So wotaa nya atiridiinini nso a ntease biara nnim? So wowɔ ɔhaw afoforo a ɛka ho? Eyi betumi ayɛ Abusua Mediterranea Atiridii (FMF)!

So wunya atiridii mpofirim a wommɔ wo kɔkɔ? So wo yafunu nso yɛ wo yaw, wo koko mu yɛ wo den, anaa wo nkwaa mu yaw? Ɛtɔ mmere bi a, saa sɛnkyerɛnne ahorow yi fi hɔ nna kakraa bi akyi, na ɛsan ba bio wɔ bere tiaa bi akyi? Ɛyɛ ade a ɛfata sɛ wobɛte ehu nka kɛse bere a eyi asi no. Ɛnnɛ yɛbɛka yareɛ bi a ɛde saa nsɛnkyerɛnneɛ yi ba ho asɛm, a ɛyɛ nwonwa kakra, nanso ɛho hia paa sɛ yɛbɛhunu ho asɛm.

Dɛn ne Abusua Mediterranea Atiridii (FMF)?

Sɛ yɛbɛka no tiawa a, Abusua Mediterranea Atiridii, anaa FMF tiawa no yɛ nkwa nna nyinaa tebea a efi yɛn awosu mu nkwaadɔm mu. Nea ɛkɔ so wɔ eyi mu ne sɛ, esiane ntease biara nti, yenya atiridii mpofirim, na bere koro no ara mu no, ɔfe ba nipadua no afã horow. Sɛ yɛbɛka no pɛpɛɛpɛ a, eyi yɛ biribi a ɛba esiane ɔhaw ketewaa bi a ɛwɔ yɛn ankasa nipadua mu ahoɔden a ɛko tia nyarewa no mu nti. Ɛno nti na wɔsan frɛ no yare a ɛma obi ho hyehye no .

Ɛka nnipa a wɔte Mediterranea aman mu titiriw. Ɛma ntini a ɛyɛ tratraa a wɔfrɛ no serous membranes (eyinom kata mmeae te sɛ koko ne yafunu mu), a wɔfrɛ no serositis no ho hyew. Ɛsan nso betumi ama synovial membranes a ɛkata yɛn nkwaa so no ayɛ hyew, a wɔfrɛ no synovitis. Mpɛn pii no, yare no ho sɛnkyerɛnne no kɔ so nna kakraa bi na afei ɛbrɛ ase.

Dɛn ne FMF ho sɛnkyerɛnne ahorow?

Mpɛn pii no, FMF ho sɛnkyerɛnne fi ase wɔ mmofraase, ansa na woadi mfe 20. Ebia saa sɛnkyerɛnne ahorow yi mu yɛ den mfiase no, nanso ebetumi atu mpɔn nkakrankakra bere a worenyin no. Sɛ wunya yare no wie a, ebia worennya yare no ho sɛnkyerɛnne biara adapɛn, asram, anaa mfe mpo. Nanso , sɛ wohu ntɛm na wɔsa yare a, ebetumi aboa ma yare no ho sɛnkyerɛnne so atew na asiw nsɛnnennen a ɛtra hɔ kyɛ te sɛ amyloidosis ano.

Afei ma yɛnhwɛ nea sɛnkyerɛnne ahorow yi yɛ:

• Atiridiinini a ano yɛ den a ɛkɔ soro kodu digrii Celsius 40.6 (Fahrenheit 105), na ɛtɔ mmere bi a atiridiinini ne ahopopo ka ho.
• Ebia ɛde tiyɛ ne kɔn a ɛyɛ den bɛba.
• Yafunu mu yaw ne yafunu a ɛho ayɛ fĩ (a ɛyɛ den).
• Yafunu mu ntini no mu yɛ den na akisikuru betumi aba.
• Koko mu yaw , a ɛkɔ soro bere a wɔrehome no.
• Nkwaa mu yaw ne ɛho ahon (mpɛn pii no wɔ nkwaa biako mu).
• Mmarima awotwaa mu ahonhon ne ɛyaw .
• Ntini mu yaw , titiriw wɔ nipadua no ase.
• Honam ani akuru kɔkɔɔ a ɛkɔ soro betumi aba nan no so .

