Nukae nye DHT? Aleke wòkpɔa ŋusẽ ɖe wò ŋutilã dzii? (Dihydrotestosterone) si wotsɔna ƒoa ƒui .

Èse DHT alo Dihydrotestosterone ŋkɔ kpɔa ? Ðewohĩ ẽ, ɖewohĩ menye nenemae o. Gake esia nye nusi le vevie ŋutɔ na míaƒe ŋutilã, vevietɔ na ŋutsuwo ƒe lãmesẽ. Eyata, egbea míaƒo nu tso DHT sia ŋu le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu.

Nukae nye DHT (dihydrotestosterone)? Kpuie ko la,...

Kpuie ko la, DHT nye lãmetsi tɔxɛ aɖe si kpena ɖe ŋutsuwo ƒe gbɔdɔdɔ ƒe nɔnɔmewo tutuɖo ŋu . Ènyaa, lãmetsiŋusẽwo le abe dɔla sue siwo kpɔa míaƒe ŋutilã ƒe dɔwɔwɔ ɖesiaɖe dzi ene. DHT hã le lãmetsiŋusẽ ƒe ƒuƒoƒo aɖe si woyɔna be Androgen me. Androgen nye ŋkɔ si wotsɔ na lãmetsi siwo hea ŋutsu ƒe nɔnɔmewo vɛ.

Bu eŋu kpɔ, DHT dzea dɔwɔwɔ gɔme le ŋutsu ƒe ŋutilã me tso esime wòle vidzidɔ me. Emegbe, akpa si DHT wɔna la trɔna le eƒe agbemeɣeyiɣi vovovowo me. Togbɔ be dzɔdzɔmeŋutinunyalawo meka ɖe alesi tututu DHT kpɔa ŋusẽ ɖe nyɔnuwo dzii dzi o hã la, wosusu be ate ŋu akpɔ ŋusẽ ɖe taɖa ƒe tsitsi le ŋutilã kple teƒe siwo ame aɖeke mele o dzi.

Androgen vevitɔ si le ŋutsu tsitsi me enye testosterone . Testosterone sia ƒe 10% lɔƒo trɔna zua DHT gbesiagbe . Nuwɔna sia dzɔna le ŋutigbalẽ si ƒo xlã vidzinuwo kple ŋutsuwo ƒe ʋuka si me ʋu sina tona me. Le nyɔnuwo gome la, esia dzɔna le ŋutigbalẽ me. Edzɔna le teƒewo abe míaƒe aklã ene hã. Esi wònye be le dzɔdzɔme nu la, testosterone sɔ gbɔ ɖe ŋutsuwo ƒe ŋutilã me ta la, woƒe DHT ƒe agbɔsɔsɔ hã sɔ gbɔ wu sã.

Nuka tututue DHT wɔna ɖe míaƒe ŋutilã ŋu?

DHT wɔa nu vovovowo le ŋutsu ƒe agbe ƒe akpa vovovowo. Ele vevie ŋutɔ le fugboe ƒe tsitsi kple eƒe sɔhɛmenɔɣi .

Gake to vovo na testosterone la, DHT mewɔa akpa gã aɖeke le ŋutilã ƒe dɔwɔwɔ me léle ɖe asi le ŋutsu tsitsi me o. Le ame tsitsi me la, wokpɔa DHT le nɔnɔmewo abe ʋuka ƒe lolome kple ŋutsu ƒe ɖa ƒe ŋeŋe ene me koŋ.

Dɔ si DHT wɔna le fugboe ƒe ɣeyiɣia me

Ne vidzĩ le vidzidɔ me la, eƒe gbɔdɔdɔ ƒe ŋutinuwo tsina abe ŋutsu alo nyɔnu ene le lãmetsiŋusẽ ƒe nɔnɔme aɖe koŋ nu. Le ŋutsuvi gome la, DHT wɔa dɔ kple lãmetsiŋusẽ bubuwo (siwo dome testosterone hã le ) tsɔ xea mɔ na nyɔnuwo ƒe gbɔdɔdɔ ƒe nɔnɔmewo ƒe tsitsi eye wòdoa ŋutsu ƒe gbɔdɔdɔ ƒe nɔnɔmewo ƒe tsitsi ɖe ŋgɔ .

