So woate Parkinson yare no ho asɛm pɛn? Anaasɛ ahomegye a ɛtɔ mmere bi a wontumi nnyina ano wɔ nan no mu, kyerɛ sɛ, Restless Legs Syndrome? Ɛnnɛ yɛrebɛka nnuru soronko bi a wɔde sa tebea horow a ɛtete saa pii ho asɛm. Wɔfrɛ eyinom Dopamine Agonists. Ɛwom sɛ edin no yɛ den kakra de, nanso ɔkwan a wɔfa so yɛ adwuma no yɛ mmerɛw yiye.
Dɛn ankasa ne nnuru a ɛko tia dopamine?
Sɛ yɛbɛte eyi ase a, momma yensusuw yɛn amemene no ho kakra. Ntini mu nkwammoaa a ɛwɔ yɛn amemene mu no nam nnuru titiriw bi so ne wɔn ho wɔn ho di nkitaho, anaasɛ sɛ yɛbɛka no yiye a, ɛsesa nkrasɛm. Yɛfrɛ saa ntini mu nkwaadɔm yi . Susuw yɛn amemene mu nkwammoaa ho sɛ apon a ɛka bom. Saa neurotransmitters yi te sɛ nsafe soronko a ebetumi abue saa apon no.
Dopamine yɛ "safe" a ɛho hia saa. Saa nnuru yi ho hia bere a yɛresua biribi, bere a yɛte anigye ne abotɔyam nka, ne bere a yɛhwɛ yɛn nipadua no kankyee so no.
Sɛ yɛbɛka no tiawa a, dopamine agonists yɛ nnuru a ɛyɛ adwuma te sɛ dopamine, nanso ɛnyɛ dopamine ankasa. Wɔte sɛ ‘safe’ a wɔfrɛ no dopamine no nsɛso. Esiane sɛ yɛn amemene mu nkwammoaa ntumi nhu nsonsonoe a ɛda abien no ntam nti, sɛ wonya dopamine agonist a, wosusuw sɛ wɔrenya dopamine ankasa. Enti, saa nnuru yi boa ma wodi ɔhaw ahorow a ɛba bere a dopamine dodow sua no so.
Nyarewa bɛn na wɔde saa aduru yi di dwuma?
Dopamine dodow a ɛso tew wɔ nipadua no mu no betumi de ayaresa tebea horow aba. Aduruyɛ mu tebea horow a wɔde dopamine agonists di dwuma titiriw no bi wɔ ase ha.
| Aduruyɛ mu tebea | Nkyerɛkyerɛmu a ɛnyɛ den |
|---|---|
| Parkinson yare ne kankyee mu haw ahorow a ɛbata ho | Tebea a dopamine a enni amemene no afã horow a ɛhwɛ nipadua no kankan so no de ba. |
| Nan a Ɛnyɛ Dwudwo Syndrome | Ɔpɛ a emu yɛ den a obi wɔ sɛ ɔbɛkanyan nan no, titiriw anadwo, ne atenka a ɛma ne ho nyɛ no dɛ. |
| Prolactinemia a ɛboro so | Hormone prolactin dodow a ɛkɔ soro wɔ nipadua no mu. Eyi betumi de ɔhaw ahorow te sɛ brayɛ a ɛnkɔ so daa aba. |
| Neuroleptic Malignant Syndrome a Ɛyɛ Fɛ a Ɛyɛ Fɛ | Ɔhaw a ɛntaa nsi nanso ɛyɛ hu a nnuru bi a wɔde sa adwenemyare betumi de aba. |
| Asikreyare a Ɛto so 2 | Dopamine agonists bi nso boa ma asikre dodow a ɛwɔ mogya mu no so. |
Mfaso bɛn na ɛwɔ nnuru yi so?
Nneɛma pii nti na nnuru kuw a wɔfrɛ no dopamine agonists no ho hia ayarefo kɛse.
