔ saa sɛnkyerɛnne ahorow yi bi, mmiako mmiako:

• Flushing: Eyi betumi ayɛ nea ɛnyɛ dɛ kakra. Ɛte sɛ nea wo ho yɛ wo hyew bere a w’ani awu, nanso sɛ ɛtaa ba a ntease biara nnim a, ɛsɛ sɛ wohaw wo ho.
• Ahomegye ne ahome a ɛyɛ tiaa (dyspnea): Ebia ɛbɛyɛ te sɛ nea ɛyɛ den sɛ wobɛhome, anaasɛ ɛte sɛ nnyigyei a ɛyɛ abɛn a efi koko mu ba.
• Yafunu mu akisikuru ne akisikuru a ɛpae, ɛtaa ba: Yafunu mu yaw a ɛkɔ so yɛ akisikuru a emu yɛ den. Ɛtɔ mmere bi a, ɛyɛ den sɛ wobedi so.
• Srade a ɛyɛ huam: Ebia poop no bɛyɛ te sɛ nea srade wom na ɛyɛ huam soronko.
• Edema anaa wo nan ne wo nan a ɛho ahonhon:Ɛtɔ mmere bi a eyi betumi ayɛ komayare ho sɛnkyerɛnne, enti ɛho hia sɛ wohwehwɛ aduruyɛfo afotu ntɛm ara.
• Ɔbarima ne ɔbea nna ho akɔnnɔ a ɛso tew anaasɛ ɔbarima ne ɔbea nna mu ɔhaw a ɛba mmarima mu: Ebia nnipa binom behyia saa tebea horow yi.
• Wora a ɛyɛ kɔkɔɔ ne aniwa fitaa (Jaundice): Eyi ne nea yɛfrɛ no ‘jaundice’. Ebetumi ayɛ mmerɛbo mu haw.
• Adwene a ɛyɛ wo yaw anaa wote nka sɛ woatɔ piti: Eyi betumi ayɛ mogya mmoroso a ɛba fam ho sɛnkyerɛnne.
• Te a wobɛte nka sɛ wo koma rebɔ: Ebia wobɛte nka kɛkɛ sɛ wo koko rebɔ ntɛmntɛm.

Sɛ wokɔ so nya saa sɛnkyerɛnne ahorow yi mu biako anaa nea ɛboro saa a, hwɛ hu sɛ wobɛkɔ oduruyɛfo nkyɛn akɔbɔ ho nkɔmmɔ. Eyinom nso betumi ayɛ tebea afoforo ho sɛnkyerɛnne, nanso ɛho hia sɛ wusi so dua sɛ wowɔ carcinoid syndrome.

Dɛn nti na saa kokoram yare yi ba?

Sɛnea madi kan aka no, sɛ wowɔ neuroendocrine tumors (NETs) a, carcinoid syndrome ba. Saa NET ahorow yi yɛ akisikuru a efi nkwammoaa titiriw a ɛwɔ wo neuroendocrine nhyehyɛe mu na ɛba. Saa nkwammoaa yi yɛ nkwaadɔm a ɛma nipadua no yɛ adwuma na woyi gu nipadua no mu.

Mpɛn pii no, saa NET ahorow yi betumi ayɛ kɛse wɔ mmeae te sɛ wo yafunu mu ntini, w’ahurututu, ne wo dwensɔtwaa mu. Nanso, mpɛn pii no, NET ahorow a ɛwɔ yafunu mu anaa ahurututu mu a ɛma nkwaboaa pii (titiriw serotonin) kɔ mogya no mu mpofirim na ɛde carcinoid syndrome ba.

Fa no sɛ faucet a ɛredan nsu no nkakrankakra, mpɛn pii no saa nkwammoaa yi yi hormone ahorow fi mu kakraa bi. Nanso sɛ NET bi ba a, ɛte sɛ nea wɔabue faucet no mpofirim kɛse, na hormone pii fi adi prɛko pɛ. Ɛno ne bere a saa yare yi ho sɛnkyerɛnne ahorow no da adi.

Hena na ɔwɔ asiane kɛse sɛ obenya carcinoid syndrome?

