Momma yensua glucagon a ɛboa ma wohwɛ asikre dodow a ɛwɔ wo nipadua mu so no ho ade pii.

So woasusuw sɛnea wɔhyɛ asikre dodow a ɛwɔ yɛn mogya mu no ho pɛn? Ade titiriw bi wɔ hɔ a ɛboa wɔ eyi ho a wɔfrɛ no Glucagon. Te sɛ ɔbran ketewaa bi a ɔwɔ yɛn nipadua mu no, Glucagon ma asikre dodow a ɛwɔ yɛn mogya mu no nkɔ fam dodo. Ɛnnɛ, yɛbɛka Glucagon yi ho asɛm kɔ akyiri na ɛnyɛ den koraa.

Dɛn ne Glucagon?

Sɛ yɛbɛka no tiawa a, glucagon yɛ abɔde mu hormone a yɛn nipadua yɛ . Wunim, alpha nkwammoaa a ɛwɔ yɛn dwensɔtwaa mu no na ɛyɛ. Sɛ yɛn mogya mu glucose dodow so tew, bere a yennidi bere tenten (mmuadadi a ɛkyɛ), sɛ yɛteɛteɛ yɛn apɔw mu denneennen, anaasɛ yedi aduan a protein pii wom a, saa glucagon yi fi adi.

Susuw ho hwɛ, glucose ne asikre titiriw a ɛwɔ yɛn mogya mu. Yenya saa glucose yi fi carbohydrates a ɛwɔ nneɛma a yedi na yɛnom mu. Saa asikre yi na ɛma yɛn nipadua no akwaa, yɛn ntini, ne yɛn ntini ahorow no nya ahoɔden. Ɛte sɛ pɛtro a wɔde yɛ kar. Enti, yɛn nipadua taa ma asikre dodow yi kɔ so yɛ nea ɛfata wɔ ɔkwan a ɛyɛ den yiye so. Sɛ́ eyi dɔɔso dodo anaasɛ ɛba fam dodo no, nyarewa ne ɔhaw ahorow betumi aba.

Glucagon a wɔde twitwiw nipadua mu ne nnuru a wɔde petepete hwene mu

Glucagon a ɛwɔ abɔde mu akyi no, glucagon ahorow a wɔayɛ nso wɔ hɔ. Wobetumi de eyinom ama sɛ aduru a wɔde twitwiw nipadua no anaasɛ wɔde petepete hwene mu a ɛyɛ dry. Ebia woahu sɛ wɔde eyi di dwuma wɔ tebea horow a egye ntɛmpɛ mu, titiriw ma nnipa a wɔwɔ asikreyare a ɛto so 1 , bere a wɔn mogya mu asikre so tew mpofirim dodo (hypoglycemia). Glucagon a wɔde ma saa bere yi no ma glucose a wɔde asie yɛn mmerɛbo mu no fi hɔ na ɛma asikre dodow a ɛwɔ yɛn mogya mu no kɔ soro ntɛmntɛm. Ɛte sɛ nea woama yɛn 'boost' kakra.

Dɛn na glucagon yɛ yɛn nipadua?

Sɛ wo dwensɔtwaa reyɛ adwuma yiye a, wo nipadua no bɛhwɛ wo mogya mu glucose dodow so yiye. Nnuru abien a wɔfrɛ no glucagon ne insulin na ɛyɛ eyi titiriw . Sɛ nhwɛso no, sɛ asikre dodow a ɛwɔ wo mogya mu no so tew dodo (hypoglycemia) a, wo dwensɔtwaa no ma glucagon pii fi adi. Saa glucagon yi boa ma asikre dodow a ɛwɔ wo mogya mu no kɔ soro wɔ akwan horow pii so:

• Nea edi kan no, glucagon kɔ yɛn mmerɛbo mu na ɛdan glucose a wɔde asie wɔ hɔ – a yɛfrɛ no glycogen – ma ɛbɛyɛ biribi a yebetumi de adi dwuma. Afei mmerɛbo no gyae kɔ mogya no mu.
• Nea ɛto so abien no, glucagon betumi asiw mmerɛbo no kwan sɛ ɛbɛfa glucose na akora so, na ama glucose pii akɔ mogya no mu.
• Nea ɛto so abiɛsa, amino acid ahorowGlucagon nso boa nipadua no ma ɛyɛ glucose fi nneɛma afoforo te sɛ:

Kae sɛ ɛte sɛ seesaw. Sɛ asikre dodow so tew wɔ mogya mu a, glucagon yɛ adwuma, na sɛ asikre dodow kɔ soro wɔ mogya mu a, insulin yɛ adwuma!

Nyarewa bɛn na ebia ɛne glucagon dwumadi ho haw ahorow wɔ abusuabɔ?

Afei ma yɛnhwɛ ɔhaw ahorow a ebetumi aba sɛ glucagon anyɛ adwuma yiye a.

