Nukae Nye Castleman Dɔléle? Mina míaƒo nu tso eŋu bɔbɔe!

Ède dzesii kpɔ be ƒoƒo sue siawo nɔa wò kɔ alo abɔta? Ɣeaɖewoɣi la, wodzɔna ne dzamezã alo asrã le ŋuwò. Gake, esia menye nane si le bɔbɔe abe ema ene ŋu nya o. Esia nye nɔnɔme si mebɔ o gake wòle vevie be woanya. Míeyɔa esia be Castleman Dɔléle .

Kpuie ko la, Castleman Dɔléle nye nɔnɔme si me míaƒe ŋutilã ƒe dɔlélenutsiŋutete wɔa dɔ akpa . Bu eŋu kpɔ, ne dɔlékui aɖe si hea dɔléle vɛ ge ɖe míaƒe ŋutilã me la, míaƒe dɔlélenutsiŋutete wɔa avu kplii abe asrafo si yina aʋa ene. Ne woda dɔlélea la, asrafo ma gazi ɖoɖoe. Gake le amesi ŋu Castleman Dɔléle le gome la, dɔlélenutsiŋutete sia ‘nɔa dɔ dzi’ ɣesiaɣi. Esia nana abi nɔa ŋutilãa me ɣeyiɣi didi, si ate ŋu agblẽ nu le míaƒe ŋutinuwo ŋu.

Le ɣeyiɣi sia me la, míaƒe ʋukawo – ʋuʋudedi sue mawoe nye nusi míeyɔna – wɔa dɔ abe ʋuʋudedi ene. Woɖea dɔlékuiwo kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo katã to wo me. Eyata esi dɔlélenutsiŋutete le dɔ wɔm ɣesiaɣi ta la, ʋuka siawo hã le dɔ wɔm gaƒoƒo geɖe wu. Emegbe lãmenugbagbevi siwo le wo me tsina akpa, eye ʋuka siwo me ʋu sina tona la vuvuna. Menye vuvu sia ɖeɖeko o, ke le Castleman Dɔléle hã me la, tɔtrɔwo vaa ʋuka siawo ƒe lãkusiwo gɔ̃ hã me.

Esia nye dɔléle si mebɔ kura o . Le kpɔɖeŋu me, le United States la, ame yeye 4,300 va ɖo 5,200 koe wokpɔna ƒe sia ƒe. Eyata ɖɔktawo gakpɔtɔ le nu geɖe srɔ̃m tso esia ŋu. Gake ne wokpɔ dɔléle sia le ŋuwò la, àxɔ atike tɔxɛ siwo ku ɖe ŋuwò koŋ.

Nukawoe nye Castleman Dɔléle ƒomevi veviwo?

Dɔléle sia ƒomevi vevi evee li.

Castleman Dɔléle si Metsia O (UCD) .

Unicentric Castleman disease (UCD) nye ne ʋuka ɖeka alo ʋɛ aɖewo koe le wò ŋutilã ƒe akpa ɖeka lolo . Bu wò kɔ ko ŋu, alo wò abɔta ko. Castleman dɔnɔ siwo ade etɔ̃ le ene ɖesiaɖe me dzena le hatsotso sia me.

Castleman Dɔléle (MCD) si ƒe teƒe vovovowoe nye .

Multicentric Castleman disease (MCD) nye nɔnɔme si me ʋukawo vuvu le ŋutilã ƒe akpa vovovowo , ke menye ɖeka ko o. Ne míagblɔe tututu la, ɖɔktawo gamaa MCD ƒomevi sia ɖe eme be:

• MCD si do ƒome kple POEMS: POEMS nye ʋumenugbagbeviɣidɔ si mebɔ kura o. Ɣeaɖewoɣi la, POEMS ate ŋu adzɔ kpe ɖe MCD ŋu.
• MCD si do ƒome kple HHV-8: Dɔlékui aɖe si woyɔna be Human Herpes Virus-8 (HHV-8) ƒe dɔléle gbɔe esia ƒomevi tsona . Ne HIV dɔlékuia le ŋuwò alo dɔlélenutsiŋutete megale ŋuwò o la, anɔ eme be MCD sia ƒomevi adze dziwò.
• MCD si womenya nusi gbɔ wòtso o (Idiopathic MCD - iMCD):Esiae nye MCD ƒomevi si bɔ wu. ‘Idiopathic’ fia be womenya nusi tututu gbɔ wòtso o.

