Ðe nèdi be yeanya nu tso Hairy Cell Leukemia hã ŋua? Mina míaƒo nu!

Ðe ɖeɖi tea ŋuwò ɣesiaɣia? Alo ɖe dzamezã kple dɔlékuiwo xɔa wò ɣesiaɣia? Ɣeaɖewoɣi la, wobua nusiawo be wosɔ, gake ƒã hafi woate ŋu anye nu bubu aɖe ƒe dzesi. Egbea míele nu ƒom tso ʋumenugbagbeviɣidɔ si mebɔ o gake wòle vevie ŋutɔ si ŋu wòle vevie ŋutɔ be woanya nu tsoe ŋu. Woyɔa esia be "Hairy Cell Leukemia".

Nukae nye "Hairy Cell Leukemia" sia?

Kpuie ko la, esia nye kansa ƒomevi aɖe si dzea egɔme tso ʋu me. Míaƒe ŋutilã ƒe akpa aɖe si woyɔna be ƒumeŋuɖui le mía si. Ƒumeŋuɖui ma mee lãmenugbagbevi ƒomevi siwo le míaƒe ʋu me la tsona. Le esiawo dome la, B-lãmenugbagbeviwo (si woyɔna hã be `B lymphocytes`) nye ʋumenugbagbevi ɣi ƒomevi aɖe. Woƒe dɔ vevitɔe nye be woawɔ avu kple dɔlékui siwo gena ɖe míaƒe ŋutilã me eye woakpɔ mía ta tso dɔlélewo me.

Eyata, le nɔnɔme sia si woyɔna be `Hairy Cell Leukemia` me la, nusi dzɔna enye be wò ƒumeŋuɖui wɔa B-lãmenugbagbevi siwo mesɔ o . Ne ètsɔ nusuekpɔmɔ̃ lé ŋku ɖe lãmenugbagbevi siawo siwo mesɔ o ŋu la, àkpɔe be nu suesuesue siwo le abe taɖa ene do go tso wo me. Esia tae woyɔa dɔléle sia be ``hary cell leukemia'' le ``fu'' ƒe dzedzeme ma ta. Dɔléleŋutinunyala siwo léa ŋku ɖe lãmenugbagbeviawo ŋu le nusuekpɔmɔ̃ me ye dea dzesii.

Nukatae esia dzɔna ɖo? Nukae dzɔna ɖe ŋutilãa dzi?

Togbɔ be womenya nusita tututu nusia dzɔna haɖe o hã la, nu ʋɛ aɖewo li siwo dzɔna ɖe ŋutilãa dzi ne nɔnɔme sia do mo ɖa. Tsɔe be amagbewo ƒe abɔ le asiwò, eye nukae adzɔ ne gbewo tsi le mɔ si dzi womate ŋu aɖu o nu? Amagbe nyuiawo bu teƒe eye wometsina nyuie o, alo? Emae nye nusi dzɔna le afisia hã.

• Ƒumeŋuɖui ƒe ŋusẽkpɔɖeamedzi: B-lãmenugbagbevi mawo siwo mesɔ o la dzea ƒoƒo ɖe ƒumeŋuɖui me, abe gbewo ene. Ema ɖea ŋutete si le ame si be wòawɔ ʋumenugbagbevi ɣi siwo le lãmesẽ me, ʋumenugbagbevi dzĩwo, kple ʋumenugbagbevi dzĩwo (lãmenugbagbevi siwo kpena ɖe ʋu ƒe sisi ŋu) dzi kpɔtɔna.
• Lãmetsiŋusẽ kple dɔgbo ƒe vuvu: Lãmenugbagbevi siawo siwo mesɔ o siwo le míaƒe ʋukawo kple dɔgbo me la dzea mama gɔme hedzina ɖe edzi, si wɔnɛ be ŋutinu mawo vuvu.
• Aklã ƒe ŋusẽkpɔɖeamedzi: Ɣeaɖewoɣi la, lãmenugbagbevi siawo siwo mesɔ o ate ŋu akaka ɖe aklãa me to ʋukawo me eye woagblẽ nu le eŋu. Esia ateŋu ana tsi naƒo ƒu ɖe ƒodo me (nɔnɔme si woyɔna be `ascites`).

