Ebia biribiara nni hɔ a ɛyɛ awerɛhow sen sɛ yebehu sɛ yɛn maame, yɛn papa, yɛn nanabea, anaa yɛn papa nua ba a ne mfe akɔ anim no werɛ afi biribiara nkakrankakra. Efi ase fi nneɛma nketenkete a yɛn werɛ fi so kosi sɛ awiei koraa no yɛrenkae onipa ko a yɛyɛ anaa onii ko a yɛn mma yɛ so no, Alzheimer yare no yɛ tebea a ɛma yɛn nyinaa yɛ nea wontumi nyɛ ho hwee ankasa sɛ abusua. Enti, sɛ owia hann ketewaa bi puei wɔ mununkum tuntum a ɛte saa mfinimfini nso ɛ? Na sɛ asɛm bi wɔ hɔ a ɛfa aduru foforo bi a ebetumi ama Alzheimer yare no akɔ so brɛoo ho nso ɛ? Ɛnnɛ yɛrebɛka nhwehwɛmu foforo bi a ɛde anidaso a ɛte saa aba ho asɛm.
Dɛn ne Donanemab? Ɔkwan bɛn so na ɛyɛ adwuma?
Sɛ yɛbɛka no tiawa a, Donanemab yɛ nhwehwɛmu aduru foforo a wɔreyɛ de asa Alzheimer yare no. Adwumakuw a wɔyɛ nnuru a wɔfrɛ no Eli Lilly na ɛyɛ.
Mprempren, wosusuw sɛ nea ɛde Alzheimer yare no ba titiriw ne protein a epira a wɔfrɛ no amyloid plaques a ɛboaboa ano wɔ amemene no mu. Te sɛ nkannare a ɛba yɛn nsu afiri mu no, saa protein ahorow yi boaboa ano wɔ ntini mu nkwammoaa a ɛwɔ amemene no mu no ntam na esiw wɔn dwumadi kwan. Bere kɔ so no, eyi na ɛde sɛnkyerɛnne ahorow te sɛ nkae a ɛyera ne adwene a ɛyɛ den ba.
Aduru Donanemab no de n’ani si saa nneɛma a ɛwɔ hɔ a wɔfrɛ no amyloid plaques yi so pɔtee. Sɛ wɔde saa aduru yi ma nipadua no a, ɛkɔ amemene no mu, hu protein a wɔmpɛ yi, na efi ase yi fi hɔ. Eyi yɛ adwuma te sɛ aduru a wɔde sa nipadua no mu nkwammoaa a ɛko tia nyarewa . Nyansahu mu nnyinaso a ɛwɔ eyi akyi ne sɛ, sɛ wɔtew amemene no ho wɔ saa kwan yi so a, ebetumi ama yare no akɔ so brɛoo.
Nea afi nhwehwɛmu yi mu aba no di yiye araa ma Eli Lilly resiesie ne ho sɛ ɔbɛbisa U.S. Aduan ne Nnuru Dwumadibea (FDA) sɛ wɔmpene saa aduru yi so sɛ wɔmfa nni dwuma wɔ ɔmanfo mu.
Nea efii mu bae a ɛyɛ nwonwa a nhwehwɛmu no daa no adi
Eyi nyɛ nhwehwɛmu biara kɛkɛ. Eyi yɛ sɔhwɛ a wɔanhyɛ da, a wɔde ani abien ayɛ, a wɔde placebo dii dwuma . Ɛne sɛ, wɔkyekyɛ ayarefo mu akuw abien, na wɔma kuw biako aduru ankasa, na wɔma kuw foforo no aduru a ɛnyɛ nokware a biribiara nni mu (placebo). Nanso ɔyarefo no anaa kuw a wɔresa no yare no mu biara nnim onii a ɔrenya aduru no. Saa kwan yi ma yetumi susuw sɛnea aduru no yɛ adwuma yiye ankasa a yɛmfa animhwɛ.
Enti momma yɛnhwɛ nea afi nhwehwɛmu yi mu aba no bi. Eyinom kyerɛ sɛnea eyi betumi ama nsakrae kɛse aba Alzheimer ayarefo asetra mu.
| Nneɛma atitiriw a wɔahu | Nea efii mu bae no ho nkyerɛkyerɛmu |
|---|---|
| Nsɛnkyerɛnne a ɛnyɛ kɛse | Wɔn a wɔnom donanemab no mu 47% ankyerɛ sɛ yare no ho sɛnkyerɛnne nkɔanim wɔ afe biako akyi, sɛ wɔde toto wɔn a wɔnom placebo no mu 29% pɛ ho a. |
| Yare no a wɔbɛma ayɛ brɛoo | Sɛ wɔde toto wɔn a wɔnom placebo no ho a, wɔn a wɔnom Donanemab no so tew 35% wɔ sɛnea yare no mu yɛɛ den no so. |
| Tumi a wotumi yɛ da biara da nnwuma | Tumi a wutumi yɛ da biara da nnwuma te sɛ ntadehyɛ ne tii a w’ankasa wobɛyɛ no so atew 40% . Eyi yɛ ahotɔ kɛse ma ɔyarefo no ne abusua no nyinaa. |
| Asiane a ɛwɔ hɔ sɛ ɛbɛkɔ so akɔ yare no fã a edi hɔ no | Wɔn a wɔnom Donanemab no, asiane a ɛwɔ hɔ sɛ wɔbɛkɔ so akɔ yare no fã a edi hɔ a emu yɛ den kɛse no so tew 39% . |
| Amemene mu amyloid dodow a ɛwɔ nipadua no mu | Wɔ asram 6 pɛ akyi bere a wɔafi ayaresa ase mpo no, amyloid plaques dodow a ɛwɔ ayarefo no amemene mu no so atew kɛse. |
Nhwehwɛmu no faa ayarefo a na wɔwɔ yare no mfiase no ho. Wɔkyekyɛɛ wɔn mu nso sɛnea tau , protein foforo a ɛkyerɛ sɛnea yare no mu yɛ den no dodow te. Nea ɛyɛ nwonwa no, ayarefo a yare no mu yɛ den kɛse na wɔnom tau kɛse mpo ahu sɛ ebinom anya aduru no so mfaso.