- Nkonimdi kɛse: Nhwehwɛmu ada no adi sɛ saa aduru yi tu mpɔn kɛse wɔ aduruyɛ mu tebea horow pii a wɔsa mu.
- Wobetumi de adi dwuma wɔ nyarewa ahorow mu: Sɛnea yɛaka ho asɛm wɔ atifi hɔ no, wɔde eyinom di dwuma ma nyarewa ahorow pii, efi amemene mu kankyee mu ɔhaw ahorow so kosi nkwaadɔm mu haw ahorow so.
- Sɛ wɔde ka nnuru afoforo ho: Nhwɛso pa ne Parkinson yare. Sɛ wɔde dopamine agonist ne aduru ‘Levodopa’ a wɔde di dwuma ma saa yare yi bom a, ebetumi ama wɔanya nkɛntɛnso kɛse bere mpo a wɔde levodopa dodow sua. Wɔboa nso ma wɔtwentwɛn levodopa ase.
- Nkwa a Wogye: Ɛtɔ mmere bi mpo a nnuru yi betumi aboa ma wɔagye nnipa nkwa. Sɛ nhwɛso no, wobetumi adi tebea bi a ɛyɛ hu a wɔfrɛ no `Neuroleptic Malignant Syndrome` so.
So asiane ne nsunsuanso bɔne biara nni hɔ?
Sɛnea ɛte wɔ nnuru biara ho no, nneɛma bɔne bi wɔ hɔ a ebetumi afi mu aba. Nanso mma nsuro. Ade a ɛho hia sen biara ne sɛ wobɛhwɛ eyinom yiye. Mpɛn pii no, dodow a dodow a wɔde ma no dɔɔso no, dodow no ara na hokwan a ɛwɔ hɔ sɛ wobenya saa nneɛma bɔne yi.
| Nneɛma bɔne a ɛtaa ba | |
|---|---|
| - Ayamtim | - a ɛyɛ akisikuru ne akisikuru |
| - a ɛyɛ atiridiinini | - Tipaeɛ |
| - a ewo aduane mu haw | - a obi totɔ piti bere a ogyina hɔ (Orthostatic hypotension) . |
Nsɛm a Ɛfa Impulse Control Ho
Eyi yɛ biribi a ɛsɛ sɛ yɛka ho asɛm kɔ akyiri. Dopamine yɛ nnuru a ɛboa ma yɛte nneɛma te sɛ anigye ne abotɔyam nka. Enti bere a nnuru yi kanyan saa adeyɛ no, ebetumi aka sɛnea nnipa binom tumi di wɔn nkate horow so nso . Ɛne sɛ, wontumi nni ɔpɛ a wɔwɔ sɛ wɔbɛyɛ biribi no so. Nhwɛsoɔ:
- Kyakyatow a ɛma obi yɛ ade tra so.
- Nneɛma a wobɛtɔ a wuntumi nni so, sɛ wunhia mpo a.
- Ɔbarima ne ɔbea nna a ɛboro so.
- Adidi boro so a wontumi nni so.
Eyi ho hia paa. Sɛ wo anaa w’abusua hu nsakrae bi a ɛyɛ soronko wɔ wo suban mu a, nfɛre na wo ne wo duruyɛfo nkasa ntɛm ara sɛnea wubetumi. Ɛho hia sɛ wobɔ wo duruyɛfo amanneɛ wɔ eyi ho, efisɛ ebetumi ayɛ aduru no ho nsunsuanso bɔne.
Sɛ wugyae aduru no nom mpofirim a, dɛn na ɛba?
