So wo mogya tu a ntease biara nnim? Momma yensua pii fa Factor V Leiden Thrombophilia ho!

Ɛnyɛ yɛn nipadua nyinaa na ɛyɛ pɛ, ɛnte saa? Ɛtɔ da bi a, yebetumi anya nsonsonoe nketenkete wɔ yɛn nipadua mu a yenhu mpo. Ɛnnɛ yɛrebɛka tebea biako a ɛte saa a yenya fii awo mu ho asɛm, a ɛma yɛn mogya tu kakra dodo, a ɛkyerɛ sɛ ɛda adi sɛ ɛbɛtɔ a ɛho nhia. Wɔfrɛ eyi Factor V Leiden Thrombophilia .

Enti dɛn ne Factor V Leiden?

Sɛ yɛbɛka no tiawa a, eyi yɛ mogya a ɛma mogya tu a wonya fi awo mu . Ɛne sɛ, wɔwo wo a nsakrae bi aba w’awosu mu. Saa nsakrae yi ma ɛyɛ mmerɛw sɛ wo mogya bɛtɔ sen sɛnea ɛte daa. Eyi de wo to asiane kɛse mu sɛ wubenya tebea horow te sɛ:

• Deep Vein Thrombosis (DVT): Eyi ne bere a mogya a ɛtɔ wo nipadua mu ntini a emu dɔ no mu , titiriw wɔ wo nan anaa wo nsa mu. Nanso, ɛtɔ mmere bi a wotumi hyehyɛ ntini mu wɔ mmeae te sɛ mmerɛbo, asaabo, amemene, ne aniwa.
• Pulmonary Embolism (PE) : Eyi yɛ nea asiane wom kakra. Nea ɛkɔ so wɔ ha ne sɛ mogya a ɛtwetwe a yɛaka ho asɛm wɔ atifi hɔ no mu biako, anaa mogya a atɔ wɔ baabi foforo, abubu, afa mogya no mu, na akɔhyɛ w’ahurututu no biako mu.

Nanso ade no ni, esiane sɛ wowɔ saa tebea yi nti, ɛnkyerɛ sɛ akyinnye biara nni ho sɛ wubenya DVT anaa PE . Nokwarem no, nnipa du biara mu bɛyɛ akron a wɔwɔ saa yare yi mu no, wɔrennya mogya a ɛnteɛ da wɔ wɔn nkwa nna mu. Nanso, ɛho hia sɛ wote ase sɛ wowɔ asiane mu kakra sen afoforo.

Sɛnea `Factor V Leiden` tebea yi ba no gu ahorow wɔ mmusuakuw ahorow mu. Wɔtaa hu no wɔ aborɔfo a wɔwɔ United States ne Europa mu.

• Nnipa 100 biara mu bɛyɛ 5 a wofi Europa.
• Nnipa 100 biara mu bɛyɛ 2 a wofi Hispanic.
• Nnipa 100 biara mu bɛyɛ 1 a ɔyɛ abibifo anaa Amerikafo Ankasa.
• Wɔ nnipa a wofi Asia mu no, ennu 100 biara mu 1.

Nanso, wɔahu sɛ nnipa baanum biara mu biako a mogya atɔ wɔn ntini mu no wɔ `Factor V Leiden` awosu mu nkwaadɔm a ɛyɛ soronko. Wɔfrɛ eyi ``Factor V Leiden.'' Nkyerɛwde V gyina hɔ ma Roma akontaahyɛde ma anum.

Dɛn ne tebea yi ho sɛnkyerɛnne?

Biribi a ɛsɛ sɛ yɛma ɛtra yɛn adwenem ni: Saa awosu mu nsakrae yi nkutoo mma yare no ho sɛnkyerɛnne biara mma . Wubetumi anya bi wo nkwa nna nyinaa a wunnim. Nanso, sɛnea yɛadi kan aka no, sɛ mogya a ɛtɔ gu nipadua no mu ba nkutoo a, na sɛnkyerɛnne ahorow no da adi.

