Ðe wò ƒumeŋuɖui mele dɔ wɔm nyuie oa? Mina míaƒo nu tso myelosuppression ŋu!

Ðe nèsena le ɖokuiwò me hã be ɖeko yeƒe lãme mesẽ o, yele dɔ lém ɣesiaɣi, alo ʋu le dodom le ye ŋu le lãɖeɖe sue aɖe gɔ̃ hã ta, eɖanye kansa alo dɔléle bubu aɖee le ye ŋu oa? Le nusiawo megbe la, ate ŋu anye be myelosuppression , si nye nɔnɔme si me ƒumeŋuɖui mewɔa dɔ nyuie o . Mègatsi dzi o, mina míaƒo nu tso esia ŋu bɔbɔe.

Nukae nye myelosuppression? Ne míagblɔe tututu la, ɖe wònye ƒumeŋuɖui ƒe gbɔdzɔgbɔdzɔa?

Kpuie ko la, ẽ! Ƒumeŋuɖui nye lãkusi falɛfalɛ si le abe ƒumeŋuɖui ene le wò ƒuwo me. Bu eŋu abe míaƒe ŋutilã ƒe ʋuwɔƒe ene . Dɔwɔƒe sia wɔa ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩ biliɔn geɖe, siwo le vevie na míaƒe agbetsitsi, eye wòtsɔa wo kpena ɖe míaƒe ʋu ŋu. Dɔ vovovoe lãmenugbagbevi ƒomevi ɖesiaɖe wɔna na míaƒe ŋutilã. Ƒumeŋuɖui dzia nuwɔwɔ sia ɖe edzi alo ɖea edzi le míaƒe ŋutilã ƒe nuhiahiãwo nu.

Fifia, le nɔnɔme aɖe si woyɔna be myelosuppression me la, ƒumeŋuɖuidɔwɔƒe sia ƒe dɔwɔwɔ me gblẽ le susu aɖewo ta. Ekema, womate ŋu awɔ ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo nyuie o. Nusi koŋ gbɔ esia tsoe nye atikewɔmɔnu zazã atsɔ ada kansa. Gake ʋumenugbagbeviɣidɔ ƒomevi aɖewo kple dɔlékui aɖewo hã ate ŋu ana ƒumeŋuɖui nawɔ dɔ nyuie.

Nukawoe nye myelosuppression ƒe dzesiwo?

Dzesiawo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ, le alesi wò ƒumeŋuɖui wɔa ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, alo ʋumenugbagbevi dzĩwo nu.

Ne ʋumenugbagbevi dzĩwo dzi ɖe kpɔtɔ - Ʋusɔgbɔdɔ

Ʋumenugbagbevi dzĩwo tsɔa ɔksidzin yia wò ŋutilã katã me. Ne womesɔ gbɔ o la , ʋusɔgbɔdɔ dzea ame dzi. Dzesiawo ate ŋu anye:

• Ɖeɖiteameŋu
• Yagbɔgbɔ kpui / gbɔgbɔtsixetsixe
• Taɖuame
• Dzi ƒe tsotso kabakaba alo esi mesɔ o / dzi ƒe tsotso ƒe dɔmawɔmawɔ nyuie
• Gbeɖiɖi si le ɖiɖim le to me ƒe seselelãme, si kpena ɖe gbeɖiɖi "thumping" kple dzi ƒe tsotso ŋu ɣeaɖewoɣi (Pulsatile tinnitus) .
• Taɖuame
• Ŋutilã ƒe amadede ƒe blɔ
• Akɔtave

Neutropenia - ʋumenugbagbevi ɣiwo (vevietɔ neutrophils) ƒe ɖiɖi .

Ʋumenugbagbevi ɣiwo wɔa avu kple dɔlékui siwo gena ɖe míaƒe ŋutilã me eye wokpɔa mía ta tso dɔlékuiwo xɔxɔ me . Woyɔa ʋumenugbagbevi ɣi ƒomevi ɖeka be neutrophils . Ne ƒumeŋuɖui mewɔa neutrophil ʋɛ aɖewo o le myelosuppression ta la, woyɔa nɔnɔmea be neutropenia . Dzesi aɖeke koŋ mele neuropenia ŋu o, ke boŋ le esia taDɔlékuiwo ate ŋu adze ame dzi enuenu, eye ɣemaɣie dzesiawo dzena.