Asiane titiriw a ɛde eyi ba ne sɛ wubenya neuroendocrine tumor (NET) wɔ wo yafunu mu anaa w’ahurututu mu . Ɔkwan foforo so no, mpɛn pii no, carcinoid syndrome nnya nkɔso a NET nni hɔ.

Ɛno kyerɛ sɛ, sɛ wɔahu sɛ wowɔ NET ahorow a, ɛsɛ sɛ wohaw wo ho wɔ saa yare yi nso ho. Ɛtɔ da bi a, sɛ obi a ɔwɔ abusua no mu anya NET a, ɛno nso betumi ayɛ asiane akodu baabi, nanso ɛntaa nsi koraa.

Dɛn ne nsɛnnennen a ebetumi afi Carcinoid Syndrome mu aba?

Carcinoid syndrome nyɛ sɛnkyerɛnne ahorow bi kɛkɛ, ebetumi de nsɛnnennen a emu yɛ den pii aba. Tebea a ɛte saa no biako ne tebea a ebetumi de nkwa ato asiane mu a wɔfrɛ no ‘carcinoid crisis’ a madi kan aka ho asɛm no.

Momma yɛnhwɛ nsɛnnennen kakraa bi bio:

• Koma mu yare a ɛyɛ carcinoid:Eyi nso ho yɛ na, nanso ebetumi de nkwa ato asiane mu. Nkwammoaa a NET ahorow no ma no nya wo koma no mu dan, wo ntini ahorow, ne wo mogya ntini ahorow no so nkɛntɛnso. Eyi betumi ama komayare mpo.
• Mesenteric fibrosis: NET betumi ama mesentery, ntini a ɛka wo dwensɔtwaa ne wo yafunu fasu bom no ho hyew na ɛyɛ akuru. Eyi betumi asiw dwensɔtwaa no dwumadi kwan.
• Adwenemhaw: Carcinoid syndrome betumi aka sɛnea wo nipadua no tumi de amino acid a ɛho hia a wɔfrɛ no tryptophan di dwuma no. Tryptophan boa ma wɔyɛ serotonin. Serotonin yɛ amemene mu nnuru a ɛhwɛ nneɛma te sɛ yɛn adwene, yɛn nneyɛe, ne yɛn nna so. Enti serotonin dodow a ɛba fam betumi ama obi anya adwenemhaw.

Tebea a asiane wom a wɔfrɛ no carcinoid crisis no

Carcinoid haw yɛ tebea a egye ntɛmpɛ a ɛntaa nsi koraa nanso ebetumi de nkwa ato asiane mu . Ebetumi aba esiane oprehyɛn, aduruyɛ mu akwan foforo, anaa opira a efi akwanhyia mu nti.

Eyi su ahorow ne:

• Nsakrae akɛse a ɛba mogya mmoroso mu: Mogya mmoroso betumi akɔ fam mpofirim dodo (hypotension) anaasɛ akɔ soro dodo.
• Nhoro a ɛyɛ den: Nipadua no nyinaa yɛ kɔkɔɔ mpofirim na ebia ɛbɛyɛ hyew.
• Ɔhome a ɛyɛ den (Dyspnea): Ɔhome a ɛyɛ tiaa kɛse betumi aba.
• Adwene a ɛyɛ basaa: Ebia wobɛte nka te sɛ nea wɔrehaw w’adwene.

Ɛho hia yiye sɛ obi a ɔwɔ carcinoid syndrome anaa neuroendocrine tumor (NET) kura krataa a ɛkyerɛ ne tebea no. Eyi betumi aboa wɔn kɛse sɛ wohia ayaresa ntɛm ara a. Afei nso, sɛ wɔbɛyɛ wo oprehyɛn a, ɛho hia sɛ woka tebea yi ho asɛm kyerɛ wo nnuruyɛfo. Afei wobetumi ama wo nnuru ansa na wɔreyɛ oprehyɛn no ne bere a wɔreyɛ oprehyɛn no na ama asiane a ɛwɔ hɔ sɛ wubenya ‘carcinoid haw’ no so atew.

Ɔkwan bɛn so na wohu sɛ obi anya Carcinoid Syndrome?

