POEMS Syndrome ye mun ye? Yala e fana b’a fɛ ka o ko dɔn wa?

Yala aw delila ka POEMS Syndrome ko mɛn wa? Nin ye bana ye min man teli ka mɛn, a man teli ka mɛn. Nka, a nafa ka bon ka dɔɔni dɔn a ko la barisa a bɛ se ka nɔ bila an farikolo sigida caman na siɲɛ kelen. N’an y’a fɔ cogo nɔgɔman na, o ye bana gɛlɛn ye min ni an joli bɛ tali kɛ ɲɔgɔn na. Bi, an bɛna kuma POEMS Syndrome ye min ye, a taamasiɲɛw ye mun ye, a bɛ sɔrɔ cogo min na, ani ni furakɛli bɛ yen.

POEMS Syndrome ye mun ye tigitigi?

Okey, an k’a lajɛ POEMS Syndrome ye mun ye. Nin ye jolilabana ye min man ca tiɲɛ na. Jolikisɛ sugu dɔ bɛ an fari la min bɛ wele ko plasma cellules. Ni POEMS syndrome (POEMS syndrome) kɛra, o joli-sira-funu-banakisɛw bɛ tila ka caya cogo la min tɛ bɛn, u tɛ se ka kunbɛn. O joli-sira-funu-banakisɛ minnu tɛ cogo la, olu bɛ farikolojɔlifɛn kɛrɛnkɛrɛnnen dɔ bɔ an joli la. A bɛ fɔ a ma ko protéine monoclonale, walima M-protéine ni a surunyalen don. Sisan, i bɛ se ka miiri, tiɲɛ tɛ? Ni o joli-sira-funu-banakisɛ minnu tɛ cogo la, n’olu ye M-protéine ye, olu cayara kojugu joli la, o bɛ se ka an farikolo ni an kɔnɔnafɛnw tiɲɛ.

POEMS tɔgɔ bɔra bana in taamasiɲɛba duuru la sɛbɛn fɔlɔw la:

• P - Polyneuropathie : O bɛ tali kɛ farikolo fan bɛɛ la farikolo yɔrɔw tiɲɛni na. POEMS kɔnɔ, o tiɲɛni bɛ se ka dimi walima dusukunnata wɛrɛw lase i ma (i n’a fɔ kirinni, jeninida, a ɲɔgɔnnaw) i senw, i bolokɔniw, i senkɔniw ani i bolow la.
• O - Organomegaly : O kɔrɔ ye ko kɔnɔnafɛnw bɛ bonya cogo la min tɛ bɛn. POEMS bɛ mɔgɔ min na, o tigi farikolo yɔrɔw bɛ se ka bonya i n’a fɔ sugunɛ, ɲɛgɛnɛsira ani ɲɛgɛnɛsiralabanaw.
• E - Endocrinopathie : N’an y’a fɔ cogo nɔgɔman na, nin ye ɔrimɔni gɛlɛya ye. POEMS kɔnɔ, an ka kɔnɔnatumuw bɛ ɔrimɔni hakɛ min bɔ, o bɛ se ka kɛ fɛn ye min tɛ bɛn. Ɔrimɔni dɔw bɛ se ka bɔ ka tɛmɛ walima ka caya.
• M - Protéine monoclonal (M-protéine): Nin ye farikolojɔlifɛn kɛrɛnkɛrɛnnen ye min bɛ lajɛ joli la POEMS kɔnɔ. Ni joli-sira-funu kelen ye a yɛrɛ kopi (klon) caman dilan, o farikolokisɛ kelen-kelen bɛɛ bɛ o M-poroteyini fara joli kan. A laban na, M-protéine hakɛ bɛ caya joli la.
• S - Fari yeli : POEMS bɛ mɔgɔ minnu na, olu bɛ se ka fari yeli suguya caman sɔrɔ, i n’a fɔ fari dibi ani fari bonya.

POEMS bana bɛ wele fana ko koloci , Crow-Fukase bana , PEP bana , ani Takatsuki bana .

Jɔn de ka teli ka kɛ ni POEMS syndrome ye?