Fifia akpa sue etɔ̃ hã le iMCD sia si womenya o si gbɔ wòtsona la ŋu:

• iMCD si do ƒome kple TAFRO ƒe dɔléle: Ɣeaɖewoɣi la, nɔnɔme aɖe si woyɔna be TAFRO ƒe dɔléle ate ŋu akpe ɖe iMCD ŋu. Woɖe ŋkɔ TAFRO tso eƒe dzesiwo ƒe ŋɔŋlɔdzesi gbãtɔwo me. Esiawoe nye: Thrombocytopenia (ʋumenugbagbevi dzĩwo ƒe ɖiɖi), Anasarca (ŋutilã ƒe vuvu kple tsi), Asrã , Ayiku (ayiku) ƒe dɔmawɔmawɔ nyuie, kple Organomegaly (aɖuɖɔtoe alo aklã ƒe lolome).
• iMCD kple Idiopathic Plasmacytic Lymphadenopathy (iMCD-IPL): Le ƒomevi sue sia me la, ʋumenugbagbevi dzĩwo ate ŋu adzi ɖe edzi. Wò ʋumenugbagbevi ɣiwo hã ate ŋu awɔ dɔlékuiwutike geɖe akpa.
• iMCD si womegblɔe bubui o (iMCD-NOS): Womenya nusi tututu gbɔ ƒomevi sia, si woyɔna be iMCD-NOS, hã tso o, eye medo ƒome kple TAFRO o.

Nukae nye Castleman Dɔléle ƒe dzesiwo?

Castleman dɔlélea ƒe dzesiwo toa vovo le ƒomevi si le ŋuwò nu. Zi geɖe la, ne unicentric Castleman disease (UCD) le ŋuwò la, ɖewohĩ dzesi gã aɖeke madze ŋuwò o. Ðewohĩ ʋuka siwo vuvu koe nye dzesi si nàde dzesii. Gake ɣeaɖewoɣi la, dzesiwo ate ŋu ado mo ɖa ne ʋuka si vuvu la te ŋutinu bubu si te ɖe eŋu.

Gake ne MCD le ŋuwò la, anɔ eme be dzesiawo adze ƒã wu. Tsɔ kpe ɖe ʋuka siwo vuvu ŋu la, àte ŋu akpɔ dzesiwo abe:

• Asrã
• Ðeɖiteameŋu (esia ate ŋu anye ʋusɔgbɔdɔ ƒe dzesi) .
• Fifia le zã me
• Aɖuɖɔtoe kple ʋuʋudedi
• Lolo dzi ɖeɖe kpɔtɔ le susu aɖeke manɔmee
• Wò afɔ, afɔkpodzi, alo ƒodo ƒe vuvu
• Aɖuɖɔtoe si lolo (splenomegaly) alo aklã si lolo (hepatomegaly) .
• Asiwo kple afɔwo ƒe ʋuʋu (peripheral neuropathy) .

Nukae hea Castleman Dɔléle vɛ?

Womenya nusi tututu gbɔ Castleman dɔléle si nye unicentric Castleman disease (UCD) tsona haɖe o, gake wokpɔe be dɔlékui aɖe si woyɔna be HHV-8 ƒe dɔléle nye nusi na Castleman dɔléle si nye multicentric Castleman (MCD) va dzea ame dzi.

