Ðe tsikɔ ​​wu wò hã ɣesiaɣi eye nèɖea aɖuɖɔ abe zi blaeve ene gbesiagbea? Ðe esia nye Arginine Vasopressin Dɔléle / Suklidɔ Insipidus?

Ðe tsikɔwuame si womate ŋu ado dzi atsɔ o hã le ŋuwòa? Ðe nèsena le ɖokuiwò me be yemate ŋu ano tsi wòasu oa? Ðe wòle be nàyi tsileƒe hã zi geɖe gbesiagbe, ɣeaɖewoɣi zi ɖeka alo zi eve gɔ̃ hã le gaƒoƒo ɖeka mea? Ne ele be nàfɔ le zã me hafi aɖu aɖuɖɔ evɔ mèdɔ alɔ̃ nyuie o la, esia menye nusi woabu nu tsɛe o. Egbea míele nu ƒom tso dɔléle aɖe si mebɔ o gake woate ŋu adae si ɖea dzesi mawo tɔgbe fiana ŋu. Do ŋgɔ la, woyɔa esia be ‘Suklidɔ si mebɔ o’.

Nukae Nye Arginine Vasopressin Dɔléle?

Kpuie ko la, nɔnɔme sia nye ne wò ŋutilã le aɖuɖɔ geɖe ɖem. Esia fia be wò ŋutilã mete ŋu léa tsi si sɔ o. Nusi koŋ gbɔ esia tsoe nye lãmetsi aɖe si woyɔna be Arginine Vasopressin (AVP) ƒe kuxi . Ðɔktawo yɔa lãmetsi sia hã be ``AVP`` be Antidiuretic Hormone (ADH) . ``AVP`` lãmetsi sia wɔa akpa vevi aɖe ŋutɔ le tsi ƒe agbɔsɔsɔ si le ŋutilã me ƒe dadasɔ me to míaƒe ayikuwo dzi.

Nɔnɔme siawo ƒomevi vevi eve li:

1. AVP ƒe anyimanɔmanɔ (AVP-D): Esia nye ne wò ŋutilã mewɔa lãmetsi si nye AVP wòde edeƒe o.

2. AVP ƒe tsitretsitsi (AVP-R): Esia nye ne wò ayikuwo mewɔa nu nyuie ɖe lãmetsi si nye AVP ŋu o. Esia fia be togbɔ be lãmetsiŋusẽa le eme hã la, ayikuawo mezãnɛ o.

Nukae nye nɔnɔme sia ƒe dzesiwo?

AVP ƒe anyimanɔmanɔ kple AVP ƒe dɔlélenutsiŋutete ƒe dzesi veviwoe nye:

• Ehiã be nàɖe aɖuɖɔ enuenu: Esia ƒe dzesi vevi aɖee nye be menye ŋkeke me koe wòle be nàfɔ aɖu aɖuɖɔ o ke le zã me hã (Nocturia) .
• Aɖuɖɔ si ƒe amadede le keklẽm alo esi me tsi le agbɔsɔsɔ gã aɖe dodo: Zi geɖe la, ame toa aɖuɖɔ si ade lita 1 va ɖo 3 gbesiagbe. Gake amesi ŋu dɔléle sia le ate ŋu ato aɖuɖɔ si ade lita 20 gbesiagbe. Bu alesi gbegbe ema nyee ŋu kpɔ!
• Tsikɔwuame si gbɔ eme (Polydipsia): Sese le ɖokuiwò me be yemele yeƒe tsikɔwuame nu tsim o eɖanye tsi agbɔsɔsɔme ka kee nèno o.

Dzesi siawo nye dzesi sẽŋu aɖe be nane mele dɔ wɔm nyuie le wò ŋutilã me o. Ele vevie ŋutɔ be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo kaba ale si nàte ŋui.

Aleke dzesi siawo gblẽa nu le ɖevi suewo ŋui?

Ne nɔnɔme sia dze ɖevi suewo dzi la, dzesiawo ate ŋu ato vovo vie. Wo dometɔ aɖewoe nye:

• Tsikuɖiɖi sesẽ .
• Miléle.
• Ʋuʋudedi.
• Dzoxɔxɔ enuenu.
• Nɔnɔme si me tɔtɔ le ŋutɔ eye wòdoa dziku la ɖeɖefia.
• Tsitsi ƒe ʋuʋu / Do kpo dzidzedzekpɔkpɔ.

Ne dzesi siawo le vidzĩwo alo ɖevi suewo ŋu la, ele be ɖɔkta nakpɔ wo enumake godoo.

Nukatae arginine vasopressin ƒe dɔléle siawo dzɔna?