Ðe esia bɔa?

`Hairy Cell Leukemia` nye dɔléle si mebɔ kura o . Le dukɔ abe Amerika ene gɔ̃ hã me la, edzena le ame siwo ade ame akpe alafa ɖeka ɖesiaɖe me. Wogblɔ hã be nɔnɔme sia bɔ ɖe yevuwo dome vie wu to bubu me tɔwo.

Nukawoe nye dzesiawo?

Ɣeaɖewoɣi la, ame siwo ŋu `Hairy Cell Leukemia` le la mate ŋu akpɔ dzesi aɖeke o . Gake ne dzesiawo dze la, woate ŋu aɖe nusiwo le abe:

• Ðeɖiteameŋu: Ðeɖiteameŋu sia ate ŋu atso ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ (ʋusɔgbɔdɔ).
• Asrã kple dɔlékuiwo xɔxɔ enuenu:Le ʋumenugbagbevi ɣi siwo le lãmesẽ me siwo wɔa avu kple dɔlékuiwo ƒe agbɔsɔsɔ si mede o ta la, dzamezã enuenu kple dɔlékui sesẽwo ate ŋu adzɔ.
• Miame ƒodo ƒe vevesese: Ne lãmenugbagbevi siwo mesɔ o le dɔgboa me ƒo ƒu eye wòna dɔgboa vuvu la, àte ŋu ase veve le miame ƒodo ƒe akpa si le anyime. Aɖuɖɔtoea ate ŋu alolo eye wòana nàse le ɖokuiwò me be yeɖi ƒo, eye àte ŋu ase le ɖokuiwò me be yeɖi ƒo ne èɖu nu sue aɖe gɔ̃ hã. Àte ŋu aɖe wò lolo hã dzi akpɔtɔ evɔ màte kpɔ o.
• Vevesese le ɖusime ƒodo si le anyime: Ne aklãa lolo la, àte ŋu ase veve le ɖusime.
• Gbɔgbɔ sesẽ: Esia hã nye ʋusɔgbɔdɔ ƒe dzesi bubu.
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu: Vevesese aɖeke ate ŋu adze le kɔ, akɔta, kple ƒodo me.
• Abi alo ʋu si mebɔ o: Esi ƒumeŋuɖui meɖea ʋumenugbagbevi dzĩ siwo kpena ɖe ʋu ŋu wòsɔa gbɔ o ta la, abi suetɔ kekeake kple ʋu si dona le ame ŋu gɔ̃ hã ate ŋu adzɔ.

Vevietɔ: Dzesi siawo dometɔ ɖeka alo esi wu nenema ƒe amesinɔnɔ mefia kokoko be Hairy Cell Leukemia le ŋuwò o. Gake ne dzesi siawo gakpɔtɔ li la, anyo wu be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo.

Nukawoe gbɔ wòtsona? Ðe afɔku aɖewo lia?

Eŋutinunyalawo menya nusi tututu gbɔ Hairy Cell Leukemia tsona haɖe o . Ke hã, numekukuwo ɖee fia be domenyiŋusẽfianu ƒe tɔtrɔ le amesiwo ŋu dɔlélea le dometɔ siwo ade 90% ŋu. Ekpɔa ŋusẽ ɖe domenyiŋusẽfianu aɖe si woyɔna be BRAF dzi. Domenyiŋusẽfianu sia kpena ɖe lãmenugbagbeviwo ŋu wotsina. Eyata ne etrɔ la, lãmenugbagbevi siwo mesɔ o dzea tsitsi gɔme hedzina ɖe edzi le mɔ si dzi womate ŋu aɖu o nu. Domenyiŋusẽfianu ƒe tɔtrɔ sia dzɔna le mía dzidzi vɔ megbe. Ke hã, womenya nusi gbɔ tɔtrɔ ma tso o.

