So worehyia akuru wɔ baabi a ɛbɛn wo nkwaa? Momma yɛnka Tumoral Calcinosis ho asɛm!

So ɛtɔ mmere bi a wote nka sɛ wowɔ akisikuru anaa baabi a ɛyɛ den wɔ wo honam ani a ɛbɛn nkwaa bi te sɛ wo nsateaa, wo mmati, anaa wo kotodwe? Ebia sɛ womia so a, ɛrenyɛ yaw, nanso ebetumi ayɛ kɛse kakra. Ɛyɛ ade a ɛfata sɛ wobɛte ehu nka kakra bere a wuhu biribi a ɛte sɛɛ no. Nanso ɛnyɛ akuru yi nyinaa na ɛyɛ kokoram a asiane wom. Ɛnnɛ yɛbɛka tebea bi a ɛda saa nsɛnkyerɛnneɛ yi adi, nanso ɛnyɛ kokoram, na ɛntaa nsi kakra nanso ɛho hia sɛ yɛhunu ho asɛm. Ɛno ne ‘Tumoral Calcinosis’ .

Dɛn ne Tumoral Calcinosis?

Sɛ yɛbɛka no tiawa a, tumoral calcinosis yɛ awosu mu tebea . Eyi ne bere a nnuru bi a wɔfrɛ no phosphate dodow a ɛwɔ wo mogya mu no dɔɔso dodo. Phosphate yɛ ade ketewaa bi a anyinam ahoɔden wom, anaa ion, a phosphorus a ɛwɔ abo mu no wom. Enti, wɔ obi a ɔwɔ tumoral calcinosis mu no, phosphorus ne calcium nyinaa boaboa ano wɔ nipadua no mu, na ɛma akisikuru ba honam ani, titiriw wɔ nkwaa no ho.

Phosphorus ne calcium nyinaa ho hia ma yɛn nipadua na ama yɛanya sẽ ne nnompe a ɛyɛ den na ɛyɛ den. Nanso sɛ ɛkɔ soro dodo a, nyini a ɛnyɛ kokoram (a ɛnyɛ papa), kyerɛ sɛ, ɛnyɛ nea asiane wom, nanso ɛte sɛ akisikuru, fi ase ba ntini ahorow no mu. Eyi ne nea yɛfrɛ no tumoral calcinosis.

So edin foforo bi wɔ hɔ a wɔde frɛ eyi?

Yiw, aduruyɛ mu din a wɔde frɛ tebea yi nyinaa ne ‘Hyperphosphatemic Familial Tumoral Calcinosis’ (HFTC) . Edin tenten kakra, ɛnte saa? Nnuruyɛfo binom nso frɛ no ‘Teutschlaender yare’. Ɛno ne sɛ yɛbɛkae Otto Teutschlaender, Germanni oduruyɛfo bi a ɔyɛɛ saa yare yi ho nhwehwɛmu fi 1930 mfe no mu kosi 1950 mfe no mu.

Dɛn na aduruyɛ mu din tenten yi kyerɛ?

So yɛbɛkyekyɛ din yi mu asinasin na yɛate ase? Ɛno bɛyɛ mmerɛw.

• Hyperphosphatemic: Eyi kyerɛ sɛ phosphate dodow a ɛwɔ mogya no mu no dɔɔso.
• Abusua: Eyi kyerɛ sɛ eyi yɛ tebea a ɛkɔ so wɔ mmusua mu na efi awosu mu.
• Tumoral: Wɔde asɛmfua yi di dwuma efisɛ saa nyinsɛn a ɛte sɛ akisikuru yi te sɛ kokoram akisikuru.
• Calcinosis: Eyi kyerɛ sɛ calcium kɔhyɛ wo ntini ne wo ntini ne nnompe nhyehyɛe no mu.

So wote nea saa din tenten no kyerɛ ase mprempren?

Ɔkwan bɛn so ankasa na Tumoral Calcinosis ka nipadua no?