Saa sɛnkyerɛnne ahorow yi betumi ada adi mpofirim wɔ nnɔnhwerew kakraa bi mu. Nanso, ɛnyɛ obiara na obehu saa sɛnkyerɛnne ahorow yi nyinaa.. Atiridiinini ne sɛnkyerɛnne a ɛtaa ba. Wɔ mmofraase no, ebia atiridiinini nkutoo ne sɛnkyerɛnne. Mpɛn pii no, yare no kɔ so nna kakraa bi.

FMF Ho Nsɛnkyerɛnne a Ɛwɔ Prodromal

Nnipa binom fi ase te yare no ho sɛnkyerɛnne nketenkete nka nna kakraa bi ansa na atiridii yi afi ase. Sɛnea nnipa binom te nka ansa na migraine anaa mmea te nka ansa na wɔn bere aba no. Yɛfrɛ eyinom prodromal sɛnkyerɛnne . Sɛ wote eyinom nka a, wunya hint sɛ ''Ah... afei saa ɔhaw no reba''.

Dɛn ne nsɛnkyerɛnne a ɛkyerɛ biribi yi?

• Dadwen, ahomegye a enni hɔ
• Abufuw a ɛma obi bo fuw
• Tipaeɛ
• Abofono
• Nipadua mu yaw
• Malaise ( anigye a wonni, nkwa a wonni ) .

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Adɛn nti na saa FMF yi ba?

Eyi fi nsakrae a ɛba MEFV awosu mu abɔde mu wɔ yɛn nipadua mu. Saa MEFV gene yi boa ma wɔyɛ protein a ɛho hia yiye, a ɛne protein a wɔfrɛ no pyrin. Yɛn awosu mu nipadua mu ahoɔden a ɛko tia nyarewa – kyerɛ sɛ, nipadua no mu tumi a ɛko tia nyarewa no fã a ɛyɛ adwuma tia ahunahuna te sɛ ɔyare mmoawa a ɛba mpofirim – de ne ho to saa pyrin protein yi so. Enti, sɛ MEFV awosu mu abɔde no ntumi nyɛ pyrin yiye a, saa protein no ntumi nyɛ adwuma yiye wɔ nipadua no mu tumi a ɛko tia nyarewa no mu. Ɛno ne bere a ɔhaw yi ba.

Wɔahu awosu mu nsakrae (nsakrae) bɛyɛ 30 a ɛde FMF ba. Eyinom mu no, nea ɛtaa ba ne V726A, M680I, E148Q, M694V ne M694I. Eyinom abu so kɛse wɔ nnipa a wofi Mediterranea ne Mfinimfini Apuei mu. Nhwɛsoɔ:

• Arabfo
• Armeniafo a wɔyɛ saa
• Helafo
• Iranfo a wɔyɛ saa
• Italiafo
• Yudafo nkurɔfo
• Kurdfo a wɔyɛ saa
• Turkeyfo

Nneɛma a ɛkanyan FMF

Ɛwom sɛ ɛte sɛ nea FMF taa ba mpofirim a ntease biara nni mu de, nanso wɔ nnipa binom fam no, nneɛma bi, anaasɛ nneɛma bi na ɛkanyan. Wɔ nnipa binom fam no, nipadua anaa adwene mu nhyɛso betumi ama tebea no aba. Nkurɔfo ka sɛ nneɛma te sɛ:

• Awɔw a wɔde wɔn ho hyɛ mu
• Apɔw-mu-teɛteɛ anaa ɔbrɛ a ɛboro so
• Nyarewa bi a wɔanya nnansa yi
• Nnansa yi ara opira anaa oprehyɛn bi
• Adwennwen a emu yɛ den (te sɛ asetra mu ɔhaw kɛse bi) .
• Bere a mmea nya wɔn bra ɔsram biara anaasɛ ovulation

