Nukae nye Acetylcholine (ACh)? Mina míakpɔ nusi tututu wòwɔna ɖe míaƒe ŋutilã ŋu!

Èse acetylcholine , alo (ACh) ŋkɔ kpɔa? Ðewohĩ wò ɖɔkta gblɔe na wò, alo èxlẽ nu tso eŋu le afi aɖe. Enye atike sue aɖe gake wòle vevie ŋutɔ le míaƒe ŋutilã me. Ele abe posudɔwɔla sue aɖe si tsɔa gbedasiwo yia míaƒe ŋutilã me ene. Eyata, egbea míaƒo nu tso acetylcholine ŋu le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu.

Nuka tututue nye Acetylcholine?

Kpuie ko la, acetylcholine nye ahɔhɔ̃mekawo ƒe dɔwɔwɔ . Bu eŋu kpɔ, ehiã be wò ahɔhɔ̃ naɖo elektrik gbedasi suewo ɖa be wòaʋuʋu wò asi, abu tame, aɖo ŋku nane dzi, nu siawo katã. Acetylcholine nye atikewo ƒe dɔla si kpena ɖe ame ŋu wòtsɔa gbedasi mawo toa lãmekawo ƒe lãmenugbagbeviwo me .

Wogayɔa esia be " excitatory " neurotransmitter . Ènya nusi ema nyea? "Enyɔa" lãmeka ƒe lãmenugbagbevi aɖe, si fia be eʋãnɛ, eye wònana wò "ɖoa" gbedasiwo ɖa kabakaba. Ele abe amesi le alɔ̃ dɔm ƒe ʋɔtru ƒoƒo gblɔm be, "Afisia, tsɔ lɛta sia."

Ŋkɔ acetylcholine tso nu eve siwo na wòzu gbɔ. Ðeka nye acetyl ƒe ƒuƒoƒo aɖe . Esia tsoa atike aɖe si woyɔna be acetyl coenzyme A, si wotsɔ sukli sukli wɔe me. Bubue nye nunyiame aɖe si woyɔna be choline . Choline le azi tutu, soya, aklã, amagbewo, kple mɔli me le dzɔdzɔme nu. Wowɔa choline hã le míaƒe aklã me.

Acetylcholine kpɔa gome le dɔ vevi geɖewo wɔwɔ me le míaƒe ŋutilã me, vevietɔ lãmekawo ƒe ʋuʋu le lɔlɔ̃nu faa me.Esia wɔa akpa vevi aɖe le míaƒe nuwɔna siwo míewɔna le susu me, abe míaƒe abɔwo ʋuʋu kple azɔlizɔzɔ ene me. Eʋãa lãmeka siwo le míaƒe lãmekawo me, si wɔnɛ be wotsia. Menye ema ɖeɖeko o, ke ele vevie ŋutɔ na lãmeka siwo le míaƒe ahɔhɔ̃ me hã, kple na dɔwɔwɔwo abe ŋkuɖoɖonudzi, tamebubu, kple nusɔsrɔ̃ ene.

Aleke acetylcholine (ACh) wɔa dɔe?

Wodzraa acetylcholine ɖo ɖe lãmekawo ƒe nuwuƒewo, vaseɖe esime wòahiã be woaɖo gbedasi aɖe ɖa. Ne “dzesi” aɖe va ɖo be yeaɖo gbedasi ɖa la, acetylcholine sia si wodzra ɖo la dona. Ne wonya ɖe asi le eŋu ko la, ezɔa mɔ yia dometsotso sue aɖe si le lãmeka eve dome. Woyɔa dometsotso sia be synaptic cleft .

Ne wotso lãmenugbagbeviwo ƒe ʋuʋudedi vɔ la, lãmenugbagbevi ƒomevi eve li siwo acetylcholine ate ŋu abla ɖe wo ŋu. Woawoe nye:

• Nikotini ƒe dɔlékuiwo
• Muscarinic ƒe dɔlélenutsiŋutetewo

Ne ebla ɖe lãmenugbagbevi siawo ŋu vɔ la, atike ƒe gbedasi la zɔna yia lãmeka ƒe lãmenugbagbevi si kplɔe ɖo gbɔ. Ne woɖo gbedasia ɖa vɔ la, acetylcholine si susɔ ɖe synaptic cleft la me la megblẽna ko o. Enzyme bubu si woyɔna be acetylcholinesterase va eye wògbãa acetylcholine sia ɖe eƒe akpa siwo nye choline kple acetate me. Emegbe wogaxɔa akpa siawo siwo gblẽ la, wogbugbɔa wo zãna, eye wozãa wo tsɔ tsɔa atike ƒe gbedasi bubu. Nuɖoanyi si wɔa dɔ nyuie ŋutɔ!

