Ðe wò ʋudodokpɔ ɖee fia be "Blast Cells"? Mina míaƒo nu tso esia ŋu!

Ɣeaɖewoɣi la, àte ŋu akpɔ nane si woyɔna be "Blast Cells" le wò ʋu ƒe nyatakaka me. Enye nusi sɔ be nàtsi dzodzodzoe vie ne èkpɔe. Nya "blast" sese gɔ̃ hã ate ŋu ado vɔvɔ̃ na ame vie. Gake hafi nàtsi dzodzodzoe la, mina míaƒo nu tso nusi tututu lãmenugbagbevi siawo siwo wotsɔna ƒoa dzoe, nusita wole vevie na míaƒe ŋutilã, kple nukae dzɔna ne woƒe xexlẽme dzi ɖe edzi ŋu kpuie?

Nukae nye blast cells? Ðe ema koe wòle be nànyaa?

Ẽ, ele vevie be nànya esia. Kpuie ko la, blast cells nye lãmenugbagbevi sue ƒomevi aɖe si metsi o, alo metsi bliboe o, le míaƒe ŋutilã me. Esiawoe nye lãmenugbagbevi siwo naa lãmenugbagbevi vovovo siwo le míaƒe ŋutilã me la dona. Gake ne èxɔ dodokpɔxɔ ƒe nyatakaka si gblɔ be "blasts" la, zi geɖe la, efia ʋumenugbagbevi siwo metsi o. Elabena ʋumenugbagbeviɣidɔdalawo kple kansadɔdalawo zãa nuwo abe blast cells ƒe xexlẽme si le wò ʋu me ene tsɔ dea dzesi dɔléle aɖewo siwo do ƒome kple ʋu, abe ʋumenugbagbeviɣidɔ sesẽ ene.

Ne blast cells siwo ƒe nɔnɔme mesɔ o alo woƒe xexlẽme sɔ gbɔ ɖe wò ʋu me la, ate ŋu anye ʋumekansa aɖe ƒe dzesi. Esia tae wòle be nàtsi dzi ɖe esia ŋu ɖo.

Eyata vovototo kae le ʋumenugbagbevi dzĩwo kple blast cells dome?

Esia adze nu sesẽ vie, gake le nyateƒe me la, ele bɔbɔe ŋutɔ. Bu eŋu kpɔ, esiawo evea siaa nye afɔɖeɖe veviwo le míaƒe lãmenugbagbeviwo ƒe tsitsi me.

Ʋumenugbagbeviɣiwo le abe vidada lãmenugbagbevi siwo dzia lãmenugbagbevi ƒomevi bubuwo katã ene.

Blast cells dona tso lãmenugbagbevi siawo me. Wogayɔa wo be "tɔgbui" alo "do ŋgɔ" lãmenugbagbeviwo. Eyae nye be wonye "do ŋgɔ" ƒe afɔɖeɖe hafi lãmenugbagbevi si tsi bliboe la tsina. To vovo na lãmenugbagbevi si wotsɔna ƒoa lãe la, woɖoe kplikpaa xoxo be lãmenugbagbevi si blaa nu nazu lãmenugbagbevi ƒomevi aɖe koŋ. Ele abe yunivɛsiti yiyi asrɔ̃ nusɔsrɔ̃ siwo wozãna le mɔ gbadza nu gbã, emegbe wò susu nanɔ dɔ aɖe koŋ ŋu ene.

Viɖe kawoe le blast cells ŋu na míaƒe ŋutilã?

Ʋumenugbagbeviɣidɔ nye ʋumenugbagbeviɣidɔ ƒe wɔwɔme ƒe gɔmedzedze ko. Wò ŋutilã le ʋumenugbagbevi yeyewo (kple blast cells) wɔm ɣesiaɣi be woatsɔ axɔ ɖe lãmenugbagbevi xoxowo teƒe. Woyɔa ʋu ƒe wɔwɔme sia be ʋumenugbagbeviɣidɔ . Esia dzɔna zi geɖe le wò ƒumeŋuɖui me .

Le wò ƒumeŋuɖui me la, lãmenugbagbevi aɖe si bɔ si woyɔna be "hematopoietic stem cell" (HSC) li. Esia naa blast cell ƒomevi vevi eve dona:

• Myeloblast: Wokpɔa blast cell sia ƒomevi tsoWowɔa ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo (le kpɔɖeŋu me, granulocytes, monocytes, neutrophils, basophils, kple eosinophils), kple ʋumenugbagbevi dzĩwo.
• Lymphoblast: Blast cell sia ƒomevi naa lymphocytes, si nye ʋumenugbagbevi ɣi ƒomevi aɖe, dona.

