Ebia woate nnubɔne te sɛ Viagra ho asɛm. Nnipa dodow no ara nim sɛ eyinom yɛ nnuru a wɔde ma wɔ nna mu ɔbrasɛe ho. Nanso so wunim sɛ wɔde nnuru a ɛwɔ kuw foforo mu, a wɔfrɛ no Phosphodiesterase Inhibitors, sa tebea horow pii, efi komayare so kosi ahurututu mu yare, honam ani yare, ne nkwaa mu yare so? Ɛnnɛ, momma yɛnka nnubɔne kuw a ɛyɛ nwonwa yi ho asɛm. Momma yɛnte nea wɔyɛ, sɛnea wɔyɛ adwuma, ne mfaso ne ɔhaw ahorow a ɛwom no ase kɛkɛ.
Sɛ yɛbɛka no tiawa a, dɛn ne Phosphodiesterase Inhibitors (PDE inhibitors)?
Eyinom yɛ aduru bi a ɛma mogya ntini a ɛwɔ yɛn nipadua mu no trɛw, ɛtew ne den so, na ɛma mogya tu ntɛmntɛm. Fa no sɛ sɛ nsu paipu siw a, sɛ woma ɛyɛ kɛse kakra a, nsu no sen ntɛmntɛm. Eyi ma mogya mmoroso so tew na ɛma mogya kɔ nipadua no afã horow yiye. Esiane saa tumi yi nti, wɔde saa aduru yi di dwuma sɛ aduru a wɔde sa nyarewa ahorow pii.
Ɔkwan bɛn so na saa aduru yi yɛ adwuma?
Sɛ yɛbɛte eyi ase a, ɛsɛ sɛ yedi kan hu nnuru sobɔfo ketewaa bi a ɛwɔ yɛn nipadua mu ho asɛm. Ne din de Phosphodiesterases , anaa PDE tiawa. Saa PDE yi yɛ enzyme bi . Enzyme te sɛ aboafo nketenkete a ɛma nnuru afoforo a ɛkɔ yɛn nipadua mu no yɛ ntɛmntɛm na ɛma ɛyɛ mmerɛw.
Saa PDE enzymes yi ahorow pii wɔ yɛn nipadua mu. Nyansahufo de akontaahyɛde adi dwuma de akyerɛ nsonsonoe a ɛda wɔn ntam. Ade titiriw ne sɛ PDE biara yɛ adwuma kɛse wɔ nipadua no mmeae pɔtee bi.
- PDE-3: Wohu saa ɔkwan yi titiriw wɔ wo koma ne wo mogya a ɛkɔ wo mogya mu no mu . Ɛsan nso ka mogya a ɛtwetwe no ho.
- PDE-4: Eyi dodow no ara wɔ ahurututu mu . Ɛyɛ adwuma denam ntini a ɛwɔ mframa kwan no mu a ɛkyekyere no so.
- PDE-5: Saa ɔkwan yi wɔ ahurututu ne mmarima awotwaa mu .
Enti, nnuru a wɔfrɛ no Phosphodiesterase Inhibitors (PDE inhibitors) yɛ adwuma denam PDE enzymes a yɛaka ho asɛm wɔ atifi hɔ no dwumadi a esiw ano no so . Ɛte sɛ nea wɔato ɔpon bi mu. Nnuru bi a esiw PDE ano yɛ adwuma wɔ ɔkwan a wɔpaw so yiye . Ɛne sɛ, wɔde wɔn ani si ɔkwan pɔtee bi so, te sɛ PDE-5 nkutoo so. Nnuru afoforo wɔ hɔ a ɛyɛ adwuma a wɔanpaw . Ɛne sɛ, wobetumi aka PDE ahorow nyinaa akodu baabi.
Tebea bɛn na wɔde aduru yi sa?
Nnwumakuw te sɛ U.S. Aduan ne Nnuru Dwumadibea (FDA) apene nnuru kuw a wɔfrɛ no PDE inhibitors so sɛ wɔmfa nsa nnuru bɛboro dumien. Wɔn mu bi ni.
| Nyarewa kuw | Aduruyɛ tebea ne nkyerɛkyerɛmu a ɛnyɛ den |
|---|---|
| Koma ne mogya a ɛkɔ nipadua no mu |
|
| Nyarewa a ɛma obi ho hyehye no |
|
| Nyarewa a ɛwɔ ɔbarima awo nhyehyɛe mu |
|
| Ɔhome nhyehyɛe mu nyarewa |
|
Mfaso bɛn na ɛwɔ PDE Inhibitors so?
Saa aduru yi so wɔ mfaso kɛse wɔ aduruyɛ mu tebea horow bi a wɔsa mu. Nneɛma pii nti na ɛte saa.
- Ɛnyɛ den sɛ wode bedi dwuma: Nnuru yi wɔ ahorow pii. Wobetumi anya bi sɛ nnuru a wɔde di dwuma wɔ ano, nnuru a wɔde gu nipadua no so, ne nnuru a wɔde twitwiw nipadua mu. Ɛsɛ sɛ wɔnom nnuru bi da biara, bere a ehia nkutoo na wobetumi anom.