DHT le vevie na ŋutsu ƒe gotagome vidzinuwo, si nye ŋutsu ƒe vidzinu kple vidzidɔ, ƒe tsitsi le fugboe me. DHT kpena ɖe ame ŋu le ʋuka si me ʋu sina tona me ƒe tsitsi hã me.

DHT le sɔhɛmenɔɣi

Ne ŋutsuvi ɖo sɔhɛmenɔɣi la, DHT kpena ɖe ŋutsu ƒe vidzinu kple vidzidɔ ŋu wògatsina ɖe edzi. Menye ema ɖeɖeko o, ke DHT hã ƒe dɔ vevitɔe nye:

• Le mo dziAɖabɛ tsitsi.
• Ŋutilã ƒe fu siwo le tsitsim.
• Taɖa ƒe tsitsi le teƒe siwo ame aɖeke mele o.
• Prostate ƒe tsitsi.

Nukae dzɔna ne DHT ƒe agbɔsɔsɔ dzi ɖe edzi?

Lãmesẽnya aɖewo do ƒome kple DHT ƒe agbɔsɔsɔ si dzi ɖe edzi. Mina míalé ŋku ɖe nusiwo wonye ŋu:

• Prostatic Hyperplasia (BPH) si me dɔléle aɖeke mele o .
• Dɔdzẽ si le ʋuka me
• Androgenetic alopecia (ŋutsu ƒe taɖa ƒe vuvu ) .
• Polycystic Ovarian Syndrome (PCOS) (le nyɔnuwo gome) .

Prostatic Hyperplasia (BPH) si me dɔléle aɖeke mele o kple DHT

Benign Prostatic Hyperplasia (BPH) nye wò ʋuka si me ʋu sina tona ƒe lolome. Enye dɔléle si bɔ ŋutɔ le ŋutsu siwo xɔ wu ƒe 50 me .

Wò ʋuka ate ŋu awɔ DHT gbogbo aɖe. DHT sia doa ŋusẽ prostate gland ƒe dɔwɔwɔ nyuie, eye zi geɖe la, enaa prostate gland la lolona. BPH sia ate ŋu ahe kuxiwo abe aɖuɖɔtoe sesẽ kple gbɔdɔdɔ ƒe dɔmawɔmawɔ nyuie ene vɛ .

Prostate cancer kple DHT

Zi geɖe la, DHT sɔa gbɔ ɖe amesiwo ŋu prostate cancer le la me. DHT ƒe dɔwɔwɔ ƒe dzidziɖedzi le wò ʋuka me, tsɔ kpe ɖe domenyiŋusẽfianu ƒe tɔtrɔ aɖewo siwo nana ʋumenugbagbeviɣidɔlékuiwo tsina le mɔ si dzi womate ŋu aɖu o ŋu ate ŋu atso ʋumenugbagbeviɣidɔ gbɔ.

Androgenetic alopecia (taɖa ƒe vuvu) kple DHT

Androgenic alopecia nye nusi míeyɔna zi geɖe be ŋutsu ƒe taɖa ƒe nɔnɔme . Le nɔnɔme sia me la, taɖa dona tso ta tame kple ŋgɔgbe. Le ɣeyiɣi aɖe megbe la, ɖaa ƒe fli la ɖiɖina.

Nusiwo gbɔ ɖa sia tsona dometɔ ɖekae nye DHT ƒe dɔwɔwɔ ƒe dzidziɖedzi le wò ɖa ƒe ƒuƒuwo me. Nu bubuwo hã li siwo gbɔ wòtsona, abe domenyiŋusẽfianu ƒe ŋusẽkpɔɖeamedziwo ene. Ne DHT ƒe agbɔsɔsɔ dzi ɖe edzi la, ɖa ƒe ƒuƒuwo dzi ɖena kpɔtɔna, ɖa ƒe tsitsi ƒe ɣeyiɣia nɔa kpuie, eye mlɔeba taɖawo gena.