Nnuruyɛfo de nhwehwɛmu ahorow pii di dwuma de hu tebea yi. Momma yɛnhwɛ nea wɔyɛ:

• Nsu mu nhwehwɛmu: Eyi hwɛ sɛnea nkwaadɔm bi wɔ wo nsu mu, titiriw serotonin bi a wɔfrɛ no 5-HIAA (5-hydroxyindoleacetic acid) .
• Nipadua mu nhwehwɛmu ne aduruyɛ ho abakɔsɛm: Carcinoid syndrome ho sɛnkyerɛnne betumi ayɛ te sɛ nyarewa afoforo a emu nyɛ den pii de, enti wo duruyɛfo bebisa wo wo sɛnkyerɛnne ahorow , bere tenten a ɛwɔ hɔ, ne sɛ ebia ɛreyɛ kɛse anaa.
• Mogya mu nhwehwɛmu:Eyinom hwɛ nneɛma dodow a efi w’akwaa ne wo ntini mu kɔ mogya no mu. Sɛ nneɛma bi dodow kɔ soro anaa ɛkɔ fam mpofirim a, ebetumi ayɛ yare ho sɛnkyerɛnne. Sɛ nhwɛso no, wɔhwɛ agyiraehyɛde bi a wɔfrɛ no Chromogranin A.
• Neuroendocrine Positron Emission Tomography (PET) scan: Eyi yɛ scan titiriw a wɔde aduru bi a wɔfrɛ no gallium 68 dotatate di dwuma de hwehwɛ baabi a neuroendocrine tumors (NETs) wɔ.
• CT scan: CT scan de X-ray ne kɔmputa yɛ w’akwaa ne wo nnompe ho mfonini a ɛwɔ afã abiɛsa (3D). Eyi nso betumi aboa ma wɔahu baabi a akuru biara wɔ ne ne kɛse.
• Ultrasound scan: Eyi de nnyigyei asorɔkye di dwuma de yɛ akwaa ahorow ho mfonini.
• MRI scan (Magnetic Resonance Imaging (MRI): Eyi de magnet kɛse, radio asorɔkye, ne kɔmputa yɛ nipadua no mu mfonini a ɛkɔ akyiri.
• Endoscopy: Wɔ sɔhwɛ yi mu no, oduruyɛfo de afiri tenten bi a ɛyɛ tratraa a mfoninitwa afiri ne kanea wom hyɛ wo nipadua mu de hwehwɛ mu. Sɛ nhwɛso no, wobetumi de saa kwan yi ahwɛ yafunu anaa dwensɔtwaa mu.

Dɛn ne ayaresa ahorow a wɔde sa Carcinoid Syndrome?

Carcinoid syndrome no fi neuroendocrine tumors (NETs) mu. Enti, sɛ wɔsa saa akisikuru no a, wɔsa syndrome no nso.

Akwan atitiriw pii wɔ hɔ a wɔfa so sa yare:

• Oprehyɛn: Wobetumi ayi neuroendocrine akisikuru no afi hɔ koraa anaasɛ wɔatew ne kɛse so. Oprehyɛn ko a wɔbɛyɛ no gyina beae a akisikuru no wɔ ne ne kɛse so.
• Somatostatin analogs: Eyinom yɛ nnuru titiriw bi. Saa nnuru yi betumi asiw wo nipadua no kwan sɛ ɛrenyɛ hormone pii. Wobetumi nso aboa ma wɔadi akisikuru no nyin so bere a kokoram nkwammoaa atrɛw akɔ nipadua no afã afoforo (metastasis). Nhwɛso ahorow bi ne nnuru a wɔfrɛ no Octreotide ne Lanreotide .
• Ayaresa a wɔde wɔn ani asi so: Eyi nso yɛ ayaresa kwan titiriw a wɔfa so kum kokoram nkwammoaa. Wɔ eyi mu no, wɔde nnuru ma de de wɔn ani si awosu mu nkwaadɔm anaa protein pɔtee bi a ɛwɔ kokoram nkwammoaa mu so.
• Nnuru a wɔde sa yare: Eyi de nnuru kum kokoram nkwammoaa. Nnuru a wɔde sa yare no nyɛ adwuma pɛpɛɛpɛ wɔ NET ahorow nyinaa ho.
• Embolization: Wɔ saa kwan yi so no, mogya ntini a ɛde mogya kɔ akisikuru no mu no siw, na ɛsɛe akisikuru no. Eyi yɛ ayaresa a wɔde di dwuma titiriw ma NET ahorow a ɛwɔ mmerɛbo mu.

