Le dzɔdzɔme nu la, ƒuƒu alo ʋuʋudedi sue aɖe didi le wò ŋutilã ŋu ate ŋu anye nusi me dziɖeleameƒo le kura. Àte ŋu akpɔe be yele eŋu bum be, "Nukae nye esia? Ðe wòate ŋu anye nu vevi aɖea?" Egbea la, míedi be míaƒo nu tso nɔnɔme aɖe si mebɔ kura o si ate ŋu adze abe ƒunukpeƒetetedɔ mawo ene ŋu : Epithelioid Sarcoma . Togbɔ be ŋkɔa aɖi nusi mènya o hã la, nɔnɔme sia gɔmesese le vevie na wò susu ƒe akɔdzeanyi kple lãmesẽ, si Nirogi Lanka tsɔ vɛ na wò.
Nuka tututue nye Epithelioid Sarcoma?
Kpuie ko la, Epithelioid Sarcoma (ES) nye kansa ƒomevi aɖe si mebɔ kura o si le ƒuƒoƒo aɖe si woyɔna be soft tissue sarcomas me . “Lãmetsi falɛfalɛ” fia lãmekawo, ami, ʋukawo, kple lãmeka siwo le wò ŋutilã katã me. Zi geɖe la, kansa sia dzɔna le lãkusi siawo me.
Zi geɖe la, edzea egɔme abe ʋuʋudedi si me vevesese aɖeke mele o ene le wò abɔwo, asiwo, asibidɛwo, afɔwo, alo afɔwo me . Gake ate ŋu adze le ŋutilãa ƒe akpa ɖesiaɖe. Ɣeaɖewoɣi la, àte ŋu akpɔ ƒunukpeƒetetedɔ siwo wu ɖeka, alo ŋutigbalẽ si le ƒunukpeƒea tame ate ŋu axɔ abi .
Nusi ɖe dzesi le Epithelioid Sarcoma ŋue nye be zi geɖe la, enye kansa si tsina blewu ŋutɔ . Nɔnɔme sia ate ŋu anɔ ame aɖewo ŋu ɣleti geɖe alo ƒe geɖe gɔ̃ hã evɔ womakpɔ dzesi aɖeke o. Esia fia be agbɔsɔsɔa ate ŋu anɔ tsitsim blewu ŋutɔ evɔ mànya gɔ̃ hã o.
Nɔnɔme sia ƒomevi vevi eve li: Distal kple Proximal. Na míalé ŋku ɖe nusi ema fia na wò ŋu.
Ðe ƒomevi vovovowo lia?
Ẽ, abe alesi míegblɔe ene la, hatsotso vevi eve li:
- Distal Type: Esiae nye ƒomevi si bɔ wu . “Distal” fia teƒe siwo didi tso ŋutilãa titina wu. Esia ƒomevi dzɔna zi geɖe le wò asiwo, abɔta, afɔkpodzi, kple afɔwo me .
- Proximal Type: Esia nye ƒomevi si mebɔ o, si me wowɔa adã le wu . “Tete” fia teƒe siwo te ɖe ŋutilãa ƒe titina ŋu wu. Proximal Epithelioid Sarcoma (PES) ate ŋu adze wò akɔta, ƒodo, abɔta, vidzinuwo (abe vidzinu alo vidzidɔ ene), alo ta kple kɔ gɔ̃ hã me .
Zi geɖe la, Proximal ƒomevi la wɔa adã wu Distal ƒomevi, si fia be ate ŋu akaka alo ayi ŋgɔ kabakaba wu, si ate ŋu ana atikewɔwɔ ƒe ɖoɖoa nasesẽ wu.
Aleke gbegbee esia bɔe, eye amekae le afɔku me?
Esia nye kansa si mebɔ kura o. Ne míagblɔe nyuie la, lãmeka falɛfalɛwo ƒe sarcomas ƒomevi siwo wu 50 ye li, eye wo katã ne wotsɔ wo katã ƒo ƒui la, wonye ame tsitsiwo ƒe kansawo katã ƒe 1% ko. Epithelioid Sarcoma tsi tre ɖi na 1% ma ƒe akpa sue aɖe ŋutɔ.