Gake wode dzesi afɔku aɖewo siwo nana dɔléle sia xɔxɔ ƒe afɔkua dzina ɖe edzi:

• Ƒe si woxɔ: Dɔléle sia dzea amesiwo xɔ tso ƒe 40 va ɖo ƒe 70 dzi wu.
• Ŋutsu alo nyɔnu nyenye: Dɔléle sia bɔ ɖe ŋutsuwo me wu nyɔnuwo.
• Agent Orange exposure: Numekulawo xɔe se be kadodo aɖe le atike sia kple B-cell leukemia si nɔa anyi didi kple lymphoma (si me hairy cell leukemia hã le) dome.

Kuxi kawoe esia ate ŋu ahe vɛ?

Hairy Cell Leukemia nana ʋumenugbagbevi ɣi siwo le wò ŋutilã me siwo wɔa avu kple dɔlékuiwo ƒe xexlẽme dzi ɖena kpɔtɔna ŋutɔ, si wɔnɛ be dɔlékuiwo xɔxɔ ƒe afɔkua dzina ɖe edzi . Esiawo ate ŋu anye dɔlékuiwo, dɔlékuiwo, alo fungi dɔlékuiwo. Ɣeaɖewoɣi la, dɔlékui siawo ate ŋu ade ame ƒe agbe afɔku me.

Mɔnukpɔkpɔ sue aɖe hã li be kansa ƒomevi evelia nadze ame dzi ƒe geɖe le ekpɔkpɔ kple edada megbe. Le kpɔɖeŋu me, numekuku siwo wowɔ ɖe amesiwo woda `Hairy Cell Leukemia` dzidzedzetɔe ƒe 10-20 ŋu la gblɔ be ame aɖewo xɔ kansa bubuwo.

Aleke wokpɔa dɔléle sia dzea sii?

Ne èyi ɖɔkta gbɔ la, abia nya wò tso nuwo abe ɣeyiɣi si me wò dzesiawo dze egɔme kple nenye be dɔlékuiwo dzea dziwò enuenu ene ŋu. Abia nya tso wò atikewɔwɔ ŋutinya hã ŋu. Emegbe, woawɔ ŋutilãmedɔdada. Woate ŋu alé ŋku ɖe wò ʋukawo, dɔgbo, kple aklã hã ŋu be wovuvu hã.

Emegbe, woate ŋu aɖo wò ɖe ʋumenugbagbeviɣidɔdala alo kansadɔdala gbɔ be woawɔ dodokpɔ bubuwo atsɔ aɖo kpe dɔlélea dzi. Dodokpɔ siawo ate ŋu anye:

• Ʋu ƒe xexlẽme blibo (CBC) kple vovototodedeameme: Esia dzidzea ʋumenugbagbevi dzĩwo kple ɣiwo, kpakple ʋumenugbagbevi dzĩwo ƒe xexlẽme. Vovototoa dzidzea ʋumenugbagbevi ɣi ƒomevi vovovowo ƒe xexlẽme.
• Ʋu si wotsɔna ƒoa ʋu le lãme na ame: Dɔléleŋutinunyalawo léa ŋku ɖe ʋu ƒe kpɔɖeŋu aɖe ŋu le nusuekpɔmɔ̃ te be yewoadi lãmenugbagbevi siwo mesɔ o siwo ƒe dodo le abe "fu" ene.
• Ƒumeŋuɖui ƒe ʋuʋu kple ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe: Dodokpɔ siawo ate ŋu ade dzesi lãmenugbagbevi siwo mesɔ o le ƒumeŋuɖui me.
• CT scan (Computed tomography - `CT` scan): `CT` scan ateŋu aɖe ŋutilã ƒe akpa si le eme ƒe foto tsitotsito. Woate ŋu azã esia atsɔ akpɔ dɔgbo, aklã, kple ʋuka siwo me ʋu sina tona ƒe lolome, alo awɔ ultrasound na ƒodoa.
• Flow cytometry: Esia léa ŋku ɖe ʋu kple ƒumeŋuɖui ŋu be lãmenugbagbevi siwo mesɔ o, abe taɖa ƒe lãmenugbagbeviwo ene, le wo me hã. Eléa ŋku ɖe lãmenugbagbeviawo ƒe lolome, woƒe nɔnɔme, kple dɔdzẽ ƒe dzesiwo ƒe anyinɔnɔ hã ŋu. Tumor markers ate ŋu anye protein siwo kansa lãmenugbagbeviwo wɔ.

