Woama oduruyɛfo bi aka nsakrae ketewaa bi a ɛbaa wo mogya mu nkwammoaa fitaa mu bere a woyɛɛ wo mogya mu nhwehwɛmu no ho asɛm akyerɛ wo pɛn? Ebetumi ayɛ Pelger-Huet Anomaly. Ebia edin no bɛyɛ te sɛ asɛm kɛse, nanso mma ɛnhaw wo , mpɛn pii no ɛnyɛ aniberesɛm saa. Momma yɛnka eyi ho asɛm nkɔ akyiri kakra, wɔ ɔkwan a ɛnyɛ den so.
Dɛn ne Pelger-Huet Anomaly no?
Sɛ yɛbɛka no tiawa a, Pelger-Huet Anomaly (PHA) yɛ awosu mu yare a ɛka neutrophils, mogya mu nkwammoaa fitaa bi a ɛwɔ yɛn nipadua mu. Neutrophils te sɛ asraafo nkumaa a wɔwɔ yɛn nipadua mu a wɔboa yɛn nipadua ma ɛko tia mmoawa.
Saa tebea yi fi nsakrae a ɛba yɛn DNA mu, titiriw wɔ awosu mu abɔde bi a wɔfrɛ no Lamin B Receptor (LBR awosu mu abɔde) mu. Saa LBR awosu mu abɔde yi ne nea ɛboa ma neutrophil nkwammoaa nyin na enyin yiye.
Afei hwɛ, neutrophil nkwammoaa biara wɔ baabi a ɛhwɛ so, na yɛfrɛ no nucleus . DNA ho nsɛm a nkwammoaa no hia na ama ayɛ adwuma na anyin nyinaa wɔ saa nuklea yi mu. Mpɛn pii no, wɔkyekyɛ neutrophil a ɛwɔ apɔwmuden no nucleus mu abiɛsa anaa nea ɛboro saa. Nanso, neutrophil nucleus a ɛwɔ obi a ɔwɔ Pelger-Huette mu no wɔ afã abien. Ɛte sɛ dumbbell, a srade wɔ n’afã abien no nyinaa na mfinimfini yɛ tratraa. Ɛntaa mma koraa sɛ wɔ nnipa binom mu no, neutrophil nucleus yi betumi ayɛ oval, kyerɛ sɛ, ayɛ te sɛ ɛmo.
Nanso ade a ɛho hia wɔ ha ne sɛ sɛ wɔwoo wo sɛ wowɔ Pelger-Huette anomaly mpo a, mpɛn pii no wo neutrophil nkwammoaa no yɛ adwuma sɛnea ɛsɛ. Eyi kyerɛ sɛ wɔnsɛe wo ho ban fi nyarewa ho kɛse. Enti, ɛtaa de akwahosan ho haw akɛse kakraa bi pɛ na ɛba.
Tebea foforo bi wɔ hɔ a wɔfrɛ no Pseudo Pelger-Huet Anomaly (PPHA) . Eyi betumi aba nnipa binom so wɔ wɔn nkwa nna a edi akyiri mu. PPHA betumi aba sɛ nnuru bi mu nsunsuanso bɔne anaasɛ tebea foforo te sɛ ɔyare mmoawa ho sɛnkyerɛnne.
Dɛn ne Pelger-Huette anomaly ho sɛnkyerɛnne ahorow?
Ɛha na ɛsɛ sɛ yɛde yɛn adwene si ahorow abien a yɛadi kan aka ho asɛm no so.
Pelger-Huet Nyarewa (HPA) a efi awosu mu .
Sɛ wowɔ Pelger-Huette anomaly (HPA), a wonya fi awo mu a, mpɛn pii no wunnya sɛnkyerɛnne biara. Ebia wunnim mpo sɛ wowɔ tebea no. Wɔtaa hu no wɔ akwanhyia mu bere a wɔyɛ mogya mu nhwehwɛmu esiane biribi foforo nti no.
Pseudo Pelger-Huet Nneyɛe a Ɛnyɛ Nhyia (PPHA) .
Nanso, sɛ wowɔ pseudo-Pelger-Huette anomaly (PPHA), a ɛkyerɛ sɛ ɛbaa akyiri yi a, wubetumi anya sɛnkyerɛnne ahorow a ɛfa tebea a ɛde bae no ho.Sɛ nhwɛso no, sɛ ɔyare mmoawa bi na ɛde PPHA ba a, ebia sɛnkyerɛnne ahorow te sɛ atiridiinini ne nipadua mu yaw a ɛfa saa ɔyare no ho bɛba.
Dɛn na ɛde Pelger-Huette anomaly ba?
Nea enti a eyi ba nso gu ahorow gyina ahorow abien a yɛadi kan aka ho asɛm no so.
Pelger-Huette a ɛyɛ awosu mu yare (HPA) .