Saa akuru yi a wɔfrɛ no tumoral calcinosis , taa ba wɔ honam ani, wɔ baabi a ɛbɛn nkwaa no . Wotumi nyin wɔ nkwaa bɛboro biako mu, nanso wotumi nyin wɔ nkwaa pii mu nso. Mmeae a wɔtaa yɛ ne:

• Hip nkwaa
• Nsateaa a wɔde yɛ nsateaa
• Mmati so
• Aseɛ
• Nsateaa nkwaa
• Akyi berɛmo a ɛfa akyi berɛmo ho
• Jaw mpɔtam hɔ

Saa tebea yi abu so dɛn?

Aduruyɛ ho abenfo nnim nnipa dodow pɔtee a wɔwɔ saa akisikuru calcinosis yi. Because it's a very rare condition , ɛtaa ba nnipa a wofi Afrika ne Mfinimfini Apuei mu. Ebetumi aka mmarima ne mmea nyinaa.

Dɛn ne Tumoral Calcinosis ahorow atitiriw?

Eyi a ɛtaa ba ne Hyperphosphatemic Familial Tumoral Calcinosis, a yɛadi kan aka ho asɛm no. Nea ɛka ho no, ahorow afoforo a wɔntaa nhu wɔ hɔ:

• - ‍ `(Hyperphosphatemia-hyperostosis syndrome - HHS)`: .
• Normophosphatemic tumoral calcinosis: Wɔtaa hu saa ɔkwan yi wɔ nnipa a wɔn asaabo ntumi nyɛ adwuma yiye no mu. Ebetumi de tebea bi a wɔfrɛ no hyperparathyroidism a ɛyɛ parathyroid ntini a ɛyɛ adwuma boro so aba.

Dɛn na ɛde Tumoral Calcinosis ba?

Tumor calcinosis yɛ nipadua mu nneɛma a ɛsakra a wonya fi awo mu . Nnipa a wɔwɔ saa tebea yi mu bɛyɛ nkyem abiɛsa mu biako wɔ nsakrae, anaa nkwaadɔm mu nsakrae, wɔ wɔn FGF23 awosu mu abɔde mu. FGF23 awosu mu abɔde no boa yɛn nnompe nkwammoaa ma wɔyɛ protein bi a wɔfrɛ no fibroblast growth factor (FGF) 23. Nnipa binom nso wɔ tebea no esiane nsakrae a ɛba GALNT3 ne KL awosu mu nkwaadɔm mu nti. Saa awosu mu nkwaadɔm yi na ɛhwɛ FGF23 a wɔyɛ so. Nnipa a wɔwɔ nomophosphatemic tumor calcinosis no wɔ nsakrae bi wɔ SAMD9 awosu mu abɔde mu.

Mpɛn pii no, protein `FGF23` na ɛkyerɛ yɛn asaabo phosphate dodow a ɛsɛ sɛ ɛsan twetwe fi mogya no mu. Nanso sɛ awosu mu nsakrae bi ba a, saa adeyɛ yi kɔ yiye. Afei asaabo no san twetwe phosphate pii sen sɛnea ɛsɛ sɛ ɛyɛ. Mpɛn pii no, asaabo no yi phosphate a ɛboro so fi nsu no mu. Nanso wɔ akisikuru mu calcinosis mu no, saa phosphate yi kyekyere calcium na ɛyɛ akisikuru wɔ ntini a ɛyɛ mmerɛw no mu.

Hena na ɔwɔ asiane mu sɛ obenya saa tebea yi?

Tumorous calcinosis yɛ yare a ɛma nipadua no tumi kɔ nipadua no mu . Ɛyɛ den kakra sɛ wobɛte eyi ase, nanso sɛ yɛbɛka no tiawa a, sɛ wubenya yare no a, ɛsɛ sɛ wunya awosu mu nkwaadɔm mu nsakrae no fi w’awofo baanu no nyinaa hɔ. W’awofo betumi ayɛ wɔn a wɔde nkwaadɔm mu nsakrae no ba, nanso ebia wonni yare no.

Sɛ awofo baanu no nyinaa yɛ asoafo a, wɔn mma no mu biara wɔ hokwan ahorow a edidi so yi:

• Hokwan wɔ 4 biara mu 1 sɛ onni awosu mu abɔde a wɔayɛ no foforo no (asiane biara nni hɔ sɛ obenya yare no).
• Hokwan wɔ 4 biara mu 1 sɛ obenya tumoral calcinosis.
• Hokwan wɔ 2 biara mu 1 sɛ obi a ɔde yare no kɔ so a onnya yare no.