POEMS syndrome ye bana ye min man ca kosɛbɛ. A bɛ mɔgɔ damadɔ dɔrɔn de minɛ diɲɛ kɔnɔ. A ka teli ka ye mɔgɔw la minnu si bɛ san 50 ni san 60 cɛ.A bɛ se ka cɛ ni muso fila bɛɛ minɛ, nka a bɛ i n’a fɔ a ka ca cɛw la.

POEMS ka bana taamasiɲɛw ye jumɛnw ye?

I n’a fɔ an y’a Fɔ cogo min na ka Tɛmɛ, sɛbɛnni minnu bɛ POEMS tɔgɔ la, olu bɛ taamasiɲɛba dɔw Jira. O kɔrɔ ye ko Polineuropathie, Organomegaly, Endocrinopathie, M-protéines (M-protéines) jiginni, ani fari caman cili ye a taamasiɲɛw ye. POEMS bɛ mɔgɔ minnu na, a bɛ se ka fɔ ko olu bɛɛ bɛ ni polineuropathie ni M-protéines elevation ye. Taamasiɲɛ wɛrɛw bɛ se ka ɲɔgɔn ta mɔgɔ kelen-kelen bɛɛ la.

Taamasiɲɛ minnu bɛ sɔrɔ polineuropathie fɛ

Taamaʃyɛn minnu bɛ sɔrɔ o nɛrɛmuguma tiɲɛni fɛ, olu de ka ca POEMS la. A ka ca a la, dimi bɛ kɛ senw ni senw de la kosɛbɛ. Nka tuma dɔw la, a bɛ se ka nɔ bila bolokɔniw ni bolow la. Aw bɛ se ka kɛ cogo min na ni nin bana in bɛ aw la, o filɛ nin ye:

• Fɛgɛnya
• Tingling (Dɔgɔtɔgɔninjɛ).
• Ɲɛgɛnɛsiraw
• Prickling / Pins-and-needles (sɔgɔsɔgɔninjɛ) sɔgɔsɔgɔninjɛ
• Jeni bɛ kɛ a la

Organomegaly - kɔnɔna yɔrɔw bonya

Dɔgɔtɔrɔw bɛ ja lajɛcogo minnu kɛ, olu bɛ se k’a dɔn ni nin farikolo yɔrɔ ninnu bonyalen don:

• Sugunɛ (Sugunɛ - `(Sugunɛbilenni)`)
• Ɲɛgɛnɛsiraw (Splenomegaly) .
• Nɔgɔsɔgɔninjɛ (Lymph nodes - `(Lymphadenopathie)`)

Endocrinopathie - ɔrimɔni gɛlɛyaw

Ɔrimɔni gɛlɛyaba min bɛ na ni POEMS ye, o ye cɛnimusoya ɔrimɔni hakɛ dɔgɔyali ye. O cɛnimusoya hormones ninnu bɛ wele ko ``Testosterone`` cɛw la ani ``Estrogen`` musow la. Ka fara o kan, aw bɛ se ka bana taamasiɲɛw ye i n’a fɔ:

• Gɛlɛya minnu bɛ sukaro hakɛ kunbɛnni na (misali la, sukarodunbana) .
• Ɲɛgɛnɛsiraw gɛlɛyaw (misali la, sɔgɔsɔgɔninjɛ dɔgɔyali) .
• Addison ka bana (Adrenal insufficience - `(Addison ka bana)`)

Cɛw bɛ se ka den sɔrɔli dɔgɔya ani ka sin bonya (Gynecomastia).

Musow ta la , kalolabɔ bɛ se ka jɔ (`(Amenorrhea)`), sinw bɛ se ka bonya. Kɔnɔmaya waati, ɔrimɔni `(Prolactin)`, min bɛ dɛmɛ don nɔnɔ bɔli la, o bɛ se ka bɔ ka tɛmɛ. O la, a bɛ se ka kɛ nɔnɔ bɛ bɔ sinbara la hali ni aw kɔnɔma tɛ.

M-Protéine (M-Protéine) cayalenba

POEMS ka ko jɔnjɔn dɔ ye M-protéine hakɛ caya ye joli la. O M-protéine tɛmɛnen bɛ se ka kɛ sababu ye ka kurukuruw sɔrɔ joli la. Ani fana, ka da M-protéine hakɛ caman kan, awKolow bɛ se ka bonya ani ka gɛlɛya (kolo sɔgɔsɔgɔninjɛ) .