- Ayaresa a wɔde wɔn ani asi so: Sɛnea madi kan aka no, nnuru bi de wɔn ani si PDE pɔtee bi so, enti ɛnyɛ den koraa sɛ ɛde nsunsuanso a wɔmpɛ (nsunsuanso bɔne) bɛba nipadua no afã afoforo so. Ɛte sɛ nea aduru no yɛ adwuma wɔ baabi a yare no wɔ no pɛpɛɛpɛ.
- Mfaso pii a ɛwɔ aduru biako so: Ɛtɔ mmere bi a, tebea abien a ɛfa ho betumi aba onipa koro so. Sɛ nhwɛso no, prostatic hyperplasia a ɛnyɛ hu (BPH) ne erectile dysfunction (ED) nyinaa betumi abom aba. Wɔapene PDE-5 inhibitor tadalafil so sɛ wɔmfa nsa tebea abien no nyinaa. Saa ara na nnuru bi wɔ hɔ a ebetumi asa gout ne ntini mu yare a ɛbata ho no nyinaa.
Dɛn ne nnuru yi mu nsunsuanso bɔne ne asiane ahorow?
Nea ɛho hia sen biara ne sɛ ɛsɛ sɛ wɔnom nnuru yi nyinaa wɔ nnuruyɛfo afotu ase nkutoo. Nneɛma bɔne a ebetumi afi mu aba no betumi ayɛ soronko wɔ nnuru biara mu ne onipa biara mu.
Nneɛma atitiriw a efi mu ba no gyina PDE inhibitor ko a aduru no ka mu so.
| PDE Inhibitor Ɔkwan a Wɔfa so Yɛ | Nsunsuanso nketenkete ne nea ɛkɔ fam | Nneɛma bɔne a ebetumi afi mu aba (ka kyerɛ wo duruyɛfo ntɛm ara) . |
|---|---|---|
| PDE-3 Nneɛma a esiw ano (ɛka koma ne mogya ntini) . | Tiyɛ, mmerɛwyɛ, ɔfe, akisikuru, ɔfe, yafunu mu yaw, adwenemhaw, honam ani akisikuru. | Koma a ɛbɔ ntɛmntɛm (arrhythmia), koko mu yaw, mogya mmoroso a ɛba fam, mogya a ɛtɔ anaasɛ akuru a ɛyɛ soronko, mmerɛbo a ɛsɛe. |
| PDE-4 Nneɛma a esiw ano (ɛka ahurututu ne ɔfe) . | Mu duru a ɛso tew, akisikuru, ɔfe, akisikuru, ɔhome akwaa a ɛwɔ soro no mu yare, tiyɛ, nna a wontumi nna, ɔfe wɔ baabi a wɔde aduru no gu no. | Adwenemhaw a ɛwɔ hɔ dedaw a ɛyɛ kɛse, adwene a ɛne sɛ obekum ne ho, nkate a ɛboro so (a ɛyɛ yaw, ɛho ahonhon, akisikuru). |
| PDE-5 Nneɛma a Wɔde Siw Ano (ɛka nna mu ahoɔden a wontumi nna ne ahurututu mu mogya mmoroso) . | Tiyɛ, hwene a ɛyɛ mmerɛw, hwene a ɛyɛ mmerɛw, akyi yaw, ntini mu yaw, akisikuru, adwenemhaw, ne ebia hann a ɛyɛ bruu a wohu (bere tiaa mu). | Priapism: Ɔsɔretia a ɛyɛ yaw a ɛtra hɔ bɛboro nnɔnhwerew 4 a wɔmfa nna ho nkannyan biara nka ho. Eyi yɛ aduruyɛ mu asɛm a egye ntɛmpɛ. Nsakrae/aniso anaa aso a ɛyera mpofirim, mmerɛbo a ɛsɛe. |
| Nneɛma a Wɔde Siw Ano a Wɔnpaw Wɔn (sɛ nhwɛso no, caffeine, theophylline) . | Ahomegye, nna a wontumi nna, wosow, akisikuru, ɔfe, akisikuru, adwenemhaw, tiyɛ. | Koma a ɛbɔ ntɛmntɛm, koma a ɛbɔ ntɛmntɛm, koko mu yaw, akisikuru. |
Kɔkɔbɔ titiriw: Sɛ worenom aduru bi te sɛ nitroglycerin wɔ tɛkrɛma ase de ayɛ wo koko mu yaw, na wo koko mu yaw wɔ nnɔnhwerew 24 akyi bere a woanom aduru a esiw PDE-5 ano (e.g. Sildenafil, Tadalafil) a, kɔ ayaresabea dwumadibea a wɔhwɛ ntɛmpɛ so (ETU) ntɛm ara. Sɛ wɔka nnuru abien yi bom a, ebetumi ama mogya mmoroso akɔ fam wɔ ɔkwan a ɛyɛ hu so.