Eyi fi nsakrae bi a ɛba Lamin B Receptor (LBR) awosu mu abɔde mu, sɛnea yɛadi kan aka no. Saa LBR awosu mu abɔde yi kyerɛ yɛn nipadua no sɛ ɛnyɛ protein ahorow a ehia na ama wɔabɔ neutrophil nkwammoaa ho ban na ama wɔanya nsusuwii a ɛfata. Wɔ Pelger-Huytt anomaly mu no, awosu mu nsakrae yi sɛe saa adeyɛ no, na ɛma neutrophils nuclei no nya saa dumbbell nsusuwii no. Eyi yɛ tebea a wobetumi anya afi awofo hɔ akɔ mmofra hɔ.
Pseudo Pelger-Huette aduru a ɛnteɛ (PPHA) .
Eyi nyɛ awosu mu tebea. Nneɛma pii wɔ hɔ a ebetumi de tebea yi aba:
- Nnompe mu nyarewa: Nhwɛso bi ne mogya mu kokoram tebea horow te sɛ myelodysplastic syndrome ne acute myeloid leukemia (AML).
- Nyarewa bi: titiriw nyarewa a ntontom de ba.
- Nnuru a ɛma nipadua no tumi ko tia nyarewa: Ebia nnuru yi a wɔde ma nyarewa bi nso na ɛde ba.
- Mframa a wɔde ma: Sɛ nhwɛso no, bere a wɔreyɛ kokoram ayaresa no.
Sɛ oduruyɛfo bi ka kyerɛ wo sɛ wowɔ `PHA` anaa `PPHA` a, ɛho hia yiye sɛ wobɛbɔ oduruyɛfo no amanneɛ wɔ nnuru a worenom nyinaa ho, vitamin mpo.
Dɛn ne asiane ahorow a ɛde tebea yi ba?
Asiane titiriw a ɛde Pelger-Huette anomaly (PHA) ba ne sɛ wubenya ɔwofo a ɔwoo no a ɔwɔ tebea no. Wei kyerɛ sɛ sɛ wo maame anaa wo papa wɔ PHA a, wowɔ bɛyɛ 50% hokwan sɛ wobɛnya bi. Ɛte sɛ nea worebɔ sika, wuntumi nka no pen, nanso ebetumi asi.
Wɔ `PPHA` tebea no ho no, aduruyɛ tebea anaa ayaresa ahorow a yɛadi kan aka ho asɛm no a wɔde wɔn ho bɛhyɛ mu no yɛ asiane ahorow.
So nsɛnnennen bi wɔ tebea yi mu?
Mpɛn pii no, Pelger-Huette anomaly (PHA) a wonya fi awo mu no mfa nsɛnnennen akɛse mma. Efisɛ, ɛwom sɛ ɛsakra sɛnea wo neutrophil nkwammoaa no te de, nanso ɛnsakra sɛnea ɛyɛ adwuma no kɛse. Wɔkɔ so ko tia mmoawa.
Nanso, sɛ wowɔ pseudopelgar-huwat anomalous (PPHA) a, aduruyɛ mu tebea a ɛda adi a ɛde bae (te sɛ mogya mu kokoram) betumi de nsɛnnennen aba. Enti, ɛho hia sɛ wo ne wo duruyɛfo kasa fa eyi ho na wuhu nea wobɛhwɛ kwan.
Ɔkwan bɛn so na nnuruyɛfo hu Pelger-Huette anomaly?
Nnuruyɛfo de mogya mu nhwehwɛmu titiriw di dwuma de hu tebea yi. Ne titiriw no, .Wɔyɛ nhwehwɛmu bi a wɔfrɛ no peripheral blood smear. Nea ɛka nhwehwɛmu yi ho ne sɛ wobɛfa wo mogya no mu kakra, atrɛw mu teateaa wɔ ahwehwɛ a wɔde twetwe nneɛma so, na wode afiri a wɔde hwɛ nneɛma nketenkete ahwɛ.
Ɔyare ho ɔbenfo anaa mogya ho ɔbenfo na ɔhwehwɛ eyi mu.
Sɛ wowɔ Pelger-Huette anomaly a, sɔhwɛ yi bɛkyerɛ sɛnea wo neutrophil nkwammoaa no nuclei (te sɛ dumbbell) no te sɛ nea ɛyɛ soronko pefee.
So aduru bi wɔ hɔ a wɔde sa Pelger-Huette anomaly?
Asɛmpa no ni! Mpɛn pii no, Pelger-Huette anomaly (PHA) a efi awosu mu no mma obi nnya yare no ho sɛnkyerɛnne biara, enti enhia ayaresa titiriw biara. Sɛ wowɔ saa tebea yi mpo a, wubetumi abɔ bra sɛnea ɛsɛ.
Nanso, wɔ `PPHA` fam no, ɛho hia sɛ wɔsa yareɛ a ɛwɔ aseɛ a ɛde baeɛ no. Sɛ wɔsa saa yareɛ no wie a, `PPHA` tebea no nso betumi akɔ.
Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?
Sɛ wuhu sɛ wowɔ Pelger-Huette anomaly a, hwɛ hu sɛ wobɛka akyerɛ wo duruyɛfo sɛ wunya sɛnkyerɛnne foforo biara (te sɛ atiridiinini, ɔbrɛ a emu yɛ den, ɔyare mmoawa a wotaa nya). Afei wo duruyɛfoɔ bɛtumi ahunu sɛ nsɛnkyerɛnneɛ no fa `PHA`, `PPHA`, anaa biribi foforɔ ho anaa.
Sɛ wokɔ oduruyɛfo nkyɛn a, ɛbɛyɛ papa nso sɛ wubebisa nsɛm yi:
- So mewɔ agyapade `(HPA)` anaasɛ atoro `(PPHA)` Pelger-Huette anomaly?
- So ebetumi aba sɛ me mma benya saa tebea yi afi awo mu? (Sɛ HPA a) .
- Mpɛn ahe na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?
- Nsɛnkyerɛnne bɛn na ɛsɛ sɛ mehwɛ so titiriw?
Dɛn na ɛsɛ sɛ mehwɛ kwan wɔ tebea yi ho?
Pelger-Huette anomaly (PHA) ankasa mma wo nte yaw biara anaasɛ ɛmma nsakrae kɛse mma w’asetra mu. Mpɛn pii no, ɛnka wo da biara da dwumadi ahorow.
Nanso, sɛ wowɔ saa tebea yi (titiriw `PPHA` no) a, ebetumi ayɛ akwahosan tebea foforo a ɛhyɛ ase ho sɛnkyerɛnne. Ɛno nti na nnuruyɛfo dwen ho no. Sɛ wo duruyɛfoɔ susu sɛ wowɔ `PHA` anaa `PPHA` a, wɔbɛyɛ nhwehwɛmu a ɛhia de asi so dua, na wɔasan nso ayɛ anammɔn bi de ayi ayaresa tebea foforɔ afiri hɔ.
Ebia wowɔ Pelger-Huette anomaly (PHA) na wunnim efisɛ wunni sɛnkyerɛnne biara. Ebia wubesusuw sɛ, "Sɛ ɛnhaw me a, dɛn nti na meredwen ho mpo?" Ɛyɛ nokware sɛ ebia worente nka sɛ woyare esiane nkwammoaa mu nsakrae pɔtee yi nti. Nanso ɛho hia sɛ woma wo duruyɛfo hu ho asɛm. Wo duruyɛfo wɔ hɔ sɛ ɔbɛboa wo ma woanya apɔwmuden. Na ɛboa sɛ wubehu nneɛma nketenkete yi ho asɛm wɔ wo nipadua mu. Esiane sɛ wowɔ Pelger-Huette anomaly nti yɛ ade foforo ara kwa a ɛma woyɛ "wo." Ɛnyɛ biribiara a ɛsɛ sɛ wohaw wo ho wɔ ho.
Nsɛm a Wɔaboaboa Ano (Nkrasɛm a Wɔde Kɔ Fie) .
Okay, enti momma yɛnsan nsusuw nneɛma a yɛkaa ho asɛm no bi ho asɛm:
- Pelger-Huet Anomaly (PHA) yɛ awosu mu tebea bi a ɛma neutrophils, mogya mu nkwammoaa fitaa bi nucleus no nsɛso yɛ nea ɛnteɛ.
- Mpɛn pii no, eyi nyɛ nea asiane wom na ɛmfa yare no ho sɛnkyerɛnne mma. Neutrophil nkwammoaa no yɛ adwuma sɛnea ɛsɛ.
- Eyi ahorow abien na ɛwɔ hɔ: `HPA`, a efi awosu mu, ne `PPHA`, a akyiri yi nyarewa anaa nnuru afoforo na ɛde ba.
- Mpɛn pii no, HPA nhia ayaresa. Wɔ PPHA fam no, wɔsa nea ɛde ba titiriw no.
- Wɔnam mogya mu nhwehwɛmu (peripheral blood smear) so hu saa tebea yi.
- Sɛ wuhu sɛ wowɔ saa tebea yi a, mma ɛnhaw wo. Nanso, wo ne wo duruyɛfo nka ho asɛm na nya afotu a ɛho hia. Sɛ yare no ho sɛnkyerɛnne foforo da adi a, ka kyerɛ wo duruyɛfo.
Mewɔ anidaso sɛ saa asɛm yi abua mo nsɛmmisa dodow no ara a ɛfa Pelger-Huette anomaly ho. Kae sɛ, sɛ wowɔ akwahosan ho asɛm biara a, ɛbɛyɛ papa sɛ wo ne wo duruyɛfo bɛkasa pefee.
` Pelger-Huet Anomaly, Neutrophils, Mogya Nkwammoaa Fitaa, Awosu mu Nyarewa, Mogya mu Nhwehwɛmu, PPHA, HPA
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