Ɛtɔ da bi a yebisa yɛn ho sɛ, "Mewɔ abusua abakɔsɛm a ɛkyerɛ sɛ mewɔ kokoram, enti misusuw sɛ ebia ɛda adi sɛ me nso menya bi anaa." Nokwarem no, kokoram ahorow bi betumi afi awosu mu nkɛntɛnso a efi awo ntoatoaso so kɔ awo ntoatoaso so na ɛde aba. Sɛ nhwɛso no, Lynch Syndrome yɛ tebea a ɛma kokoram ho asiane yɛ kɛse, nanso wɔnka ho asɛm pii. Ɛho hia yiye sɛ wubehu eyi. Enti momma yɛnka ho asɛm nnɛ ara kwa.
Sɛ yɛbɛka no tiawa a, dɛn ne Lynch Syndrome?
Lynch syndrome yɛ awosu mu yare a efi ɔwofo hɔ kɔ abofra mu, anaasɛ awosu mu . Obi a ɔwɔ saa tebea yi betumi anya kokoram ahorow bi, anaasɛ ɔwɔ asiane mu sen afoforo.
Ne titiriw no, obi a ɔwɔ saa tebea yi wɔ hokwan kɛse 40% kosi 80% sɛ obenya kokoram wɔ ne menewa mu bere a wadi mfe 70. Asiane kɛse nso wɔ hɔ sɛ obenya kokoram wɔ awotwaa, awotwaa, ne yafunu mu. Nea ɛyɛ soronko wɔ eyi ho ne sɛ kokoram betumi anya ntɛm koraa sen mfe a kokoram betumi adi, ebia wɔ mfe 30 anaa 40 mu.
Bere bi a atwam no, nnuruyɛfo frɛɛ no HNPCC (Hereditary Non-Polyposis Colorectal Cancer) nso, nanso seesei wɔtaa de edin Lynch syndrome di dwuma.
Dɛn na ɛde tebea yi ba?
Sɛ yɛbɛte eyi ase a, momma yensusuw yɛn nipadua ho kakra. Nkwammoaa ɔpepepem pii na ɛka bom yɛ yɛn nipadua. Saa nkwammoaa yi mu paapae bere nyinaa na ɛreyɛ nkwammoaa foforo. Fa no sɛ ɛte sɛ nea wode afiri a wɔde twetwe mfonini reyɛ mfonini ahorow. Sɛ nkwammoaa mu paapae wɔ saa kwan yi so a, ɛtɔ mmere bi a mfomso nketenkete ba. Nanso anigyesɛm ne sɛ, ‘awosu mu nkwaadɔm a ɛsiesie a ɛne ne ho nhyia’ titiriw bi wɔ yɛn nipadua no DNA mu a ehu mfomso ahorow yi na esiesie.
Obi a ɔwɔ Lynch syndrome wɔ sintɔ anaa mfomso bi wɔ saa ‘checker genes’ yi biako mu . Afei, sɛ saa nkwammoaa no mu paapae a, wɔansiesie mfomso afoforo no, na nkwammoaa a asɛe no kɔ so mu paapae, na nkwammoaa foforo pii a asɛe no fi ase hyehyɛ nipadua no mu. Bere kɔ so no, saa nkwammoaa a asɛe yi dan kokoram.
Sɛ wo maame anaa wo papa wɔ saa tebea yi a, wowɔ hokwan 50% sɛ wobɛnya bi nso.
Dɛn ne sɛnkyerɛnne ahorow a ebetumi akyerɛ sɛ Lynch yare no?
Nsɛntitiriw pii wɔ hɔ a ebetumi ama tebea yi ho dadwen aba. Sɛ eyinom mu biako anaa nea ɛboro saa fa wo anaa w’abusua ho a, ɛho hia paa sɛ wo ne oduruyɛfo kasa.
| Bere a ɛsɛ sɛ wususuw sɛ Lynch Syndrome | |
|---|---|
| Ankorankoro kokoram ho abakɔsɛm | Wowɔ kokoram a ɛwɔ wo wo akyi berɛmo mu ansa na woadi mfe 50. |
| Abusua kokoram ho abakɔsɛm |
|
| Akisikuru a ɛnyɛ kokoram | Polyps, nyin a ɛnyɛ kokoram wɔ akyi berɛmo mu no ba wɔ ne mmofraase. |
Ɔkwan bɛn so na wobehu tebea yi?
Sɛ wo anaa w’abusua mu obi anya kokoram na wo duruyɛfo susuw sɛ ebia efi Lynch syndrome a, wobetumi asɔ kokoram no kakraa bi ahwɛ. Akwan titiriw abien na ɛwɔ hɔ a wobɛfa so ayɛ eyi:
- Immunohistochemistry (IHC) sɔhwɛ: Eyi hwehwɛ protein ahorow a wohu wɔ kokoram nkwammoaa mu. Sɛ protein ahorow a ‘checker genes’ a yɛadi kan aka ho asɛm no yɛ no nni saa nkwammoaa no mu a, ebetumi ayɛ Lynch syndrome ho sɛnkyerɛnne.
- Microsatellite instability (MSI) sɔhwɛ: Eyi hwɛ tẽẽ sɛ mfomso bi wɔ kokoram nkwammoaa DNA mu anaa.
Sɛ nhwehwɛmu ahorow yi si so dua sɛ wowɔ Lynch syndrome, anaasɛ wususuw sɛ wowɔ asiane mu esiane sɛ obi a ɔwɔ w’abusua mu wɔ tebea no nti a, wubetumi ama wɔayɛ awosu mu nhwehwɛmu wɔ mogya bi so de ahu sɛ ebia wo nso wowɔ saa awosu mu dɛmdi yi anaa.
