So obi wɔ w’abusua mu, ebia wo maame, wo papa, anaa wo nanabea, werɛ fi nneɛma nketenkete? Sɛ wuntumi nkae nneɛma nketenkete mpo a, yɛte awerɛhow ne ehu kɛse nso nka. Ebia ade titiriw a ɛde eyi ba ne Alzheimer yare no. Nokwarem no, wonnya nnyaa saa yare yi ano aduru. Nanso, ayaresa foforo bi wɔ hɔ a ebetumi aboa ma wɔasiw yare no trɛw ntɛmntɛm so na ama ne nkɔanim brɛoo. Kisunla yɛ nnuru a ɛte saa no mu biako a ɛde anidaso foforo aba. Momma yɛnka eyi ho asɛm tiawa na emu nna hɔ nnɛ.
Alzheimer yare ne sɛnea Kisunla yɛ adwuma
Sɛ yɛbɛka no tiawa a, Alzheimer yɛ amemene mu yare a ɛkɔ so nkakrankakra bere a bere kɔ so no. Ebia woate ho asɛm sɛ ɛyɛ yare a ɛma obi kae ade a abu so wɔ mpanyimfo a wɔn mfe akɔ anim mu. Sɛ saa yare yi ba a, yɛn amemene no afã horow a ɛhwɛ nneɛma a ɛho hia te sɛ nkae, ntease, kasa, adwene, ne nsusuwii so no sɛe. Ade titiriw nti a ɛte saa ne protein a awuduru wom a wɔfrɛ no amyloid a ɛboaboa ano wɔ amemene mu nkwammoaa ntam.
Sɛnea efĩ siw nsu paipu a ɛwɔ yɛn fie mu na ɛmma nsu no nkɔ no, sɛ saa amyloid protein yi boaboa ano wɔ amemene mu nkwammoaa ntam a, amemene mu nkwammoaa no ntumi ne wɔn ho wɔn ho nni nkitaho na ɛnyɛ adwuma yiye.
Ebia woate sɛ Alzheimer yare no yɛ adwenemhaw bi. Dementia yɛ asɛmfua a wɔde frɛ tebea horow a ɛma ɛyɛ den sɛ wubesusuw nneɛma ho yiye araa ma wuntumi nyɛ da biara da nnwuma.
Nnuruyɛfo taa kyekyɛ yare no mu afã horow pii. Wɔ mfiase no, bere tiaa mu nkae a wɔhwere no ne sɛnkyerɛnne titiriw. Bere a yare no kɔ so no, da biara da nnwuma te sɛ aduan a wobɛhyehyɛ, ɔkwan a wobɛfa so ahwehwɛ, ne sika a wobɛhwɛ so mpo bɛyɛ den. Wɔ akyiri yi mu no, wubetumi nso ada adwene mu sɛnkyerɛnne te sɛ fekubɔ a wobɛtwe wo ho afi afoforo ho, biribiara ho anigye a worenhwere, ne basabasayɛ nso adi.
Enti, dɛn na aduru foforo a wɔfrɛ no Kisunla yi yɛ? Ɛwɔ aduru titiriw bi a ɛko tia nyarewa a wɔfrɛ no donanemab-azbt . Nea ɛyɛ ne sɛ ɛde n’ani si amyloid protein ahorow a madi kan aka ho asɛm a ɛboaboa ano wɔ amemene no mu na eyi fi amemene no mu no so. Wɔ saa kwan yi so no, Kisunla boa ma amemene a ɛsɛe ade no so tew na ɛma yare no mu yɛ den ntɛmntɛm.
Sɛnea wɔde Kisunla aduru di dwuma?
Kisunla nyɛ aduru a wɔde sa yare. Wɔde ma sɛ aduru a wɔde fa ntini mu (IV) . Sɛnea anka yebenya nkyene no, ɛsɛ sɛ wonya saa ayaresa yi wɔ ayaresabea anaa ayaresabea, na egye bɛyɛ simma 30.
Sɛ wufi ase sa yare a, wɔbɛma wo miligram 700 (700 mg) mprɛnsa adapɛn anan biara. Ɛno akyi no, wo duruyɛfo no bɛma dodow no akɔ soro akodu miligram 1400 (1400 mg) adapɛn anan biara.
