Momma yensua nnuru a wɔde ma komayare ne nna mu ɔhaw ahorow no ho ade? (Nnuru a Wɔde Siw Phosphodiesterase Ano) .

Ebia woahu obi wɔ w’abusua mu, ebia wo papa anaa wo papa nua barima, sɛ ɔrenom nnuru a wɔde sa komayare, mogya mmoroso, anaa ɔbarima ne ɔbea nna a ɛnyɛ den. Saa ara nso na nnuruyɛfo kyerɛw nnuru ahorow a wɔde sa honam ani nyarewa, ɔhome mu nyarewa te sɛ ayamtu, ne nea ɛkeka ho So wunim sɛ nnuru kuw bi a ɛho hia yiye wɔ hɔ a wɔde sa tebea horow yi pii? Saa nnuru kuw no, a ɛne Phosphodiesterase Inhibitors, ne nea yɛrebɛka ho asɛm wɔ asɛm yi mu nnɛ, wɔ ɔkwan tiawa ne nidi mu.

Sɛ yɛbɛka no tiawa a, dɛn ne saa Phosphodiesterase Inhibitors yi?

Ebia eyi bɛyɛ te sɛ edin a ɛyɛ den, nanso nokwarem no, ɛyɛ mmerɛw koraa. Eyinom yɛ nnuru ahorow bi a ɛboa ma mogya ntini a ɛwɔ yɛn nipadua mu no dwo na ɛtrɛw, na ɛma ɛyɛ mmerɛw sɛ ɛbɛkyinkyin. Sɛ mogya kɔ yiye a, wɔhwɛ mogya mmoroso nso so. Eyi nti na wɔde saa nnuru yi sa tebea horow pii, efi honam ani, nkwaa, koma, ne ahurututu mu haw ahorow so kosi nna mu ɔhaw ahorow so.

Ɔkwan bɛn so na saa aduru yi yɛ adwuma wɔ nipadua no mu?

Enzyme bi a wɔfrɛ no Phosphodiesterases (PDEs) wɔ yɛn nipadua mu . Sɛ yɛbɛka no tiawa a, enzymes te sɛ mmoa nketewa a ɛma nnuru kɔ yɛn nipadua mu ntɛmntɛm. Saa PDE enzymes yi ahorow pii wɔ hɔ. Wɔakan wɔn na wɔatetew wɔn mu. Nea ɛyɛ soronko ne sɛ wohu PDE enzyme biara wɔ mmeae pɔtee bi wɔ nipadua no mu.

Phosphodiesterase Inhibitors (PDE Inhibitors) yɛ adwuma denam PDE enzymes a yɛadi kan aka ho asɛm no dwumadi a esiw ano no so. Ɛte sɛ nea wɔato ɔpon bi mu. PDE Inhibitors binom de wɔn ani si enzyme biako pɛ so (a wɔpaw), bere a afoforo betumi aka PDE enzymes wɔ ɔkwan a ɛkɔ akyiri so (a ɛnyɛ nea wɔpaw).

Tebea atitiriw bɛn na wɔde aduru yi sa?

Wɔapene so sɛ nnuru yi ntumi nsa tebea horow bɛboro dumien. Momma yɛnhwɛ akuw atitiriw no bi.

Koma ne mogya a ɛkɔ nipadua no mu nyarewa

• Koma a entumi nyɛ adwuma yiye: Bere a koma no yɛ mmerɛw na entumi mfa mogya nkɔ nipadua no mu sɛnea ɛho hia no.
• Ahurututu mu mogya mmoroso: Mogya a ɛkɔ soro wɔ mogya ntini a ɛwɔ ahurututu mu no mu.
• Mogya a ɛkɔ akwaa no mu a ɛso tew (Peripheral artery disease - PAD): Mogya a ɛnnɔɔso, titiriw wɔ nan no mu.
• Mogya a ɛbɛtɔ wɔ oprehyɛn akyi a wobesiw ano: Mogya a ɛbɛtɔ wɔ oprehyɛn akyi no betumi de tebea horow a ɛyɛ hu te sɛ akisikuru, komayare, ne ahurututu mu ntini a ɛma mogya tu aba. Siw wɔn kwan.
• Thrombocythemia: Ntini mu nkwammoaa a ɛma mogya tu dodo, na ɛboa ma mogya tu.

Nyarewa a ɛma obi ho hyehye no wɔ honam ani ne nkwaa mu

• Eczema (Atopic dermatitis): Ɔfe, honam ani kɔkɔɔ a ɛyɛ yaw.
• Psoriasis: Honam ani ɔfe a nipadua no mu tumi a ɛko tia nyarewa a ɛyɛ adwuma boro so na ɛde ba.
• Psoriatic arthritis: Ntini a ɛyɛ hyew a ɛba bere a psoriasis ba no.

Nyarewa a ɛfa mmarima awo nhyehyɛe ho

• Benign prostatic hyperplasia: Prostate ntini a ɛho ahonhon esiane nneɛma a ɛnyɛ kokoram nti.
• Erectile dysfunction: Ɛyɛ den sɛ wobenya ɔbarima ne ɔbea nna.