Dzɔdzɔmeŋutinunyalawo gale numekuku wɔm tso nu bubu siwo ate ŋu ahe UCD kple iMCD vɛ ŋu. Le kpɔɖeŋu me, wole dɔlékui bubu siwo menye HHV-8 o, domenyiŋusẽfianu ƒe tɔtrɔ , kple dɔlélenutsiŋutete ƒe ŋuɖoɖowo me dzrom .

Amekawoe le afɔku me wu be woaxɔ dɔléle sia?

Womekpɔ de dzesi afɔku tɔxɛ siwo ate ŋu ahe UCD alo iMCD vɛ haɖe o. Gake ne HIV dɔlékuia le ŋuwò alo dɔléle bubu aɖe si na wò dɔlélenutsiŋutete gbɔdzɔ la, ke èle afɔku me be nàxɔ MCD si do ƒome kple HHV-8.

Castleman dɔléle ate ŋu adzɔ le ƒe ɖesiaɖe me, gake wokpɔnɛ zi geɖe le amesiwo xɔ tso ƒe 30 va ɖo ƒe 60 me .

Nukawoe nye kuxi siwo ate ŋu ado tso Castleman Dɔléle me?

Castleman dɔlélea nana kansa xɔxɔ ƒe afɔkua dzina ɖe edzi, vevietɔ ʋumenugbagbeviɣidɔ .

Azɔ hã, togbɔ be ƒã ŋutɔ hã la, amesiwo ŋu UCD le la ate ŋu axɔ dɔléle sesẽ aɖe si woyɔna be Paraneoplastic Pemphigus (PNP) . MCD hã nana be dɔlékui siwo ate ŋu agblẽ nu le wò ŋutinuwo ŋu la xɔxɔ ƒe afɔkua dzina ɖe edzi. Nusiwo gblẽ sia ate ŋu ade ame ƒe agbe afɔku me ne womewɔ atike nɛ nyuie o.

Mègatsi dzi o, wò ɖɔkta alé ŋku ɖe wò nɔnɔmea ŋu ɣesiaɣi eye wòakpe ɖe ŋuwò nàxe mɔ ɖe kuxi mawo nu ɣesiaɣi si wòanya wɔ.

Aleke ɖɔktawo wɔa dea dzesi Castleman Dɔléle?

Castleman Dɔléle ƒe dzesiwo ate ŋu asɔ kple dɔléle bubu siwo bɔ, abe dzamezã alo dzamezã ene, ƒe dzesiwo. Eyata wò ɖɔkta aɖe nɔnɔme mawo ɖa gbã. Emegbe, woawɔ dodokpɔwo atsɔ anya Castleman Dɔlélea eye woanya ƒomevi si le eŋu.

Dodokpɔwo kple dɔwɔwɔwo ate ŋu anye:

• Dodokpɔ siwo woawɔ le dodokpɔxɔ me: Wò ɖɔkta alé ŋku ɖe wò ʋumenugbagbeviɣiwo ŋu be womesɔ o kple Castleman dɔlélea ƒe dzesi bubu siwo wokpɔna le nusuekpɔmɔ̃ me hã. Woate ŋu adɔ hã be woado HIV dɔlékuia kpɔ . Ne MCD si do ƒome kple HHV-8 le ŋuwò la, wò dodokpɔ ate ŋu anye be HIV dɔlékuia le ŋuwò.
• Nɔnɔmetatawo dodokpɔ: Dodokpɔwo abe CT scan kple PET scan ene ate ŋu akpe ɖe ŋuwò nàke ɖe ʋuka siwo vuvu le wò ŋutilã me ŋu, eye nàlé ŋku ɖe Castleman dɔlélea ƒe dzesi bubuwo abe aklã alo aklã si lolo ene hã ŋu.
• Lymph node biopsy: Mɔ ɖeka kolia si dzi nàto anya kple kakaɖedzi ne Castleman dɔlélea le ŋuwòe nye be woawɔ biopsy. Esia bia be woaɖe lãkusi sue aɖe tso ʋuka aɖe me ahadoe kpɔ le nusuekpɔmɔ̃ me. Esiae afia ne dɔlélea ƒe dzesi aɖewo li.