Dɛn ne Tumoral Calcinosis ho sɛnkyerɛnne ahorow?

Saa tebea yi ma akuru a ɛsono ne kɛse ba baabi a ɛbɛn nkwaa biako anaa nea ɛboro saa. Saa akuru yi taa pue wɔ mmofraase anaa mmerantebere ne mmabaabere mu . Nanso, wobetumi anya nkɔso wɔ nkokoaa ne mpanyimfo a wɔn mfe akɔ anim nso mu. Ɛtɔ mmere bi a, akuru kakraa bi pɛ na ɛba wɔ nkwa nna nyinaa mu. Anaasɛ, ebia akuru pii bɛba prɛko pɛ.

Ebia wubenya yare no ho sɛnkyerɛnne te sɛ eyinom:

• Ɛyɛ den sɛ wobɛkanyan nkwaa a asɛe no anaasɛ wobɛbɔ no yiye.
• Nkuruwa a ɛyɛ den a ɛnyɛ yaw (akuru bi betumi ayɛ yaw kakra sɛ woka a).
• Ntini ne nnompe mu ɛyaw.

Ɔkwan bɛn so na wohu Tumoral Calcinosis?

Nnompe ho oduruyɛfo yɛ oduruyɛfo a ne ho akokwaw wɔ nnompe ne nkwaa mu haw ahorow mu. Ɔbɛhwehwɛ wo mu na wabisa wo yareɛ no ho sɛnkyerɛnne. Afei obetumi ayɛ X-ray ahorow a edidi so yi mu biako anaa nea ɛboro saa de ahwehwɛ saa akisikuru yi ne nnompe mu haw afoforo:

• X-ray nhwehwɛmu `(X-ray)`
• CT scan a wɔde yɛ adwuma
• MRI scan `(MRI)`

Tebea afoforo bɛn na ɛkyerɛ sɛnkyerɛnne a ɛte sɛ Tumoral Calcinosis?

Eyi ho hia paa. Efisɛ ɛho hia sɛ wonya yare no ho nhwehwɛmu a ɛteɛ . Nea enti a ɛte saa ne sɛ tebea afoforo wɔ hɔ a ɛda sɛnkyerɛnne a ɛte saa ara adi, nanso ɛyɛ aniberesɛm kɛse. Tebea horow yi bi ne:

• Ntini a ɛyɛ mmerɛw a ɛnyɛ hu ne ntini a ɛyɛ mmerɛw a ɛyɛ hu
• Calcific myonecrosis (akisikuru a ɛma calcium a ɛwɔ nan ntini mu) .
• Calcific tendonitis (calcium a ɛwɔ ntini mu a ɛka ho) .
• Calcinosis circumscripta (calcium a ɛwɔ honam ani ne nsa ne nan ntini mu) .
• Calcinosis a ɛma asaabo (asaabo) a entumi nyɛ adwuma yiye (calcium a ɛwɔ nnipa a wɔreyɛ dialysis mu) .
• Calcinosis universalis (calcium nkyene a ɛba honam ani, ntini, ntini, ne ntini mu) .
• Ntini a ɛka bom yɛ nyarewa
• Gout
• Myositis ossificans (ntini a ɛdannan dompe) .
• Osteosarcoma ne sarcoma (nnompe mu kokoram) .
• Synovial chondromatosis (ntini a ɛwɔ nkwaa mu) .

Hwɛ? Ɛwom mpo sɛ sɛnkyerɛnne ahorow no yɛ pɛ de, nanso nea ɛde ba no betumi ayɛ soronko koraa. Ɛno nti na ɛho hia sɛ wuhu nea ɛrekɔ so ankasa no.

Dɛn ne ayaresa ahorow a ɛnyɛ oprehyɛn?

Ebia wo duruyɛfo bɛtew phosphate dodow a ɛwɔ wo mogya mu no so.Wobetumi akyerɛw nnuru a ɛkyekyere phosphate. Sɛ wɔde nnuru a ɛkyekyere phosphate yi ka aduru bi a wɔfrɛ no acetazolamide (a wɔtaa de di dwuma ma akisikuru ne atiridiinini) ho a, ebetumi asiw nipadua no tumi a ɛtwetwe phosphorus no ano. Ebia ɛho behia nso sɛ wudi aduan a phosphorus nnim .