Ansa na wubefi ayaresa yi ase no, wo duruyɛfo bɛkra sɛ wɔnyɛ amemene mu nhwehwɛmu titiriw bi a wɔfrɛ no tau positron emission tomography (PET) . Eyi hwɛ amyloid dodow a wɔde ahyɛ w’amemene mu. Sɛ scan no kyerɛ sɛ amyloid dodow a ɛwɔ w’amemene mu no so atew kɛse a, ebia wo duruyɛfo no besi gyinae sɛ obegyae ayaresa.
Nsɛntitiriw titiriw a ɛsɛ sɛ yɛhwɛ yiye wɔ ho ne nea efi mu ba
Nneɛma bɔne bi a anibere wom wɔ hɔ a ɛsɛ sɛ yɛhwɛ yiye wɔ ho titiriw bere a yɛresa Kisunla yare no. Wɔfrɛ no ARIA (mfonini a ɛnyɛ ne kwan so a ɛfa amyloid ho) . Sɛ yɛbɛka no tiawa a, saa aduru yi ma wohu nsakrae a ɛnteɛ wɔ amemene no MRI mfonini mu. Ɛnyɛ bere nyinaa na eyi de yare no ho sɛnkyerɛnne ba.
Nanso, wɔ tebea horow a ɛntaa nsi mu no, nnipa binom betumi anya yare no ho sɛnkyerɛnne te sɛ eyinom:
- Tipaeɛ
- Kesereneeyɛ
- Ɔfe a wɔfe
- Anisoadehu sesa
- Kari a wɔhwere bere a wɔnantew no
Ɛtɔ mmere bi a, ARIA ho sɛnkyerɛnne betumi ayɛ te sɛ nea ɛwɔ ɔyare a ɛma obi hwe ase no ara pɛ. Enti, ɛho hia yiye sɛ wobɛka nnuru a worenom nyinaa ho asɛm kyerɛ wo duruyɛfo sɛnea ɛbɛyɛ a obetumi ahu sɛ ebia efi ARIA anaa biribi foforo.
Hena na ɔwɔ asiane kɛse mu sɛ obenya ARIA?
Nnipa binom wɔ asiane kɛse sɛ wobenya ARIA a egyina wɔn awosu mu nneɛma so. Nnipa a wɔwɔ awosu mu abɔde a wɔfrɛ no apolipoprotein E e4 (ApoE e4) no mfonini abien no wɔ asiane kɛse mu sɛ wobenya ɔhaw ahorow a emu yɛ den te sɛ amemene a ɛho ahonhon anaasɛ mogya a ɛbɛtɔ wɔ amemene no mu. Enti, ɛda adi sɛ wo duruyɛfo bɛhyɛ sɛ wɔnyɛ awosu mu nhwehwɛmu mfa nhwɛ asiane a ɛwɔ hɔ sɛ wubenya ARIA ansa na woafi ase de Kisunla sa yare. Ɛho behia nso sɛ woyɛ MRI scan daa de hwɛ tebea yi bere a wɔreyɛ ayaresa no.
Ɔkwan bɛn so na wɔyɛɛ sɛnea Kisunla aduru no dii yiye ho nhwehwɛmu?
Wɔayɛ ayaresabea nhwehwɛmu kɛse bi de ahu sɛnea aduru yi tu mpɔn. Ayarefo dodow bi a wɔwɔ Alzheimer yare a edi kan no de wɔn ho ahyɛ eyi mu.
Nhwehwɛmufo no kyekyɛɛ saa nnipa yi mu yɛɛ wɔn akuw abien.
