Boa wɔ asikreyare ne mu duru a ɛso tew ho? Momma yensua GLP-1 Agonists ho ade wɔ ɔkwan a ɛnyɛ den so

So wowɔ asikreyare a ɛto so abien? Anaasɛ worepere wo ho wɔ wo nipadua mu duru a ɛboro so (kɛse mmoroso) ho? Afei ebia wo duruyɛfo no aka aduru foforo bi a nnipa pii reka ho asɛm nnansa yi ho asɛm akyerɛ wo. Enti ɛnnɛ, momma yɛnka nnuru kuw yi a wɔfrɛ no GLP-1 agonists yi ho asɛm. Momma yɛnka nea eyinom yɛ, sɛnea ɛyɛ adwuma, ne onii ko a wɔfata no ho asɛm.

Dɛn ne nnuru a wɔde siw GLP-1 ano?

Sɛ yɛbɛka no tiawa a, GLP-1 agonists yɛ nnuru kuw bi a ɛboa ma asikre (glucose) dodow a ɛwɔ mogya mu no so, titiriw wɔ nnipa a wɔwɔ asikreyare a ɛto so abien mu . Nnuru yi bi nso boa ma wodi kɛseyɛ mmoroso, anaa nipadua mu duru a ɛboro so so .

Nnuru yi mu dodow no ara ba sɛ aduru a wɔde twitwiw nipadua no mu. Wei kyerɛ sɛ ɛsɛ sɛ wode syringe ne needle di dwuma de twitwa aduru a ɛyɛ nsu mu. Wɔde saa aduru yi gu srade a ɛwɔ honam ani (subcutaneous injection). Wɔtaa de saa aduru yi ma wɔ mmeae a srade wɔ yafunu, asen akyi, asen atifi, ne abasa akyi. Nnuru a wɔnom nso wɔ hɔ, te sɛ Semaglutide aduru (Rybelsus®).

Wɔde din afoforo pii nso frɛ nnuru kuw yi:

• Nnuru a ɛte sɛ glucagon a wɔfrɛ no peptide-1 agonists
• Nnuru a ɛma GLP-1 agyefo
• Incretin a wɔde suasua nneɛma

Saa nnuru yi yɛ foforo koraa. Wɔpenee GLP-1 agonist (exenatide) a edi kan no so wɔ afe 2005. Nhwehwɛmufo da so ara rehwehwɛ sɛnea wɔde nnuru yi di dwuma afoforo mu.

Ɔkwan bɛn so na saa aduru yi yɛ adwuma wɔ nipadua no mu?

Sɛ yɛbɛte sɛnea aduru yi yɛ adwuma ase a, momma yenni kan nhwɛ hormone bi a efi awosu mu yɛ wɔ yɛn nipadua mu a wɔfrɛ no GLP-1. GLP-1 yɛ hormone a yɛn dwensɔtwaa ketewaa no na ɛyɛ. Ɛyɛ nneɛma pii wɔ yɛn nipadua mu.

• Ɛboa ma dwensɔtwaa no ma insulin: Insulin yɛ hormone a ɛho hia na ama aduan a yedi no adan ahoɔden. Ɛma asikre dodow a ɛwɔ mogya no mu no so tew. Sɛ insulin nnɔɔso a, asikre dodow a ɛwɔ mogya mu no kɔ soro na asikreyare ba.
• Glucagon hormone no asiw ano: Glucagon yɛ hormone a ɛma asikre dodow kɔ soro wɔ mogya mu bere a ɛho hia no. Enti, GLP-1 siw eyi ano, na ɛmma asikre a ɛho nhia nboaboa ano wɔ mogya no mu.
• Ɛbrɛ sɛnea yafunu no mu da hɔ brɛoo: Sɛ wɔyam aduan a yedi no na wɔpam fi yafunu no mu brɛoo a, asikre a efi aduan no mu no kɔ mogya no mu. Eyi na ɛhwɛ asikre a ɛkɔ soro mpofirim wɔ mogya mu no so.
• Adidi ma wote nka sɛ woayɛ ma (satiety):GLP-1 hormone no ka yɛn amemene no afã horow a ɛhwɛ ɔkɔm ne aduan a ɛyɛ dɛ so no.

Afei, nea saa GLP-1 agonist aduru yi yɛ ne sɛ ɛyɛ n’ade te sɛ GLP-1 hormone a ɛwɔ yɛn nipadua mu no pɛpɛɛpɛ. Ɛne sɛ, ɛyɛ adwuma ‘te sɛ’ no. Saa aduru yi kyekyere GLP-1 agyefo no na ɛde nneyɛe koro no ara a abɔde mu hormone no yɛ no ba. Dodow a aduru no dodow kɔ soro no, dodow no ara na saa nkɛntɛnso yi yɛ kɛse.

Henanom na wɔkamfo aduru yi kyerɛ wɔn?

Nnuruyɛfo kyerɛw nnuru a ɛma GLP-1 agonist yi titiriw ma tebea abien: Asikreyare a ɛto so abien ne kɛseyɛ mmoroso.

