Ðe dɔdzẽ aɖe si mebɔ o le wò lãmekawo mea? (Malignant Peripheral Nerve Sheath Tumor - MPNST) Mina míasrɔ̃ nu tso eŋu.

Ðe nèse ƒu aɖe le wò ŋutilã ƒe teƒe aɖe, ɖewohĩ le alɔ alo afɔ aɖe dzi, si va nɔa gã dom vivivi kpɔa? Kpe siawo, siwo ate ŋu adze egɔme tso sue abe pea ene ɣeaɖewoɣi eye woatsi abe amititsetse ene, ye nye nusi ŋu míaƒo nu tsoe egbea. Esia nye nɔnɔme sesẽ aɖe, gake ƒã ŋutɔ. Woyɔa esia be malignant peripheral nerve sheath tumor, alo MPNST kpuie.

Nukae nye lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖi (MPNST)?

Kpuie ko la, MPNST (Malignant Peripheral Nerve Sheath Tumor) nye kansadɔ si mebɔ kura o si dona le ametakpɔnu siwo ƒo xlã lãmeka siwo le wò ŋutilã me la me. Esiawo le lãmeka falɛfalɛwo ƒe sarcoma ƒomevi aɖe me . Wodoa mo ɖa le wò lãmeka siwo le gota gome . Bu eŋu kpɔ, àte ŋu axɔ dɔdzẽ siawo ɖe wò abɔwo kple afɔwo dzi. Menye ema ɖeɖeko o, ɣeaɖewoɣi la, woate ŋu adze le akɔta, ƒodo, ta, kple kɔ hã me. Woate ŋu ada dɔdzẽ siawo ne woɖe wo ɖa to amekoko me. Gake ele be míaɖo ŋku edzi hã be ɣeaɖewoɣi la, dɔdzẽ siawo ate ŋu agadzɔ ake .

Aleke gbegbee MPNST mebɔ o?

Esia nye nɔnɔme si mebɔ kura o ŋutɔ. Ame siwo ade ɖeka le 100,000 ɖesiaɖe me koe wokpɔa dɔléle vɔ̃ɖi sia le ƒe sia ƒe. Zi geɖe la , edzea amesiwo xɔ tso ƒe 30 va ɖo ƒe 50 dzi .

Tsɔ kpe ɖe eŋu la, amesiwo ŋu domenyiŋusẽfianu ƒe dɔléle aɖe si woyɔna be Neurofibromatosis type 1 (NF1) le la ate ŋu axɔ MPNST. Wokpɔe be NF1 hã le amesiwo ŋu MPNST le dometɔ 25% va ɖo 50% ŋu .

Le goawo katã me la, MPNST ate ŋu adze egɔme kaba le amesiwo ŋu NF1 le me wu amesiwo ŋu NF1 mele o. Azɔ hã, ŋutsu siwo ŋu NF1 le la ate ŋu axɔ MPNST vie wu amesiwo si NF1 mele o.

Nukae nye MPNST ƒe dzesiwo?

MPNST ate ŋu adze le wò lãmeka siwo le gota gome ƒe afisiafi, gake zi geɖe la, wokpɔa ŋusẽ ɖe teƒewo abe wò abɔwo kple afɔwo ene dzi. Ɣeaɖewoɣi la, woate ŋu adze le teƒewo abe wò akɔta, akɔta, ƒodo, alo ta kple kɔ ene hã. MPNST ƒe dzesiwo dometɔ aɖewoe nye:

• Kpe si tsina blewu le ŋutigbalẽa te. Kpe siawo ate ŋu anɔ sue abe pea ene (anɔ abe sentimeta 2 ene) alo alolo abe aŋutiɖiɖi ene (anɔ abe sentimeta 10 ene).
• Vevesese ƒe seselelãme (vevietɔ ne NF1 le ŋuwò).
• Nuveviwɔame (Paresthesia).
• Gbɔdzɔgbɔdzɔ ƒe seselelãme le abɔwo kple afɔwo ŋu.