Aleke wowɔa atike nɛ?

Ne dɔlékui aɖe le ŋuwò la, ahiã be nàdae gbã. Emegbe la, woadze atikewɔwɔ bubuwo gɔme be woatsɔ aɖu `Hairy Cell Leukemia` ƒe dzesiwo dzi. Ke hã, abe alesi míegblɔe va yi ene la, menye amesiamee akpɔ dzesiawo o. Le ame mawo gome la, wò ʋumenugbagbeviɣidɔdala alo kansaŋutinunyala ate ŋu aɖo aɖaŋu aɖe si woyɔna be active surveillance . Ne dzesiwo li la, woate ŋu aŋlɔ atikewo na wò.

Dzɔdzɔmenuwo Dzi Kpɔkpɔ Vevie

Hairy Cell Leukemia nye dɔléle si tsina blewu ŋutɔ . Ate ŋu axɔ ƒe geɖe hafi dzesiawo nadze. Esi wònye be kansa dada ate ŋu ahe kuxiwo kple kuxiwo vɛ ta la, ne dzesi aɖeke mele ŋuwò o la, wò ɖɔkta ate ŋu atso nya me be yeahe edada gɔmedzedze ɖe megbe vaseɖe esime dzesiawo nadze.

Le ŋkuléle ɖe ŋuwò vevie me la, àkpɔ wò ɖɔkta le ɣleti etɔ̃ va ɖo ade ɖesiaɖe me. Le sasrãkpɔ mawo me la:

• Woabia nya tso wò lãmesẽ bliboa ŋu, vevietɔ ne èse le ɖokuiwò me be ɖeɖi te ye ŋu wu alesi nèwɔna ɖaa.
• Woado ŋutilãmedɔ akpɔe ɖa be aklã kple dɔgbo vuvu hã.
• Woɖe gbe be woado ʋu kpɔ be woalé ŋku ɖe ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ŋu.

Ate ŋu asesẽ vie le seselelãme gome be woalala be dzesiawo nadze hafi adze atikewɔwɔ gɔme. Gake wò ɖɔkta ase wò seselelãmewo gɔme eye wòaɖe nusita wokafui be nàlé ŋku ɖe ŋuwò vevie la me.

Atikewo zazã

Atike vevitɔ si wozãna na amesiwo ŋu ʋumenugbagbeviɣidɔ le enye atikewɔmɔnu . Atike siwo wozãna wu tsɔ wua kansae nye Cladribine (Leustatin®) alo Pentostatin (Nipent®).

Ne atikewɔmɔnu mewɔ dɔ o, alo ne dɔlélea gadze ake la, atikewɔwɔ bubuwo li:

• Dɔlélenutsiŋutete ƒe atikewɔwɔ: `Rituximab (Rituxan®)` nye `monoclonal antibody` dɔdamɔnu si wozãna na `Hairy Cell Leukemia`. Woate ŋu anae abe atikewɔmɔnu gbãtɔ ene kple atikewɔmɔnu alo ne dɔlélea gadze egɔme ake. Dɔlélenutsiŋutete ƒe dɔdamɔnu bubu enye `Recombinant Interferon Alfa-2b (Intron A®)`.
• Atikewɔwɔ si woɖo taɖodzinu na: Le Hairy Cell Leukemia si gbugbɔna gome la, woate ŋu azã atike siwo woyɔna be Rituximab kple Moxetumomab pasudotox (Lumoxiti®) (esia nye dɔlékuiwutike kple atike ƒe ƒuƒoƒo ƒomevi aɖe).
• Aɖuɖɔtoe ɖeɖe ɖa: Ƒã ŋutɔ la, woate ŋu akafu amekoko sia ne atikewɔwɔ abe atikewɔmɔnu ene mekpena ɖe ame ŋu o eye dɔgboa yi edzi le vuvum le lãmenugbagbevi siwo mesɔ o le dɔgboa me ta.