Wɔ Asikreyare a Ɛto so 2 ho

Ebia wo duruyɛfo bɛkyerɛw GLP-1 agonists ama wo, sɛ wɔde ka asikreyare aduru titiriw (metformin) ho, sɛ entumi nni asikre a ɛwɔ wo mogya mu no so yiye a, anaasɛ esiane nneɛma afoforo nti. Ne titiriw no:

• Sɛ asikre a ɛwɔ mogya mu no nnɔɔso wɔ metformin nkutoo mu a.
• Sɛ wuntumi nnom metformin esiane akwahosan ho nneɛma afoforo nti a.
• Sɛ wo A1C level no korɔn koraa sen botae no a.
• Sɛ wowɔ asikreyare ka tebea afoforo te sɛ komayare, koma a ɛyɛ den, anaa asaabo mu yare a enni sabea ho a.

Wɔ Kɛseyɛ mmoroso ho

Wɔapene GLP-1 agonists te sɛ Semaglutide ne Liraglutide nso so sɛ ayaresa a wɔde sa kɛseyɛ mmoroso efisɛ ɛboa ma obi mu duru so tew. Wɔkyerɛ kɛseyɛ mmoroso ase sɛ nipadua mu duru (BMI) a ɛyɛ 30 anaa nea ɛboro saa. Nnuruyɛfo nso betumi akyerɛw nnuru yi ama nnipa a wɔn mu duru boro so (BMI 25-29.9) na wɔwɔ akwahosan ho haw afoforo (e.g., mogya mmoroso, srade), efisɛ sɛ obi mu duru so tew a, ebetumi aboa ma wɔadi saa tebea horow no so.

So nnipa a wɔwɔ asikreyare a ɛto so 1 betumi anom eyinom?

Eyi da so ara wɔ nhwehwɛmu fã no mu. Wɔnnya nnyee ntom wɔ aban kwan so sɛ aduru a wɔde sa asikreyare a ɛto so 1. Nanso, nnuruyɛfo binom betumi akyerɛw ama no "off-label" sɛnea ɛho hia. Ɛyɛ papa sɛ wo ne wo duruyɛfo bɛkasa afa eyi ho.

Sua nnuru a wɔde di dwuma ne nea efi mu ba ho ade.

Wo duruyɛfo na obesi mpɛn dodow a ɛsɛ sɛ wonom saa aduru yi ho gyinae. Ɛho hia paa sɛ wubedi saa akwankyerɛ ahorow no akyi pɛpɛɛpɛ.

Dɛn ne aduru yi mu nsunsuanso bɔne?

Te sɛ nnuru biara no, eyinom betumi anya ɔhaw ahorow.

• Nneɛma bɔne a ɛtaa ba: Wɔtaa hu eyinom ntɛm wɔ ayaresa no mu.
• Akɔnnɔ
• Abofono
• Ɔfe a wɔfe
• Ayamtuo
• Nneɛma afoforo a ɛde ba:
• Adwene a ɛyɛ basaa
• Koma a ɛbɔ ntɛmntɛm kakra
• Tipaeɛ
• Yafunu a ɛyɛ yaw
• Nneɛma bɔne a ɛntaa nsi nanso ebetumi ayɛ aniberesɛm:
• Pancreatitis a ɛyɛ yare
• Ntini mu kokoram bi (Medullary thyroid cancer) .
• Asaabo mu opira a emu yɛ den
• Asikreyare a ɛde asikreyare ba no retinopathy a ɛreyɛ kɛse

Asiane bɛn na ɛwɔ nnuru yi mu?

Ɛwom sɛ mpɛn pii no, saa aduru yi yɛ nea asiane biara nni ho de, nanso nneɛma kakraa bi wɔ hɔ a ɛsɛ sɛ wohwɛ yiye.

Nneɛma a ɛma obi ho yɛ no yaw

Ebia nnipa binom adwenem yɛ wɔn naa wɔ aduru yi ho. Sɛ wo ho yɛ wo yaw anaasɛ wo ho yɛ kɔkɔɔ bere nyinaa wɔ baabi a wɔde aduru no guu wo no a, ka kyerɛ wo duruyɛfo. Nanso, akisikuru a emu yɛ den a wɔfrɛ no anaphylaxis yɛ ade a egye ntɛmpɛ.

Fa di dwuma bere a wonyinsɛn no

Wɔnkamfo nkyerɛ sɛ wɔmfa nnuru a ekum GLP-1 nni dwuma bere a wɔyem . Sɛ worenom saa aduru yi a, ɛsɛ sɛ wode ɔkwan a wotumi de ho to so a wɔfa so siw awo ano di dwuma. Sɛ wunyinsɛn bere a worenom aduru yi a, kɔ wo duruyɛfo nkyɛn ntɛm ara.

Asikre a ɛwɔ mogya mu a ɛba fam (Hypoglycemia) .

Asiane a ɛwɔ hɔ sɛ mogya mu asikre bɛkɔ fam no sua bere a wonom aduru yi nkutoo no. Nanso, sɛ wode ka asikreyare nnuru afoforo te sɛ insulin anaa sulfonylureas ho a, asiane a ɛwɔ hɔ sɛ asikreyare a ɛbɛkɔ fam no yɛ kɛse. Sɛ asikre a ɛwɔ wo mogya mu no so tew sen 70 mg/dL a, wubetumi anya sɛnkyerɛnne ahorow te sɛ wosow, fifiri, adwenemhaw, ne ɔkɔm a ano yɛ den. Sɛ eyi ba a, ɛsɛ sɛ wudi biribi a asikre wom (te sɛ anonne a asikre wom, banana) ntɛm ara sɛnea wubetumi.