PCOS kple DHT

Polycystic Ovarian Syndrome (PCOS) nye lãmetsiŋusẽ ƒe masɔmasɔ si dzea nyɔnuwo dzi. Edzɔna ne woƒe azigolowo wɔ androgen lãmetsi geɖe akpa, siwo dome testosterone hã le. Esia wɔnɛ be DHT ƒe agbɔsɔsɔ dzina ɖe edzi. Esia ate ŋu ahe dzesi vovovowo vɛ, siwo dometɔ aɖewoe nye dzinukpɔkpɔ si mesɔ o, ŋutilã me fu ƒe tsitsi fũ akpa (hirsutism), kple aklãdɔ .

Nukae dzɔna ne DHT ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ?

Nɔnɔme aɖewo do ƒome kple DHT ƒe agbɔsɔsɔ si bɔbɔ. Mina míalé ŋku ɖe nusiwo wonye ŋu:

• 5-alfa reductase ƒe anyimanɔmanɔ `(5-alfa reductase ƒe anyimanɔmanɔ)`
• Testosterone si bɔbɔ / ŋutsu ƒe ʋumenugbagbeviɣidɔ

DHT ƒe agbɔsɔsɔ si bɔbɔ ɖe anyi wu alesi wòle be wòagblẽ nu le ŋutsuwo koŋ ŋu. Dzɔdzɔmeŋutinunyala aɖewo xɔe se be DHT ƒe agbɔsɔsɔ si bɔbɔ ɖe anyi le nyɔnuviwo me ate ŋu ahe sɔhɛmenɔɣi ɖe megbe.

5-alpha reductase ƒe anyimanɔmanɔ kple DHT

5-alpha reductase nye enzyme si kpena ɖe ame ŋu wòtrɔa testosterone wòzua DHT. Domenyiŋusẽfianu ƒe tɔtrɔ si kpɔa ŋusẽ ɖe enzyme sia ƒe wɔwɔ dzi ate ŋu ana DHT ƒe agbɔsɔsɔ naɖiɖi alo manɔ anyi o. Woyɔa esia be 5-alpha reductase ƒe anyimanɔmanɔ. Esia nye nɔnɔme si ƒe dome wonyi tso dzilawo gbɔ na viwo (autosomal recessive pattern) .

5-alpha reductase ƒe anyimanɔmanɔ kpɔa ŋusẽ ɖe fugboe siwo ƒe domenyiŋusẽfianu nye ŋutsuwo (siwo si XY domenyiŋusẽfianu le) ƒe gbɔdɔdɔ ƒe tsitsi dzi. Zi geɖe la, vidzĩ ŋutsu siwo wodzi kple gbɔdzɔgbɔdzɔ sia ɖea nɔnɔme siwo gbɔna fiana:

• Vidzinu siwo le gota la metsi bliboe o.
• Vidzidɔ siwo le dɔ wɔm ƒe anyinɔnɔ le ŋutilãa me (medo go o).
• Prostate gland sue alo esi mele afima o.

Vevietɔ: Le 5-alpha reductase ƒe anyimanɔmanɔ sesẽwo me la, nyɔnu ƒe vidzinu siwo le gota ate ŋu anɔ vidzĩ siwo nye ŋutsu siwo ƒe domenyiŋusẽfianu ŋu XY domenyiŋusẽfianu le. Gake DHT si dzi ɖe kpɔtɔ mekpɔa ŋusẽ ɖe vidzidɔa (woate ŋu awɔ tsinyenye kokoko) kple vidzinuwo ƒe tsitsi dzi o. Esia to vovo na nɔnɔme si woyɔna be Androgen Insensitivity Syndrome. Amesiwo ŋu dɔléle sia le ƒe vidzidɔwo sɔ eye testosterone ƒe agbɔsɔsɔ si sɔ alo sɔ gbɔ, gake androgen-xɔla mele wo si o, eyata wometu gbɔdɔdɔ ƒe nɔnɔme evelia ɖo o, eye womedzia vi hã o.

Ŋutsuvi siwo ŋu domenyiŋusẽfianu ƒe dɔléle si nye 5-alpha reductase ƒe anyimanɔmanɔ le la mekpɔa mo ƒe fu ne woɖo sɔhɛme o. Gake woƒe ŋutilã gakpɔtɔ wɔa testosterone, si hea nuwo abe gbe si de to, lãmekawo ƒe tsitsi, kple ŋutsu ƒe vidzinu ƒe lolome ene vɛ.