Ʋumenugbagbevi siwo tsi bliboe, siwo tsi nyuie la dona le ƒumeŋuɖui me hezɔa mɔ to wò ʋukawo me. Gake lãmenugbagbevi siwo gbãna siwo gakpɔtɔ le tsitsim la le wò ƒumeŋuɖui me, ke menye wò ʋu me o. Esia tae dodokpɔxɔ ƒe nyatakaka si ɖe blast cells fia le wò ʋu me ate ŋu anye kuxi ɖo.

Nukatae lãmenugbagbevi siawo siwo wotsɔna gbãa nu le dzidzim ɖe edzi? Ðe nane gblẽa?

Ne dodokpɔxɔ ƒe nyatakaka aɖe ɖee fia be blast cells sɔ gbɔ ɖe wò ƒumeŋuɖui alo ʋu me la, ate ŋu anye ʋumenugbagbeviɣidɔ abe ʋumenugbagbeviɣidɔ ene ƒe dzesi. Vevietɔ ne lãmenugbagbeviawo dze abe ɖe womesɔ o ene ne wokpɔ wo le nusuekpɔmɔ̃ me. Zi geɖe la, ʋumenugbagbevi siwo katã le wò ƒumeŋuɖui me ƒe 5% koe wòle be woanye blast cells. Menyo be lãmenugbagbevi siwo wotsɔna blaa nu aɖeke nanɔ wò ʋu me kura o.

Susu vevi geɖewo li siwo tae blast cells dzina ɖe edzi ɖo:

• Ʋumenugbagbeviɣidɔ sesẽ (AML) .
• Lãmetsiŋusẽ ƒe dɔléle (MDS) .
• Ʋumenugbagbeviɣidɔ si nɔa anyi didi (CML) .
• Ʋumenugbagbeviɣidɔ sesẽ (ALL) .
• Nɔnɔme kple atikewɔwɔ aɖewo siwo menye kansa o

Mina míalé ŋku ɖe esiawo dometɔ ɖesiaɖe ŋu tsitotsito vie.

Mina míasrɔ̃ nu tso Acute Myeloid Leukemia (AML) ŋu .

Zi geɖe la, ne ɖɔktawo le nu ƒom tso blast cells ŋu la, acute myeloid leukemia (AML) ŋue wole nu ƒom tsoe . AML nye kansa ƒomevi aɖe si nu sẽ ŋutɔ si kakana kabakaba ŋutɔ. Eyata ele vevie ŋutɔ be woanya dɔlélea eye woadze edada gɔme kaba ale si woate ŋui. Dodokpɔ hena lãmenugbagbevi siawo siwo wotsɔna gbãa nu nye mɔ vevi aɖe si dzi woato ade dzesi dɔlélea kaba.

Le AML me la, blast cells siwo mesɔ o ƒoa ƒu ɖe wò ƒumeŋuɖui me eye wodoa go yia wò ʋu me. Esiawo ƒe akpa gãtɔ nye lãmenugbagbevi ƒomevi aɖe si woyɔna be myeloblasts. Esiawo le klalo be yewoazu ʋumenugbagbevi ɣiwo (granulocytes) hafi woazu kansa lãmenugbagbeviwo.

Esi blast cell siawo metsi o eye womele dzɔdzɔme nu o ta la, womewɔa dɔ nyui aɖeke na ŋutilãa o. Ke boŋ woxɔa teƒe geɖe le ƒumeŋuɖui me ale gbegbe be woxea mɔ na wò ŋutilã be wòagawɔ ʋumenugbagbevi yeye siwo le lãmesẽ me siwo wòhiã o. Ne ʋumenugbagbevi tsitsi siwo le dɔ wɔm nyuie meli o la, wò ŋutilã mate ŋu awɔ dɔ nyuie o.

Ne blast cells 20% alo esi wu nenema le wò ƒumeŋuɖui alo ʋu me la, ke enye AML ƒe dzesi.

Nukae nye Myelodysplastic Syndrome (MDS) ƒe dɔléle?