Eyi nso yɛ asɛm a ɛho hia paa. Sɛ wugyae dopamine agonist nnuru a wode di dwuma mpofirim anaasɛ wotew dodow so a wunni aduruyɛfo afotu biara a , ebia nnipa binom behyia ɔhaw ahorow a ɛtoatoa so. Yɛfrɛ eyi Dopamine Agonist Withdrawal Syndrome (DAWS) . Nsɛnkyerɛnne a ebetumi aba ne:
- Dadwen ne ahomegye a wonni
- Fifiri a ɛboro so
- Ɔbrɛ
- Nipadua mu yaw
- Abofono
Enti, ade a ɛho hia sen biara a ɛsɛ sɛ wokae ne sɛ worennyae aduru yi nom da anaasɛ worensesa dodow a wo duruyɛfo nka ho.
So tebea horow bi wɔ hɔ a ɛnyɛ papa sɛ wobɛnom saa aduru yi?
Yiw, nnipa binom mfata mma saa aduru yi. Yɛfrɛ eyinom "contraindications".
- Ɛnanom a wɔyem ne wɔn a wɔma nufu:Wɔnkamfo saa aduru yi nkyerɛ wɔ saa mmere yi mu efisɛ ebetumi aka nufu a wɔde ma.
- Nnipa a mogya mmoroso: Nnuru bi a ɛma mogya mmoroso yɛ dopamine agonists betumi ama mogya mmoroso akɔ soro bio.
- Nnipa a wɔwɔ asaabo anaa mmerɛbo mu yare: Efisɛ saa nyarewa yi ka ɔkwan a wɔfa so yi nnuru fi nipadua no mu no.
- Nnipa a wɔnom nnuru afoforo bi: Titiriw sɛ worenom MAOI nnuru a, anyɛ yiye koraa no, ɛsɛ sɛ wugyae nom adapɛn abien ansa na woafi saa nnuru yi ase.
- Nnipa a wɔanya adwene mu yare ho abakɔsɛm: Nnuru yi betumi ama asiane a ɛwɔ hɔ sɛ wobenya adwene mu yare ho sɛnkyerɛnne no ayɛ kɛse.
Sɛ wowɔ saa tebea horow yi bi a, ka ho asɛm kyerɛ wo duruyɛfo ansa na woafi ayaresa ase.
Nsonsonoe bɛn na ɛwɔ dopamine ne dopamine agonists ntam?
Eyi yɛ asɛmmisa a nnipa pii wɔ. Sɛ dopamine sua a, dɛn nti na wɔma dopamine agonists mmom sen sɛ wɔbɛma dopamine tẽẽ? Nneɛma pii nti na ɛte saa.
Nea enti titiriw ne mogya ne amemene akwanside no . Fa yɛn amemene no sɛ ade a ɛbɔ yɛn ho ban. Dopamine a wɔde ma wɔ abɔnten no ntumi mfa saa afiri yi mu nkɔ amemene no mu. Nanso, nnuru a ɛma dopamine agonist tumi fa akwanside yi mu na ɛkɔ amemene no mu tẽẽ. Ɛno nti na etu mpɔn kɛse no.
Nkrasɛm a Wɔde Kɔ Fie
- Dopamine agonist yɛ aduru bi a ɛkanyan amemene mu nkwammoaa wɔ ɔkwan a ɛte sɛ nnuru dopamine so, nanso ɛnyɛ dopamine ankasa.
- Wɔde eyinom sa tebea horow pii te sɛ Parkinson yare ne Restless Legs Syndrome.
- Te sɛ nnuru nyinaa no, eyinom betumi anya nsunsuanso bɔne, titiriw nsɛm a ɛfa nkate a wɔde di dwuma ho.
- Sɛ wo anaa w’abusua hu nsakrae bi a ɛyɛ soronko a, wo ne wo duruyɛfo nkasa ntɛm ara.
- Mma nnnyae saa aduru yi nom mpofirim da anaasɛ nsakra dodow a wode ma a wunni aduruyɛfo afotu biara da.
- Sɛ wo ne wo duruyɛfo bɛkasa pefee na woadi nokware a, ɛno ne ɔkwan a eye sen biara a wobɛfa so anya nea edi mu sen biara.
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