Nukawoe hea MPNST vɛ?

Numekukuwo ɖee fia be neurofibromatosis type 1 (NF1) gbɔe lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖiwo ƒe 50% tsona.Woyɔa nɔnɔmea be. Susu bubuwo ate ŋu anye:

• Kekeli ƒe atikewɔwɔ: Ame siwo ŋu MPNST le la dometɔ siwo ade 10% xɔ keklẽŋusẽ ƒe atikewɔwɔ na dɔléle bubuwo.
• Domenyiŋusẽfianu ƒe tɔtrɔ: Numekulawo kpɔe be domenyiŋusẽfianu ƒe tɔtrɔ vovovo geɖe li siwo nana lãmenugbagbevi siwo le lãmekawo me siwo sɔ la zua lãmenugbagbevi siwo mesɔ o, wodzina ɖe edzi, eye wowɔa dɔdzẽ.
• Ahɔhɔ̃mekawo ƒe dɔléle ƒomevi aɖewo: Amesiwo ŋu plexiform neurofibroma le la le afɔku me be woaxɔ MPNST.

Aleke wowɔna dea dzesi MPNST?

Ne èyi ɖɔkta gbɔ la, awɔ ŋutilãmedɔ gbã eye wòabia wò lãmesẽ bliboa ŋu nya. Esia alɔ biabia tso wò atikewɔwɔ ŋutinya, ƒomea ƒe atikewɔwɔ ŋutinya, kple dzesi ɖesiaɖe si nàte ŋu akpɔ ɖe eme ŋu. Tsɔ kpe ɖe eŋu la, woate ŋu awɔ nu siwo gbɔna:

• Nɔnɔmetatawo dodokpɔ: Ðɔktawo ate ŋu awɔ dodokpɔwo abe MRI (Magnetic Resonance Imaging) kple PET (Positron Emission Tomography) scans ene .
• Biopsy: Ðɔkta ate ŋu awɔ biopsy, axɔ lãmenugbagbeviwo ƒe kpɔɖeŋu eye wòana dɔléleŋutinunyala nadoe kpɔ le nusuekpɔmɔ̃ me .
• Domenyiŋusẽfianu dodokpɔ: Ne lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖi aɖe le ŋuwò la, wò ɖɔkta ate ŋu aɖo aɖaŋu be nàdo domenyiŋusẽfianu kpɔ akpɔe ɖa be neurofibromatosis type 1 (NF1) alo nerve sheath tumor ƒomevi bubu , neurofibromatosis type 2 (Schwannomatosis) , le ŋuwò alo wò ƒometɔ kplikplikpli aɖe ŋu hã.

Nukae nye atike siwo wozãna na MPNST?

Zi geɖe la, ɖɔktawo wɔa dɔ tsɔ ɖea lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖi aɖe ɖa. Gake nɔnɔme aɖewo li siwo me amekoko mate ŋu adzɔ o. Le kpɔɖeŋu me:

• Nuku gãwo (nuku siwo ƒe didime nye sentimeta 5 alo esi lolo wu).
• Dɔdzẽ siwo kaka ɖe teƒe bubuwo.
• Dɔdzẽ siwo te ɖe lãmeka siwo sesẽ ŋu ŋutɔ ate ŋu agblẽ le amekoko me.

Le nɔnɔme siawo me la, ɖɔktawo ate ŋu atsɔ amekoko, atikewɔmɔnu , alo keklẽŋusẽdɔdamɔnu vovovowo ada MPNST . Woate ŋu awɔ keklẽŋusẽdɔdamɔnu do ŋgɔ na amekoko alo le amekoko vɔ megbe.