Susuawo to vovo, le ƒomevi si míeyɔ va yi nu.

Nusiwo gbɔ AVP ƒe anyimanɔmanɔ tsona `(AVP-D)`

Tsã la, woyɔnɛ be suklidɔ si nye central diabetes insipidus , eye lãmetsi si nye arginine vasopressin (AVP) ƒe anyimanɔmanɔ gbɔe esia tsona. Esiae nye ƒomevi si bɔ wu.

Esia ate ŋu atso:

• Nusiwo gblẽ le hypothalamus alo pituitary gland ŋu (esiawo nye ahɔhɔ̃a ƒe akpa vevi siwo kpɔa lãmetsiwo dzi). Nusiwo gblẽ sia ate ŋu atso amekoko alo ta ƒe abixɔxɔ gbɔ.
• Domenyiŋusẽfianu ƒe tɔtrɔ aɖewo (Domenyiŋusẽfianu ƒe tɔtrɔ si dome wonyi) .
• Dɔdzẽ ƒe wɔwɔme .
• Dzoxɔxɔ / Granulomas si tso atikewɔwɔ ƒe nɔnɔme aɖewo gbɔ, abe sarcoidosis alo yɔmekpe ene.
• Ɣeaɖewoɣi la, womate ŋu ake ɖe nusi gbɔ wòtso ŋu o (idiopathic) . Esia fia be le dɔnɔawo ƒe afã lɔƒo gome la, womenya nusi gbɔ wòtso o.

Nusiwo gbɔ AVP ƒe dɔlélenutsiŋutete tsona (AVP-R) .

Tsã la, woyɔa suklidɔ sia ƒomevi be nephrogenic diabetes insipidus . Le go sia me la, ayiku si woyɔna be pituitary gland ye wɔa lãmetsi si nye AVP, gake ayikuawo mewɔa nu ɖe ​​eŋu nyuie o.

Susu geɖewo tae wòle alea ɖo:

• Domenyiŋusẽfianu ƒe tɔtrɔ aɖewo.
• Aɖuɖɔtoe si xe .
• Atike aɖewo zazã ɣeyiɣi didi , vevietɔ lithium .
• Calcium ƒe agbɔsɔsɔ si dzina ɖe edzi le ʋu me (Hypercalcemia) .
• Potassium ƒe agbɔsɔsɔ si bɔbɔ ɖe ʋu me (Hypokalemia) .

Ƒomevi tɔxɛ aɖe si dzɔna le fufɔɣi

Woyɔa esia be Fufɔfɔ ƒe Arginine Vasopressin Dɔléle (gAVP-d) . Esia mebɔ kura o. Le fufɔɣi la, vidzidɔa wɔa enzyme aɖe si gblẽa lãmetsi si nye AVP me fũ akpa.

Anɔ eme be nɔnɔme sia anɔ ŋuwò wu, le susu aɖewo ta :

• Ne èle venɔvi alo vi siwo wu nenema tsɔm .
• Ne dɔléle aɖe le ŋuwò si gblẽa nu le aklã ƒe dɔwɔwɔ ŋu, abe preeclampsia alo HELLP syndrome ene .

Nya nyuia enye be zi geɖe la, `gAVP-d` nɔnɔme sia nu yina le kwasiɖa eve va ɖo etɔ̃ le vidzidzi megbe.

Nukawoe nye nɔnɔme sia ƒe kuxiwo?

Kuxi vevitɔ si le AVP-D kple AVP-R ŋue nye tsikuɖiɖi , si nye tsi kple elektrikŋusẽ siwo hiã be ŋutilãa nate ŋu awɔ dɔ la ƒe bu.

Zi geɖe la, àte ŋu aɖu wò aɖuɖɔ ƒe dodo dzi ne èno tsi geɖe wu esi nèhiã, gake ne mènoe o la, tsi ate ŋu agbɔdzɔ wò kaba ŋutɔ.

Tsikunɔamesi ate ŋu ade ame ƒe agbe afɔku me. Ne tsikuɖiɖi ƒe dzesiwo le ŋuwò, abe taɖuame, lãmetutudɔ, alo ɖeɖiteameŋu si gbɔ eme ene la, yi kɔdzi si te ɖe ŋuwò kaba ale si nàte ŋui.

Aleke ɖɔktawo dea dzesi esia?

Esi wònye be tsikɔwuame kple aɖuɖɔtoe enuenu ƒe dzesiwo ateŋu atso nɔnɔme bubu siwo bɔ hã gbɔ ta la, ɖɔktawo gbea nɔnɔme bubuwo gbã ne wole dzesi dem `AVP-D` alo `AVP-R`. Ne dzesi siawo le ŋuwò la, anɔ eme be wò ɖɔkta aɖe gbe be woadoe kpɔ zi geɖe.

