Ðe ɖeɖi tea ŋuwò hã ɣesiaɣia? Ðe nèsena le ɖokuiwò me be ŋusẽ aɖeke mele ye ŋu oa? Ðewohĩ wò ɖɔkta lé ŋku ɖe ʋu ƒe nyatakaka aɖe ŋu eye wògblɔ be "iron ƒe anyimanɔmanɔ" alo "ʋusɔgbɔdɔ". Esia nye kuxi si le ame geɖe ŋu le míaƒe dukɔa me. Eyata ènya amesi kpɔa ŋusẽ ɖe nu vevi sia si woyɔna be iron dzi le míaƒe ŋutilã mea? "Dɔmemegã" ŋutɔŋutɔ aɖe li nɛ. Woyɔe be Hepcidin . Ðewohĩ mèse ŋkɔ sia gɔ̃ hã kpɔ o. Gake dɔ si wòwɔna be míaƒe ŋutilã nanɔ lãmesẽ me la menye nu sue aɖeke o. Mina míaƒo nu egbea tso "iron boss" sia si le míaƒe ŋutilã me ŋu.
Kpuie ko la, amekae nye Hepcidin sia?
Hepcidin nye lãmetsi aɖe si míaƒe aklã wɔna eye wòdona ɖe ʋua me. Lãmetsiŋusẽwo le abe dɔla siwo kpɔa míaƒe ŋutilã ƒe dɔwɔwɔ ɖesiaɖe dzi ene. Eyata dɔ vevitɔ si dɔla si woyɔna be hepcidin wɔnae nye be wòakpɔ alesi míaƒe ŋutilã zãa gayibɔe dzi. Ne míagblɔe tututu la, eyae tsoa nya me le gayibɔ agbɔsɔsɔme si ŋutilãa hiã, agbɔsɔsɔme si wòhiã be wòadzra ɖo, kple ɣeyiɣi si wòahiã be wòazã gayibɔ ma ŋu. Esia tae ame aɖewo yɔa hepcidin be "Master Iron Regulator".
Eyata nukatae gayibɔ le vevie na mí nenema gbegbe ɖo?
Tsɔe be dɔwɔƒe aɖe li si tsɔa ɔksidzin yia míaƒe ŋutilã katã me. Ʋu siwo wotsɔ ɖoa ʋu ma ƒe ʋuwoe nye ʋumenugbagbevi dzĩwo . Ame si ƒoa oxygen si le ʋu mawo me lae nye protein si woyɔna be hemoglobin . Eyata iron nye nu vevi aɖe si wotsɔ wɔa ʋumenugbagbeviɣidɔ sia. Iron manɔmee la, womate ŋu awɔ hemoglobin o. Ekema ʋumenugbagbevi dzĩawo mate ŋu atsɔ ɔksidzin o. Ɣemaɣie ɖeɖi tea mía ŋu eye gbɔgbɔ sesẽna na mí.
Menye ema ɖeɖeko o, iron hã hiã hafi woate ŋu awɔ protein si nye myoglobin, si naa oxygen míaƒe lãmekawo kple dzi.
Kpuie ko la, gayibɔe nye dzi si naa oxygen-tsɔna si naa agbe míaƒe ŋutilã ƒe lãmenugbagbeviwo. Eyata ele vevie ŋutɔ be nàna gayibɔ ƒe agbɔsɔsɔ sia nada asɔ. Ne iron mesɔ gbɔ o la, dɔlélewo abe ʋusɔgbɔdɔ si me iron mele o ene doa mo ɖa. Ne iron sɔ gbɔ ɖe eme la, ate ŋu azu aɖi na míaƒe ŋutilã eye wòagblẽ nu le ŋutinuwo ŋu. Dadasɔ ma me léle ɖe asi ye nye hepcidin ƒe dɔ vevitɔ.
Aleke hepcidin kpɔa ŋusẽ ɖe gayibɔ sia dzii?
Esia nye nuwɔna wɔnuku aɖe ŋutɔ. Míekpɔa iron tso nuɖuɖu siwo míeɖuna (lã, tɔmelã, amagbewo, nukuwo) me. Gake to vovo na tomenu bubuwo la, mɔ aɖeke mele míaƒe ŋutilã si dzi wòato aɖe iron si sɔ gbɔ ɖe eme la ɖa o. Le kpɔɖeŋu me, ne sodium (dze) sɔ gbɔ ɖe mía me akpa la, ado le aɖuɖɔ me. Gake gayibɔ medona le lãme na ame bɔbɔe nenema o.