Eŋutinunyalawo bu akɔnta be le dukɔwo abe United States ene me la, amesiwo le dɔ lém la mede 1,000 o. Abe alesi nàte ŋu akpɔe ene la, enye dɔléle si wokpɔna si mebɔ kura o.
Le nyateƒe me la,:
- Distal Type ES – si bɔ – dzea ƒewuiviwo kple sɔhɛ tsitsiwo dzi zi geɖe .
- Proximal Type ES – si mebɔ o, si me wowɔa adã le wu – dzena le ame tsitsiwo me wu .
Nukawoe nye dzesiawo, eye aleke wowɔna dea dzesii?
Le gɔmedzedzea me la, Epithelioid Sarcoma ate ŋu ahe dzesi aɖeke vɛ kura o, si fia be ate ŋu anɔ anyi evɔ màse le ɖokuiwò me be yeƒe ŋutilã me tɔtrɔ aɖeke o. Gake ne agbɔsɔsɔa le dzidzim ɖe edzi la, àte ŋu ade dzesii be:
- Kpe alo ʋuʋudedi yeye si ate ŋu anɔ sue alo lolo.
- Ŋutilã ƒe abi siwo le afisi ƒunukpeƒea le, si dzena abe abi sue aɖe si wotsɔ ƒoe alo abi si mehaya o ene.
- Vevesese , togbɔ be zi geɖe la, ne dɔdzẽa lolo ale gbegbe be wòate ɖe lãmeka alo lãmeka siwo ƒo xlãe ŋu ko hafi esia dzɔna hã. Menye amesiamee sea veve o.
- Seselelãme si nye be ƒunukpeƒetetedɔ si nɔ anyi do ŋgɔ la ƒe lolome le dzidzim ɖe edzi vivivi .
Vevietɔ: Ne ède dzesii be ƒuƒu alo vuvu yeye aɖe le eŋu, alo edze abe ɖe si li xoxo le tsitsim ene la, taflatse yi ɖɔkta gbɔ enumake . Ate ŋu anye nya bɔbɔe aɖe, gake dɔwɔla bibi aɖe ƒe numekuku xɔxɔe nye afɔɖeɖe si le dedie wu.
Nukatae wòdzɔna ɖo?
Ne míagblɔe tututu la, atikewɔlawo menya nusi tututu gbɔ Epithelioid Sarcoma tsona haɖe o. Gake numekukuwo ɖee fia be zi geɖe la, edo ƒome kple nusiwo mesɔ o le SMARCB1 domenyiŋusẽfianu me . Domenyiŋusẽfianu sia naa mɔfiame ŋutilãa be wòawɔ protein aɖewo. Zi geɖe la, domenyiŋusẽfianu ƒe tɔtrɔ siawo sua ame si le wò agbenɔɣi, si fia be zi geɖe la, menye nɔnɔme si ƒe dome nèle o .
Abe alesi wòle le lãmeka falɛfalɛ geɖe ƒe sarcoma gome ene la, zi geɖe la, edzɔna nusi gbɔ wòtso si me kɔ o. Gake ame ɖekaɖeka siwo xɔ keklẽŋusẽdɔdamɔnu na kansa bubuwo va yi la ate ŋu adzi afɔkua ɖe edzi vie.
Tsɔ kpe ɖe eŋu la, domenyiŋusẽfianu ƒe kansadɔ aɖewo ate ŋu ana Epithelioid Sarcoma xɔxɔ ƒe afɔkua nadzi ɖe edzi vie. Esiawo dometɔ aɖewoe nye:
- Gardner ƒe dɔlélea
- Neurofibromatosis Ƒomevi 1 kple Ƒomevi 2
- Retinoblastoma ƒe dɔléle
- Li-Fraumeni ƒe dɔlélea
- Tuberous sclerosis ƒe dɔléle sesẽ
- Werner ƒe dɔlélea
- Gorlin ƒe dɔlélea
Nya siawo sesẽ, gake wò atikewɔwɔ ŋutinya nyanya le vevie ŋutɔ. Ne dɔléle siawo dometɔ aɖe le ŋuwò la, taflatse dzro wo me kple wò ɖɔkta.
Ðe wòkaka ɖe ŋutilã bliboa mea?