Nea ɛho hia: Sɛ wususuw sɛ wowɔ `DVT` anaa `PE` ho sɛnkyerɛnne a, frɛ 911 anaa wo mpɔtam hɔ nɔma a egye ntɛmpɛ ntɛm ara . Sɛ ɛnte saa a, wo ne obi kɔ ayaresabea dwumadibea a ɛhwɛ ntɛmpɛ a ɛbɛn wo no ntɛm ara sɛnea wubetumi. Eyi nyɛ biribi a ɛsɛ sɛ yɛtwentwɛn so.

Nsɛnkyerɛnne a ɛkyerɛ sɛ obi anya ntini a emu dɔ mu thrombosis (DVT) no bi ne:

• Nan anaa nsa a ɛho ahonhon, sɛ woka a, ɛyɛ hyew, na ne honam ani kɔla sesa (ebia ɛbɛyɛ kɔkɔɔ anaa bruu).
• Ɛyaw a wobɛte nka bere a wode wo nsa ka saa nan anaa nsa no, ɛyaw bere a woamia .
• Ntini a ɛwɔ honam ani a ɛsõ sen sɛnea ɛte daa na wotumi hu wɔ honam ani .
• Sɛ mogya tu wɔ ntini a ɛwɔ yafunu no mu no mu a, wubetumi ate yafunu mu yaw anaa ɛyaw wɔ yafunu no ase .
• Sɛ mogya a ɛtɔ wɔ amemene no mu a, ebetumi ama obi ti ayɛ no yaw mpofirim na/anaasɛ ne ho ayɛ no yaw .

Ahurututu mu ntini a ɛma mogya tu (PE) ho sɛnkyerɛnne betumi ayɛ:

• Ɔhome a ɛyɛ den mpofirim .
• Ɛyaw a ano yɛ den a ɛba ne koko mu bere a ɔrehome denneennen, ɔfefe, anaasɛ ɔrefefe no.
• Ɔfe, ɛtɔ mmere bi a mogya kakra fi adi ka nsu a ɛyɛ nwini no ho .
• Nnyigyei a ɛyɛ hu bere a wɔrehome no.
• Koma a ɛbɔ ntɛmntɛm yiye (tachycardia) .
• Dadwen ne ahomegye a wɔte nka .
• Sɛ wote nka sɛ wo ho ayɛ wo hyew, wo te nka sɛ woreyɛ ahwere w’adwene (ɛntaa mma, ebia w’adwene mpo bɛyera) .

Dɛn na ɛde Factor V Leiden ba?

Ade titiriw nti a ɛte saa ne awosu mu nkwaadɔm a ɛyɛ soronko . Protein bi wɔ yɛn nipadua mu a ɛboa ma mogya tu, wɔfrɛ no `Coagulation factor V` . Sɛ yɛbɛka no pɛpɛɛpɛ a, ɛboa ma mogya tu bere a obi apira no. Enti, wɔde awosu mu abɔde bi a wɔfrɛ no `F5` kyerɛ yɛn nipadua sɛ yɛnyɛ saa protein yi.

Mpɛn pii no, yɛn nyinaa nya saa `F5` awosu mu abɔde yi mfonini abien a ɛfata. Nanso, sɛ wunya saa awosu mu abɔde yi mfonini biako anaa nea ɛboro saa a ɛnyɛ ne kwan so a, wɔka sɛ wowɔ `Factor V Leiden` variant (ɛtɔ mmere bi a wɔfrɛ no `mutation`). Edin `Leiden` no fi Leiden kurow a ɛwɔ Netherlands a nhwehwɛmufo huu saa awosu mu nkwaadɔm a ɛyɛ soronko yi.