Fari bɛ yɛlɛma

Yɛlɛma suguya caman bɛ se ka kɛ fari la, i n’a fɔ:

• Fari min ka di
• Fari min ka bon
• Boloci finmanw
• Dɔ farala kunsigi falen kan aw ɲɛda ni aw senw na
• Joli siraw falenni minnu bɛ i n’a fɔ seri misɛnniw disi fari la

Taamasiɲɛ wɛrɛw

Ka fara o kan, taamasiɲɛ wɛrɛw bɛ se ka ye:

• Bolo ni senw fununi
• Kisɛya dɔgɔyali kun tɛ
• Dimi bɛ kɛ kolotugudaw ni kolotugudaw la
• Yeli gɛlɛyaw
• Ninakili gɛlɛya
• Sɛgɛn
• Farigan

POEMS bana bɛ mɔgɔ dɔw la fana, bana dɔ bɛ se ka kɛ u la min bɛ wele ko Castleman Disease (CD), o bɛ ɲɛgɛnɛsiralabanaw minɛ. Ni Castleman bana taamasiɲɛw bɛ aw la, aw ka dɔgɔtɔrɔ fana bɛ se ka sigasiga POEMS la.

Mun de bɛ POEMS ka bana bila mɔgɔ la?

Ni POEMS bɛ aw la, aw bɛ taamasiɲɛ ni nɔ suguya caman sɔrɔ ka a sababu kɛ joli-sira-funu-banakisɛ kelen ye . N’an y’a fɔ cogo nɔgɔman na, joli-sira-funu-banakisɛ min tɛ cogo la, o bɛ a yɛrɛ kopi caman dilan. Ni o farikolokisɛw ka ca, u bɛ se ka tiɲɛni caman kɛ farikolo yɔrɔw la. O farikolokisɛw bɛ M-protéine fara joli kan, o bɛ kɛ sababu ye ka M-protéine hakɛ caya joli la. O farikolokisɛw ni M-poroteyini tɛmɛnenw de bɛ farikolo ka sigida suguya caman tiɲɛ.

Nka, dɔnnikɛlaw t’a dɔn hali bi tigitigi mun na o joli-sira-funu-kɔnɔ-fɛnw bɛ daminɛ ka bonya cogo la min tɛ cogo la fɔlɔ.

Sɛgɛsɛgɛlikɛlaw y’a ye ko farikolojɔlifɛn dɔ bɛ se ka kɛ a la min bɛ wele ko Vascular Endothelial Growth Factor (VEGF) . POEMS banakisɛ bɛ mɔgɔ minnu na, olu fanba ka VEGF hakɛ ka ca u joli la. Sɛgɛsɛgɛli bɛ senna hali bi jɛɲɔgɔnya min bɛ VEGF ni POEMS ka bana cɛ.

POEMS ka bana bɛ sɔrɔ cogo di? (Sɛgɛsɛgɛli) .

Aw ka dɔgɔtɔrɔ bɛna aw ɲininka fɔlɔ aw ka furakɛli tariku ni a taamasiɲɛw la sisan. O kɔfɛ, u bɛna farikoloɲɛnajɛ kɛ walasa ka POEMS ka bana taamasiɲɛw lajɛ.

Ka fara o kan, dɔgɔtɔrɔ bɛ se ka sɛgɛsɛgɛli caman fana kɛ, i n’a fɔ:

• Joli ni sugunɛ sɛgɛsɛgɛli : Nin sɛgɛsɛgɛli ninnu bɛ se ka dɛmɛ don ka a lajɛ ni M-protéine walima VEGF hakɛ caman bɛ aw joli walima sugunɛ na. U bɛ se fana ka a lajɛ ni joli kuru hakɛ tɛ kelen ye walima ni joli kuru minnu bɛ i n’a fɔ a tɛ kelen ye. Olu bɛ Se ka Kɛ POYI taamaʃyɛnw ye.
• Jala sɛgɛsɛgɛliw : Sɛgɛsɛgɛliw i n’a fɔ X-ray ni CT scans, olu bɛ se k’a jira ni aw kolotugudaw ka bon walima ni u gɛlɛyara. O fɛn caman bɛ se ka kɛ ni M-poroteyini hakɛ cayara.
• Kolotuguda biyopisi : O bɛ se k’a dɔn ni joli segin furakisɛw bɛ aw kolotugudaw la minnu ɲɛ tɛ kelen ye, walima ni joli segin furakisɛw hakɛ ka ca kojugu.
• Elektɔromiyɔgramu (EMG): EMG ye sɛgɛsɛgɛli ye min bɛ farikolo yɔrɔw baara jateminɛ. A bɛ se ka dɔgɔtɔrɔ dɛmɛ ka farikolojidɛsɛbana sɛgɛsɛgɛ.