• Asrã (si woyɔna ɣeaɖewoɣi be febrile neutropenia ) .
• Ðeɖiteameŋu
• Kɔmeve/dɔlékui (Kɔti me vevesese/aɖuɖɔtoedɔléle) .
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu
• Abi siwo le nu me alo ƒo xlã aɖuɖɔtoe
• Dɔmetɔtrɔ
• Dzobibi ne èle aɖuɖɔ tom, sese le ɖokuiwò me be ehiã be yeaɖe aɖuɖɔ kabakaba, aɖuɖɔtoe enuenu

Ne ʋumenugbagbevi dzĩwo dzi ɖe kpɔtɔ - Thrombocytopenia

Ʋumenugbagbeviɣidɔ kpena ɖe ame ŋu be wòaɖu ʋu si dona le ame ŋu dzi . Ne agbɔsɔsɔ siawo dzi ɖe kpɔtɔ la, nɔnɔme aɖe si woyɔna be ʋumenugbagbeviɣidɔ dzɔna. Esia ate ŋu ana:

• Ʋu si dona le ame ŋu si medzudzɔna ɣeyiɣi didi o, tso abi sue aɖe gɔ̃ hã gbɔ, alo esesẽna be wòatɔ te ʋu si dona le ŋɔti me.
• Abiwo dzena kabakaba wu alesi wònɔna ɖaa.
• Teƒe dzĩ suesuesuewo (abe ʋuʋudedi ene) ƒe dzedzeme le afɔ siwo le ete - woyɔa esia be petechiae .
• Teƒe dzĩ, aŋutiɖiɖi, alo aŋutiɖiɖi le ŋutigbalẽa ŋu - woyɔa esia be purpura .

Ne ʋumenugbagbevi ƒomeviwo katã dzi ɖe kpɔtɔ - Pancytopenia

Ɣeaɖewoɣi la, ʋumenugbagbevi etɔ̃ siawo katã—ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩwo—ate ŋu aɖiɖi le ɣeyiɣi ɖeka me . Woyɔa nɔnɔme sia be pancytopenia . Abe neutropenia ene la, esia menye dɔléle le eɖokui si o, gake ate ŋu anye atikewɔwɔ me nɔnɔme aɖe si gbɔ wòtso ƒe dzesi.

Nukatae myelosuppression dzɔna? Nukawoe gbɔ wòtsona?

Abe alesi míegblɔe va yi ene la, atikewɔmɔnue nye nusi gbɔ wòtsona wu . Ke hã, nu bubuwo hã li siwo gbɔ wòtsona.

Atikewɔwɔ, dɔlélenutsiŋutete ƒe atikewɔwɔ, kple myelosuppression

Atike ƒomevi geɖe siwo wozãna tsɔ daa dɔe ate ŋu ahe esia vɛ. Wo dometɔ aɖewo siwo bɔ wue nye:

• Fluorouracil ƒe dɔlékuiwutike
• Oxaliplatin ƒe atike
• Irinotecan ƒe atike
• Capecitabine ƒe atike

Tsɔ kpe ɖe eŋu la, CAR T-cell therapy, si nye dɔlélenutsiŋutete ƒe atikewɔwɔ ƒomevi aɖe , hã ate ŋu agblẽ nu le ƒumeŋuɖui ƒe dɔwɔwɔ ŋu eye wòaɖe ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe wɔwɔ dzi akpɔtɔ.

Ʋume Kansa Kple Lãmetsiŋusẽ ƒe Dɔléle

Ʋumenugbagbeviɣidɔ aɖewo hã ate ŋu ado kplamatse ʋumenugbagbeviɣidɔ si sɔ. Le kpɔɖeŋu me, le kansawo abe ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, kple myeloma , me la, kansadɔlékui siwo mesɔ o tsina akpa le ƒumeŋuɖui me eye wodzudzɔa ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo wɔwɔ.