Saa `Factor V Leiden` gene variant yi de nsakrae ketewaa bi ba nhyehyɛe mu wɔ `factor V` protein a wɔyɛ wɔ yɛn nipadua mu no mu. Esiane nsakrae yi nti, saa `factor V` protein a wɔasesa yi ntumi nnyina protein afoforo abien a ɛho hia a ɛhwɛ mogya a ɛtwetwe so , Protein C (`Protein C`) ne Protein S (`Protein S`) dwumadi ano. Sɛ yɛbɛka no tiawa a, saa protein ahorow a ɛhyɛ so no ntumi nsiw ano. Afei, `factor V` protein no yɛ adwuma sen sɛnea ɛsɛ sɛ ɛyɛ, na mogya no fi ase twetwe a ɛho nhia, bere mpo a ɛho nhia no.

So eyi yɛ biribi a efi abusua mu kɔ abusua mu?

Yiw, koraa. Wubetumi anya tebea yi afi wo maame anaa wo papa hɔ, anaa n’abien nyinaa hɔ. Factor V Leiden nya agyapade wɔ autosomal dominant agyapade nhyehyɛe mu.Ɛno kyerɛ sɛ, sɛ wunya saa awosu mu nkwaadɔm a ɛnyɛ ne kwan so yi fi w’awofo no mu biako nkutoo hɔ mpo a, wubetumi anya tebea yi fi awo mu.

Nnipa dodow no ara (a Factor V Leiden ka ho) nya awosu mu abɔde no bi a ɛnyɛ ne kwan so biako pɛ. Wɔfrɛ eyi sɛ heterozygous . Ɛntaa mma koraa sɛ wubetumi anya awosu mu abɔde no mfonini a ɛnyɛ ne kwan so abien no nyinaa afi wo maame ne wo papa nyinaa hɔ. Wɔfrɛ eyi homozygous .

Nneɛma foforo bɛn na ɛma asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no yɛ kɛse?

Obi a ɔwɔ Factor V Leiden betumi anya mogya a ɛbɛtɔ no kɛse sɛ:

• Sɛ woanya `F5` awosu mu abɔde a ɛnteɛ no mfonini abien no nyinaa sɛnea yɛadi kan aka ho asɛm no (sɛ woyɛ `homozygous` a) .
• Sɛ wo mogya abusuafo (te sɛ ɛna, agya, nuanom) wɔ DVT anaa PE abakɔsɛm a .
• Sɛ wowɔ tebea afoforo a ɛma mogya tu a .
• Sɛ wɔreyɛ wo oprehyɛn (titiriw wɔ oprehyɛn kɛse akyi, efisɛ wobɛtra beae biako akyɛ).
• Sɛ wonyinsɛn (wɔ saa bere yi mu no, hormone mu nsakrae na akokoaa no betumi de nhyɛso aba ntini no so).
• Sɛ worenom nnuru ahorow bi a wɔde siw awo ano (a estrogen wom) anaa aduru a wɔde si hormone ananmu a .

Sɛ wowɔ asiane ahorow yi bi a, ɛho hia yiye sɛ wo ne wo duruyɛfo kasa na wusua asiane a ɛwɔ mogya a ɛbɛtɔ mu ne ahwɛyiye a wubetumi ayɛ ho ade.

Nsɛnnennen bɛn na ebetumi aba esiane tebea yi nti?

Sɛ wowɔ Factor V Leiden Thrombophilia a, ebia wubenya nea edidi so yi:

• `DVT` anaa `PE` a wobenya ansa na wɔadi mfe 50 .
• Bɛboro pɛnkoro, a ɛkyerɛ sɛ `DVT` anaa `PE` a ɛba mpɛn pii .
• Mogya a ɛtɔ wɔ ntini a mpɛn pii no ɛnyɛ mogya a ɛtɔ pii mu , sɛ nhwɛso no, mmerɛbo, amemene, ne asaabo ntini mu.
• DVT anaa PE bere a wɔyem anaa awo akyi .
• DVT anaa PE betumi aba wɔ bere tiaa bi mu bere a wɔafi ase de nnuru a wɔde siw awo ano akyi .

Ɔkwan bɛn so na nnuruyɛfo hu saa tebea yi?