Nsɛnnennen a ebetumi aba wɔ FMF mu

Ɛwom sɛ FMF atiridiinini no brɛ ase nna kakraa bi akyi de, nanso ɔfe a ɛkɔ so wɔ nipadua no mu no betumi aka yɛn nipadua bere tenten. Ɛno nti na nnuruyɛfo kamfo kyerɛ sɛ wɔnkɔ so sa yare yi. Sɛ ɔhyew a ɛkɔ so te sɛ eyi kɔ so a, wɔde yɛn nipadua mu tumi a ɛko tia nyarewa no hyɛ nhyɛso kɛse ase, na nyarewa afoforo nso betumi aba.

Eyi mu ɔhaw a emu yɛ den sen biara ne tebea bi a wɔfrɛ no secondary amyloidosis . Eyi betumi ama asaabo mpo ayɛ adwuma yiye. Ɛno nti na ɛho hia paa sɛ yɛhwɛ yie wɔ eyi ho.

Nsɛnnennen afoforo nso betumi ayɛ:

• Splenomegaly (akisikuru) .
• Awo a wontumi nwo
• Nyarewa afoforo a nipadua no tumi ko tia nyarewa (Secondary autoimmune disease) .

Ɔkwan bɛn so na wohu FMF?

Ɔkwan bɛn so na oduruyɛfo hu FMF? Wɔyɛ nneɛma te sɛ:

• Wɔde ahwɛyiye betie wo yare no ho sɛnkyerɛnne ahorow, mpɛn dodow a ɛba, ne bere tenten a ɛwɔ hɔ .
• Wobebisa sɛ ebia obi wɔ w'abusua mu anya saa yare yi ne sɛnea w'awosu mu agyapade te .
• Sɛ woyare a, wɔbɛhwehwɛ wo mu ahwɛ sɛ ebia ɔfe anaa abufuw bi wɔ wo nipadua mu anaa .
• Bere a yare no yɛ mogya mu nhwehwɛmu de hwɛ sɛ ebia sɛnkyerɛnne bi wɔ hɔ a ɛkyerɛ sɛ ɔfe .
• Wɔkamfo kyerɛ sɛ wɔnyɛ awosu mu nhwehwɛmu mfa nhwɛ sɛ nsakrae bi aba MEFV awosu mu abɔde a ɛtaa de FMF ba no mu anaa.
• Wɔbɛsan nso ahwɛ sɛnea woyɛ w’ade wɔ ayaresa ahorow a wɔde sa FMF no ho.

Ayaresa a wɔde sa FMF

FMF ayaresa titiriw ne aduru a ekum ɔyare mmoawa a wɔfrɛ no colchicine. Eyi yɛ adwuma denam mogya mu nkwammoaa fitaa bi a wɔfrɛ no neutrophils a ɛka ho wɔ ɔfe mu no dwumadi a ɛtew so no so. Colchicine betumi aboa ma wɔasiw FMF ogyaframa a ɛtaa ba no ano anaasɛ ɛbɛtew, na ɛtew asiane a ɛwɔ hɔ sɛ ɔhaw ahorow bɛba no so. Nnipa a wɔwɔ FMF bɛboro 90% na wɔsa wɔn yare . Ɛsɛ sɛ nnipa dodow no ara nom saa aduru yi da biara da wɔ wɔn nkwa nna nyinaa mu.

Nanso, nnipa kakraa bi pɛ nnya nea wɔpɛ mfi colchicine mu, anaasɛ ebia wontumi nnom saa aduru yi esiane akwahosan ho nneɛma afoforo nti. Wɔ nnipa a wɔte saa fam no, nnuruyɛfo kyerɛ sɛ wɔmfa nnuru afoforo nni dwuma. Ebi ne:

• Anakinra (Anakinra) .
• Rilonacept
• Canakinumab

Sɛ wowɔ FMF a, dɛn na ɛba?