Le go geɖe me la, Epithelioid Sarcoma si le teƒe ɖeka la mekakana ɖe teƒe bubuwo (kaka o). Gake Proximal ƒomevi siwo wɔa adã wu la ate ŋu akaka. Ne ekaka la, zi geɖe la, egblẽa nu le ʋukawo, lãkusiwo, kple ƒuwo ŋu .
Aleke wokpɔa dɔlélea dzea sii?
Ðɔkta azã dodokpɔ geɖe atsɔ aɖo kpe Epithelioid Sarcoma dzi pɛpɛpɛ alo aɖee ɖa. Mɔnu vevi siwo wozãna tsɔ dia dɔlélea dometɔ aɖewoe nye:
- Lãmesẽdodokpɔ: Wò ɖɔkta awɔ ŋutilãmedɔdada tsitotsito atsɔ ada afisi ƒunukpeƒea le, eƒe lolome, kple eƒe nɔnɔmewo kpɔ.
- Biopsy: Esiae nye dodokpɔ vevitɔ kekeake . Woɖea ƒunukpeƒea ƒe kpɔɖeŋu sue aɖe ɖa hedaa eŋu le nusuekpɔmɔ̃ me. Esia ɖo kpe edzi nenye be kansae tsitsia nye eye ne ele nenema la, efiaa ƒomevi si koŋ wòle.
- Ʋudodokpɔ hena kansa: Woate ŋu ade dzesi dɔdzẽ ƒe dzesi aɖewo ɣeaɖewoɣi to ʋudɔwɔwɔ me.
- Magnetic Resonance Imaging (MRI): Esia naa nukpɔkpɔ si me kɔ ŋutɔ, si kpena ɖe wò ɖɔkta ŋu wòdea dzesi afisi tututu dɔdzẽa le, eƒe lolome, kple nenye be elɔ lãkusi siwo ƒo xlãe ɖe eme.
- Computed Tomography (CT scans): Wozãa scan siawo tsɔ léa ŋku ɖe dɔdzẽa ŋu hekpɔnɛ ɖa be kansa la kaka ɖe teƒe bubuwo abe lãkusi ene hã.
- Positron Emission Tomography (PET scans): Esiawo ɖea vi le dzesidede kansa lãmenugbagbeviwo ƒe tsitsi si le dɔ wɔm le ŋutilã bliboa me.
Ðewohĩ màhiã dodokpɔ siawo katã o. Wò ɖɔkta anɔ te ɖe wò dɔdamɔnu tɔxɛ si nèzãna dzi anya dɔwɔnu siwo hiã be woatsɔ akpɔ dɔlélewoe.
Dɔdamɔnu kawoe li?
Wò ɖɔkta atrɔ asi le wò atikewɔwɔ ƒe ɖoɖoa ŋu to nusiwo nye dɔdzẽa ƒe lolome kple afisi wòle, ne ekaka, wò lãmesẽ bliboa, kple wò ŋutɔ wò didiwo ŋu bubu me.
Amekoko
Amekoko be woaɖe dɔdzẽa ɖae nye atike gbãtɔ si wozãna na epithelioid sarcoma eye wòbɔ wu . Ne kansa la kaka ɖe ʋuka siwo te ɖe ŋuwò me la, wò amekola ate ŋu aɖe esiawo hã ɖa.
Kekeli ƒe Dɔdamɔnu
Esia nye kansa dada si bɔ si me wozãa X-ray siwo me ŋusẽ geɖe lebe woatsɔ atsrɔ̃ kansa lãmenugbagbeviwo. Wò ɖɔkta ate ŋu aɖo aɖaŋu be nàzã keklẽŋusẽ hafi awɔ dɔ na wò be dɔdzẽa naɖiɖi, alo le amekoko vɔ megbe be nàɖe kansadɔlékui siwo susɔ la ɖa.
Atikewo zazã
Ne kansa la kaka ɖe wò ŋutilã ƒe akpa bubuwo la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàzã atikewo . Esia bia be woazã atike tɔxɛwo atsɔ atsi kansa lãmenugbagbeviwo nu alo awu wo. Togbɔ be zi geɖe la, wodoa nusiawo to ʋuka me hã la, woate ŋu ana wo ɣeaɖewoɣi abe atikekui, tsi, atike siwo wotsɔna tsia lãme na ame, alo atike siwo wodona ɖe lãme na ame ene.