Hena na ɛnsɛ sɛ ɔnom saa aduru yi?
Wɔ nnipa binom fam no, ebia nnuru a wɔfrɛ no PDE inhibitors yi mfata esiane wɔn ayaresa tebea afoforo anaa nnuru afoforo a wɔnom nti. Yɛfrɛ saa nneɛma a ɛne ne ho nhyia yi . Eyinom ahorow abien na ɛwɔ hɔ:
1. Nneɛma a ɛne no bɔ abira koraa:
- Wɔ PDE inhibitor biara ho: Sɛ woadi kan anya aduru yi anaa nea ɛte saa ho adwenemhaw a emu yɛ den (hypersensitivity) a.
- Cilostazol ho: Sɛ wowɔ komayare biara a.
- Wɔ nnuru a esiw PDE-5 ano (te sɛ Sildenafil, Tadalafil): komayare a emu yɛ den, koko mu yaw a entumi nnyina (angina a entumi nnyina), komayare anaa ɔyare a ɛma obi hwe ase nnansa yi.
2. Nneɛma a ɛne ne ho bɔ abira a ɛfa ho:
- Wɔ nnuru a esiw PDE-5 ano ho: Sɛ worenom nitrates anaa alpha-blockers a, ɛsɛ sɛ wo ne wo duruyɛfo kasa efisɛ ebetumi ama wo mogya mmoroso akɔ fam wɔ ɔkwan a ɛyɛ hu so.
- Wɔ Cilostazol ho: Sɛ wowɔ mogyatɔw ho haw a.
- Wɔ Pentoxifylline ho: Sɛ mogya atu w’amemene anaa w’ani nnansa yi a.
Sɛ woanyinsɛn, worebɔ mmɔden sɛ wubenyinsɛn, anaa worema nufu a, bere nyinaa wo ne wo duruyɛfo nkasa ansa na woanom aduru biara. Adanse wɔ hɔ a ɛkyerɛ sɛ nnuru bi a esiw PDE ano betumi aka akokoaa no wɔ mmoa ho nhwehwɛmu mu.
Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn?
Sɛ wo yare no ho sɛnkyerɛnne sesa anaasɛ ɛka wo da biara da dwumadi ahorow a, ɛbɛyɛ papa sɛ wobɛka akyerɛ wo duruyɛfo. Nanso, sɛ wuhyia nea edidi so yi mu biara , kɔ ayaresabea anaa baabi a wɔhwɛ wɔn a wɔwɔ yare a egye ntɛmpɛ (ETU) ntɛm ara.
- Komayare ho sɛnkyerɛnne: koko mu yaw, ahome a ɛyɛ tiaa, fifiri, adwenemhaw, akisikuru.
- Priapism: Ɔsɔretia a ɛyɛ yaw a ɛtra hɔ bɛboro nnɔnhwerew 4 a wɔmfa nna ho nkannyan biara nka ho. Eyi betumi asɛe ade daa sɛ wɔansa no ntɛm a.
- Anisoadehu anaa aso a ɛyera mpofirim: Sɛ wuhu mpofirim, wunhu ade yiye, anaasɛ wote asɛm a, kɔ ayaresabea ntɛm ara. Sɛ wɔkyɛ a, ebetumi asɛe ade daa.
Nkrasɛm a Wɔde Kɔ Fie
- Phosphodiesterase inhibitors (PDE inhibitors) yɛ nnuru a mfaso wɔ so kɛse a ɛnyɛ nna mu ɔhaw nko na wɔde di dwuma, na mmom wɔde ma koma, ahurututu, honam ani, ne nkwaa mu nyarewa dodow bi nso.
- Ɛsɛ sɛ wɔnom nnuru yi nyinaa bere a oduruyɛfo akamfo akyerɛ nkutoo.Ka nyarewa foforo biara a wowɔ ne nnuru foforo biara a wonom ho asɛm kyerɛ wo duruyɛfo.
- Nsunsuanso bɔne betumi aba, enti hwɛ yiye ansa na woafi aduru no ase.
- Sɛ wo nya sɛnkyerɛnne a emu yɛ den te sɛ wo koko mu yaw, ahome a ɛyɛ tiaa a ɛkyɛ bɛboro nnɔnhwerew 4, anaasɛ wotumi hu ade/aso mpofirim a, kɔ Dwumadibea a Ɛho Hia Ntɛmntɛm (ETU) ntɛm ara.
- Saa aduru yi a wɔde di dwuma a oduruyɛfo nkyerɛw krataa, denam afoforo a wobebisa wɔn anaasɛ wobebisa wɔ nnurutɔnbea ahorow so no betumi de nea emu yɛ den aba, na ɛde nkwa mpo ato asiane mu.
💬 Comments (0)
Wɔnnya nyɛɛ nsɛm biara. Fa wo nsɛm no ka ho wɔ ha nea edi kan.
Fa wo nsɛm no ka ho