So wobetumi asiw Carcinoid Syndrome ano?

Pa ara,Ɔkwan biara nni hɔ a wɔbɛfa so asiw carcinoid syndrome ano efisɛ ɛne neuroendocrine tumors (NETs) wɔ abusuabɔ. Esiane sɛ wonnim ɔkwan biara a wɔbɛfa so asiw NET ahorow a ɛbɛba no ano nti, ɔkwan biara nni hɔ a wɔbɛfa so asiw sɛnkyerɛnne ahorow a efi mu ba no ano.

Nanso, sɛ wunim sɛ wowɔ NET a, sɛ wuhu carcinoid syndrome ho sɛnkyerɛnne ntɛm na wufi ase sa yare a, ebetumi atew asiane a ɛwɔ hɔ sɛ wubenya nsɛnnennen no so.

Mɛyɛ dɛn ahwɛ me ho? / Mɛyɛ dɛn adi sɛnkyerɛnne ahorow ho dwuma?

Sɛ wowɔ carcinoid syndrome a, ebia wowɔ neuroendocrine tumor (NET) nso. Enti, sɛ wowɔ carcinoid syndrome ho sɛnkyerɛnne a, ka kyerɛ wo duruyɛfo ntɛm ara. Wobetumi asusuw wo tebea no ho na wɔakamfo sɔhwɛ ahorow a ɛho hia ahwɛ sɛ wowɔ NET anaa.

Carcinoid syndrome ho sɛnkyerɛnne atitiriw abiɛsa ne sɛ obi ho yɛ nwini, ne ho yɛ no yaw, ne ne dwensɔtwaa. Nneɛma kakraa bi a wubetumi ayɛ de aboa ma woadi eyinom ho dwuma ni:

• Flushing: Eyi ne sɛnea wo ntini ahorow no yɛ n’ade wɔ honam fam anaa adwene mu nhyɛso ho. Nea ɛbɛyɛ na eyi so atew no, home yiye, fa ntama a ɛyɛ nwini popa w’anim ne wo moma so, anaa fa mframa pa bi fi abɔnten. Nsã a wobɛkwati nso betumi aboa.
• Ahomegye: Sɛ wo home yɛ tiaa a, bɔ mmɔden sɛ wobɛnom nhabannuru tii anaasɛ wode afiri a wɔde home anaa nea ɛma mframa bɔ bedi dwuma . Sɛ wonom sigaret a, bɔ mmɔden sɛ wubegyae. Sigaretnom betumi ama wo mframa kwan no ayɛ hyew kɛse.
• Atiridiinini: Sɛ akisikuru yɛ ɔhaw ma wo a, wo ne wo duruyɛfo nkasa mfa akwan a wobɛfa so atew mpɛn dodow a ɛba ne sɛnea emu yɛ den so. Nnuru titiriw bi wɔ hɔ a wɔayɛ sɛ wɔde besiw akisikuru a carcinoid syndrome de ba no ano. Afei nso, nnuan a srade wom, nnuhwam, ne nufusu mu nnuan betumi ama tebea yi asɛe kɛse ama nnipa binom. Enti hwɛ yiye wɔ nea wudi ho.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn? / Bere bɛn na ɛsɛ sɛ mekɔ baabi a wɔhwɛ wɔn a wɔwɔ tebea a egye ntɛmpɛ mu?

Sɛ wo carcinoid syndrome ho sɛnkyerɛnne no mu yɛ den a, hwɛ hu sɛ wobɛkɔ oduruyɛfo nkyɛn. Sɛ wɔresa wo yare wɔ NET ho a, sɛ wuhu nsakrae foforo bi wɔ wo nipadua mu a ebetumi ayɛ te sɛ NET sɛnkyerɛnne a, ka kyerɛ wo duruyɛfo. Ebia nsakrae yi ne wo NET a woahu no nni abusuabɔ, nanso ɔkwan a eye sen biara a wobɛfa so ahu no yiye ne sɛ wo ne wo duruyɛfo bɛkasa. Afei nso, sɛ wo yare no ho sɛnkyerɛnne anaa nsunsuanso bɔne a efi w’ayaresa no mu no mu yɛ den a, ka kyerɛ wo duruyɛfo.