Nnuruyɛfo betumi afa mogya mu nhwehwɛmu so ahu sɛ wowɔ saa tebea yi anaa . Ebia eyi nso ka awosu mu nhwehwɛmu ho . Ebia wo duruyɛfo bɛkyerɛ sɛ wɔnyɛ saa tebea yi mu nhwehwɛmu, titiriw:

• Sɛ woanya DVT anaa PE pɛn a , titiriw sɛ esii bere a na woyɛ abofra sen sɛnea na wɔhwɛ kwan a.
• Sɛ w'abusuafo a wɔwɔ mogya mu biako anaa nea ɛboro saa wɔ abakɔsɛm a ɛkyerɛ sɛ mogya atɔw .

Ɔkwan bɛn so na wɔsa Factor V Leiden yare?

Factor V Leiden yɛ tebea a ɛwɔ ne nkwa nna nyinaa mu. Ɛno kyerɛ sɛ mprempren wonni ayaresa pɔtee biara anaa ayaresa biara mma saa awosu mu nkwaadɔm a ɛyɛ soronko yi. Mmom no, ayaresa ahorow yɛ adwuma de tew mogya a ɛwɔ hɔ dedaw no na ɛtew asiane a ɛwɔ hɔ sɛ daakye bɛtwetwe mogya no so . Ebia wo duruyɛfo bɛkamfo ayaresa ahorow te sɛ:

• Nnuru a ɛko tia mogya a ɛtwetwe (a wɔsan frɛ no mogya a ɛma mogya tu) : Eyinom boa ma mogya a ɛwɔ nipadua no mu dedaw no tew na ɛmma mogya a ɛtɔ foforo no ntumi nkɔ.
• Compression stockings : Eyinom yɛ sɔks soronko a ɛyɛ den a wɔhyɛ wɔ nan so na ama mogya no akɔ yiye na ɛtew asiane a ɛwɔ hɔ sɛ mogya bɛtɔ no so.
• Vena cava filter placement : Eyi yɛ afiri ketewaa bi a wɔde gu ntini kɛse bi mu na amma mogya a ɛbɛtɔ no ankɔ ahurututu no mu. Ɛnyɛ obiara na ohia.
• Oprehyɛn a wɔde yi mogya a ɛtɔ gu nipadua no mu : Wɔ tebea horow bi mu no, ebia ɛho behia sɛ wɔyɛ oprehyɛn de yi mogya a ɛtɔ kɛse no fi hɔ.

Bere tenten a ɛsɛ sɛ wonom nnuru a ɛma mogya yɛ mmerɛw no gyina asiane a ɛwɔ hɔ sɛ wubenya mogya a ɛbɛtɔ bio no so. Ɛho hia sɛ nnipa binom nom saa aduru yi asram kakraa bi pɛ. Ebia ɛho behia sɛ afoforo fa bere tenten, wɔn nkwa nna nyinaa mpo. Wo duruyɛfo bɛkyerɛkyerɛ ayaresa nhyehyɛe a eye ma wo mu.

Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn?

Sɛ wunim sɛ wowɔ saa yare yi a, ɛho hia sɛ wo ne oduruyɛfo di nkitaho daa.

• Anyɛ yiye koraa no kɔ aduruyɛ mu nhwehwɛmu a wɔyɛ no nyinaa pɛnkoro afe biara .
• Sɛ wowɔ DVT anaa PE na worenya ayaresa a, ɛho behia sɛ wokɔ wo duruyɛfo nkyɛn kɔhwɛ wo daa na woahu sɛnea ayaresa no rekɔ so.
• Sɛ worenom aduru a ɛma mogya yɛ mmerɛw te sɛ Warfarin , ɛsɛ sɛ woyɛ mogya mu nhwehwɛmu (Prothrombin time test - PT/INR test) daa de hwɛ sɛ aduru no reyɛ adwuma yiye na dodow a wɔde ma no teɛ anaa.

Afei nso, ɛho hia sɛ wo ne oduruyɛfo kasa wɔ nsɛm te sɛ eyinom mu:

• Ansa na wode awo ano aduru bedi dwuma (titiriw nea estrogen wom).
• Ansa na wobefi ase ayɛ aduru a wɔde si hormone ananmu .
• Sɛ woreyɛ nhyehyɛe sɛ wubenyinsɛn a, ansa na ɛno .