Aleke wodaa Castleman Dɔléleae?

Castleman dɔlélea dada toa vovo le ƒomevi si le ŋuwò nu.

Unicentric Castleman Dɔléle (UCD) ƒe Atikewɔwɔ .

UCD ƒe atikewɔwɔ vevitɔe nye be woawɔ dɔ na ame be woaɖe ʋuka siwo ŋu dɔlélea le la ɖa . Ɣeaɖewoɣi la, ahiã be woawɔ keklẽŋusẽdɔdamɔnu alo dɔlélenutsiŋutete ƒe dɔdamɔnu hafi woawɔ dɔ na wò. Dɔdamɔnu siawo ɖea tsitsi siwo le ʋukawo me dzi kpɔtɔna, si wɔnɛ be wo ɖeɖe ɖa nɔa bɔbɔe.

Gake ne amekolawo mete ŋu ɖe ʋuka si ŋu dɔlélea le la ɖa o, eye dzesi aɖeke mele ŋuwò o la, wò ɖɔkta ate ŋu alé ŋku ɖe eŋu le esi teƒe be wòadae. Ne dzesiwo le ŋuwò eye màte ŋu awɔ dɔ na wò o la, woate ŋu aɖo aɖaŋu na wò be nàda MCD.

Castleman dɔléle si me nu geɖe le (MCD) dada .

MCD dada sesẽ vie wu UCD. Esi wòkaka ɖe ŋutilã bliboa me ta la, zi geɖe la, womezãa amekoko alo keklẽŋusẽdɔdamɔnu o. Ke boŋ atikewɔwɔ nɔ te ɖe nenye be HHV-8 dɔlékui le ŋuwò kple alesi dɔlélea nu sẽe dzi.

Wò ɖɔkta ate ŋu azã atikewɔmɔnuwo abe:

• Corticosteroids: Atike siawo kpena ɖe ame ŋu be dɔdzẽ dzi ɖena kpɔtɔna eye wònaa gbɔdzɔe tso dzesiawo me.
• Atike siwo wozãna tsɔ daa dɔlékuiwoe: Atike siwo wozãna tsɔ daa dɔlékuiwoe kpɔa lãmenugbagbeviwo ƒe tsitsi fũu akpa le wò ʋukawo me dzi. Rituximab nye atike si woŋlɔna zi geɖe na MCD si do ƒome kple HHV-8.
• Dɔlélenutsiŋutete ƒe atikewɔwɔ: Dɔdamɔnu sia bia be woazã nuwo abe dɔlékuiwutike siwo nye monoclonal antibodies . Esiawo kpena ɖe ŋuwò be wò ŋutilã ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ fa. Siltuximab (Sylvant®) koe nye atike si dzi U.S. Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) da asi ɖo na iMCD.
• Dɔlékuiwutikewo: Ne MCD si do ƒome kple HHV-8 le ŋuwò la, àte ŋu ahiã dɔlékuiwutikewo be woatsɔ ada HIV alo HHV-8 dɔlékui.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne ède dzesii be ƒu alo tsitsi aɖe le wò kɔ, akɔta, alo akɔta la, yi ɖɔkta enumake . Azɔ hã, ne Castleman Dɔléle ƒe dzesi bubu siwo míeyɔ ɖe etame dometɔ aɖe le ŋuwò si meva nyona ɖe edzi le kwasiɖa ʋɛ aɖewo megbe o la, gblɔ wo hã na wò ɖɔkta.

Ɣeyiɣi didi kae nàte ŋu anɔ agbe kple dɔléle sia?