Dɔlékuiwo kple myelosuppression

Dɔlékui aɖewo hã ate ŋu agblẽ ʋu ƒe wɔwɔme le ƒumeŋuɖui me. Tsɔe be ne dɔlékui aɖe ge ɖe ŋutilãa me la, míaƒe ŋutilã ƒe ametakpɔnu siwo nye ʋumenugbagbevi ɣiwo wɔa avu kple dɔlékuia. Le avuwɔwɔ sia me la, ƒumeŋuɖui ate ŋu awɔ ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ sue aɖe. Numekuku aɖewo ɖee fia be dɔlékui aɖewo xɔa ʋumenugbagbevi siwo le ƒumeŋuɖui me tẽ, si wɔnɛ be ʋumenugbagbeviwo ƒe xexlẽme dzi ɖena kpɔtɔna. Dɔlékui aɖewo siwo wokpɔ be wodo ƒome kple myelosuppression ƒe nɔnɔme siae nye:

• Epstein-Barr dɔlékui (EBV) .
• Aklãdɔlékui C ƒe dɔlékui
• Parvovirus B19 ƒe dɔlékui
• Dɔlékuiwutike si woyɔna be Cytomegalovirus (CMV) .
• Dɔlékui si hea koklozi vɛ (Koklozi / varicella zoster) .
• Amegbetɔ ƒe dɔlélenutsiŋutete ƒe dɔlékui (HIV) .
• Dengue ƒe dɔléle

Ðe myelosuppression ate ŋu ahe kuxi sesẽwo vɛa?

Ẽ, ɣeaɖewoɣi la, esia ate ŋu ahe kuxi siwo ate ŋu ade ame ƒe agbe afɔku me vɛ . Le kpɔɖeŋu me, ʋumenugbagbevi dzĩwo ƒe ɖiɖi kpata (ʋusɔgbɔdɔ sesẽ) alo ʋumenugbagbevi dzĩwo ƒe ɖiɖi (ʋu si dona le ame ŋu si dzi womate ŋu aɖu o) .

Vevietɔ: Ne èkpɔ dzesi siawo dometɔ aɖe, vevietɔ ne èle kansadɔ dam la, ele vevie ŋutɔ be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo enumake.

Aleke ɖɔktawo wɔa anya dɔléle sia pɛpɛpɛ?

Ʋudodokpɔ koŋ mee wokpɔa esia dzea sii . Ʋudodokpɔ siawo léa ŋku ɖe eŋu nenye be wò ƒumeŋuɖui le ʋumenugbagbeviwo kple ʋumenugbagbevi dzĩwo wɔm le mɔ si sɔ nu.

Woate ŋu awɔ ʋudodokpɔwo abe esiawo ene:

• Ʋu ƒe xexlẽme bliboa (CBC) .
• MCV dodokpɔ (Ŋutilã ƒe lolome le mama dedie nu / MCV dodokpɔ) .
• RDW dodokpɔ (Red cell mama ƒe kekeme / RDW dodokpɔ) .
• Reticulocyte ƒe xexlẽme
• Ʋu si wotsɔna ƒoa ʋu le gota gome
• MPV dodokpɔ (Ʋumenugbagbevi dzĩwo ƒe lolome le mama dedie nu / MPV dodokpɔ) .

Nukawoe nye atike siwo wozãna na myelosuppression?

Ðɔktawo tsɔa mɔnu siawo daa esia:

• Ne atikewɔmɔnue nye nusi gbɔ myelosuppression tsona la, ele be woaɖe atikewɔmɔnu ƒe agbɔsɔsɔme dzi akpɔtɔ alo adzudzɔe hena ɣeyiɣi aɖe .
• Ʋudodo be woatsɔ adzi ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ɖe edzi.
• Atike siwo kpena ɖe wò ƒumeŋuɖui ŋu be ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo nasɔ gbɔ la nana wò .

Ðe woate ŋu axe mɔ ɖe nɔnɔme sia nu be wòagadzɔ oa?