Dɛn na eyi ka fa nkwa nna ho?

Wɔ nnipa dodow no ara fam no, Factor V Leiden a wobenya no nka wɔn nkwa nna a ɛfata . Sɛ wo mogya tu mpo a, sɛ wonya ayaresa ntɛm na ɛfata a, wubetumi asiw nea efi mu ba a anibere wom ano . Sɛ wowɔ nneɛma bi a ɛhaw wo wɔ wo nkwa nna anaa daakye nsɛnnennen ho a, wo ne wo duruyɛfo nka ho asɛm.

Sɛ yɛwɔ Factor V Leiden a, dɛn na ɛsɛ sɛ yɛkwati?

Wo duruyɛfo begyina w’ankorankoro tebea so de afotu ama wo, nanso mpɛn pii no, eye sɛ wobɛkwati saa nneɛma yi:

• Sigaretnom, vaping, ne tawa afoforo a wɔde di dwuma .
• Tenabea koro no ara a wobɛtra bere tenten (e.g., adwuma a wobɛyɛ wɔ adwumayɛbea, bɔs anaa keteke a wobɛfa bere tenten, anaa wimhyɛn a wobɛfa nnɔnhwerew pii). Sɛ ɛbɛyɛ yiye a, sɔre na anyɛ yiye koraa no nantew pɛnkoro dɔnhwerew biara.
• Kwati sɛ wobɛnom nsa pii , titiriw wɔ wimhyɛn a ɛware mu.
• Nnuru a wɔde siw awo ano ne nnuru a wɔde si hormone ananmu a estrogen wom (akyinnye biara nni ho sɛ ɛsɛ sɛ wo ne wo duruyɛfo kasa ansa na wode eyinom adi dwuma).

So Factor V a enni hɔ ne Factor V Leiden yɛ ade koro?

Yiw, mma abien no nnyɛ basaa. Eyinom yɛ awosu mu tebea abien a ɛsono emu biara koraa . Nanso, saa tebea abien yi nyinaa ne nsakrae a ɛba `F5` awosu mu abɔde mu no wɔ abusuabɔ.

Wɔ Factor V Leiden Thrombophilia mu no, awosu mu nsakrae ma wo mogya tu ntɛmntɛm.

Nanso, wɔ tebea bi a wɔfrɛ no `Factor V deficiency` mu no, awosu mu nsakrae mma wo mogya ntumi nkɔ yiye bere a ɛho hia no. Eyi kyerɛ sɛ wowɔ asiane mu sɛ mogya bɛtɔ wo. `Factor V deficiency` yɛ mogyatɔw a ɛntaa nsi koraa (bɛyɛ ɔpepem biako biara mu biako). Ebetumi ama nneɛma te sɛ mogya a ɛtaa tu fi hwene mu, mogya a ɛtɔ kɛse bere a obi rekɔ brayɛ mu, ne mogya a ɛkɔ so tu wɔ oprehyɛn akyi.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Enti, sɛ wuhu sɛ wo anaa obi a wunim no wɔ Factor V Leiden Thrombophilia a, mma wo ho nnpopo ntɛm ara. Kae sɛ nnipa dodow no ara a wɔwɔ saa tebea yi betumi atra ase pa a wɔrennya mogya mu ntini biara .

Nanso, sɛ wo mogya tu a, ayaresa ahorow a etu mpɔn wɔ hɔ a wobetumi de adi dwuma . Ade a ɛho hia sen biara ne sɛ wubedi wo duruyɛfo akwankyerɛ akyi yiye, ayɛ nhwehwɛmu ne ayaresa a wuhia, na woabɔ bra a ɛfata na anigye wɔ tebea no ho, na woadi ho dwuma yiye ansa na abɛyɛ ɔhaw.

` Factor V Leiden, Thrombophilia, mogya a ɛtwetwe, DVT, PE, awosu mu yare, mogya a ɛtwetwe, awosu mu yare