Atike Siwo Wozãna ƒe Atikewɔwɔ si Woɖo Tae
Esia nye egbegbe mɔnu si tɔa ŋku domenyiŋusẽfianu kple protein tɔxɛ siwo kpɔa alesi kansa lãmenugbagbeviwo tsina hemãna dzi, si kpena ɖe ame ŋu be wòaɖe nusiwo gblẽ le lãmenugbagbevi siwo le lãmesẽ me ŋu dzi akpɔtɔ. Wò ɖɔkta awɔ ɖoɖo tɔxɛ aɖe na wò; le kpɔɖeŋu me, Tazemetostat nye atike si wozãna na epithelioid sarcoma, vevietɔ ne womate ŋu aɖe dɔdzẽa ɖa keŋkeŋ to amekoko me o.
Ðe woate ŋu axe mɔ ɖe esia nua?
Nublanuitɔe la, esi wònye be zi geɖe la, epithelioid sarcoma dzɔna evɔ womete ŋu dea dzesi nusi gbɔ wòtso nyuie o ta la, mɔ aɖeke meli si wonya si dzi woato axe mɔ ɖe enu o . Agbenɔnɔ ƒe tɔtrɔ aɖeke koŋ meli si ana woakpɔ ame ta tso eŋu o.
Nukae dzɔna ne wokpɔe be epithelioid sarcoma le ŋunye? Ðe woate ŋu adaea?
Enye dzɔdzɔme nu be nàtsi dzimaɖi, gake woate ŋu ada epithelioid sarcoma , vevietɔ ne wokpɔe kaba . Wò ɖɔkta azã dodokpɔa me tsonu atsɔ ada nɔnɔmea ƒe afɔɖeɖe kpɔ eye wòawɔ atikewɔwɔ ƒe ɖoɖo si sɔ na wò.
Anɔ eme be ƒuƒoƒo aɖe si me tɔwo wɔa dɔ vovovowo, siwo dometɔ aɖewoe nye:
- Wò atikewɔla vevitɔ .
- Kansaŋutinunyalawo: Eŋutinunyala bibiwo abe ƒumeŋuɖuiŋutinunyalawo, kansadɔdala siwo wɔa amekoko, kple ɖɔkta siwo bi ɖe atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu me ene.
- Ŋutilãŋutinunyalawo: Be woakpɔ nusiwo ŋu ŋutigbalẽa tsi dzi ɖo gbɔ.
- Dɔléleŋutinunyalawo: Eŋutinunyala siwo léa ŋku ɖe wò ʋu kple ʋumenugbagbeviɣidɔ ƒe kpɔɖeŋuwo ŋu.
- Atikewɔlawo/Aɖaŋuɖolawo: Dɔnyala bibiwo be woakpe ɖe ŋuwò nàto seselelãme ƒe nuteɖeamedzi kple dzimaɖitsitsi siwo ate ŋu akpe ɖe dɔléle si wokpɔ ŋu.
Mɔ ɖeka kolia si dzi woato ada epithelioid sarcoma enye be woawɔ dɔ na amekoko be woaɖe dɔdzẽa ɖa keŋkeŋ . Gake menye ɣesiaɣie woate ŋu aɖee ɖa keŋkeŋ le go ɖesiaɖe me o.
Ne amekola mate ŋu aɖe dɔdzẽ bliboa ɖa o la, anɔ eme be wò ɖɔkta aɖo aɖaŋu na wò be nàzã atike vovovowo atsɔ akpɔ wò dɔlélea gbɔe. Esi wònye be zi geɖe la, epithelioid sarcoma nyea kansa si tsina blewu ta la, dɔnɔ geɖe gakpɔtɔ te ŋu nɔa agbe didi, eye woƒe dzi dzea eme.
Togbɔ be woƒo nu tso agbetsitsi ƒe agbɔsɔsɔme ŋu le atikewɔnyawo ŋuti nyatakaka vovovowo me hã la, woto vovo ŋutɔ elabena esia nye dɔléle si mebɔ kura o. Agbetsitsi ŋuti akɔntabubuwo to vovo le alesi kansa la le kple alesi amea wɔa nui ɖe atikewɔwɔ ŋu nu.