Fifia numekulawo le ŋku lém ɖe eŋu nenye be woate ŋu azã dɔlélenutsiŋutete ƒe dɔdamɔnu alo atikewɔwɔ si woɖo taɖodzinu na abe atike yeyewo ene. Ne lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖi aɖe le ŋuwò la, àte ŋu adze na dɔdamɔnu dodokpɔ si ado atike yeyewo kpɔ.Anyo be nàƒo nu kple wò ɖɔkta tso gomekpɔkpɔ le eme ŋu.

Kuxi alo nugbegblẽ kawoe ate ŋu ado tso atikewɔwɔ me?

Kuxi siwo ate ŋu ado mo ɖa le amekoko me dometɔ aɖewoe nye:

• Alesi wowɔa nui ɖe atike si wua alɔ̃dɔdɔ ŋu.
• Ʋu si dona fũu akpa (ʋu si dona le ame ŋu).
• Vevesese.
• Amekoko ƒe abi siwo woxɔna.
• Amekoko ƒe abi ƒe dɔléle.

Atikewɔwɔ abe atikewɔmɔnu alo keklẽŋusẽdɔdamɔnu ene ate ŋu ahe nugbegblẽ le ame ŋu abe:

• Dɔmetɔtrɔ.
• Ɖeɖiteameŋu.
• Aɖuɖɔtoe kple ʋuʋudedi.

Nukae nye ŋgɔdonya na amesi ŋu MPNST le?

Nyagblɔɖi nye alesi wò atikewɔlawo susu be nànɔ ne èwu atikewɔwɔ nu. Le MPNST gome la, nu geɖee dea dzesi nyagblɔɖi sia:

• NF1 ƒe nɔnɔme: Ne dɔdzẽ siawo do mo ɖa le amesiwo ŋu NF1 le me la, nusiwo wogblɔ ɖi be woahaya ate ŋu aɖiɖi vie wu amesiwo ŋu NF1 mele o.
• Dɔdzẽ ƒe dzeside: Dɔléleŋutinunyalawo léa ŋku ɖe lãmenugbagbeviawo ŋu le nusuekpɔmɔ̃ me eye wobua dɔdzẽwo ɖe hatsotso si me tɔwo ƒe dzesi deŋgɔ alo esiwo mebɔ o me . Mɔnukpɔkpɔ geɖe wu li be kansa lãmenugbagbevi siwo mãna kabakaba ŋutɔ eye wokakana la nanɔ dɔdzẽ siwo ƒe nyonyome de ŋgɔ me.
• Dɔdzẽ ƒe lolome: MPNST dɔdzẽ ate ŋu alolo abe sentimeta 10 ene. Zi geɖe la, esesẽna be woaɖe dɔdzẽ gãwo ɖa to amekoko me.
• Dɔdzẽa kaka: Ne dɔdzẽa kaka ɖe teƒe bubuwo tso afisi wòdze egɔme tsoe la, ate ŋu asesẽ be woadae.

Abe alesi nàte ŋu akpɔe ene la, nu geɖe li siwo ate ŋu akpɔ ŋusẽ ɖe wò hayahaya ƒe mɔkpɔkpɔ dzi, eye ɖewohĩ menye nu siawo katãe aku ɖe ŋuwò o. Eyata anyo wu be nàbia wò ɖɔkta be wòagblɔ wò nɔnɔmea ŋuti nyatakaka siwo tututu. Esi wònya wò nɔnɔmea ta la, ate ŋu ana nyatakaka siwo nèhiã la wò.

Nukae nye agbetsitsi ƒe agbɔsɔsɔme na MPNST?

Wobu akɔnta le agbetsitsi ƒe agbɔsɔsɔme ŋu ɖe ame bubu siwo ŋu lãmeka siwo le gota ƒe dɔdzẽ vɔ̃ɖiwo le ƒe nuteƒekpɔkpɔwo dzi. Esi wònye be dɔdzẽ siawo mebɔ o ta la, esesẽna na eŋutinunyalawo be woagblɔ agbɔsɔsɔme si sɔ pɛpɛpɛ. Dukɔa ƒe Kansa Dɔwɔƒe (U.S.) gblɔ be amesiwo ŋu MPNST le ƒe 23% va ɖo 69% nɔa agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Ema nye range gã aɖe, alo? Eyata anyo wu be nàbia wò ɖɔkta tso wò nɔnɔmea ŋu.