1. Wɔmaa kuw biako: Kisunla aduru.
2. Kuw foforo no: wɔmaa wɔn biribi a ɛte sɛ aduru no, nanso na enni ade a ɛyɛ adwuma biara (yɛfrɛ eyi placebo ).
Nea afi mu aba no hyɛ nkuran ankasa. Momma yɛnte saa nea efii mu bae no ase mfi pon a ɛwɔ ase ha no so kɛkɛ.
| Mfasoɔ | Nea nhwehwɛmu no hui |
|---|---|
| Yare no a ɛretrɛw brɛoo | Yareɛ no nkɔsoɔ dodoɔ wɔ wɔn a wɔmaa wɔn Kisunla no mu no yɛɛ brɛoo bɛyɛ 20% sene wɔn a wɔmaa wɔn placebo no. |
| Nsɛnkyerɛnne a ɛnyɛ kɛse | Wɔn a wɔmaa wɔn Kisunla no mu ɔha biara mu aduanan ason no, wɔn yare no ankɔ so ansɛe wɔ afe biako mu, bere a wɔde toto wɔn a wɔwɔ placebo kuw no mu no mu 29% pɛ ho no. |
| Amyloid a ɛso tew wɔ amemene no mu | Wɔ nhwehwɛmu no awiei no, wɔn a wɔmaa wɔn Kisunla no mu 76% na amyloid a ɛwɔ wɔn amemene mu no sua koraa. |
Nea afi mu aba yi kyerɛ sɛ Kisunla betumi ama Alzheimer yare no akɔ so brɛoo kɛse.
Bere tenten ahe na egye ansa na aduru no ayɛ adwuma na so ɛne nnuru afoforo di nkitaho bi?
Sɛ wo nsa ka Kisunla dodow a edi kan ara pɛ a, efi ase yɛ adwuma denam amyloid a ɛde n’ani si amemene no so no so. Nanso, ebetumi agye asram pii ansa na wo, wɔn a wɔhwɛ wo, ne wo duruyɛfo ahu sɛ wo yare no ho sɛnkyerɛnne so tew na yare no kɔ brɛoo.
Nkitahodi a ɛda nnuru afoforo ntam
Esiane asiane a ɛwɔ hɔ sɛ amemene mu mogya bɛtu wɔ ARIA mu nti, ɛsɛ sɛ wɔhwɛ yiye titiriw bere a wɔde Kisunla ne nnuru a ɛma mogya tu redi dwuma no . Ɛwom sɛ adanse biara nni hɔ a emu da hɔ de, nanso sɛ worenom nnuru a ɛma mogya tu a, akyinnye biara nni ho sɛ ɛsɛ sɛ wo ne wo duruyɛfo susuw eyi ho ansa na woafi Kisunla ayaresa ase.
Adeɛ a ɛho hia paa ne sɛ wobɛbɔ wo duruyɛfoɔ amanneɛ wɔ nnuru a worenom nyinaa ho - sɛ ɛyɛ wo duruyɛfoɔ na ɔkyerɛw ama wo, nnuru a wɔtɔn, vitamin, Ayurvedic anaa Sinhala nnuru.
Sɛ wuhu sɛnkyerɛnne biara te sɛ tiyɛ bere a woreyɛ ayaresa a, mmu w’ani ngu so. Ebetumi ayɛ ARIA ho sɛnkyerɛnne, enti ka kyerɛ wo duruyɛfo ntɛm ara .
Nkrasɛm a Wɔde Kɔ Fie
- Kisunla yɛ aduru foforo a wɔde sa Alzheimer yare no mfiase .
- Eyi yɛ adwuma denam protein a awuduru wom a wɔfrɛ no amyloid a ɛboaboa ano wɔ amemene no mu a woyi fi hɔ na ɛma yare no mu yɛ den ntɛmntɛm no so.
- Eyi yɛ aduru a wɔde fa ntini mu (IV) na ɛsɛ sɛ wɔde ma wɔ ayaresabea anaa ayaresabea.
- Ɛho hia yiye sɛ wuhu nkɛntɛnso bɔne a anibere wom a wɔfrɛ no ARIA no. Eyi hwehwɛ sɛ wɔyɛ MRI nhwehwɛmu daa ansa na wɔayɛ ayaresa ne bere a wɔresa no yare.
- Ɛho hia sɛ wo ne wo duruyɛfo kasa pefee fa nnuru a wonom nyinaa (a nnuru a ɛma mogya yɛ mmerɛw ka ho) ne sɛnkyerɛnne foforo biara a worehu ho.
- Ɛwom sɛ eyi nyɛ aduru de, nanso ɛma yare no kɔ brɛoo kɛse na ɛma ayarefo ne wɔn mmusua nya anidaso foforo.
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