Dɛn ne aduan a phosphorus nnim?

Sɛ wowɔ tumoral calcinosis a, ebia wo duruyɛfo bɛkamfo aduan a phosphorus nnim akyerɛ wo. Phosphorus fi awosu mu wɔ nam, mpataa, ne nufusu mu nneɛma mu. Wɔde phosphorus nso ka nnuan afoforo bi ho sɛ ade a ɛkora so anaasɛ ɛma ɛyɛ dɛ.

Bɔ mmɔden sɛ wobɛtew nnuan ne anonne a phosphorus pii wom te sɛ:

• Beer, colas, ice tea ne chocolate a wɔnom.
• Chocolate ne caramel ahorow ahorow.
• Nufusu mu nnuan (nufusu, kyiisi, ice cream, yogurt a ɛnyɛ Helafo, soup a wɔde cream ayɛ).
• Po mu nnuan te sɛ oysters ne sardines, ne emu akwaa te sɛ nantwinam ne akokɔ mmerɛbo.
• Nam a wɔayɛ (hot dogs, awia nam, bacon, soseji).
• Nneɛma a wɔde oat bran na ɛyɛ.

Ɛyɛ papa sɛ wo ne wo duruyɛfo anaa aduannuru ho ɔbenfo bɛkasa afa eyi ho na woanya nsɛm pii.

Dɛn ne oprehyɛn ayaresa ahorow no?

Ebia ebehia sɛ wɔyɛ wo oprehyɛn de yi akisikuru a ɛsõ dodo sɛ ɛbɛyɛ adwuma yiye no afi hɔ. Nanso, ɛda adi sɛ saa akisikuru yi bɛsan anyin . Wo duruyɛfo nso betumi afa ntini a wɔayi afi mu no bi na wayɛ biopsy de akyerɛ sɛ woahu sɛ ɔwɔ yare no.

Dɛn ne nsɛnnennen a ebetumi afi Tumoral Calcinosis mu aba?

Ɛntaa mma sɛ saa tebea yi betumi aka wo mogya ntini anaa w’amemene, na ama asiane a ɛwɔ hɔ sɛ wubenya akwahosan ho haw a emu yɛ den te sɛ komayare ne ɔyare a ɛma obi hwe ase no ayɛ kɛse.

Nea ɛka ho no, saa tebea yi nso betumi de nea edidi so yi aba:

• Aniwa mu calcifications anaa angioid streaks (red streaks) wɔ aniwa no mu.
• Nsõ ho haw ahorow.
• Nnompe a enyin dodo (hyperostosis).
• Nnompe atenten (diaphysis) a ɛwɔ wo nan anaa wo nsa mu a ɛyɛ hyew.

So wobetumi asiw Tumoral Calcinosis ano?

Sɛ wo ne wo hokafo nyinaa wɔ awosu mu nkwaadɔm mu nsakrae a ɛde akisikuru mu calcinosis ba a, wubetumi ne awosu mu ɔfotufo bi akasa afa akwan a wobɛfa so atew asiane a ɛwɔ hɔ sɛ wo mma benya mutation no afi awo mu no ho. Nnipa binom paw ɔkwan bi a wɔfrɛ no Preimplantation Genetic Diagnosis (PGD) . Nea ɛka eyi ho ne sɛ wobehu nkwaboaa a enni mutation no. Afei wo duruyɛfo de ɔkwan bi a wɔfrɛ no In Vitro Fertilization (IVF) di dwuma de nkwaboaa a ɛte apɔw no kɔ ɔbea no awo nhyehyɛe mu. Sɛ woyɛ saa adeyɛ yi a, wo ba no rennya awosu mu nkwaadɔm mu nsakrae a ɛde yare no ba no.

Dɛn ne obi a ɔwɔ Tumoral Calcinosis no anidaso?