Ka kɛɲɛ ni aw ka bana taamasiɲɛw ye, aw ka dɔgɔtɔrɔ bɛ se ka sɛgɛsɛgɛli wɛrɛw fana kɛ, i n’a fɔ ninakili sɛgɛsɛgɛli, dusukun tantanni sɛgɛsɛgɛli, walima kɔnɔnatumuw sɛgɛsɛgɛli.

Ni a sɔrɔla ko bana dɔ bɛ aw la min bɛ wele ko Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , aw ka dɔgɔtɔrɔ bɛ se ka aw sɛgɛsɛgɛ fana walasa ka a dɔn ni POEMS syndrome bɛ aw la.

POEMS ka bana bɛ furakɛ walima ka furakɛ cogo di?

Fura tɛ yen min bɛ wele ko POEMS syndrome. Nka, furakɛlicogo bɛ se ka dɛmɛ don ka bana taamasiɲɛw kunbɛn ani ka u kunbɛn. Furakɛli suguya dɔw ye:

• Fiɲɛ furakɛli: O ye ka fiɲɛ hakɛ caman bila joli la farikolokisɛw la minnu tɛ cogo la walasa k’u tiɲɛ.
• Simifura : Kansɛrifura minnu bɛ wele fana ko ``Sikimiyɔmu'', olu bɛ kɛ ka joli segin furakisɛw faga walima ka u bonya sumaya. POEMS ka chimiothérapie ni miyɛloma caman furakɛli bɛ tali kɛ ɲɔgɔn na. Nin furakɛli ninnu nafa ka bon kosɛbɛ wa a ka ca a la u tɛ kɔlɔlɔ jugumanw lase mɔgɔ ma.
• Autologous stem cell transplant: Nin wale in bɛ aw ka joli segin furakisɛ kɛnɛmanw bila u nɔ na. Stem cellules ye farikolokisɛw ye minnu bɛ yiriwa ka kɛ selilu kɔgɔlenw ye i n’a fɔ joli-sira-funu. Nin jiginni in na, aw ka dɔgɔtɔrɔ bɛ fɔlɔ ka jirisun kɛnɛman dɔw bɔ aw fari la. O kɔfɛ, u bɛ chimiothérapie walima radiation therapy kɛ ka joli segin furakisɛw tiɲɛ minnu tɛ cogo la. Furakɛli kɔfɛ, jirisun minnu bɔra, olu bɛ segin ka don aw fari la. O kɔfɛ, u bɛ bonya ka kɛ joli-sira-funu kɛnɛmanw ye.
• Farikoloɲɛnajɛ : Ni taama ka gɛlɛn aw ma ka a sababu kɛ farikolojidɛsɛ ye, o furakɛli bɛ se ka aw dɛmɛ.

Ka fara o kan, dɔgɔtɔrɔ bɛ se ka furaw di a ma i n’a fɔ stɛroyiw walasa ka bana taamasiɲɛw lajɔ ani sugunɛbilenni furaw (ji furakisɛw) walasa ka funu dɔgɔya.

Gɛlɛya jumɛnw bɛ sɔrɔ POEMS ka bana na?

Ni POEMS syndrome ye, farikolojidɛsɛ ni fanga dɔgɔyali bɛ se ka caya waati tɛmɛnen kɔfɛ. A bɛ se ka kɛ sababu ye fana ka yaala-yaala gɛlɛya. Ni ji caman bɛ ɲɔgɔn sɔrɔ fogonfogon kɛrɛfɛ walima disi kɔnɔ, o bɛ se ka disidimi bila mɔgɔ la ani ka ninakili gɛlɛya.