Ɛwom sɛ wonni FMF aduru biara de, nanso wobetumi de nnuru adi ho dwuma yiye . Wɔ nnipa pii fam no, ɛkame ayɛ sɛ atiridiinini ne nipadua mu yaw no yera koraa bere a wofi ase nom nnuru no. Wɔ afoforo fam no, mpɛn dodow a ogya hyew ne mpɛn dodow a ɛbɔ no so tew. Nanso, sɛ nnuru yi bɛyɛ adwuma yiye a, ɛsɛ sɛ wɔnom daa, bere mpo a enni sɛnkyerɛnne biara.. Sɛ wonom saa aduru yi bere a woyare dedaw a, ɛremma yare no nnyae ntɛm ara. Saa aduru yi siw yare no ano nkutoo.

So wobetumi asiw FMF ano?

Nnipa pii nnim mpo sɛ wɔwɔ gene variant a ɛde FMF ba no. Sɛ wubenya FMF a, ɛsɛ sɛ wunya gene variant no abien fi wo maame ne wo papa nyinaa hɔ. Sɛ wowɔ biako pɛ a, worennya FMF ho sɛnkyerɛnne. Nanso wubetumi de saa awosu mu nkwaadɔm a ɛyɛ soronko no akɔma wo mma. Sɛ wo hokafo nso wɔ saa awosu mu nkwaadɔm a ɛyɛ soronko no a, ebia wo mma no wɔ FMF. Awosu mu nhwehwɛmu betumi aboa wo ma woahu sɛ ebia woyɛ obi a ɔwɔ awosu mu nkwaadɔm a ɛyɛ soronko no anaa.

Wɔabɔ amanneɛ sɛ atiridiinini a ɛtaa ba saa fi tete. Ebia saa yareɛ a wɔfrɛ no FMF yi nso akyɛ saa ara. Nhwehwɛmufo binom susuw sɛ ebia saa tebea yi sɔree sɛ ɔkwan a wɔfa so boa ma wɔko tia nyarewa akɛse te sɛ nsamanwaw a na abu so saa bere no. Nokwarem no, mfaso bi wɔ ɔfe a ɛwɔ nipadua no mu so, nanso ɛyɛ bere a ɛdɔɔso dodo nkutoo na ɛbɛyɛ ɔhaw. Nea eye ne sɛ, mprempren nnuru pa wɔ hɔ a wɔde siw tebea yi ano. Enti sɛ wowɔ FMF mpo a, wubetumi atra ase sɛnea ɛte daa.

Ade a ɛho hia sen biara a ɛsɛ sɛ wokae! (Nkrasɛm a Wɔde Kɔ Fie)

Okay, enti seesei woanya nteaseɛ pa wɔ deɛ yɛkaa ho asɛm nnɛ no ho, FMF. Adeɛ a ɛho hia paa ne sɛ, sɛ wo anaa w’abusua mu obi nya atiridiinini a nteaseɛ biara nni mu, yafunu mu yaw, nkwaa mu yaw, ne nea ɛkeka ho a, mmu no sɛ ɛyɛ atiridii kɛkɛ, na mmom kɔ oduruyɛfoɔ nkyɛn kɔhunu deɛ ɛrekɔ so pɛpɛɛpɛ. Sɛ wuhu yare no na wufi ase sa yare ntɛm a, wubetumi asiw nsɛnnennen pii ano na woabɔ bra sɛnea ɛsɛ. Kae sɛ ɛho hia yiye nso sɛ wode aduru a wo duruyɛfo akyerɛw ama wo no di dwuma pɛpɛɛpɛ, sɛnea wɔakyerɛ wo no. Mma wo werɛ mmfi sɛ wo ne wo duruyɛfo bɛkasa afa nsɛmmisa anaa dadwen biara a ebia wowɔ ho.