Bere a ɛsɛ sɛ wokɔ Ayaresa a Ɛho Hia Ntɛmntɛm (ETU) .

Sɛ wɔannya carcinoid syndrome a, bere kɔ so no, sɛnkyerɛnne ahorow no betumi asɛe kɛse na abɛyɛ tebea a ɛde nkwa to asiane mu a wɔfrɛ no ‘carcinoid haw.’ Enti, kɔ ayaresabea dwumadibea a wɔhwɛ ntɛmpɛ so ntɛm ara sɛ wowɔ:

• Sɛ wo koma bɔ anaasɛ wo koko yɛ wo yaw a.
• Sɛ wowɔ atiridiinini a emu yɛ den nna pii a.
• Sɛ wo yafunu mu yɛ wo yaw kɛse a.
• Sɛ wote nka sɛ woatɔ piti a.
• Sɛ w’anim, wo kɔn, ne wo moma so ayɛ wo hyew mpofirim a emu yɛ den (a ɛyɛ wo hyew denneennen).

Nsɛm bɛn na ɛsɛ sɛ mibisa me duruyɛfo?

Carcinoid syndrome betumi ayɛ sɛnkyerɛnne a ɛkyerɛ sɛ wowɔ neuroendocrine tumor (NET). Enti sɛ wowɔ nsɛmmisa bi fa carcinoid syndrome ho a, ebia wowɔ nsɛmmisa pii fa NETs ho. Nsɛmmisa bi a wubetumi abisa wo duruyɛfo ni:

• Sɛ mewɔ carcinoid syndrome a, mɛyɛ dɛn ahu sɛ mewɔ neuroendocrine tumor?
• Sɛ mewɔ akisikuru a, ɛhe na ɛwɔ me nipadua mu?
• Dɛn ne ayaresa ahorow a wɔde sa me akisikuru no?
• Dɛn ne ayaresa no mu nsunsuanso bɔne?
• So wobetumi asa neuroendocrine tumor a ɛde me carcinoid syndrome bae no koraa?
• So carcinoid syndrome bɛsan aba bio bere a wɔasa me neuroendocrine tumor no akyi?

Nkrasɛm a Etwa To a Wɔde Kɔ Fie

Carcinoid Syndrome yɛ tebea a ɛntaa nsi a ebetumi aba obi a ɔwɔ neuroendocrine tumor (NET) so. Mpɛn pii no, nnipa a wɔwɔ carcinoid syndrome nim dedaw sɛ wɔwɔ NET. Ɛtɔ da bi a, nkurɔfo di kan hu sɛ wɔwɔ NET bere a wɔahu sɛ wɔwɔ carcinoid syndrome akyi.

Nea eye sen biara ne sɛ NET ahorow no yɛ nea wotumi sa. Nim a wubehu sɛ wowɔ carcinoid syndrome no ne ade a edi kan a wobɛfa so ahu sɛ wowɔ kokoram anaa, na sɛ ɛte saa a, sɛnea wobɛsa. Enti, sɛ wɔahu sɛ wowɔ carcinoid syndrome a, nsuro sɛ wo ne wo duruyɛfo bɛkasa na woabisa nea edi hɔ a wobɛfa so asi so dua sɛ wowɔ NETs anaa. Ade a ɛho hia sen biara ne sɛ wobehu yare no na wɔasa no yare ntɛm.

Kae sɛ ɛnyɛ wo nko ara. Wɔ tebea a ɛte sɛɛ mu no, ɛho hia paa sɛ wudi nnuruyɛfo afotu akyi na wohwehwɛ mmoa fi w’abusua hɔ.

` Carcinoid syndrome, neuroendocrine tumors, NETs, ​​serotonin, sɛnkyerɛnne ahorow, kokoram, hormone ahorow