Nnipa dodow no ara a wɔwɔ tumoral calcinosis no tra ase a ɛyɛ nnam na wɔyɛ nnam . Tebea no ntaa mfa akwahosan ho haw a emu yɛ den mma. Nanso, ɛho behia sɛ wokɔ wo duruyɛfo nkyɛn daa kɔhwɛ sɛ ebia ɛsan ba bio anaa.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Sɛ wowɔ saa sɛnkyerɛnne ahorow yi a, kɔ oduruyɛfo nkyɛn:

• Sɛnea nkwaa bi tumi keka ne ho no so tew.
• Nkwaa mu yaw, nnompe mu yaw, anaa ntini mu yaw.
• Akisikuru anaa akisikuru bi a ɛda adi wɔ honam ani.

Dɛn na ɛsɛ sɛ mibisa me duruyɛfo?

Wubetumi abisa oduruyɛfo no nsɛm te sɛ eyinom:

• Dɛn nti na minyaa tumoral calcinosis?
• Dɛn ne ayaresa a eye sen biara ma me?
• So ɛsɛ sɛ wɔyɛ me oprehyɛn?
• Nnuan ahorow bɛn na ɛsɛ sɛ metew so?
• So ɛsɛ sɛ nsɛnnennen a ɛbɛba no haw me?
• So ɛsɛ sɛ wɔyɛ m’abusua mufo a aka no awosu mu nhwehwɛmu?

So Tumoral Calcinosis betumi ayɛ Kokoram?

Ɛmfa ho asɛmfua "akisikuru" wɔ din no mu no, akisikuru a ɛba esiane akisikuru mu calcinosis nti no nyɛ kokoram ankasa . Asiane biara nni hɔ sɛ saa akisikuru yi bɛyɛ nea ɛyɛ hu. Enti mma ɛnhaw wo wɔ ho.

Ɛyɛ nokware sɛ akisikuru a ɛwɔ honam ani esiane akisikuru calcinosis nti no betumi ayɛ nea ɛnyɛ dɛ kakra na ɛyɛ hu. Nanso wɔ nnipa dodow no ara fam no, saa akisikuru yi mfa ɔhaw kɛse biara mma. Nnuru betumi ama phosphorus dodow a ɛwɔ mogya no mu no so atew. Ebia wo duruyɛfo nso bɛkamfo akyerɛ sɛ kɔ aduannuru ho ɔbenfo nkyɛn na waboa wo ma woadi aduan a phosphorus nnim. Sɛ ɛyaw wɔ wo nkwaa, wo nnompe, anaa wo ntini mu a ɛmma wuntumi nkɔ baabiara a, ka kyerɛ wo duruyɛfo. Ɛwom mpo sɛ wobetumi de oprehyɛn ayi akisikuru no afi hɔ de, nanso ma ɛntra w’adwenem sɛ ebetumi asan aba.

Nkrasɛm a Wɔde Kɔ Fie (Nneɛma a Ɛsɛ sɛ Wokae) .

Okay, enti momma yɛnsan nsusuw nsɛm a ɛho hia sen biara a yɛkaa ho asɛm nnɛ a ɛfa Tumoral Calcinosis ho no ho asɛm:

• Eyi yɛ tebea a ɛntaa nsi, a wonya fi awo mu. Phosphate dodow a ɛkɔ soro wɔ mogya no mu no ma ɛne calcium bom yɛ akuru wɔ baabi a ɛbɛn nkwaa no.
• Saa akisikuru yi nyɛ kokoram .
• Eyinom ntaa nyɛ yaw, nanso ebetumi asiw nkwaa no kwan.
• Nea ɛka ayaresa ho ne nnuru a ɛma phosphate so tew, aduan a phosphorus nnim, ne sɛ ɛho hia a, oprehyɛn.
• Sɛ wuhu akuru a ɛte sɛɛ a, mma wo ho nnpopo na hwehwɛ aduruyɛ mu afotu. Nhwehwɛmu a ɛteɛ a wɔde hu yare no ho hia yiye.
• Nnipa pii de tebea yi tra ase sɛnea ɛsɛ, na wɔyɛ nnam.

Enti, sɛ wo anaa obi a wunim no wɔ saa sɛnkyerɛnne ahorow yi a, ɛbɛyɛ papa sɛ wobɛkɔ oduruyɛfo nkyɛn akɔhwehwɛ afotu.

` Tumorous calcinosis, nkwaa mu cysts, phosphate, calcium, awosu mu nyarewa, honam ani ntini, nnompe mu nyarewa