Le ame akpa gãtɔ siwo ŋu UCD le gome la, ŋgɔdonya, alo nukpɔsusua nyo ŋutɔ. Ne woɖe ʋuka siwo ŋu dɔlélea le ɖa la, ate ŋu ada dɔlélea. Le atikewɔwɔ me la, zi geɖe la, UCD mekpɔa ŋusẽ ɖe agbenɔƒe dzi o.

Gake alesi MCD le amesiwo ŋu MCD le ƒe mɔkpɔkpɔ nɔ te ɖe MCD ƒomevi si le wo ŋu kple alesi dɔlélea nu sẽe dzi. Le ame aɖewo gome la, dzesiawo ate ŋu adze kpata eye woate ŋu ade woƒe agbe afɔku me. Le ame bubuwo gome la, dzesiawo ate ŋu anɔ anyi eteƒe nadidi. Ame siwo ŋu wokpɔ MCD le la dometɔ 65% va ɖo 75% gakpɔtɔ le agbe le ƒe atɔ̃ megbe . Ne wozã atike yeyewo la, mɔkpɔkpɔ li be nɔnɔme sia anyo ɖe edzi.

Ŋuɖoɖo bɔbɔe aɖeke meli ne wole nu ƒom tso Castleman ƒe dɔlélea ŋu o. Wò nuteƒekpɔkpɔ anɔ te ɖe Castleman dɔléle ƒomevi si le ŋuwò dzi. Nɔnɔme bubuwo, abe HIV, alo nɔnɔme siwo do ƒome kplii, abe TAFRO kple POEMS ene, hã ate ŋu akpɔ ŋusẽ ɖe wò nuteƒekpɔkpɔ dzi. Le go aɖewo me la, amekoko kple ŋkuléle ɖe nu ŋu nyuie koe hiã. Alo, àte ŋu ahiã atikewɔwɔ vovovowo le wò agbemeŋkekewo katã me be nàxe mɔ ɖe kuxiwo nu. Bia wò ɖɔkta alesi wò dɔlélea akpɔ ŋusẽ ɖe wò atikewɔwɔ kple nukpɔsusu dzii hã.

Eyata nu vevi kawo dzie wòle be míaɖo ŋkui tso esia me?

• Castleman Dɔléle nye dɔlélenutsiŋutete ƒe dɔléle si mebɔ o gake ate ŋu anye nu sesẽ si me míaƒe dɔlélenutsiŋutete wɔa dɔ fũ akpa le.
• Wole ƒomevi vevi eve: UCD kple MCD. Le UCD me la, ʋukawo vuvu le teƒe ɖeka, gake le MCD me la, wovuvuna le teƒe geɖe.
• Dzesiawo to vovo. Ɣeaɖewoɣi la, ɖewohĩ dzesi aɖeke manɔ eŋu kura o, ke boŋ ƒunukpeƒetetedɔ si vuvu koe. Alo dzesiwo abe asrã, ɖeɖiteameŋu, kple lolo dzi ɖeɖe kpɔtɔ ene ate ŋu anɔ anyi.
• Menye ɣesiaɣie nusiwo gbɔ wòtso la me kɔna o, gake wogblɔ be HHV-8 dɔlékuia do ƒome kple MCD. Ame siwo ŋu HIV dɔlékuia le la le afɔku gã aɖe me.
• Zi geɖe la, ne wokpɔe kaba eye wodae nyuie la, ate ŋu ana nu nyuiwo nado tso eme. Eyata ne ède dzesi ƒunukpeƒetetedɔ, vuvu, alo dzesi bubu siwo mebɔ o le wò ŋutilã ŋu la, di atikewɔlawo ƒe aɖaŋuɖoɖo enumake. Nu vevitɔ kekeakee nye be nànɔ nyatakaka nam eye màgatsi dzodzodzoe o.

` Castleman Dɔléle, Lãmetsiŋusẽ, Lãmetsiŋusẽ ƒe Dɔléle, Dɔlélenutsiŋutete, UCD, MCD, HHV-8, Dzesiwo, Atikewɔwɔ