Ɔhome nhyehyɛe mu nyarewa

• Chronic obstructive pulmonary disorder (COPD): Nyarewa kuw bi a ɛma ɛyɛ den sɛ wɔbɛhome.
• Neonatal apnea: Ɔhome mu haw a ɛba nkokoaa a wɔawo wɔn ntɛm so , titiriw wɔn a wɔwo wɔn ansa na wɔadi adapɛn 7.

Mfaso bɛn na ɛwɔ saa aduru yi so?

Mfaso pii wɔ nnuru yi a wɔde di dwuma so.

• Nneɛma a ɛfata: Eyinom yɛ nnuru a wɔnom, nnuru a wɔde gu nipadua no so, ne nnuru a wɔde twitwiw nipadua mu. Ɛsɛ sɛ wɔnom nnuru bi da biara, bere a ehia nkutoo na wobetumi anom.
• Ayaresa a wɔde asi wɔn ani so:Sɛnea yɛadi kan aka ho asɛm no, esiane sɛ wobetumi de ayaresa no asi PDE enzyme pɔtee bi nkutoo so nti, wobetumi atew nsunsuanso bɔne a wɔmpɛ so kɛse.
• Mfaso pii a ɛwɔ aduru biako so: Ɛtɔ mmere bi a, wobetumi de aduru biako asa nyarewa abien a ɛbom ba. Sɛ nhwɛso no, wobetumi ama obi a ne prostate ayɛ kɛse ne ne ho a ɛnyɛ den sɛ ɔbɛsɔre no nyinaa ayɛ PDE-5 inhibitor tadalafil . Saa ara nso na wɔde Apremilast sa psoriasis ne psoriatic arthritis nyinaa.

Momma yɛnhwɛ nsunsuanso bɔne ne asiane ahorow nso.

Te sɛ nnuru biara no, eyinom betumi de ɔhaw ahorow aba. Saa nsunsuanso bɔne yi gyina PDE inhibitor ko a worenom so titiriw.

Ase hɔ no yɛ nsunsuanso bɔne bi a ebetumi aba a ɛfa nnuru ahorow atitiriw no ho.

Bere bɛn na ɛnsɛ sɛ wonom saa aduru yi?

Saa aduru yi betumi ayɛ nea asiane wom ama nnipa binom. Sɛ wowɔ tebea horow a edidi so yi mu biara a, akyinnye biara nni ho sɛ ɛsɛ sɛ wo ne wo duruyɛfo kasa ansa na woanom saa aduru yi.

• Wɔ PDE inhibitor biara ho: Sɛ woadi kan anya aduru anaa ade biara ho adwenemhaw a emu yɛ den (hypersensitivity) a.
• Cilostazol (PDE-3): Sɛ wowɔ komayare biara a, wɔmfa eyi nkyerɛ.
• PDE-5 inhibitors: Ɛsɛ sɛ wokwati sɛ wobɛnom eyinom sɛ wowɔ komayare a emu yɛ den, woanya komayare anaa akisikuru nnansa yi, anaasɛ wowɔ angina a entumi nnyina a.
• Sɛ worenom nitrates , nnuru a esiw PDE-5 ano a wobɛnom no betumi ama wo mogya mmoroso akɔ fam dodo.
• PDE inhibitors bi (e.g. Cilostazol) mfata sɛ wowɔ mogyatɔw ho haw a.

Fa di dwuma bere a wonyinsɛn no

Sɛ woanyinsɛn anaasɛ woreyɛ nhyehyɛe sɛ wubenyinsɛn a, ebia ɛbɛyɛ nea nyansa wom sɛ wobɛkwati sɛ wobɛnom nnuru ahorow bi a esiw PDE ano. Kɔ wo duruyɛfo nkyɛn wɔ eyi ho.

Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn ntɛm ara?

Sɛ wuhu sɛnkyerɛnne bi a ɛyɛ soronko bere a wode aduru yi redi dwuma a, ɛbɛyɛ papa sɛ wobɛka akyerɛ wo duruyɛfo. Nanso, sɛ nea edidi so yi mu bi si a, kɔ ayaresabea bi Dwumadibea a Ɛhwɛ Nneɛma a Egye Ntɛmpɛ So (ETU) a ɛnntwentwɛn wo nan ase.

• Komayare ho sɛnkyerɛnne:Nneɛma te sɛ koko mu yaw, a ɛyɛ den, ahome a ɛyɛ den, fifiri, adwenemhaw, akisikuru.
• Priapism: Ɔsɔretia a ɛyɛ yaw a ɛtra hɔ bɛboro nnɔnhwerew 4 a wɔmfa nna ho nkannyan biara nka ho. Eyi yɛ tebea a ehia sɛ wɔsa no ntɛm ara.
• Aniwa anaa aso a ɛyera mpofirim/ɛtew: Ɛsɛ sɛ wɔsa eyinom ansa na asɛe daa.

Saa nnuru yi ho hia yiye, egye nkwa na ɛma asetra yɛ papa. Nanso ɛsɛ sɛ wɔnom bere nyinaa bere a oduruyɛfo akamfo akyerɛ ne dodow a wɔakyerɛw ama wɔn nkutoo.