Yenim nneɛma bɔne a efi mu ba nso.
Sɛnea ɛte wɔ nnuru biara ho no, wɔbɔ amanneɛ sɛ ɛde ɔhaw ahorow bi ba. Bere a yɛreka anidaso ho asɛm no, ɛsɛ sɛ yedi nokware wɔ asiane ahorow yi ho.
Nsunsuanso titiriw a wohu wɔ aduru yi ho ne tebea bi a wɔfrɛ no ARIA (Amyloid-Related Imaging Abnormalities) . Sɛ yɛbɛka no tiawa a, eyi yɛ amemene no mu a ɛho ahonhon bere tiaa bi anaasɛ mogya ketewaa bi a ɛba amemene no mu. Wogye di sɛ ɛne ɔkwan a wɔfa so yi amyloid no wɔ abusuabɔ.
- Wɔn a wɔnom Donanemab no mu 24%Amemene mu ahonhon aba, nanso nnipa 6% pɛ na wɔada sɛnkyerɛnne ahorow adi.
- Mogya nketenkete bi sii wɔ ayarefo bɛyɛ 31% mu (eyi nso sii wɔ wɔn a wɔnom placebo no mu 14% mu).
Nea eye sen biara ne sɛ ARIA tebea horow yi mu dodow no ara yɛ nea emu nyɛ den anaasɛ ɛyɛ mmerɛw na wobetumi asa anaasɛ wɔde aduru a ɛfata asiesie.
Nanso, ɛnsɛ sɛ yɛn werɛ fi nokwasɛm yi nso. Awerɛhosɛm ne sɛ, wɔabɔ nnipa baasa a wowuwui wɔ ARIA tebea yi ho nso ho amanneɛ wɔ nhwehwɛmu yi mu. Eyi ma yehu sɛnea nnuruyɛfo hwɛ a wɔbɛn no yiye ho hia bere a wɔde aduru a ano yɛ den saa redi dwuma no.
Dɛn na abenfo ka fa eyi ho?
Ntini ho animdefo a wɔwɔ wiase nyinaa ani agye nea afi mu aba yi ho. Ebinom reka sɛ, "Seesei yɛahyɛn bere a wɔde sa Alzheimer yare no mu."
Onimdefo bi kae sɛ: “Wɔ mfe pii nhwehwɛmu a ankosi hwee akyi no, mprempren yɛrenya nea efi mu ba a ɛkɔ so daa a ɛkyerɛ sɛ amyloid a woyi fi hɔ no betumi asakra yare no kwan.”
Ade foforo a ɛyɛ soronko wɔ aduru yi ho ne ɔkwan a wɔfa so de ma no. Nhwehwɛmu ada no adi sɛ sɛ wɔtew amyloid protein a epira a ɛwɔ amemene no mu no so kodu baabi a, wobetumi agyae aduru no . Wɔagyae ayaresa wɔ ayarefo 52% mu wɔ afe biako mu ne 72% wɔ asram 18 mu. Eyi te sɛ "inducing remission" yare no na wohu no a wonnya ayaresa. Eyi betumi ayɛ mfaso kɛse ama ayarefo ne ayaresa ho ka nso.
Nanso abenfo binom da so ara yɛ ahwɛyiye kakra. Wɔka sɛ, "Saa nsunsuanso yi hwɛ yiye paa, nanso ɛsɛ sɛ yehu data no nyinaa. Nsunsuanso bɔne a ɛho hia wɔ hɔ, na ɛsɛ sɛ yehu pii fa sɛnea ɛka ayarefo no ho."
Nkrasɛm a Wɔde Kɔ Fie
- Donanemab nyɛ Alzheimer yareɛ aduru , nanso ɛyɛ aduru a ɛma yareɛ no kɔ so brɛoo kɛseɛ , na ɛma daakye ho anidasoɔ kɛseɛ.
- Eyi yɛ adwuma denam amyloid ntini a epira a ɛboaboa ano wɔ amemene no mu a woyi fi hɔ no so.
- Eyi boa ayarefo, titiriw wɔ yare no mfiase no , ma wɔkae ade na wotumi yɛ da biara da nnwuma bere tenten.
- Amemene mu ahonhon ne mogya nketenkete a ɛtɔ (ARIA) .Asiane wɔ hɔ sɛ wubenya nsunsuanso bɔne a emu yɛ den, enti sɛ wopaw sɛ wobɛyɛ saa ayaresa yi a, ɛsɛ sɛ woyɛ no wɔ aduruyɛfo hwɛ a emu yɛ den paa ase.
- Saa aduru yi da so ara wɔ nhwehwɛmu fã. Egye bere kakra ansa na wɔatumi de adi dwuma wɔ Sri Lanka. Enti, sɛ obi a ɔwɔ w’abusua mu reda Alzheimer yare ho sɛnkyerɛnne adi a, ade a eye sen biara a ɛsɛ sɛ woyɛ ne sɛ wobɛkɔ oduruyɛfo a ɔfata ntɛm ara sɛnea wubetumi na woahwehwɛ afotu.
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