Mmoa a efi Awosu Ho Ɔfotufo bi hɔ
Saa bere yi de, ebia wo duruyɛfo de wo bɛkɔ awosu ho ɔfotufo nkyɛn. Wɔbɛkyerɛkyerɛ nneɛma pii mu akyerɛ wo wɔ eyi ho.
- Sɛnea Lynch yare no nya fi awo mu wɔ abusua bi mu.
- Nea nea afi w’awosu mu nhwehwɛmu amanneɛbɔ mu aba no kyerɛ.
- Sɛnea nea efi mu ba yi ka wo kokoram ho asiane.
- Sɛnea ɛbɛyɛ yiye sɛ wo mma benya saa awosu mu abɔde yi afi wo hɔ.
- Nneɛma a wubetumi apaw de asiw kokoram ano.
Kae sɛ, sɛ wohu sɛ wowɔ Lynch syndrome a , ɛnkyerɛ sɛ akyinnye biara nni ho sɛ wubenya kokoram . Nea ɛkyerɛ ara ne sɛ asiane a ɛwɔ wo mu no dɔɔso sen afoforo koraa.
Sɛ wowɔ Lynch syndrome a, ɔkwan bɛn so na wodi ho dwuma?
Ade a eye sen biara a ɛsɛ sɛ woyɛ bere a wunim sɛ wowɔ saa tebea yi ne sɛ wobɛkɔ akɔyɛ nhwehwɛmu daa akɔhwɛ sɛ wowɔ kokoram anaa. Afei, sɛ kokoram nya mpo a, ɛda adi kɛse sɛ wobehu no ntɛm ara na wɔasa no koraa . Sɛ nhwɛso no, sɛ wohu ntɛm a, wobetumi asa kokoram a ɛwɔ akyi berɛmo mu no wɔ 90% mu.
Wo duruyɛfo na obesi nhwehwɛmu a ɛsɛ sɛ woyɛ ne mpɛn dodow a wuhia ho gyinae. Sɔhwɛ ahorow a wɔtaa kamfo kyerɛ ne:
- Colonoscopies: Efi mfe 20-25 no, wobetumi aka akyerɛ wo sɛ yɛ nhwehwɛmu yi afe anaa abien biara. Eyi hwɛ sɛ ebia polyps anaa kokoram ho sɛnkyerɛnne bi wɔ dwensɔtwaa kɛse no mu anaa.
- Endoscopies: Efi wo mfe 30 mu no, wobetumi ayɛ eyi mfe 3-5 biara de ahwehwɛ yafunu ne dwensɔtwaa mu.
- Nhwehwɛmu a wɔbɛyɛ ama mmea: Sɛ wodi mfe 30 a, wobetumi akamfo nhwehwɛmu te sɛ akyi berɛmo mu nhwehwɛmu, transvaginal ultrasound, anaa awotwaa mu nhwehwɛmu afe biara de ahwɛ awotwaa ne awotwaa mu.
Nnipa binom, titiriw mmea a wɔawo mma, ne wɔn duruyɛfo kasa fa oprehyɛn a wɔde siw ano ho na ama kokoram ho asiane a ɛwɔ hɔ no so atew. Eyi kyerɛ sɛ wɔbɛyɛ oprehyɛn ayi akyi berɛmo, awotwaa, anaa awotwaa mu ansa na kokoram aba. Eyi yɛ obi ankasa gyinaesi koraa.
Asetra kwan a ahoɔden wom ho hia
Bere a wɔyɛ nhwehwɛmu daa no, asetra pa a wobɛtra ase nso boa ma asiane yi so tew.
- Di aduan a nhabannuru, nnuaba, atoko, ne aburow a wɔayam pii wom.
- Yɛ apɔw-mu-teɛteɛ daa .
- Di wo mu duru so.
- To nsa a wonom ano hye.
Nhwehwɛmu ahorow bi ada no adi sɛ aspirin a wɔmfa nni dwuma pii a wɔnom da biara no betumi atew asiane yi so, nanso nhwehwɛmu pii ho hia wɔ eyi ho. Enti , mfi ase nnom nnuru da wɔ w’ankasa wo ho a wonkɔ wo duruyɛfo nkyɛn.
Nkrasɛm a Wɔde Kɔ Fie
- Lynch syndrome yɛ awosu mu yare a wɔde ma awo ntoatoaso ahorow. Ɛma asiane a ɛwɔ hɔ sɛ wobenya kokoram pii, a kokoram a ɛwɔ akyi berɛmo ne awotwaa mu ka ho no yɛ kɛse.
- Sɛ obi a ɔwɔ w’abusua mu anya kokoram wɔ ne mmofraase (titiriw nea ɛwɔ akyi berɛmo anaa awotwaa mu) a, ɛno betumi ayɛ asiane.
- Sɛ wowɔ adwenem naayɛ anaa dadwen bi wɔ eyi ho a, hwɛ hu sɛ wo ne wo duruyɛfo bɛkasa. Ɔde akwankyerɛ a ɛho hia bɛma wo.
- Sɛ wohu sɛ ɔwɔ saa tebea yi a, ɛnkyerɛ sɛ kokoram benya. Ɛyɛ hokwan a wode bɛyɛ nneɛma bi de abɔ wo ho ban afi kokoram ho ntɛm.
- Sini a wɔyɛ no daa ne w’akode a tumi wom sen biara. Sɛ kokoram ba ampa a, wobetumi akyere no ntɛm na wɔasa no yiye.
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