Zi geɖe la, myelosuppression dzɔna abe kansa dada ƒe nugbegblẽ le ame ŋu ene. Eyata ɖɔktawo nɔa ŋudzɔ ɣesiaɣi be yewoakpɔ nugbegblẽ le ame ŋu siawo le kansa dada me. Woalé ŋku ɖe wò ʋudodokpɔwo ŋu edziedzi eye woawɔ tɔtrɔ le wò atikewɔwɔ ƒe ɖoɖoa ŋu ne ehiã.

Nukae mate ŋu akpɔ mɔ na ne myelosuppression le ŋunye?

Ame geɖe xɔa nɔnɔme sia le esi wole atikewo zãm ta. Ne nenemae la, wò ɖɔkta alé ŋku ɖe alesi atikewɔmɔnua le ŋusẽ kpɔm ɖe wò ƒumeŋuɖui dzii ŋu nyuie . Ðewohĩ ahiã be nàgbɔ ɖe eme vie tso kansa dada me be wò ƒumeŋuɖui nagate ŋu atu eƒe ʋumenugbagbeviɣiwo ɖo.

Aleke malé be na ɖokuinye?

Myelosuppression ate ŋu ana dɔlékuiwo xɔxɔ kple ʋu nado le ŋuwò nadzi ɖe edzi . Àte ŋu awɔ nusiawo atsɔ aɖe afɔku sia dzi akpɔtɔ:

• Na atike siwo woatsɔ akpɔ wo ta tso dɔlékui siwo bɔ me.
• Dzadzɛnyenye ƒe nɔnɔme nyuiwo wɔwɔ , abe asikɔklɔ enuenu kple adzɔge tso ame siwo dze dɔ gbɔ ene.
• Takpɔ ɖokuiwò ta tso nɔnɔme siwo me nàte ŋu axɔ abi alo atso wò me . Le kpɔɖeŋu me, kpɔ nyuie ne èle aʋawɔnu ɖaɖɛwo zãm.

Nya kawoe wòle be mabia nye ɖɔkta?

Àte ŋu abia ɖɔktaa nyawo abe:

• Nukatae nye lãmekawo ƒe dɔwɔwɔ ƒe dɔléle sia le ŋunye?
• Aleke nɔnɔme sia kpɔa ŋusẽ ɖe nye ŋutilã dzii?
• Atikewɔwɔmɔnu kawoe le asinye?
• Ðe atikewɔwɔ ada nye myelosuppression keŋkeŋa?

Kpuie ko la: Nusiwo dzi wòle be woaɖo ŋkui (Take-Home Message) .

Wò ƒumeŋuɖui nye wò ŋutilã ƒe akpa vevi aɖe. Ʋumenugbagbevi dzĩ siwo tsɔa oxygen, ʋumenugbagbevi ɣi siwo wɔa avu kple dɔlékuiwo, ʋumenugbagbevi dzĩ siwo kpena ɖe wò ʋu ŋu be wòatsi – afimae wowɔ wo katã le. Myelosuppression nye ne wò ƒumeŋuɖui dzudzɔ dɔwɔwɔ le susu aɖe ta. Nusi gbɔ wòtsona wue nye atikewɔmɔnu na kansa, gake ate ŋu atso ʋu me kansa kple dɔlékui aɖewo hã gbɔ. Mega tsi dzi o. Ðɔktawo ake ɖe nusi gbɔ wòtso ŋu eye woawɔ atike nɛ ɖe edzi. Nu vevitɔe nye be nàdi atikewɔƒe ne dzesi aɖewo siwo mebɔ o le ŋuwò eye nàwɔ ɖe woƒe aɖaŋuɖoɖowo dzi nyuie. Menye wò ɖeka koe o, eye ɖɔkta aɖewo li siwo ate ŋu akpe ɖe ŋuwò le mɔzɔzɔ sia me.

` Myelosuppression, Ƒumeŋuɖui Suppression, Ƒumeŋuɖui, Ʋumenugbagbevi dzĩwo, Ʋumenugbagbeviɣiwo, Ʋumenugbagbevi dzĩwo, Chemotherapy, Kansa, Ʋusɔgbɔdɔ, Neutropenia, Thrombocytopenia, Dɔlékuiwo