Nka, i hakili to a la ko .Furakɛli ka ɲɛ, o bɛ se ka farikolojidɛsɛ dabila walima ka a sumaya. A bɛ se ka dɛmɛ fana ka bana taamasiɲɛ wɛrɛw lajɔ. Hali farikolojidɛsɛ bɛ se ka kɛnɛya dɔɔni dɔɔni waati tɛmɛnen kɔfɛ.

Yala farati dɔw bɛ POEMS ka bana na wa?

Sisan, farati si ma dɔn POEMS banakisɛ sɔrɔli la.

Yala POEMS syndrome bɛ se ka bali wa?

A fɔ man di nka, POEMS ka bana tɛ se ka bali.

POEMS syndrome bɛ mɔgɔ minnu na, olu ka ɲɛnamaya ɲɛfɔcogo ye mun ye?

Aw ka kɛnɛya bɛ bɔ fɛn caman na, i n’a fɔ aw farikolo yɔrɔ minnu bɛ bana sɔrɔ, bana in bɛ sɔrɔ joona cogo min na ani a furakɛli bɛ daminɛ cogo min na, ani aw bɛ furakɛli kɛ cogo min na.

A nafa ka bon ka furakɛli sɔrɔ POEMS la. POEMS syndrome bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la ni a ma furakɛ. Faan wɛrɛ fɛ, furakɛli ɲɛnama minnu bɛ joli-sira-funu-banakisɛw tiɲɛ, olu bɛ se k’aw dɛmɛ ka ɲɛnamaya kɛ ka mɛn. Ka fara o kan, furakɛli bɛ se ka bana taamasiɲɛw lajɔ ani ka aw ka ɲɛnamaya kɛcogo ɲɛ.

POEMS bɛ mɔgɔ minnu na, olu fanba ka ɲɛnamaya hakɛ cɛmancɛ bɛ se san 14 ɲɔgɔn ma. O kɔrɔ ye ko mɔgɔ tilancɛ ɲɔgɔn si tɛ san 14 bɔ, k’a sɔrɔ tilancɛ tɔ bɛ mɛn ka tɛmɛ o kan. Aw si hakɛ bɛ bɔ aw ka bana kɛrɛnkɛrɛnnenw kɛcogo la ani a furakɛcogo la.

Aw ye dɔgɔtɔrɔ ɲininka aw ka siniɲɛsigi la i n’a fɔ mɔgɔ min bɛ balo ni POEMS syndrome ye.

Tuma jumɛn na aw ka kan ka taa dɔgɔtɔrɔso la POEMS ka bana ko la?

Ni aw ye taamasiɲɛ dɔw ye minnu bɛ tali kɛ POEMS ka bana na, kɛrɛnkɛrɛnnenya la bolokɔniw ni senw fanga dɔgɔyali , aw bɛ taa dɔgɔtɔrɔso la joona.

Ne ka kan ka ɲininkali jumɛnw kɛ n ka dɔgɔtɔrɔ la POEMS syndrome kan?

Aw bɛ se ka ɲininkaliw kɛ i n’a fɔ ninnu:

• Ne ka bana juguyara cogo di?
• Furakɛli suguya jumɛnw bɛ ne bolo?
• Ne ka kan ka mun kɛ walasa ka kɔlɔlɔw dɔgɔya walima ka u kunbɛn?
• Dɛmɛn baara jumɛnw bɛ se ka kɛ ne bolo?
• Yala ne ka kan ka taa dɔgɔtɔrɔso la min ka baara ɲɛsinnen bɛ joli-sira-funu-banaw ma walasa ka ne ka furakɛli ɲɛminɛ wa?

Tuma jumɛn na ne bɛ se ka segin ne ka baara kɛcogo kɔrɔw la ni POEMS syndrome bɛ ne la?

POEMS syndrome bɛ se ka nɔ bila i ka se ka i ka don o don baara kɛ. Aw ka dɔgɔtɔrɔ bɛna a ɲɛfɔ aw ye cogo min na nin bana in bɛna nɔ bila aw ka don o don ɲɛnamaya la.

Yala POEMS syndrome ye bana ye min bɛ sɔrɔ farikolo tangacogo fɛ wa?