Myelodysplastic syndrome (MDS) hã nye ʋumenugbagbeviɣidɔ ƒomevi aɖe. Nusi dzɔna le afisiae nye be blast cells metsina zua ʋumenugbagbevi siwo sɔ o. Zi geɖe la, lãmenugbagbevi siawo siwo wogbãna la kuna hafi te ŋu tsina nyuie. Togbɔ be blast cells sɔ gbɔ akpa hã la, ne lãmenugbagbevi tsitsi siwo ate ŋu awɔ woƒe dɔa mesɔ gbɔ akpa o la, kuxiwo abe ʋusɔgbɔdɔ ene ate ŋu ado mo ɖa. Azɔ hã, àte ŋu axɔ dɔlékuiwo enuenu (le ʋumenugbagbevi ɣiwo ƒe ʋɛnyenye ta) eye ʋu nado alo abi bɔbɔe (le ʋumenugbagbevi dzĩwo ƒe ʋɛnyenye ta).

Ne blast cells le wò ƒumeŋuɖui me le 5% va ɖo 20% la, enye nɔnɔme aɖe si woyɔna be `MDS.` ƒe dzesi

Mina míalé ŋku ɖe Chronic Myeloid Leukemia (CML) hã ŋu.

Ʋumenugbagbeviɣidɔ si nɔa anyi didi (CML) nye ʋumenugbagbeviɣidɔ si nɔa anyi didi (si nɔa anyi didi). Enaa blast cells siwo le ƒumeŋuɖui alo ʋu me hã dzina ɖe edzi. Ðɔktawo nɔa te ɖe wò blast cell ƒe agbɔsɔsɔ dzi daa dɔlélea ƒe sesẽme ɖe hatsotsowo me:

• Chronic Phase CML: Lãmenugbagbevi siwo le wò ʋu alo ƒumeŋuɖui me ƒe 10% mede blast cells o.
• Accelerated Phase CML: Lãmenugbagbevi siwo le wò ʋu me ƒe 10% va ɖo 19% nye blast cells.
• Blast Phase CML (blast crisis): Lãmenugbagbevi siwo wu 20% le wò ʋu me nye blast cells. Esia sɔ kple AML tɔ.

Nukae nye Ʋumenugbagbeviɣidɔ (ALL)?

Acute lymphoblastic leukemia (ALL) ye nye kansa ƒomevi si bɔ wu le ɖeviwo me. Le WO KAtã me la, ƒumeŋuɖui wɔa lãmenugbagbevi siwo mesɔ o (kansa) siwo woyɔna be lymphoblasts. Lãmenugbagbevi siawo siwo mesɔ o la mãna kabakaba eye wowɔa wo ɖokui ƒe kɔpi geɖe. Esia wɔnɛ be esesẽna na ƒumeŋuɖui be wòawɔ lãmenugbagbevi siwo sɔ siwo wò ŋutilã hiã.

Le WO KAtã me la, ʋumenugbagbevi siwo le wò ƒumeŋuɖui me ƒe 20% ya teti nye blast cells. Ame akpa gãtɔ siwo ŋu wokpɔ dɔlélea le (anɔ abe 90%) hã ƒe ʋu me lãmenugbagbevi siwo woyɔna be blast cells le.

Ðe blast cells ate ŋu adzi ɖe edzi le nu bubu siwo gbɔ wòtso tsɔ wu kansa ta?

Ẽ, esia le vevie ŋutɔ. Mègasusu be kansa tso dodokpɔxɔ ƒe nyatakaka aɖe si ɖe blast cells geɖe fia gbɔ o. Nɔnɔme aɖewo siwo menye kansa o kple nusiwo gbɔ wòtso hã ate ŋu ana blast cells nadzi ɖe edzi hena ɣeyiɣi aɖe. Kpɔɖeŋu aɖewoe nye:

• Dɔlékui sesẽwo: Ne dɔléle sesẽ aɖe, abe dɔlékui sesẽ aɖe (sepsis) ene dze wò ŋutilã dzi la, blast cells ate ŋu age ɖe ʋua me.
• Granulocyte-colony stimulating factor (G-CSF) dɔdamɔnu: Woate ŋu akpɔ lãmenugbagbevi siwo blana le ʋua me kokoko le atike ƒomevi aɖe si woyɔna be G-CSF dodo vɔ megbe. Atike siawo ʋãa wò ƒumeŋuɖui be wòawɔ ʋumenugbagbevi ɣi geɖe wu be woakpɔ tawò tso dɔlékuiwo me. Esiawo ate ŋu ahiã ne èle atikewo zãm alo ne ʋumenugbagbevi ɣiwo ƒe xexlẽme le sue (neutropenia).
• Lãmenugbagbeviwo dodo na ame: Ne wodo lãmenugbagbeviwo na wò kpɔ abe atikewɔwɔ na dɔléle aɖe ene la, ke ɖewohĩ blast cells hã adzi ɖe edzi. Ðewohĩ ahiã be woado ʋumenugbagbevi dzĩwo na ame le nɔnɔmewo abe ʋumenugbagbeviɣidɔ, kansa, alo dɔléle siwo dɔlélenutsiŋutete wɔna siwo me wò ŋutilã mate ŋu awɔ ʋumenugbagbevi siwo sɔ o ene ta.