Sɛ wowɔ asikreyare a, ebia wo nipadua no rentumi nyi glucagon a ɛdɔɔso mfi mu bere a asikre a ɛwɔ wo mogya mu no sua no. Eyi betumi ama asikre a ɛwɔ wo mogya mu no ayɛ mmerɛw mpɛn pii, anaasɛ asikre a ɛwɔ wo mogya mu no so atew kɛse mpo . Asiane yi yɛ kɛse titiriw sɛ wonom nnuru a ɛtew asikre a ɛwɔ wo mogya mu te sɛ insulin anaa sulfonylureas a.

Wɔ nnipa bi a wɔwɔ asikreyare a ɛto so abien mu no, ebia glucagon dodow bɛkɔ soro asen sɛnea ɛte daa, bere a wɔde toto asikre dodow a ɛwɔ mogya mu ho no. Eyi nso yɛ ade biako nti a asikre dodow kɔ soro wɔ mogya mu.

Ɛntaa mma koraa sɛ ɔhaw ahorow a ɛfa glucagon a wɔyɛ ho no bɛba a asikreyare nni hɔ, nanso tebea horow kakraa bi wɔ hɔ a ebetumi aba:

• Pancreatitis: Sɛ wunya asikreyare esiane pancreatitis nti na wonom insulin ma no a, wubetumi nso anya glucagon a enni wo mu. Eyi ma asiane a ɛwɔ hɔ sɛ asikre a ɛwɔ mogya mu no bɛkɔ fam no yɛ kɛse.
• Glucagonoma: Eyi yɛ akisikuru a ɛntaa nsi koraa wɔ dwensɔtwaa mu. Ɛma glucagon pii fi adi. Eyi de sɛnkyerɛnne ahorow te sɛ asikre a ɛdɔɔso wɔ mogya mu, honam ani akisikuru, ne mu duru a ɛso tew ba.
• Multiple Endocrine Neoplasia (MEN): Eyi nso yɛ awosu mu tebea a ɛntaa nsi koraa. Wɔ eyi mu no, akisikuru nyin wɔ ntini bɛboro biako mu wɔ wo endocrine nhyehyɛe no mu. Nea ɛka eyi ho ne dwensɔtwaa no.
• Pancreatectomy nsunsuanso bɔne: Sɛ biribi nti woyi wo dwensɔtwaa no fã bi anaa ne nyinaa fi hɔ a, nkwammoaa a ɛma glucagon ne insulin no yera.

Dɛn ne ɔhaw ahorow a ɛfa glucagon ho no ho sɛnkyerɛnne?

Sɛnea yɛadi kan aka ho asɛm no, glucagon dodow a ɛnteɛ betumi ama asikre a ɛwɔ mogya mu akɔ fam (hypoglycemia) anaasɛ asikre a ɛwɔ mogya mu akɔ soro (hyperglycemia). Momma yɛnhwɛ nea saa sɛnkyerɛnne ahorow no yɛ.

Nsɛnkyerɛnne a ɛkyerɛ sɛ asikre a ɛwɔ mogya mu sua (Hypoglycemia) .

Fa no sɛ w’adamfo Nilanthi renom nnuru a wɔde sa asikreyare. Da bi, mpofirim ara, ofi ase wosow, ne ho fifiri fi ne ho, na ne ti yɛ no yaw. Ɛte sɛ nea ɔbɔ ne nsɛm no animtiaa nso bere a ɔrekasa no. Sɛ saa sɛnkyerɛnne ahorow yi ba a, ebetumi akyerɛ sɛ asikre a ɛwɔ ne mogya mu no so tew koraa.

Nsɛnkyerɛnne a ɛtaa ba no bi ne:

• Wosow, wo ho popo
• Fifiri ne awɔw a wɔte nka
• Adwene a ɛyɛ basaa, te nka sɛ ne ti ayɛ hare
• Koma a ɛbɔ denneennen
• Ɔkɔm de
• Ɛyɛ den sɛ wode w’adwene besi biribi so, adwene a ɛyɛ basaa

Nea ɛho hia: Sɛ wuhu saa sɛnkyerɛnne ahorow yi a, ɛho hia yiye sɛ wudi biribi a asikre wom, aduan anaa anonne a carbohydrate wom ntɛm ara sɛnea wubetumi . Eyi bɛboa ma asikre dodow a ɛwɔ wo mogya mu no asan ayɛ sɛnea na ɛte kan no. Sɛ wotaa hu saa sɛnkyerɛnne ahorow yi a, akyinnye biara nni ho sɛ ɛsɛ sɛ wokɔ wo duruyɛfo nkyɛn.

Asikre a ɛwɔ mogya mu a ɛkɔ soro ho sɛnkyerɛnne (Hyperglycemia) .