Ne wole dɔléle sia kpɔm la, ehiã be woakpɔe ɖa be `AVP-D` alo `AVP-R` ye eye nusi gbɔ wòtso.

Dodokpɔ siwo wowɔna tsɔ dia dɔlélewoe

• Tsi ƒe veve dodokpɔ: Esiae nye mɔ si ŋu kakaɖedzi le wu si dzi woato anya AVP-D alo AVP-R. Woalé ŋku ɖe ŋuwò nyuie le dodokpɔ sia wɔwɔ me, elabena esia ate ŋu ana tsi nagbɔdzɔ. Dodokpɔ sia bia be màno tsi aɖeke gaƒoƒo geɖe o eye nàkpɔ alesi wò ŋutilã wɔa nui. Ne dɔléle sia le ŋuwò la, àyi edzi anɔ aɖuɖɔ gbogbo aɖewo siwo me tsi le, siwo ƒe amadede le keklẽm la tom. Ne nɔnɔme sia mele ŋuwò o la, aɖuɖɔ sue aɖe si me wodea amii, si ƒe amadede nye ɣie la koe nàto.
• Copeptin ƒe ʋudodokpɔ: Copeptin nye lãmetsi si nye AVP ƒe akpa aɖe.
• Suklidɔ dodokpɔ le ʋu me: Wowɔa esia tsɔ léa ŋku ɖe suklidɔ, si hã ƒe dzesiwo sɔ kple wo nɔewo ŋu.
• Aɖuɖɔtoe me dzodzro: Esia doa osmolality ( aɖuɖɔ ƒe agbɔsɔsɔ) kple ketone siwo le aɖuɖɔ me kpɔna.
• Nɔnɔmetata dodokpɔwo abe MRI scans (MRI - Magnetic Resonance Imaging): Wowɔa esiawo be woakpɔe ɖa be nu gblẽ le pituitary gland alo hypothalamus ŋu hã.

Aleke wowɔa nu ɖe ​​`AVP-D` kple `AVP-R` siawo ŋui?

Atikewɔwɔ nɔ te ɖe nenye be `AVP-D` alo `AVP-R` le ŋuwò dzi. Eɖanye atikewɔwɔ ka kee ɖale eŋu o, ele vevie be nàno tsi geɖe be tsi nagage ɖe eme o.

AVP-D (Dzesidede) ƒe Atikewɔwɔ

Desmopressin ye nye atike vevitɔ si wozãna na AVP-D. Enye atike si wɔa dɔ abe alesi lãmetsiŋusẽ si nye AVP wɔa dɔe ene. Woate ŋu anoe le nɔnɔme vovovowo me (e.g., abe atike si wotsɔna ƒua gbe ɖe no me ene, abe atikekui ene).

Wozãa desmopressin ɣeaɖewoɣi na fufɔfɔ ƒe nɔnɔme si mebɔ o ``(gAVP-d)''. Gake ɣeaɖewoɣi le fufɔɣi la, woate ŋu aɖu edzi ne wono tsi geɖe.

AVP-R (Tsitretsitsi) ƒe Dɔdamɔnu

`AVP-R` dada sesẽ vie. Ɣeaɖewoɣi la, ehiãna be woazã mɔnu vovovowo ɖekae. Le kpɔɖeŋu me:

• Thiazide ƒe tsinyegoe me tsiwo(Togbɔ be atike siawo nye atike ƒomevi aɖe si dzia aɖuɖɔtoe ɖe edzi hã la, wowɔa dɔ le mɔ bubu nu le nɔnɔme sia me)
• Atike siwo me steroid mele o siwo tsia dzodzodzoetsitsi nu (NSAIDs) .

Ne atike aɖe si zãm nèle gbɔe `AVP-R` nɔnɔmea tso la, wò ɖɔkta ateŋu ada dɔlélea to asitɔtrɔ le ŋuwò ɖe atike bubu ŋu me.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne `AVP-D` alo `AVP-R` le ŋuwò la, ele vevie ŋutɔ be nàkpɔ wò ɖɔkta edziedzi hena aɖaŋuɖoɖo. To mɔ sia dzi la, wò ɖɔkta ate ŋu awɔ dodokpɔwo atsɔ alé ŋku ɖe wò nɔnɔmea ŋu ahakpɔ egbɔ be wò atikewɔwɔa le dɔ wɔm nyuie.