Gake nu vevitɔe nye be, to vovo na blast cells siwo do ƒome kple kansa la, zi geɖe la, blast cells siwo wokpɔna le nɔnɔme siawo me la dzena le lãmesẽ me le nusuekpɔmɔ̃ me. Woate ŋu atrɔ ava zu ʋumenugbagbevi siwo sɔ hã. Le ɣeyiɣi aɖe megbe la, xexlẽme sia dzi ɖena kpɔtɔna.

Aleke nèwɔna léa ŋku ɖe blast cells ƒe agbɔsɔsɔme ŋu pɛpɛpɛ? Nukawoe nye dodokpɔ mawo?

Dodokpɔ geɖe li siwo ɖea blast cell ƒe agbɔsɔsɔ fiana:

• Peripheral blood smear (PBS): Dodokpɔ sia ɖenɛ fiana be blast cells le wò ʋu me. Le PBS me la, dɔléleŋutinunyala aɖe léa ŋku ɖe wò ʋu ƒe kpɔɖeŋu aɖe ŋu le nusuekpɔmɔ̃ me be yeakpɔe ɖa be lãmenugbagbevi siwo wogbãna sɔ gbɔ akpa alo ne wodze abe ɖe womesɔ o ene.
• Ƒumeŋuɖui dodokpɔ: Dodokpɔƒe dodokpɔ siwo wowɔna le ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe alo aspiration megbe ate ŋu ade dzesi blast cells le ƒumeŋuɖui me. Esiawo ate ŋu anye dodokpɔwo abe flow cytometry, immunohistochemistry, alo fluorescence in situ hybridization (FISH) ene be woatsɔ adi domenyiŋusẽfianu ƒe tɔtrɔ le lãmenugbagbeviwo me .
• Ðewohĩ ahiã hã be nàwɔ ʋu ƒe xexlẽme blibo (CBC) si me vovototo le be nàlé ŋku ɖe wò ʋumenugbagbevi dzĩwo kple ɣiwo kpakple ʋumenugbagbevi dzĩwo ƒe xexlẽme ŋu, elabena ʋumenugbagbevi siwo le lãmesẽ me ƒe xexlẽme ate ŋu aɖiɖi ne ʋumenugbagbevi dzĩwo ƒe xexlẽme le dzidzim ɖe edzi.

Ðɔktawo bua dodokpɔ me tsonu vovovowo kple nu vovovowo ŋu hafi kpɔa dɔléle aɖe abe ʋumenugbagbeviɣidɔ ene. Womenɔa te ɖe dodokpɔ ɖeka ko dzi wɔa nyametsotso gãwo o.

Mlɔeba la, nu ʋɛ aɖewo siwo dzi wòle be woaɖo ŋkui

Nu vevitɔe nye be màgatsi dzodzodzoe ne èkpɔ nya "blasts" le wò lab report me o.Enye nyateƒe be ne blast cells le wò ʋu me la, ate ŋu anye dɔléle sesẽ aɖe ƒe dzesi. Gake enɔ te ɖe wò lãmesẽ dzi. Ɣeaɖewoɣi la, blast cells ƒe dzidziɖedzi nyea ɣeyiɣi kpui aɖe ko. Xexlẽmea dzi ɖena kpɔtɔna le ɣeyiɣi aɖe megbe. Ɣebubuɣiwo la, ate ŋu anye nane si nu sẽ wu, abe ʋumenugbagbeviɣidɔ sesẽ ene, ƒe dzesi. Wò ɖɔkta koe ate ŋu aɖe nusi tututu wò emetsonuwo fia na wò lãmesẽ me. Eyata ne nya aɖe le asiwò la, mègahe ɖe megbe le wò ɖɔkta biabia me o.

` Blast cells, ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, ƒumeŋuɖui, ʋudodokpɔ, lãmenugbagbeviwo, lãmesẽ