Ðe atikewɔwɔa ƒe nugbegblẽ aɖewo lia?

Abe kansadɔdamɔnu ɖesiaɖe ene la, ate ŋu agblẽ nu le ame ŋu. Vevietɔ la, atike siwo wozãna tsɔ daa ʋumenugbagbeviɣidɔ si me fu le dzia dɔlékui siwo ate ŋu ade ame ƒe agbe afɔku me ƒe afɔkua ɖe edzi . Wò ɖɔkta aɖe afɔ siwo nàte ŋu aɖe atsɔ axe mɔ ɖe dɔlékuiwo xɔxɔ nu kple tɔtrɔ siwo ava wò ŋutilã me ate ŋu anye dɔlékuiwo ƒe dzesiwo me na wò.

Nukae nàte ŋu akpɔ mɔ na esime nèle agbe kple dɔléle sia?

Fifia la, womekpɔ atike aɖeke na Hairy Cell Leukemia o. Gake numekukuwo ɖee fia be atikewɔwɔ, si me atikewo zazã hã le, ate ŋu ana dɔlélea nagbɔdzɔ ƒe 10 alo esi wu nenema . Dɔlélea ƒe tsɔtsɔke fia be dzesi aɖeke mele ŋuwò o eye womate ŋu akpɔ dɔlélea ƒe dzesi aɖeke le dodokpɔwo me o. Numekuku aɖe si me wodzro amesiwo ŋu Hairy Cell Leukemia le ƒe nuteƒekpɔkpɔwo me ɖee fia be ne woda dɔ na wo vɔ la, woate ŋu anɔ agbe didi abe amesiwo ŋu dɔlélea mele o ene.

Gake ʋumenugbagbeviɣidɔ si me fu le ate ŋu agadzɔ ake ƒe geɖe le atikewɔwɔ gbãtɔ megbe. Gake ne edzɔ alea la, atikewɔmɔnu aɖewo li siwo ate ŋu ana dɔlélea nagbɔdzɔ ake.

Ame geɖe hiã atikewɔwɔ kple kpekpeɖeŋu le woƒe agbemeŋkekewo katã me, elabena ehiã be ɖɔktawo nalé ŋku ɖe eŋu be dɔlélea nagadzɔ ake hã. Ne dɔlélea le ŋuwò gake dzesi aɖeke mele ŋuwò o hã la, ahiã be woado wò kpɔ ahawɔ ɣeyiɣi siwo woatsɔ akplɔ wò ɖo ɣleti etɔ̃ va ɖo ade ɖesiaɖe le dɔlélea kpɔkpɔ vɔ megbe.

Nukae nye alesi wohayanae?

Leukemia and Lymphoma Society gblɔ be amesiwo wotsɔ atike si nye Cladribine da dɔ na la dometɔ 90% le agbe ƒe atɔ̃ le atikewɔwɔ vɔ megbe. Gake wò nyagblɔɖi — nusi dzɔna le atikewɔwɔ vɔ megbe — nɔ te ɖe nu geɖe dzi . Wò ƒexɔxɔ, wò lãmesẽ bliboa, dɔlélea ƒe dzesiwo, kple alesi wò ŋutilã wɔa nu ɖe ​​atikewɔwɔ ŋui katã wɔa akpa aɖe. Ne nya aɖe le asiwò ku ɖe esia ŋu la, bia wò ɖɔkta.

Aleke wòle be malé be na nye lãmesẽ?