POEMS ye bana ye min bɛ wele ko paranéoplastique syndrome.A tɛ bana ye min bɛ sɔrɔ farikolo tangalanw fɛ. Paranéoplastique syndrome ye taamasiɲɛw dalajɛlen ye minnu bɛ sɔrɔ furakɛli cogoya dɔ fɛ min bɛ a kɔnɔ. POEMS kɔnɔ, gɛlɛya min bɛ a kɔnɔ, o ye ko joli-sira-funu-banakisɛ minnu tɛ cogo la, olu bɛ M-protéine caman dilan joli la (joli-banakisɛ kelen-kelen). POEMS taamasiɲɛw bɛ sɔrɔ joli-sira-funu-banakisɛw ni M-protéine (M-protéine) fɛ minnu bɛ farikolo yɔrɔw tiɲɛ.

Yala POEMS syndrome ni miyɛloma multiple ye kelen ye wa?

Miyɛloma caman ye kansɛri ye min bɛ joli segin furakisɛw minɛ. POEMS syndrome ye taamasiɲɛw dalajɛlen ye minnu bɛ sɔrɔ joli segin furakisɛw la minnu tɛ cogo la ani M-protéine caya. POEMS banakisɛ ka ɲɛnamaya hakɛ ka fisa ni miyɛloma caman si hakɛ ye.

Nka, POEMS ni miyɛloma caman furakɛli minnu bɛ kɛ ni chimiothérapie ye, olu ka teli ka kɛ kelen ye. A taamasiɲɛ dɔw fana bɛ se ka kɛ ɲɔgɔn fɛ.

POEMS syndrome ye bana sɛgɛsɛgɛli gɛlɛn ye. A bɛ se ka waati dɔ ta aw ka dɔgɔtɔrɔ fɛ walasa k’a dɔn ko aw ka bana taamasiɲɛw bɛ sɔrɔ POEMS ka bana fɛ, a tɛ sɔrɔ bana wɛrɛ fɛ. Ni aw ye bana sɔrɔ ka ban, aw ni aw ka dɔgɔtɔrɔso jɛkulu ka baara kɛ ɲɔgɔn fɛ walasa ka a dɔn furakɛli minnu bɛna aw lafiya kosɛbɛ aw ka bana taamasiɲɛw la. Aw ye dɔgɔtɔrɔ ɲininka jɛkuluw walima dɛmɛjɛkuluw ko la minnu bɛ mɔgɔ kelen-kelen bɛɛ ni denbayaw dɛmɛ minnu bɛ banaw ɲɛnabɔ i n’a fɔ POEMS syndrome.

Take-Home cikan

Okey, donc an ye kuma caman fɔ POEMS Syndrome kan bi. Min nafa ka bon, o ye k’a faamu ko nin ye bana ye min man teli ka sɔrɔ, nka a ka jugu . A bɛ se ka nɔ bila an farikolo sigida caman na.

• POEMS tɔgɔ bɔra tubabukan tɔgɔ fɔlɔw la minnu bɛ taamasiɲɛba duuru jira (sɔgɔsɔgɔninjɛ, kɔnɔnafɛnw bonya, ɔrimɔni gɛlɛyaw, M-poroteyini caya, ani fari caman yeli).
• O sababuba ye joli-sira-funu-banakisɛw ye minnu tɛ cogo la ani u bɛ M-protéine min dilan.
• Hali ni fura dafalen tɛ yen, fura ɲumanw bɛ yen minnu bɛ se ka bana taamasiɲɛw kunbɛn ani ka ɲɛnamaya kɛcogo ɲɛ.
• a nafa ka bon kosɛbɛ ka bana in sɛgɛsɛgɛ ani ka furakɛli daminɛ joona .

Ni nin taamasiɲɛ ninnu dɔ bɛ aw la, aw bɛ dɔgɔtɔrɔ ka ladilikan ɲini. Aw kana siran, ni kunnafoni ɲumanw ni dɔgɔtɔrɔso dɛmɛni bɛ aw bolo, aw bɛ se ka nin ko in kunbɛn.

` POEMS syndrome, jolilabanaw, farikolojidɛsɛ, ɔrimɔni gɛlɛyaw, M-protéine, fari caman yeli, joli-sira-funu