Aleke malé be na ɖokuinye?

Ne dɔdzẽ vɔ̃ɖi aɖe le ŋuwò la, ke èle kansa si mebɔ o si ate ŋu atrɔ ava le atikewɔwɔ vɔ megbe la me tom. Ðoɖo vovovowo li siwo ate ŋu akpe ɖe ŋuwò le nɔnɔme sia me:

• Beléle na ame ƒe dziɖeɖi:Le dɔlélenutsiŋutete ƒe dɔlélenutsiŋutete me la, àwɔ dɔ kple ɖɔkta siwo wona hehee etɔxɛe ƒe ƒuƒoƒo aɖe si ate ŋu akpe ɖe ŋuwò nàkpɔ MPNST ƒe dzesiwo kple atikewɔwɔ ƒe nugbegblẽ le ame ŋu gbɔ. Gawu la, woana susuŋutinunya ƒe kpekpeɖeŋu hã wò.
• Kansa ƒe agbetsitsi ƒe ɖoɖowo: Kansa le abe mɔzɔzɔ ene. Kansa ƒe agbetsitsi ƒe ɖoɖowo fiaa mɔ wò tso gbesigbe wokpɔ dɔlélea le ŋuwò, to wò atikewɔwɔ me, kple nusi nàwɔ ne kansa la gatrɔ gbɔ.

Ne èkpɔe gbã la, dɔdzẽ vɔ̃ɖi si le wò alɔnu alo afɔ ŋu (MPNST) ate ŋu adze abe ƒunukpeƒetetedɔ si ate ŋu axɔ abi alo aƒo wò bɔbɔe ene. Ne èva nya be ƒunukpeƒea nye kansa ƒomevi aɖe si mebɔ o eye be ehiã be woawɔ dɔ nɛ la, ate ŋu awɔ nuku na ame. Ate ŋu asesẽ be nàxɔe.Ne nya aɖewo le asiwò ku ɖe wò nɔnɔmea alo nusi nàkpɔ mɔ na ŋu la, wò atikewɔlawo ƒe ƒuƒoƒoa se egɔme. Adzɔ dzi na wo be yewoadi ɣeyiɣi aɖo wò biabiawo ŋu ahakpɔ nusiwo ŋu nètsi dzi ɖo la gbɔ.

Gbedasi si woatsɔ ayi aƒemee tso nyati sia me

Enyo, eyata mele mɔ kpɔm be èse kansa ƒe nɔnɔme sia si mebɔ o si woyɔna be MPNST si ŋu míeƒo nu tsoe egbea gɔme vie. Ðo ŋku edzi be nɔnɔme sia nye esi mebɔ kura o. Ne ƒunukpeƒetetedɔ, vevesese, lãmetutudɔ, kple bubuawo le wò ŋutilã ŋu si mebɔ o si nɔa anyi ɖaa la, ke yi ɖɔkta gbɔ godoo eye nàxɔ aɖaŋuɖoɖo. Zi alesi wokpɔe kaba la, zi nenemae edada nɔa bɔbɔe.

Nu vevitɔ kekeakee nye be menye wò ɖeka koe le eme o. Wò atikewɔlawo ƒe ƒuƒoƒo, ƒometɔwo, kple xɔlɔ̃wo katã le afima be yewoakpe ɖe ŋuwò. Nu vevitɔe nye be nànɔ te sesĩe eye nàwɔ ɖe wò ɖɔkta ƒe aɖaŋuɖoɖo dzi.

` Malignant peripheral nerve sheath tumor, MPNST, lãmeka me kansa, tumor, kansa, neurofibromatosis, NF1, amekoko, keklẽŋusẽ ƒe atikewɔwɔ, atikewɔmɔnu