Eyata efia gayibɔ si sɔ gbɔ la dzadzraɖo be woazã emegbe. Míaƒe ƒumeŋuɖui me koŋue gayibɔ sia dzrana ɖo , .Le aklã kple aklã me la .
Afi siae hepcidin va wɔa dɔ le. Hepcidin dea nu gayibɔ sia zazã me le mɔ vevi etɔ̃ nu:
1. Ekpɔa iron ƒe xɔxlɔ̃ le nuɖuɖu me dzi: Ne nuɖuɖu si míeɖuna yi míaƒe dɔgbo sue la me la, lãmenugbagbevi siwo le afima xɔa iron ɖe ʋua me. Hepcidin ye afia gayibɔ agbɔsɔsɔme si dona ɖe ʋua me kple agbɔsɔsɔme si wodzrana ɖo.
2. Egbugbɔa iron si le ʋumenugbagbevi dzĩ xoxowo me zãna: Míaƒe ʋumenugbagbevi dzĩwo ƒe agbenɔƒe le mama dedie nu anɔ abe ŋkeke 120 ene. Ne ɣeyiɣi ma wu enu la, macrophages , si nye ʋumenugbagbevi ɣi ƒomevi aɖe (abe ŋutilãa ƒe ‘kɔklɔdɔwɔla’ ene), tsrɔ̃a ʋumenugbagbevi dzĩ xoxo siawo. Gake ne wowɔe la, woléa gayibɔ xɔasi si le wo me la hedzraa wo ɖo. Eyata hepcidin tsoa nya me nenye be ele be woagbugbɔ gayibɔ sia si wodzra ɖo la ana ʋumenugbagbevi dzĩ siwo wowɔ yeyee, alo nenye be woadzrae ɖo hena ɣeyiɣi aɖe wu.
3. Ekpɔa iron si wodzra ɖo ɖe teƒewo abe aklã ene ƒe dodo dzi: Hepcidin ye gblɔna na ŋutilãa nenye be wòaɖe iron si wodzra ɖo ɖe aklã me lãmenugbagbeviwo ( hepatocytes ) kple dɔgbo sue me lãmenugbagbeviwo ( enterocytes ) me ɖe ʋu me ne ehiã.
Aleke tututu esia wɔa dɔe?
Be míase esia gɔme la, ele be míanya ame bubu. Ame ma nye protein si woyɔna be ferroportin . Bu eŋu abe nudzraɖoƒe si le gaxɔ aɖe me si me wodzraa gayibɔ ɖo ene. Ferroportin nye "agbo si naa gayibɔ dona" le nudzraɖoƒe ma. Hafi gayibɔ nate ŋu age ɖe ʋua me la, ele be woaʋu agbo sia.
Nusi hepcidin wɔnae nye be eɖua agbo sia dzi.
- Ne hepcidin ƒe agbɔsɔsɔ le ŋutilãa me dzi ɖe edzi , hepcidin blana ɖe agbo aɖe si woyɔna be ferroportin ŋu eye wòtuae . Ekema, gayibɔ si le lãmenugbagbeviawo me mate ŋu age ɖe ʋua me o. Iron ƒe xɔxlɔ̃ dzi ɖena kpɔtɔna.
- Ne hepcidin ƒe agbɔsɔsɔ le ŋutilãa me dzi ɖe kpɔtɔ , ferroportin ƒe agbo la mexea mɔ o. Eyata agbo la le ʋuʋu ɖi . Gayibɔ si le lãmenugbagbeviawo me gena ɖe ʋua me bɔbɔe. Iron ƒe xɔxlɔ̃ dzina ɖe edzi.
Nukawoe hea tɔtrɔ siwo vaa hepcidin ƒe agbɔsɔsɔ me vɛ?