Àte ŋu akpɔe be anyo be yeabia nya siawo wò ɖɔkta:

• Ðe `AVP-D` alo `AVP-R` le asinyea?
• Nuka tae wòle alea ɖo?
• Ðe esia nye nɔnɔme si nɔa anyi didi (si nɔa anyi didi) loo alo ɣeyiɣi kpui aɖe ƒe dɔlélea?
• Atikewɔwɔmɔnu kawoe le asinye?
• Tsi nenie wòle be mano gbesiagbe?
• Nukae magate ŋu awɔ atsɔ akpɔ nɔnɔme sia gbɔe?
• Ðe nye ƒomea hã le afɔku me be woaxɔ arginine vasopressin dɔlélea?

Nukae mateŋu akpɔ mɔ na ne `AVP-D` alo `AVP-R` le asinye?

Mɔkpɔkpɔ (emetsonu) na `AVP-D` kple `AVP-R` nɔnɔmewo nyo le goawo katã me. Ne èzã atike nyuitɔ eye nèno tsi si sɔ la, mele be kuxi sesẽ aɖeke nado mo ɖa o.

Gake kuxiwo ate ŋu adze ame siawo dzi wu:

• Vidzĩwo
• Ame siwo xɔ wu ƒe 65
• Ame siwo ŋu susu ƒe lãmesẽkuxi aɖewo alo tsitsi ƒe gbɔdzɔgbɔdzɔwo le

Ate ŋu asesẽ na ame siawo be woade dzesi woƒe tsikɔwuame, alo womate ŋu awɔ afɔɖeɖe ɖe eŋu o.

Nukatae womeyɔ esia be ‘Diabetes Insipidus’ fifia o?

Le ƒe 2022 me la, atikewɔha geɖewo tso nya me be yewoatrɔ ŋkɔ na `Diabetes Insipidus` wòazu `Arginine Vasopressin Deficiency` kple `Arginine Vasopressin Resistance`. Nusi koŋ gbɔ esia tsoe nye tɔtɔ si nya `suklidɔ` he vɛ kple lãmesẽkuxi gbegblẽ siwo wòhe vɛ.

Ne ame akpa gãtɔ gblɔ ko be "suklidɔ" la, wofia suklidɔ . Sukli ƒe agbɔsɔsɔ si sɔ gbɔ ɖe ʋu me gbɔe wòtsona. Dzesiwo abe tsikɔwuame kple aɖuɖɔtoe enuenu ene hã le eŋu. Ke hã, ebɔ wu nɔnɔme siwo nye `AVP-D` kple `AVP-R` (si woyɔna tsã be `Diabetes Insipidus`). Azɔ hã, suklidɔ ƒe atikewɔwɔ to vovo kura tso `AVP-D` kple `AVP-R` ƒe atikewɔwɔ gbɔ.

Nya "suklidɔ" tso Helagbe me nya "suklidɔ," si gɔmee nye "be woato eme." Wozã ŋkɔ ma elabena abe alesi wòle le suklidɔ gome ene la, tsiwo toa ŋutilãa me kabakaba akpa, si nye nusi dzɔna le arginine vasopressin ƒe dɔléle siawo me.

Mlɔeba la, ele nam be magblɔe na wò... (Take-Home Message)

Ne `AVP-D` (arginine vasopressin ƒe anyimanɔmanɔ) alo `AVP-R` (arginine vasopressin ƒe dɔlélenutsiŋutete) le ŋuwò la, àte ŋu ase le ɖokuiwò me be yezã yeƒe agbe ƒe akpa gãtɔ le tsileƒe, màte ŋu atsi wò tsikɔwuame nu o eɖanye tsi agbɔsɔsɔme ka kee nèno o. Gake nya nyuiae nye be woate ŋu aɖu nɔnɔme siawo dzi.

Wò ɖɔkta awɔ atikewɔwɔ ƒe ɖoɖo aɖe si awɔ dɔ na wò, eye wòagblɔ tsi agbɔsɔsɔme si wòle be nàno gbesiagbe be tsi nanɔ eme hã na wò. Mègatsi dzodzodzoe o. Na wò ɖɔkta nakpe ɖe ŋuwò ahafia mɔ wò. Ðo ŋku edzi be menye "suklidɔ" ye nye esia o. Esia tae wòle vevie be woakpɔ dɔlélea nyuie ahadae nyuie ɖo. Menye wò ɖeka koe o, nɔ nyanya nam, eye nàsẽ ŋu.

` Arginine Vasopressin Dɔlélewo, Suklidɔ Insipidus, AVP, ADH, Tsikɔwuame si gbɔ eme, Aɖuɖɔɖɔɖɔ Enuenu, Tsikuɖiɖi, Polydipsia, Nocturia, Desmopressin, Ayiku, Lãmetsiŋusẽwo