Mpɛn pii no, insulin a enni mogya mu asikre a ɛkɔ soro (hyperglycemia) na ɛde ba, na ɛnyɛ glucagon nkutoo ho haw. Nanso, glucagon ho haw a ɛntaa nsi nso betumi ama asikre a ɛwɔ mogya mu akɔ soro. Nsɛnkyerɛnne a edi kan ne:

• Sukɔm a ɛtaa de ne/anaasɛ ɔkɔm
• Anisoadehu a ɛyɛ kusuu
• Nsu a wɔtaa tow ( tow a wɔtaa tow ) .
• Tipaeɛ

Sɛ wowɔ saa nsɛnkyerɛnne yi a, ɛho hia paa sɛ wobɛkɔ oduruyɛfo nkyɛn.

Nhwehwɛmu bɛn na wɔyɛ de hwɛ glucagon dodow?

Sɛ wowɔ sɛnkyerɛnne ahorow bi a, wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ wo mogya mu nhwehwɛmu mfa nhu wo glucagon dodow. Wɔ sɔhwɛ yi mu no, oduruyɛfo anaa ɔyarehwɛfo de ade bi di dwuma de yi mogya fi wo ntini mu. Afei wɔde kɔ lab bi ma wɔsɔ hwɛ.

Dɛn ne glucagon dodow a ɛfata?

Mpɛn pii no, glucagon dodow a ɛsɛ sɛ yenya wɔ yɛn mogya mu no yɛ picogram 50 kosi 100 wɔ mililita biara mu (pg/mL) . Picogram yɛ gram nkyem ɔpepepem biako! Sika kakraa bi pɛ, ɛnte saa?

Nanso kae sɛ, saa gyinapɛn ahorow a ɛfata yi betumi ayɛ soronko kakra wɔ lab biara mu. Wobetumi nso ayɛ soronko a egyina bere tenten a wode adi mmuada ne asikre dodow a na ɛwɔ wo mogya mu bere a wɔreyɛ nhwehwɛmu no so. Enti, fa nea efi mu ba no toto gyinapɛn ahorow a ɛwɔ wo mogya mu nhwehwɛmu amanneɛbɔ so no ho bere nyinaa . Sɛ wowɔ nsɛmmisa bi a, wo ne wo duruyɛfo nkasa.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn fa me glucagon dodow ho asɛm?

Sɛ wowɔ asikreyare na asikre a ɛwɔ wo mogya mu a ɛba fam anaa ɛdɔɔso taa ba a, ɛho hia sɛ wokɔ oduruyɛfo nkyɛn. Wɔntaa nsusuw glucagon dodow wɔ nnipa a wɔwɔ asikreyare mu. Nanso, ebia ebehia sɛ wosakra sɛnea wohwɛ asikreyare no so na ama saa nsɛm yi ayɛ ketewaa bi.

Ɛwom sɛ ɔhaw afoforo a ɛfa glucagon ho ntaa mma de, nanso sɛ wowɔ sɛnkyerɛnne ahorow a, ɛho hia sɛ wuhu nea ɛde ba. Enti, hwɛ hu sɛ wobɛkɔ wo duruyɛfo nkyɛn.

Nsonsonoe bɛn na ɛda Glucagon ne Glycogen ntam?

So saa abien yi nyɛ ade koro? Glycogen yɛ glucose (asikre) bi a wɔkora so wɔ mmerɛbo no mu.Yɛn nipadua no sie glycogen wɔ mmerɛbo ne ntini mu titiriw.

Glucagon yɛ hormone bi a ɛma mmerɛbo no dannan glycogen san ma ɛbɛyɛ glucose. Afei saa glucose no kɔ mogya no mu na yɛn nipadua betumi de adi dwuma sɛ ahoɔden.

Dɛn na ɛba glucagon so bere a wɔredi mmuada?

Sɛ yɛredi mmuada a, glucagon ho hia yiye na ama asikre dodow a ɛwɔ yɛn mogya mu no ankɔ fam dodo. Nea enti a ɛte saa ne sɛ yɛn nipadua no nnya glucose mfi aduan mu saa bere no.

Sɛ yɛdi mmuada kyɛ a, glucagon ma nipadua no yɛ glucose fi nneɛma a ɛnyɛ carbohydrate mu – te sɛ lipids, amino acids, ne proteins. Wɔfrɛ saa adeyɛ yi gluconeogenesis .

Awiei koraa no, ɛsɛ sɛ meka sɛ... (Take-Home Message)

Enti, ebia wobɛte ase sɛ glucagon yɛ hormone a ɛho hia yiye a ɛboa ma yɛn mogya mu asikre dodow yɛ yiye ‘wɔ akyi’. Ɛnyɛ nea ɛda adi koraa sɛ wowɔ asikreyare anaa ɔhaw ahorow a ɛfa glucagon ho.

Nanso, sɛ wotaa hu sɛnkyerɛnne ahorow a ɛkyerɛ sɛ asikre a ɛwɔ wo mogya mu anaa asikre a ɛdɔɔso wɔ wo mogya mu a, yɛsrɛ wo kɔ wo duruyɛfo nkyɛn. Afei wobetumi ahu nea ɛde ba na wɔakyerɛw ayaresa a wuhia ama wo. W’akwahosan a wobɛhwɛ so yiye ne ade a ɛho hia sen biara.

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