Ɣekaɣie wòle be nàkpɔ ɖɔkta?
Ne ède dzesi ƒunukpeƒetetedɔ alo vuvu si mebɔ o le wò ŋutilã ƒe akpa ɖesiaɖe la, mègaŋe aɖaba ƒu edzi o. Kpɔ wò ɖɔkta enumake. Togbɔ be ƒunukpeƒetetedɔ siawo bɔ ɖe abɔta, asiwo, asibidɛwo, afɔwo, alo afɔwo dzi wu hã la, woate ŋu adze le ŋutilãa ƒe akpa sia akpa.
Nya siwo wòle be nàbia wò ɖɔkta
Ne wokpɔ dɔléle si nye epithelioid sarcoma le wò alo wò lɔlɔ̃tɔ aɖe ŋu la, bu nya siawo biabia ŋu kpɔ:
- Afikae dɔdzẽa le?
- Ðe dɔdzẽ ɖeka koe lia, alo ɖe wòdze le teƒe bubuwoa?
- Ðe kansa la kaka ɖe nye ŋutilã ƒe akpa bubuwoa?
- Atikewɔwɔmɔnu kae nèkafu?
- Ɣeyiɣi didi kae nye atikewɔwɔ axɔ?
- Aleke mase le ɖokuinye me le atikewɔwɔ me, eye nukawoe ate ŋu ado tso eme?
- Ðe dɔwɔnu alo kpekpeɖeŋunaha siwo ŋu kakaɖedzi le li siwo me mate ŋu asrɔ̃ nu geɖe lea?
Enye nusi sɔ kura be vɔvɔ̃, dziku, alo nutete le ame ŋu le dɔléle sia tɔgbe kpɔkpɔ vɔ megbe. Dzro nusiwo nèkpɔ mɔ na me kple wò ɖɔkta le afɔɖeɖe ɖesiaɖe me. Tsɔ kpe ɖe eŋu la, nuƒoƒo kple aɖaŋuɖola alo gege ɖe kpekpeɖeŋunaha aɖe me ate ŋu akpe ɖe ame ŋu ŋutɔ le mɔzɔzɔ sia ƒe seselelãme sesẽwo gbɔ kpɔkpɔ me. Menye wò ɖeka koe o; wò atikewɔlawo ƒe ƒuƒoƒo kple wò lɔlɔ̃tɔwo le afima be yewoado alɔ wò.
Nu Vevi Siwo Wotsɔna Yia Nu
- Epithelioid sarcoma nye kansa si mebɔ kura o, si tsina blewu le lãmeka falɛfalɛwo me .
- Zi geɖe la, edzena abe ƒunukpeƒetetedɔ ene , eye ɣeaɖewoɣi la, ŋutigbalẽ ƒe abiwo kpena ɖe eŋu.
- Ðewohĩ maɖe dzesiwo afia le eƒe gɔmedzedze o.
- Edo ƒome kple domenyiŋusẽfianu si nye SMARCB1 ƒe tɔtrɔ , togbɔ be womenya nusi tututu gbɔ wòtso o hã.
- Amekokoe nye atikewɔwɔ vevitɔ , eye wotsɔa keklẽŋusẽ, atikewɔmɔnu, kple atike siwo woɖo taɖodzinu na kpena ɖe eŋu.
- Togbɔ be mɔxexe ɖe enu sesẽ hã la , woate ŋu adae ne wokpɔe kaba .
- Ne ède dzesii be ƒu yeye aɖe le eŋu la, yi ɖɔkta gbɔ enumake.
- Nɔ anyi kpoo, nɔ nu wɔm do ŋgɔ, eye nàwɔ ɖe atikewɔla bibiwo ƒe aɖaŋuɖoɖowo dzi . Dɔnyala bibiwo ƒe ƒuƒoƒo aɖe le asiwò siwo kpena ɖe ŋuwò le afɔɖeɖe ɖesiaɖe me.
Taflatse nenɔ susu me na wò be hehenana koe nyatakaka siawo nye. Ne lãmesẽnya aɖe koŋ le ŋuwò la, nu nyuitɔ si nàwɔe nye be nàbia lãmesẽdɔwɔla bibi aɖe.