Hairy Cell Leukemia dzia dɔlékui siwo ate ŋu ade ame ƒe agbe afɔku me ƒe afɔkua ɖe edzi. Àte ŋu ado ŋusẽ wò dɔlélenutsiŋutete eye nàkpɔ ɖokuiwò ta tso dɔlékuiwo me . Aɖaŋuɖoɖo aɖewoe nye esi:

• Ƒo nuɖuɖu si naa lãmesẽ: Nuwo abe atikutsetsewo, amagbewo, protein siwo me ami mele o, kple nuku blibowo ene kpena ɖe dɔlélenutsiŋutete ŋu wòwɔa dɔ.
• Kamedede gbesiagbe: Kamedede gbesiagbe nyo na wò lãmesẽ ƒe akpa geɖe, eye wò dɔlélenutsiŋutete hã le eme.
• Dɔ alɔ̃ nyuie: Ne mèdɔ alɔ̃ nyuie o la, ate ŋu ana wò dɔlélenutsiŋutete nagawɔ dɔ nyuie o.
• Na wò atikewo naɖo ɖe game dzi: Atikewo naa hehe wò ŋutilã be wòawɔ avu kple dɔlékui siwo hea dɔléle vɛ. Ƒo nu kple wò ɖɔkta tso atike siwo nèhiã kple ɣeyiɣi si nàxɔe ŋu.

Ɣekaɣie wòle be nàkpɔ ɖɔkta?

Hairy Cell Leukemia kple edada ate ŋu ana dɔlékui sesẽ siwo ate ŋu ade wò agbe afɔku me la xɔxɔ ƒe afɔkua nadzi ɖe edzi. Kpɔ ɖɔkta enumake ne dzesi siawo le ŋuwò:

• Asrã si ƒe dzoxɔxɔ wu Celsius 38 (Fahrenheit 100.4) eye meɖiɖina o.
• Kɔmeve si nɔa anyi wu ŋkeke ʋee aɖewo alo nu sẽna ɖe edzi.
• Ƒodo me vevesese si nu metsina o alo nu sẽna ɖe edzi.

Kpuie Kple Mlɔeba (Gbedasi si Wotsɔ Yi Aƒeme) .

Ðewohĩ ɖeɖi te ŋuwò wu tsã le susu aɖeke manɔmee. Alo ɖewohĩ ènɔ gbɔgbɔtsixetsixe aɖe si medzo o togbɔ be èzã atike gbogbo aɖewo hã ŋu bum. Fifia dodokpɔwo ɖee fia be ʋumekansa si mebɔ o si woyɔna be `Hairy Cell Leukemia`, si womate ŋu ada kura ne wodae o la le ŋuwò.

Gake mègatsi dzi o . Atikewɔmɔnu aɖewo li siwo ate ŋu ana nɔnɔmea naɖu dzi ƒe geɖe evɔ dzesi aɖeke manɔ eŋu o. `Kpɔɖeŋu` si nɔa anyi didi fia be wò lãmesẽnyawo gbɔ kpɔha alé ŋku ɖe wò lãmesẽ ŋu le wò agbemeŋkekewo katã me. Eye, ne Hairy Cell Leukemia trɔ gbɔ nyateƒe la, numekulawo yi edzi le mɔ siwo dzi woato agbugbɔ nɔnɔmea ade `remission` me dim.

Nu aɖewo li nàte ŋu awɔ le wò akpa dzi. Le kpɔɖeŋu me, kansa dada ate ŋu ana dɔlékuiwo xɔxɔ ƒe afɔkua nadzi ɖe edzi. Bia wò ɖɔkta tso atikewɔmɔnuwo kple afɔɖeɖe bubu siwo nàte ŋu aɖe atsɔ aɖe dɔlékuiwo xɔxɔ ƒe afɔkua dzi akpɔtɔ ŋu.Menye wò ɖeka koe o, ɖɔktawo kple lãmesẽdɔwɔlawo li siwo akpe ɖe ŋuwò le mɔzɔzɔ sia me.

` Hairy Cell Ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, B lãmenugbagbeviwo, ƒumeŋuɖui, dɔgbo, dzesiwo