Testosterone ƒe agbɔsɔsɔ si bɔbɔ kple DHT

Testosterone si le wò ŋutilã me ye trɔna zua DHT. Eyata ne wò testosterone ƒe agbɔsɔsɔ le sue la, wò DHT ƒe agbɔsɔsɔ hã aɖiɖi wu alesi wòle dzɔdzɔmee. Ŋkɔ bubu si wotsɔ na testosterone ƒe agbɔsɔsɔ si bɔbɔ enye ŋutsuwo ƒe ʋumenugbagbeviɣidɔ.

Ŋutsuwo ƒe ʋumenugbagbeviɣidɔ ƒomevi vevi eve li: blema (si nɔa anyi le edziɣi alo emegbe le eƒe agbe me) kple esi dzea egɔme megbe. Le ƒe si nèxɔ nu la, ŋutsuwo ƒe ʋumenugbagbeviɣidɔ ate ŋu ahe kuxi vovovowo vɛ.

Ðe wòle be makpɔ ɖɔkta tso nye DHT ƒe agbɔsɔsɔ ŋua?

Ne èsusu be dɔléle aɖe ate ŋu anɔ ye alo viwò ŋu si tso DHT si bɔbɔ alo esi sɔ gbɔ gbɔ la, kpɔ egbɔ be yeƒo nu kple ɖɔkta.Emegbe ate ŋu awɔ dodokpɔ siwo hiã alo aɖo wò ɖe ame aɖe si bi ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ me, abe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋuti nunyala ene gbɔ.

Dihydrotestosterone, alo DHT, le vevie na ŋutsu ƒe gbɔdɔdɔ ƒe tsitsi. Gake ne eƒe agbɔsɔsɔ sɔ gbɔ akpa alo bɔbɔ akpa la, ate ŋu ahe kuxiwo abe gotagome vidzinuwo ƒe tsitsi nyuie, ʋuka si lolo, kple ɖa ƒe vuvu ene vɛ. Ne nane tsi dzi na wò le wò DHT ƒe agbɔsɔsɔ ŋu la, mègahe ɖe megbe le nuƒoƒo kple wò ɖɔkta me o. Woate ŋu awɔ dodokpɔwo eye woakafu atikewɔmɔnu siwo ate ŋu akpe ɖe ŋuwò.

Nu vevitɔ kekeake siwo dzi wòle be woaɖo ŋkui tso nyati sia me (Take-Home Message) .

• DHT nye androgen lãmetsi si kpena ɖe ŋutsuwo ƒe gbɔdɔdɔ ƒe nɔnɔmewo ŋu koŋ .
• DHT le vevie na ŋutsu ƒe gotagome vidzinuwo ƒe tsitsi le fugboe ƒe ɣeyiɣi me kple mo ƒe fu kple ŋutilã ƒe fu ƒe tsitsi le sɔhɛmenɔɣi.
• DHT ƒe agbɔsɔsɔ si dzi ɖe edzi ate ŋu ahe nɔnɔmewo abe benign prostatic hyperplasia (BPH), prostate cancer, ɖa ƒe vuvu le ŋutsuwo me, kple PCOS le nyɔnuwo me vɛ.
• Ne DHT ƒe agbɔsɔsɔ le sue la, nɔnɔmewo abe 5-alpha reductase ƒe anyimanɔmanɔ ene ate ŋu akpɔ ŋusẽ ɖe ŋutsu ƒe gbɔdɔdɔ ƒe tsitsi dzi.
• Ne ɖikeke alo dzitsitsi aɖe le wò DHT ƒe agbɔsɔsɔ ŋu la, anyo wu be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo .

Mele mɔ kpɔm be fifia èse DHT gɔme nyuie wu. Nu siawo tɔgbe nyanya le vevie ŋutɔ na wò lãmesẽ!

` DHT, dihydrotestosterone, lãmetsiwo, ŋutsuwo ƒe lãmesẽ, testosterone, prostate, ɖa ƒe vuvu, PCOS