Míaƒe ŋutilã ƒe tagbɔ kɔ ŋutɔ. Wodzia hepcidin ƒe agbɔsɔsɔ ɖe edzi heɖea edzi le woƒe hiahiãwo nu le ɣeyiɣi ɖesiaɖe me. Nu vevi geɖewo li siwo kpɔa ŋusẽ ɖe esia dzi.
| Nusi Ŋu Ŋusẽkpɔɖeamedzi Le | Ŋusẽkpɔɖeamedzi ɖe Hepcidin dzi Kple Emetsonu |
|---|---|
| Iron ƒe agbɔsɔsɔ bliboa le ŋutilã me | Ne iron sɔ gbɔ ɖe ŋutilãa me , ke ŋutilãa wɔa hepcidin geɖe wu . Ema wɔnɛ be megaxɔa gayibɔ geɖe o. Ne iron ƒe agbɔsɔsɔ le eme la , ŋutilãa mewɔa hepcidin fũ o . Ema ʋua ʋɔtruawo be gayibɔ geɖe nate ŋu axɔ ɖe eme. |
| Ʋumenugbagbevi dzĩwo wɔwɔ | Ne ehiã be ŋutilãa nawɔ ʋumenugbagbevi dzĩ yeye geɖe (le kpɔɖeŋu me, le ʋu dodo vɔ megbe) la, ehiã be iron geɖe nate ŋu awɔ hemoglobin. Emegbe ŋutilãa ɖea hepcidin ƒe agbɔsɔsɔ dzi kpɔtɔna . Esia ɖea gayibɔ si wodzra ɖo la doa goe eye wòkpena ɖe ame ŋu wòwɔa lãmenugbagbevi yeyewo. |
| Oxygen ƒe agbɔsɔsɔ si bɔbɔ (Hypoxia) . | Ne oxygen ƒe agbɔsɔsɔ si ɖoa lãmekawo gbɔ dzi ɖe kpɔtɔ la, ŋutilãa susuna be ehiã be yeawɔ oxygen tsɔla (ʋumenugbagbevi dzĩwo) geɖe wu. Esi wònye be esia bia gayibɔ ta la, eɖea hepcidin ƒe agbɔsɔsɔ dzi kpɔtɔna eye wòʋua gayibɔ ƒe agboawo. |
| Dɔlékui alo Dzoxɔxɔ | Esia le vevie ŋutɔ. Ne dɔlékui aɖe (e.g. dɔlékuiwo) ge ɖe míaƒe ŋutilã me la, dɔlékuia hiã iron hafi wòatsi. Eyata míaƒe ŋutilã si me nunya le la xea mɔ na dɔlékui la be megaxɔ gayibɔ o. Be woate ŋu awɔ esia la, ŋutilãa dzia hepcidin ƒe agbɔsɔsɔ ɖe edzi kabakaba . Emegbe gayibɔgboawo tu, eye gayibɔawo katã ɣla ɖe gaxɔawo me. Dɔlékuia gbɔdzɔna ne gayibɔ mele eme o. |
Nukae dzɔna ne hepcidin ƒe agbɔsɔsɔ mesɔ o?
Ne gayibɔdzikpɔmɔ̃ sia ƒe dɔwɔwɔ meva yi nyuie o vie la, ate ŋu ahe kuxi gãwo vɛ. Ne hepcidin ƒe agbɔsɔsɔ le sue akpa la, iron asɔ gbɔ ɖe ŋutilãa me (Iron Overload). Ne hepcidin ƒe agbɔsɔsɔ sɔ gbɔ akpa la, iron ʋɛ aɖewo koe anɔ ŋutilãa me (Iron Deficiency).
| Nᴐnᴐme | Nukae dzɔna, ne míagblɔe kpuie ko? |
|---|---|
| Nɔnɔme siwo hepcidin ƒe agbɔsɔsɔ si mede o (iron ƒe agbɔsɔsɔ fũ) hena vɛ . | |
| Domenyiŋusẽfianu si nye Hemochromatosis | Esia nye domenyiŋusẽfianu ƒe dɔléle. Le go sia me la, aklãa mate ŋu awɔ hepcidin si sɔ o. Esia wɔnɛ be gayibɔ ƒe agboawo (ferroportin) ʋuna ɣesiaɣi. Ŋutilãa xɔa gayibɔ geɖe wu esi wòhiã eye wòdea ŋutinuwo abe dzi, aklã, kple dɔgbo ene me, si gblẽa nu le wo ŋu. |
| Ʋusɔgbɔdɔ siwo me iron sɔ gbɔ ɖo | Le ʋusɔgbɔdɔ ƒomevi aɖewo me la, le nyateƒe me la, iron sɔa gbɔ ɖe eme. Gblẽƒe siwo le ʋumenugbagbevi dzĩwo wɔwɔ me ɖea hepcidin ƒe wɔwɔ dzi kpɔtɔna, si wɔnɛ be iron ƒe xɔxlɔ̃ dzina ɖe edzi. |