Nukae dzɔna ɖe acetylcholine (ACh) dzi?

Viɖe geɖe le acetylcholine ŋu na míaƒe ŋutilã. Na míalé ŋku ɖe vevitɔwo ŋu.

Xɔla ƒomevi evea siaa kpɔa gome le míaƒe ŋkuɖoɖonudzi me . Eyae nye be wole vevie na ŋkuɖoɖonudzi ɣeyiɣi didi, ŋkuɖoɖonudzi ɣeyiɣi kpui aɖe, ŋkuɖodzinuwo ƒe wɔwɔme, wo ƒoƒo ƒu ɖekae, kple wo gbugbɔgaxɔ. Le ahɔhɔ̃a me la, acetylcholine kpɔa gome le nu bubuwo me. Edoa ʋiʋli, ɖetsɔleme/lé ŋku ɖe nu ŋu, nusɔsrɔ̃, kple REM alɔ̃dɔdɔ (alɔ̃dɔdɔ ƒe afɔɖeɖe si me míekua drɔ̃e le) ɖe ŋgɔ.

Nɔnɔme kawoe dzɔna ne acetylcholine (ACh) ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ?

Acetylcholine, alo eƒe anyimanɔmanɔ, ate ŋu ahe dɔléle geɖe vɛ. Esiawo dometɔ vevitɔwoe nye:

• Alzheimer ƒe dɔléle : Ame siwo ŋu Alzheimer ƒe dɔlélea le la mekpɔa acetylcholine si sɔ gbɔ ɖe woƒe ahɔhɔ̃ me o. Esia wɔe be ŋkuɖoɖonudzi ƒe gbɔdzɔgbɔdzɔ nye dzesi vevi aɖe.
• Lambert-Eaton myasthenic syndrome : Dɔléle sia tsoa acetylcholine ƒe dodo tso lãmekawo me dzi ɖeɖe kpɔtɔ gbɔ.
• Myasthenia gravis : Esia nye dɔléle si dɔlélenutsiŋutete wɔna si nana ƒunukpeƒewo gbɔdzɔna kabakaba ne wozãe enuenu vɔ.

Nukawoe nye atike siwo tɔa ŋku acetylcholine (ACh)?

Cholinesterase mɔxenuwo nye atikewo ƒe hatsotso aɖe si wɔa dɔ to enzyme si gblẽa acetylcholine me la ƒe dɔmawɔmawɔ kple acetylcholine xɔlawo ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me. Wozãa wo tsɔ daa Alzheimer ƒe dɔléle kple myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), kple Galantamine (Razadyne®) nye atike siawo dometɔ aɖewo.

Nuɖuɖu kawoe me choline le, si kpena ɖe ame ŋu wòwɔa acetylcholine (ACh)?

Choline, si nye nunyiame si trɔna zua acetylcholine, le nuɖuɖu geɖe me. Le kpɔɖeŋu me:

• Nyilã ƒe aklã
• Azi (vevietɔ azi tutu) .
• Nyilã tame goglo
• Soya-ku si wotɔ dzoe, ayiku-ku siwo wotsɔ gaze me
• Koklozi ƒe akɔta si wotɔ dzoe
• Cod tɔmelã `(Cod)`
• Quinoa si woɖa
• Shiitake lãmi siwo woɖa, broccoli si woɖa kple Brussels sprouts
• Notsi (1%) `(Notsi (1%))`, vanilla yogurt si me ami mele o `(vanilla yogurt si me ami mele o)`

Tee kpɔ nàtsɔ nuɖuɖu siawo akpe ɖe wò nuɖuɖu ŋu. Nuɖuɖu si da sɔ le vevie ŋutɔ na agbe nyui nɔnɔ.