| Aklãdɔléle C | Dɔlékui sia gblẽa nu le aklãa ŋu, si wɔnɛ be eƒe ŋutete be wòawɔ hepcidin dzi ɖena kpɔtɔna. |
| Suklidɔ ƒomevi 2 lia | Numekuku aɖewo ɖee fia be suklidɔlélawo ƒe hepcidin ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ eye iron ƒe agbɔsɔsɔ dzi ɖe edzi. |
| Nɔnɔme siwo hepcidin ƒe agbɔsɔsɔ si dzi ɖe edzi (iron ƒe anyimanɔmanɔ) hena vɛ . | |
| Ʋusɔgbɔdɔ si Le Dɔléle Siwo Nɔa Anyi Me (ACD) . | Esia nye nɔnɔme si bɔ ŋutɔ. Ne dɔléle aɖe le ame aɖe ŋu ɣeyiɣi didi (e.g. ayikudɔ, kansa, Crohn ƒe dɔléle) la, dɔdzẽ nɔa ŋutilãa me ɣesiaɣi. Dzoxɔxɔ sia nana hepcidin ƒe agbɔsɔsɔ si le ŋutilãa me dzina ɖe edzi . Emegbe gayibɔgboawo tu. Togbɔ be gayibɔ le ŋutilãa ƒe nudzraɖoƒewo hã la, womate ŋu azã wo o. Esia hea ʋusɔgbɔdɔ vɛ. |
| Dɔlékui siwo nɔa anyi didi | Dɔlékui siwo nɔa ame ŋu ɣeyiɣi didi hã ate ŋu ana abi nadzi ɖe edzi le ŋutilã me, ana hepcidin ƒe agbɔsɔsɔ nadzi ɖe edzi, eye wòana iron nagbɔdzɔ. |
Mlɔeba la, hepcidin nye lãmetsi vevi aɖe ŋutɔ si hiã vevie be iron nada asɔ le míaƒe ŋutilã me. To gayibɔ ƒe agbowo tutu kple gayibɔ dzi ɖuɖu me la, ekpɔa hemoglobin kple ʋumenugbagbevi dzĩwo ƒe wɔwɔ dzi le mɔ si mele tẽ o nu, kpakple oxygen ƒe tsɔtsɔ yi ŋutilã bliboa me dzi. Hepcidin hã kpɔa mía ta tso nusiwo ate ŋu agblẽ le ame ŋu vevie ne gayibɔ geɖe ge ɖe ŋutilãa me la me.
Gbedasi si Wotsɔ Yi Aƒeme
- Hepcidin ye nye lãmetsiŋusẽ vevitɔ si míaƒe aklã wɔna si kpɔa iron ƒe agbɔsɔsɔ si le ŋutilãa me dzi.
- Ewɔa dɔ to mɔxexe ɖe "agbo" si tsɔa gayibɔ si woyɔna be ferroportin nu. Ne hepcidin sɔ gbɔ la, iron ƒe xɔxlɔ̃ dzi ɖena kpɔtɔna, eye ne hepcidin mesɔ gbɔ o la, iron ƒe xɔxlɔ̃ dzina ɖe edzi.
- Hepcidin ƒe agbɔsɔsɔ toa vovo le nusiwo abe iron ƒe agbɔsɔsɔ le ŋutilãa me, ʋumenugbagbevi dzĩwo ƒe hiahiã, oxygen ƒe agbɔsɔsɔ, kple dɔlékuiwo ene nu.
- Hepcidin ƒe agbɔsɔsɔ si mesɔ o ate ŋu ana iron nagbɔ eme eye wòagblẽ nu le ŋutinuwo ŋu (e.g., hemochromatosis), gake ne agbɔsɔsɔ si mesɔ o ate ŋu ana iron nagbɔdzɔ eye ʋusɔgbɔdɔ nasu ame si (e.g., ʋusɔgbɔdɔ si tso dɔléle si nɔa anyi didi me).
- Ne ɖeɖiteameŋu atraɖii, ŋutigbalẽ ƒe amadede dzẽ, alo ʋusɔgbɔdɔ ŋu tsi dzi na wò la, ke yi ɖɔkta gbɔ ɣesiaɣi hafi nàwɔ nyametsotso aɖeke le ɖokuiwò si . Ðɔkta koe ate ŋu awɔ dodokpɔ siwo hiã be woake ɖe nusi tututu gbɔ wòtso ŋu eye wòana atike nyuitɔ.
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